Abstract: This invention relates to the production of dual models of Congenital Heart Defects and Hypertrophic Cardiomyopathy with the use of mice which are genetically modified by transgenic (gene-knockout) techniques. The present invention produces knockout mice that show multiple cardiovascular malformations which will serve as a model of cardiovascular diseases for the screening of potential drugs against ventricular remodeling, malignant arrhythmias, primary pulmonary hypertension, and degenerative valvular diseases, and congenital heart disease.

Abstract: An audio device includes an internal sound producer, an earphone jack, a detection circuit, a volume adjustor, and an amplifier. The detection circuit detects a connection between the earphone jack and an external sound producer, generates a first state signal when the connection is established, generates a second state signal when no connection is established. The volume adjustor is preset with first predetermined volume levels and second predetermined volume levels, generates first adjustment signals based on the first predetermined volume levels in response to the first state signal, and generates a second adjustment signal based on the second predetermined volume levels in response to the second state signal. The amplifier amplifies audio signals and adjusts the volume of the amplified audio signals according to the adjustment signals, then sends the amplified audio signals to the internal sound producer and earphone jack.

Abstract: An audio device includes a jack, a switch, an amplifier, an internal sound producer, and a determining circuit. The jack establishes a connection with an external sound producer. The switch is in an opened state when the connection is established, and in a closed state when the connection is open. The amplifier amplifies audio signals to amplified audio signals and sends the amplified audio signals to the switch. The determining circuit receives the amplified audio signals from the switch, and generates a high voltage to control the amplifier not to output the amplified audio signals to the internal sound producer when the switch is in the closed state, and generates a low voltage to control the amplifier to output the amplified audio signals to the internal sound producer. The determined circuit further filters out the amplified audio signals when the switch is in the opened state.

Abstract: Seismic data are processed to reduce or eliminate aliasing due, for example to sparse or irregular sampling. An iterative method includes an inhibiting function used in conjunction with a function evaluating a magnitude of Fourier coefficients that together act to reduce the effects of aliased energies and preferentially select true energies. Computational steps are conducted primarily in k-space, without returning to x-space, thereby reducing computational costs.

Abstract: A television includes a display unit, a speaker, a first function module and a second function module. The first function module is electrically connected with the display unit and the speaker is configured for receiving and reproducing broadcast television signals. The second function module is electrically connected with the display unit and the speaker is configured for processing files stored in the television, the second function module includes a memory, a playing unit, and a loading module. The memory provided stores the files. The playing unit electrically connected with the memory plays the files stored in the memory. The loading module electrically connected with the memory loads the files in a periphery device which communicates with the television and transmits the loaded files to the memory.

Abstract: A supporting structure is applied to a backlight module including several optical sheets. The supporting structure includes a fixing component and a supporting component. The fixing component has a through-hole and an opening connected to each other. The supporting component includes a supporting pin, a block, a plate and a protrusion. The supporting pin has a top end for supporting the optical sheets and a bottom end at which the block is disposed. The plate is disposed on the supporting pin. The protrusion is disposed on the plate and faces the bottom end. After the block goes through the through-hole and rotates an angle, the plate and the block respectively press against upper and lower surfaces of the fixing component for clamping the fixing component. The protrusion is engaged in the opening for positioning the supporting component, so that the supporting component is fixed onto the fixing component.

Abstract: A system design for a digital electronic sign board comprises a main circuit module, an adapter module and a computer module; wherein the adapter module is fixed between the main circuit module and the computer module. The main circuit module and the adapter module are fixed in the digital electronic sign board. The computer module is externally inserted into the digital electronic sign board. Therefore the computer module and the main circuit module are electrically connected through the adapter module. The system design of the present invention removable and attached the computer module with the main circuit module. As a result, when a maintenance worker needs to perform maintenance on the computer module, he or she can conveniently pull out the computer module from the digital electronic sign board and insert the computer module back to the digital electronic sign board after maintenance is done so as to improve the efficiency and quality of maintenance.

Abstract: A wireless communication system utilizes a protocol for creating a multi-to-multi point, extendable, ad-hoc wireless network. A hardware platform enables an electronic device to connect in an ad-hoc network. Accordingly, each electronic device with such a hardware platform of a plurality of such electronic devices functions as node in a network. The nodes function according to the protocol for form ad-hoc networks and to communicate data therebetween.

Abstract: Efficient chemical processes for preparing high yields, purities, and different polymorphic forms of 17-allyl amino geldanamycin (17-AAG) and other ansamycins are described and claimed.

Abstract: A torsion sensor using an optical waveguide in optical communication with a diffraction grating, preferably a tilted grating, and most preferably a tilted Bragg grating, which provides the optical waveguide and grating with a torsion-dependent collective optical transmission spectrum. Changes in the collective optical transmission spectrum of the waveguide and grating, induced by changes in the amount of torsion applied to the waveguide, may be detected by detecting a corresponding change in the intensity of optical radiation transmitted through the grating from a controlled optical source. The degree of change in the collective optical transmission spectrum is dependent upon the degree of torsion (twist) applied to the optical waveguide. Measuring the magnitude and/or sense (i.e. increase/decrease) in the intensity of optical radiation transmitted through the grating from an optical source enables torsion to be sensed.

