Abstract: The present invention provides compounds of Formula (I) or (II), pharmaceutical compositions thereof, and methods of using compounds of Formula (I) or (II) to prevent and/or treat immune-related disorders.

Abstract: The present disclosure relates to the field of biotechnology, and in particular to an application of inhibitors targeting CD226 molecules in anti-tumor metastasis. In view of the important role of platelets in mediating tumor metastasis, the present disclosure develops small-molecule inhibitors with blocking effects by targeting CD226 molecules, an important target. It can destroy the interaction between platelets and tumor cells, and inhibit the metastasis of tumor cells, and it is important for research and development of new methods to control tumor metastasis.

Abstract: The display substrate of the present disclosure includes: a substrate having a display side and a back side opposite to each other; a display structure on the display side of the substrate, the display structure including a positive voltage interface for supplying a positive voltage and a plurality of pixel circuits, each pixel circuit including a plurality of transistors; a shielding structure between the substrate and the display structure, the shielding structure being made of a conductive material and electrically coupled to the positive voltage interface; wherein an orthographic projection of active regions of at least a portion of the transistors on the substrate coincides with an orthographic projection of the shielding structure on the substrate; and an insulating isolation layer between the shielding structure and the display structure.

Abstract: A display panel and a display device are provided. The display panel includes: a base substrate including a display region and a peripheral region; a pixel defining layer having a first part located in the display region and a second part located in the peripheral region, the second part and the first part being formed as an integral structure; and a spacer layer arranged on a side of the pixel defining layer away from the base substrate. The spacer layer includes a first spacer repetitive unit located in the display region and a second spacer repetitive unit located in the peripheral region. An orthographic projection of the second spacer repetitive unit on the base substrate falls within that of the second part on the base substrate and is located on a side, facing the display region, of a boundary, which is away from the display region, of the second part.

Abstract: A 3D memory device includes a complementary metal-oxide-semiconductor (CMOS) structure having a page buffer region and a string driver region respectively corresponding to a cell region and a string region in an array structure, wherein the CMOS structure further includes a plurality of page buffers in a folded structure formed in the page buffer region; and string driver circuits formed in the string region.

Abstract: A method for forming a 3D memory device includes forming an array wafer based on a first substrate having at least one cell region for forming a plurality of memory cells and at least one string structure region for forming a string structure; forming a first complementary metal-oxide-semiconductor (CMOS) wafer based on a second substrate having at least one string driver region corresponding to the at least one string structure region, and at least one page buffer high-voltage (HV) circuit region corresponding to the at least one cell region; forming a second CMOS wafer based on a third substrate having at least one page buffer region corresponding to the at least one cell region; and forming the 3D memory device based on the array wafer, the first CMOS wafer, and the second CMOS wafer stacked together.

Abstract: Systems, methods, apparatuses, and computer program products for channel occupancy time (COT) sharing for sidelink (SL) in unlicensed spectrum are provided. One method may include, upon acquiring a COT, an initiating user equipment (UE) transmitting a first indication to one or more responding UEs. The first indication may include at least a duration of the channel occupancy time (COT) and/or configuration information for at least one second indication. The method may also include transmitting the at least one second indication to the one or more responding UEs prior to a SL transmission from the one or more responding UEs. The at least one second indication may include an indication of a listen before talk (LBT) type that the one or more responding UEs should apply for the SL transmission taking place within the COT duration and/or an indication of a new COT duration.

Abstract: Disclosed in the present text are a magnetic shielding structure for wireless charging and a manufacturing method therefor, which belong to the technical field of wireless charging. The magnetic shielding structure comprises: a plurality of nanocrystalline units and a heat conduction unit, wherein the heat conduction unit is arranged between the nanocrystalline units, and is used for connecting the nanocrystalline units and conducting heat; and each nanocrystalline unit comprises a multilayer nanocrystalline material. Provided in the application are a magnetic shielding structure and a manufacturing method therefor, which magnetic shielding structure has a relatively small eddy-current loss, a good heat dissipation performance and insulation performance, high flexibility and reliability, and a small volume and a light weight, and is suitable for high-power wireless charging.

