Abstract: The present disclosure provides JAK inhibitor analogs, and compositions and methods thereof for treating diseases or disorders (e.g., inflammatory bowel disease and ulcerative colitis).

Abstract: The present invention relates to compounds of formula (I), wherein R1 to R7, A1 and A2 are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Abstract: Provided herein are mutant CD24 proteins, RNAs, compositions thereof, and the use of the proteins and compositions in cancer therapy and as vaccines for cancer prophylaxis.

Abstract: The present invention is directed to novel compounds that inhibit Nav1.8 sodium channels, methods of making, and methods of using thereof. The present disclosure is further directed to administering the disclosed compounds as therapeutic solutions for chronic pain, primary pain, idiopathic pain, gastrointestinal pain, neuropathic pain, musculoskeletal pain, acute pain, inflammatory pain, cancer-related pain, idiopathic pain, postoperative pain, visceral pain, multiple sclerosis, Summer-Marr-Tuff syndrome, incontinence, pathological cough, or arrhythmia to a subject in need thereof.

Abstract: A method is described for automatically detecting shear-wave (S-wave) microseismic reflections using distributed acoustic sensing (DAS). The method includes obtaining raw DAS data; performing passive seismic event detection and phase picking; extracting a passive seismic event based on the passive seismic event phase picks to generate a seismic S-wave event gather; reducing noise in the raw DAS data; using the passive seismic S-wave event gather and the passive seismic event phases to identify an apex of a passive seismic S-wave event in the denoised DAS dataset and dividing it into two portions based on the apex; dip filtering the two portions to remove the direct arrival of the passive seismic S-wave events to generate a dip-filtered gather; and generating an S-wave microseismic reflection gather based on the dip-filtered gather.

Abstract: A dynamic-balance test method for a rigid rotor includes: acquiring a counterweight influence coefficient library, initial vibration swing data and an initial vibration vector; determining an initial test weight mass and an initial test weight phase according to the initial vibration swing data and the counterweight influence coefficient library, and triggering a speed increase test according to the initial test weight mass and the initial test weight phase to obtain a target vibration vector; determining a target configuration influence coefficient according to the initial vibration vector, the target vibration vector and the initial test weight mass; calculating a residual vibration swing value; and determining a target test weight adjustment scheme according to the residual vibration swing value, a rotor operation vibration standard, a target test weight mass and a target test weight phase.

Abstract: A rapid assembly and automatic sampling drilling tool for frozen soil layer exploration includes a fixed flow divider, a flow guide pipe, a coring pipe and a drill bit. The fixed flow divider is connected to the drill bit through the flow guide pipe and the coring pipe mounted between the fixed flow divider and the drill bit. Two ends of the flow guide pipe communicate with the fixed flow divider and a main flow channel in the drill bit respectively. Hot water in the fixed flow divider can be conveyed into the drill bit through the flow guide pipe and sprayed from a nozzle arranged on the drill bit for drilling and coring operations. An inlet of the coring pipe communicates with a coring channel in an inner cavity in the drill bit, and a core sample drilled by the drill bit is taken out through the coring pipe.

Abstract: A method of synchronization test of a generator set outlet switch apparatus includes that: prior to a synchronization grid-connected closing of an outlet switch apparatus of a target generator set, a wiring phase sequence of a synchronization apparatus is determined to be correct; then three-phase closings of the outlet switch apparatus are determined to be synchronous; two-side voltage waveform data at a closing moment of the outlet switch apparatus is measured and recorded; and a simulated synchronization closing quality coefficient of the outlet switch apparatus of the target generator set is determined according to the two-side voltage waveform data, and a synchronization closing performance of the outlet switch apparatus of the target generator set is evaluated according to the simulated synchronization closing quality coefficient.

Abstract: A portable heater including an intake module configured to draw air into the heater; a heating module coupled to the intake module and configured to heat the air drawn into the heater; and an exhaust module coupled to the heating module and configured to exhaust the heated air. The intake module is further configured to draw air into the heater from locations other than a first region where the heater is located.

Abstract: A disk generator integrated with a flywheel, a hybrid powertrain, and a vehicle. The disk generator includes the flywheel, a rotor, and a stator that are sequentially arranged adjacent to each other in an axial direction of the generator. The flywheel is configured to: be in transmission connection with an engine, and drive the rotor to rotate through a torsional vibration damper, and the torsional vibration damper includes a drive disk and a plurality of circumferential buffer members. The groove is configured to accommodate the drive disk and the plurality of circumferential buffer members, and the circumferential buffer member is configured to elastically connect the drive disk to the groove in a circumferential direction of the drive disk. The disk generator reduces an overall volume on the premise of ensuring transmission efficiency.