Abstract: A heat dissipation system for digital electronic signboard includes a first heat dissipation subsystem disposed in a main circuit board area of a digital electronic signboard, and a second heat dissipation subsystem disposed in a computer mainboard area of the digital electronic signboard. The main circuit board area has a plurality of heat dissipation fans disposed therein, wherein one heat dissipation fan is disposed at a side of the main circuit board area, while another heat dissipation fan is disposed at a side of a power supply and can be externally connected to an air guide pipe. The computer mainboard area can also have a plurality of heat dissipation fans disposed therein, wherein one heat dissipation fan is disposed at a side of the computer mainboard, while another heat dissipation fan is disposed on the top of a microprocessor of the computer mainboard.

Abstract: A heat dissipation system for digital electronic signboard includes a first heat dissipation subsystem disposed in a main circuit board area of a digital electronic signboard, and a second heat dissipation subsystem disposed in a computer mainboard area of the digital electronic signboard. The main circuit board area has a plurality of heat dissipation fans disposed therein, wherein one heat dissipation fan is disposed at a side of the main circuit board area, while another heat dissipation fan is disposed at a side of a power supply and can be externally connected to an air guide pipe. The computer mainboard area can also have a plurality of heat dissipation fans disposed therein, wherein one heat dissipation fan is disposed at a side of the computer mainboard, while another heat dissipation fan is disposed on the top of a microprocessor of the computer mainboard.

Abstract: The invention provides a computer module replacement design of a digital signage. The digital signage has a main circuit board and a plug-board disposed therein and connected to each other. The plug-board has a plug-card with a plug-slot, and a track disposed on each side thereof. The digital signage is covered up by a back cover so that an opening can be formed at one side edge of the digital signage. The computer module has a frame and a motherboard. The frame has a rail disposed on each side thereof and the motherboard has a slot and a connecting terminal disposed thereon. The slot has an interface socket card. The computer module can be placed into the digital signage through the opening with the rail placed into the track. Therefore, the connecting terminal is connected to the plug-slot and the computer module can be drawn out for maintenance.

Abstract: An audio apparatus includes an input, a first resistor, a first capacitor, an amplifier, a second resistor, a second capacitor, and an output. The input is used for inputting audio signals. The first resistor and the amplifier are serially connected to the input; wherein the first resistor is connected to the inverting input of the amplifier and the non-inverting input of the amplifier is connected to ground. The first capacitor has one end connected to a node between the first resistor and the inverting input of the amplifier, the other end connected to ground. The second resistor has one end connected to a node between the first resistor and the inverting input of the amplifier, the other end connected to the output of the amplifier. The second capacitor is connected between the inverting input and the output of the amplifier. The output is connected to the output of the amplifier, for outputting the audio signals after processing.

Abstract: 4b,5,6,7,8,8a-cis-hexahydro-2-hydroxy-4b,8,8a-trimethylphenanthren-9,10-dione (OHCT) is a fully oxidized compound based on the 2-hydroxy-cis-terpenone (HCT). Because OHCT is fully oxidized, it is more stable and less likely to damage cells or cell constituents such as DNA. OHCT has antimalarial activity, noncompetitive inhibitory activity against carcinogenic conversion of aflotoxin B1 (AFB1) to exo-AFB1-epoxide thus inihibiting AFB1 induced cellular toxicity, and inhibitory activity against TCDD induced cellular toxicity.

Abstract: The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase.

Abstract: Methods are provided for marking products with unique identification codes, associating times with at least some of the unique identification codes, and associating other times with certain events pertaining to the production of the marked products. These times can be used to subsequently determine whether a marked product belongs to a population that was produced before or after an event.

Abstract: A solid unit oral pharmaceutical dosage form of saquinavir mesylate is provided comprising micronized saquinavir mesylate in an amount of from 250 mg to 800 mg calculated as free base, and a pharmaceutically acceptable binder, disintegrant, and water soluble carrier. A solid unit dosage form of saquinavir mesylate is provided comprising from 60% to 80% micronized saquinavir mesylate based on the mesylate salt, 4% to 8% water soluble binder, a disintegrant and a carrier, wherein each percentage is of the kernel weight.

Abstract: A bus arbitration device includes a top arbiter, and the hierarchical bus arbitration device also includes a first arbiter. The said first arbiter arbitrates the first kind of requests, wherein the first kind of requests relates to the first kind of master units. The said second arbiter arbitrates the second kind of requests different from the first kind of requests, wherein the second kind of requests relates to the second kind of master units different from the first kind of master units. Wherein the said first arbiter and the said second arbiter are downward respectively from the top arbiter to form the hierarchical bus arbitration structure. Bus arbitration efficiency increases by this bus arbitration device.

Abstract: Ligand binding assays as applied to HSP90s as receptors or ligands, and reagents useful therefore, are described and claimed, as are methods of assaying for HSP90 modulators and methods of using the resulting products identified thereby.