Abstract: Provided herein is a class of a rapidly metabolized lipid compound, and particularly relates to compounds represented by formula (I), or pharmaceutically acceptable salts, isotopic variants, tautomers, or stereoisomers thereof. Also provided is a nanoparticle pharmaceutical composition comprising said compound, and the application of said compound and its composition in the delivery of nucleic acids.

Abstract: Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

Abstract: Systems and methods are described for hiding a primary user's sensitive information in collaborative virtual desktop sessions where multiple secondary users access the primary user's virtual desktop. In particular, embodiments described herein leverage a mechanism for monitoring when designated sensitive applications are opened in the virtual desktop. After the primary user sets up a collaborative session on their virtual desktop, if a sensitive application opens in the virtual desktop during the collaborative session, the sharing of the desktop graphical user interface (GUI) can be stopped and the user can be prompted (e.g., via a warning dialog that pops up) to choose how to proceed. For example, the user can choose to hide the entire desktop, to minimize or close the sensitive application, or to continue sharing the desktop but pop-out the sensitive application from the remote desktop in a separate window that is not shared with the collaborators.

Abstract: Provided are a signal transmission method and apparatus, a device, and a computer storage medium. A method for sending a measurement reference signal includes: determining parameter information of the measurement reference signal according to received signaling information and/or a pre-negotiated parameter determination rule; and sending the measurement reference signal according to the determined parameter information.

Abstract: In accordance with an embodiment, an earphone includes: a housing having a cavity structure disposed within, and a sound output port in communication with the cavity structure; and a first sound transducer, a second sound transducer, and a third sound transducer disposed in the cavity structure, wherein: a sound production frequency of the second sound transducer is greater than a sound production frequency of the third sound transducer and is less than a sound production frequency of the first sound transducer, and the third sound transducer is a micro-electro-mechanical-system located between the first sound transducer and the sound output port.

Abstract: Described herein are systems, methods, and instrumentalities associated with automatic determination of hemodynamic characteristics. An apparatus as described may implement a first artificial neural network (ANN) and a second ANN. The first ANN may model a mapping from a set of 3D points associated with one or more blood vessels to a set of hemodynamic characteristics of the one or more blood vessels, while the second ANN may generate, based on a geometric relationship of the set of points in a 3D space, parameters for controlling the mapping. The apparatus may obtain a 3D anatomical model representing at least one blood vessel of a patient based on one or more medical images of the patient, and determine, based on the first ANN and the second ANN, a hemodynamic characteristic of the at least one blood vessel of the patient at a target location of the 3D anatomical model.

Abstract: Disclosed herein are deep-learning based systems, methods, and instrumentalities for medical decision-making. A system as described herein may implement an artificial neural network (ANN) that may include multiple encoder neural networks and a decoder neural network. The multiple encoder neural networks may be configured to receive multiple types of patient data (e.g., text and image based patient data) and generate respective encoded representations of the patient data. The decoder neural network (e.g., a transformer decoder) may be configured to receive the encoded representations and generate a medical decision, a medical summary, or a medical questionnaire based on the encoded representations. In examples, the decoder neural network may be configured to implement a large language model (LLM) that may be pre-trained for performing the aforementioned tasks.

Abstract: A cooling apparatus is provided. An external cooling fluid flows into an external inlet opening from an external inlet pipe and passes through a heat exchanger to flow out of an external outlet opening to an external outlet pipe. An internal cooling fluid flows into an internal inlet pipe from the server and flows into an internal inlet opening from the internal inlet pipe and passes through the heat exchanger for heat exchange with the external cooling fluid to flow out of an internal outlet opening to an internal outlet pipe. A hot-swap pump has a pump main body, an inlet anti-leakage pipe, an outlet anti-leakage pipe and a hot-swap connector. The inlet anti-leakage pipe includes an inlet connector and an inlet anti-leakage valve. The outlet anti-leakage pipe includes an outlet connector and an outlet anti-leakage valve. The hot-swap connector is electrically connected to the pump main body.

Abstract: The optical lenses include a first lenses part including a first lens and a second lenses part including a second lens. The second lens and the first lens constitute an imageable optical system. A first adhesive material is located in a first gap between the first and second lenses parts, the first adhesive material supporting and fixing the first and second lenses parts. The first lenses part has a first bottom surface, and the second lenses part has a second top surface. An adhesive applying area for arranging the first adhesive material is provided on the first bottom surface and/or the second top surface. A first adhesive blocking portion is provided on the first bottom surface and/or a third adhesive blocking portion is provided on the second top surface.

Abstract: A gamepad and a joystick feedback force device therefor are disclosed. The joystick feedback force device comprises a joystick that is configured to accept a user's operation and is rotatably installed in a casing of the gamepad. The joystick feedback force device further comprises a torque output device, and an output shaft of the torque output device is connected with a rotating shaft of the joystick, so that a torque is applied to the rotating shaft to form a feedback force to the joystick.