Abstract: A method and a device used in wireless communication nodes are disclosed. A first receiver receiving a first signal, and a first transmitter sending a first bit block and a second bit block in a first PUCCH. The resources occupied by the first PUCCH belong to a first resource set, the first resource set belongs to a first resource pool, the first resource pool includes multiple resource sets, and the first signal is used to determine the first resource set from the first resource pool. A first value is equal to a sum of a number of bits included in the first bit block and the number of bits included in the second bit block, a second value is linearly related to the number of bits included in the first bit block or the second bit block, and the second value is not equal to the first value.

Abstract: Methods, systems, and devices for wireless communications are described. Some wireless communications systems may support coexistence of broadcast communication protocols. In such cases, a first network node, such as a network entity, may broadcast a cell acquisition subframe (CAS) in accordance with a first broadcast communication protocol whose frequency resources overlap with frequency resources allocated in accordance with a second broadcast communication protocol. The CAS may indicate a modification to transmission of one or more subsequent CASs in accordance with the first broadcast communication protocol. For example, the modification may be a muting pattern, an updated periodicity, or both.

Abstract: A reciprocating stimulation device includes a handle portion, a stimulation body disposed over the handle portion and including a stimulation component arranged at a tip thereof, a first drive assembly having a first motor configured to drive the stimulation body in a reciprocating motion, and a second drive assembly having a second motor configured to drive the stimulation component in a thrusting motion.

Abstract: The present disclosure relates to a nonwoven substrate having a top surface and an opposite bottom surface comprising: an upper layer forming the top surface of the nonwoven substrate, the upper layer comprising hydrophobic fibers, and a lower layer forming the bottom surface of the nonwoven substrate, the lower layer comprising hydrophilic fibers, wherein the top surface of the nonwoven substrate has a first contact angle of no lower than about 90 degrees as measured according to Contact Angle Test, wherein the bottom surface of the nonwoven substrate has a second contact angle of lower than about 90 degrees as measured according to Contact Angle Test, wherein the nonwoven has a unitary structure, and wherein the upper layer has a thickness no greater than about 1400 ?m as measured according to the Thickness Test.

Abstract: The present invention is in the field of antiperspirant compositions, in particular, compositions comprising antiperspirant actives. Disclosed is an antiperspirant composition comprising (i) at least one hydrophobic sorbitan ester having HLB value between 1 and 7.0; (ii) at least one hydrophilic sorbitan ester having HLB value between 7.0 and 20; (iii) at least one organic compound selected from C7-C24 fatty acid, or C7-C24 fatty alcohol; and (iv) a cosmetically acceptable carrier; wherein said composition comprises less than 50% of water; wherein said composition comprises at least 2% said hydrophobic sorbitan ester by weight of the composition; wherein the weight ratio of organic compound to the combination of the hydrophobic sorbitan ester and the hydrophilic sorbitan ester is from 1:10 to 5:1; wherein the composition is free from antiperspirant active which comprises aluminium or zirconium.

Abstract: The present disclosure relates to a nonwoven substrate having a top surface and an opposite bottom surface, and comprising a plurality of apertures, wherein the top surface has a first contact angle of no lower than about 90 degrees as measured according to Contact Angle Test, wherein the bottom surface has a second contact angle of lower than about 90 degrees as measured according to Contact Angle Test, and wherein the plurality of apertures comprise at least one aperture having at least three adjacent apertures that are spaced apart from by an edge-to-edge space no greater than about 2.5 mm. Also disclosed herein is an absorbent article having a topsheet comprising the nonwoven substrate.