Abstract: An induction rotor assembly is provided. The induction rotor assembly includes a laminated stack, a plurality of foils, a plurality of conductor bars, a first end ring, and a second end ring. The laminated stack includes a body with an outer circumferential surface with a plurality of grooves extending from the first end to the second end. Each one of the plurality of foils is disposed within one of the grooves. Each of the foils is disposed between each of the conductor bars and each of the grooves. Each of the plurality of conductor bars includes a first conductor end and a second conductor end. The first end ring mates with a surface of each first conductor end. The second end ring mates with a surface of each second conductor end, and the plurality of conductor bars extends between the first end ring and the second end ring.

Abstract: Methods, systems, and apparatuses include training a graph neural network. Content items are received for a user of an online system, the content items including skills. An input graph is generated using the content items, the input graph including nodes and edges linking the nodes. The input graph is sampled using a source node and skills to generate a first computational graph. The input graph is sampled using a target node and skills to generate a second computational graph. A source node embedding is generated by encoding the first computational graph. A target node embedding is generated by encoding the second computational graph. A prediction score is calculated by decoding the source node embedding and the target node embedding. Weights of the graph neural network are updated using the prediction score.

Abstract: The various implementations described herein include methods and systems for coding video. In one aspect, a method includes receiving a video bitstream comprising a plurality of blocks that includes a current block; identifying a block vector for the current block; determining a minimum-cost position in a predetermined area of a location indicated by the block vector; deriving a sub-pixel position based on the minimum-cost position; and reconstructing the current block using the sub-pixel position.

Abstract: A user equipment (UE) is described. The UE may comprise a receiver and a transmitter; wherein if values of the first field are associated with types of channel access procedure. the transmitter is configured to determine a type of channel access procedure based on a value of the first field and perform sensing prior to the sidelink transmission.

Abstract: The application discloses a terminal aggregation establishment method and apparatus, a terminal aggregation establishment configuration method and apparatus, and a communication device. The method includes: sending, by a first terminal, information about a second terminal to a network-side device, where the information about the second terminal is used to assist the network-side device in configuring configuration information for establishing multi-terminal aggregation; receiving, by the first terminal, the configuration information sent by the network-side device; and establishing, by the second terminal, multi-path transmission for multi-terminal aggregation with the first terminal based on the configuration information.

Abstract: A method of operating an IC includes receiving a power supply voltage at a first pickup structure and a reference voltage at a second pickup structure, using the first pickup structure to bias an n-well shared among a first set of more than two rows of IC devices, and using the second pickup structure to bias a p-well shared among a second set of more than two rows of the IC devices.

Abstract: The present disclosure provides a fine detection device and method for crack initiation and propagation of a rock specimen during loading process. The device comprises an organic glass skeleton, a plurality of sensor support skeletons, a multi-parameter dynamic acquisition system, a servo press bearing platform and a computer, wherein the organic glass skeleton is placed in the middle of the servo press bearing platform, the sensor support skeletons are arranged inside the organic glass skeleton, the rock specimen is arranged inside the sensor support skeleton, the multi-parameter dynamic acquisition system is fixedly arranged on the sensor support skeleton, the multi-parameter dynamic acquisition system is in contact with the rock specimen, and the multi-parameter dynamic acquisition system and the servo press bearing platform are electrically connected to the computer.

Abstract: Provided herein are multivalent signal-regulatory protein ? (SIRP?) fusion polypeptides and methods of use thereof. The compositions and methods described herein may be used to treat a variety of diseases or disorders, such as cardiovascular disease.

Abstract: An additive manufacturing apparatus includes a build module. A feed module is configured to support a first portion of a resin support. The first portion of the resin support is supported by a feed mounting panel. A take-up module is configured to support a second portion of the resin support. The second portion of the resin support is supported by a take-up mounting panel and is positioned on an opposing side of the radiant energy device from the feed module. An adjustment assembly is configured to adjust a position of at least one of a feed mandrel within the feed module or a take-up mandrel within the take-up module.

Abstract: A semiconductor device manufacturing method according to the present embodiment includes forming a recessed part in a first insulating film. The present manufacturing method also includes forming a first conductive film containing a first metal on an inner side surface and a bottom surface of the recessed part. The present manufacturing method also includes forming an amorphous layer on the first conductive film. The present manufacturing method also includes forming a second conductive film containing the first metal on the amorphous layer.