Abstract: The invention discloses a filter device. The filter device comprises a substrate, at least one transmission conductor, and a reference conductor having a slotted structure. The substrate is provided at a first surface thereof with the transmission conductor, and provided at a second surface thereof with the reference conductor. The slotted structure comprises a frame portion, a slotted portion, and a hollow portion. The slotted portion surrounds the frame portion, and the hollow portion is formed in the frame portion. At least one impedance unit is configured on the frame portion. The equivalent filter circuit of the filter device is formed between the transmission conductor, the slotted structure, the reference conductor, and the impedance unit. Thereby, the equivalent filter circuit absorbs at least one noise at at least one specific frequency by the impedance unit to avoid the noise reflected to affect the transmission quality of signal.

Abstract: The present disclosure provides a storage control method, including: sending a command acquisition request for at least one first queue, where the at least one first queue is a queue among a plurality of queues which accumulates at least one queue request message, and a command acquisition request for each first queue of the at least one first queue corresponds to all accumulated queue request messages of the first queue; and receiving a storage command for each first queue in the at least one first queue.

Abstract: The present disclosure provides a magnetic nano-drug with double targeting vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor (VEGFR), and a preparation method and application thereof, and belongs to the technical field of biomedicine. The magnetic nano-drug of the present disclosure includes aminated ZnFe2O4 hollow porous magnetic nano-particles, lactate dehydrogenase-silk fibroin (LDH-SF), ethylene dichloride (EDC), and n-hydroxy succinimide (NHS). A mass ratio of the aminated ZnFe2O4 hollow porous magnetic nano-particles to the EDC to the NHS to the LDH-SF is (5-10):(1-5):(1-6):(1-8). The magnetic nano-drug according to the present disclosure can position a VEGF ligand through magnetic targeting of hollow zinc ferrite particles, use magnetic particles to regulate reprogramming of macrophages in an intervertebral disc so as to indirectly regulate down-regulation of the VEGF, and inhibit angiogenesis.

Abstract: A method for preparing nanomaterial macroscopic composites through substrate heating and solvent evaporation is provided, and the method includes setting a substrate, and preparing a reaction precursor solution required for the synthesis of nanomaterials; evenly dropping a small volume of the precursor solution on/in the substrate; performing a heating method to make the substrate generate a heat and transferring the heat to the precursor solution on/in the substrate; after a period of time, terminating the heating of the substrate to finish the synthesis, removing and cleaning the substrate, thus obtaining corresponding nanomaterial macroscopic composites.

Abstract: The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-12 or IL-18.

Abstract: A method for maintaining lamellar structure of cell, configured to manufacture a lamellar cell product, comprises the following steps of: seeding a predetermined number of cells in a culture device containing a first culture medium and culturing the predetermined number of cells for a predetermined time to form a cell planar structure; placing a mold in the culture device to cover at least an outer portion of the cell planar structure; adding a gel into the culture device with the mold to envelop the cell planar structure; and separating the gel and the cell planar structure enveloped therein from the culture device and the mold to form the lamellar cell product.

Abstract: A nano-delivery carrier for targeted tumor administration and an application thereof are provided, which relate to the technical field of targeted anti-tumor dugs. A preparation method of the nano-delivery carrier for targeted tumor administration includes: mixing a NucA targeting a tumor and DSPE-PEG2000-NHS with DMF to obtain a mixture, adding triethylamine into the mixture, adjusting a pH of the mixture added with the triethylamine to 8-9 to react at room temperature, to thereby obtain the nano-delivery carrier for targeted tumor administration. An anti-tumor drug based on the nano-delivery carrier can correctly target to the tumor to be killed, for example, an anti-tumor drug based on the nano-delivery carrier and including RVT can target and kill ovarian cancer cells without damaging normal tissues.

Abstract: The present invention provides alkaline phosphatase enzyme peptides, particularly microbial alkaline phosphatase enzyme peptides, that are mutant peptides altered in sequence and having increased heat tolerance while retaining enzymatic activity, and their use and application including in animal feed and for beneficial health and growth effects in animals.

Abstract: A manufacturing method of a resin composition includes the following steps. An inorganic filler, a first solvent, and a dispersant are mixed, wherein a material of the dispersant is silane and/or polysiloxane including an organic-philic end and an inorganic-philic end, and the dispersant and the inorganic filler undergo a dealcoholization condensation reaction reaction to form a dispersion including a modified inorganic filler. The organic-philic end includes a carbonyl group, an epoxy group, and/or an amine group. Epoxy resin is dissolved into the dispersion.

Abstract: An oscillator device includes a current generating circuit, a current source and an oscillator circuit. The current generating circuit generates first, second, third and fourth currents. The current source generates a first reference current according to the first current and the second current and a second reference current according to the third current and the fourth current. The oscillator circuit receives the first reference current and the second reference current and generates an oscillating signal. The temperature coefficient of the oscillator circuit is compensated for by the first reference current and the second reference current. At least two of the first current, the second current, the third current and the fourth current are different. The first reference current is different from the second reference current.