Abstract: A safety injector includes: an injection module having an injection cylinder and a pullable piston rod; a needle module including a needle seat and an injection needle; the needle seat having a seat body and a buckle. In installation state, a safety sleeve covering movably around the injection cylinder between an installation position and a protection position. In the installing position, a first end portion of the safety sleeve is near the buckle and the second end portion thereof is near the handhold portion; while in the protection position, the first end portion is protruded from the injection cylinder for covering the injection needle and the second end portion is near the head portion of the injection cylinder. An inner side of the sleeve body is formed with a first and a second annular flange; and an annular groove is formed therebetween for confining the buckle.

Abstract: The present disclosure provides an absorbent article comprising a liquid permeable topsheet comprising a wearer facing surface and an opposite garment facing surface and a nonwoven, the nonwoven comprising a plurality of apertures, a liquid impermeable backsheet, an absorbent core disposed between the topsheet and the backsheet; and a fluid management layer disposed between the topsheet and the absorbent core, the fluid management layer comprising a spacer woven fabric, wherein the nonwoven comprises a first surface forming the wearer facing surface of the topsheet, and a second surface forming the garment facing surface of the topsheet, the first surface having a first contact angle of no lower than about 90 degrees, and wherein the spacer woven fabric comprises a top face, a bottom face, and a plurality of yarns interconnecting the first and second faces, wherein the first and second faces are spaced apart from each other.

Abstract: A method for assisting a patient in weaning from a therapy, the method being executed by a controller, and the controller being configurable with different at least one weaning strategy. The method includes setting, based on at least one input by a user, a target weaning strategy among the at least one weaning strategy, where the at least one input corresponds to a clinical decision determined by the user.

Abstract: Tropomyosin-related kinase inhibitors (Trk inhibitors) are small molecule compounds useful in the treatment of disease. Trk inhibitors can be used as pharmaceutical agents and in pharmaceutical compositions. Trk inhibitors are useful in the treatment of inflammatory diseases, autoimmune disease, defects of bone metabolism and/or cancer, and are particularly useful in the treatment of osteoarthritis (OA), pain, and pain associated with OA. Trk inhibitors are also useful for inhibiting tropomyosin-related kinase A (TrkA), tropomyosin-related kinase B (TrkB), tropomyosin-related kinase C (TrkC), and/or c-FMS (the cellular receptor for colony stimulating factor-1 (CSF-1)).

Abstract: A ventilation and noise reduction housing and assembly, a ventilation and moisture retention apparatus, a breathing mask assembly and a breathing support device are provided. The ventilation and noise reduction housing includes a respiratory passage segment, one end thereof is a ventilation and noise reduction housing connection end, and the other end thereof is a respiratory tube communication end. The wall of the respiratory passage segment includes a mounting wall segment, that is provided with exhaust vents and a supporting protrusion structure protruding from the outer surface of the mounting wall segment, the supporting protrusion structure is used for supporting a ventilation and noise reduction core of a ventilation and noise reduction unit provided on the mounting wall segment, such that a ventilation gap is at least partially maintained between the ventilation and noise reduction core and the outer surface of the mounting wall segment.

Abstract: A method for spraying Robinia pseudoacacia on exposed shale wall to efficiently and rapidly restore green and improve soil pH value is provided. External-soil spray seeding is used to spray mixed microorganisms, organic fertilizer, and soil on exposed shale walls with a green plant of Robinia pseudoacacia to efficiently and rapidly restore green and improve soil pH value. The mixed microorganisms include Kocuria sp. X-22, Microbacterium sp. X-26, Bacillus sp. X-28 and Microbacterium sp. X-18, and the mixed microorganisms are added to organic fertilizer and soil by fermentation broth. The weight ratio of mixed microorganisms, organic fertilizer and soil is 1:1:8. The method can promote the rapid growth of Robinia pseudoacacia on the exposed shale wall and significantly increase organic matter content, effective phosphorus content, and pH value of the Robinia pseudoacacia soil.