Abstract: Receiving point of interest zones and alerts on user devices comprises communicating, by a user computing device to a remote computing device, a request for point of interest data corresponding to points of interest within a proximity of the user device; presenting the received point of interest data; identifying a particular point of interest; and outputting an alert regarding the particular point of interest. Receiving point of interest zones on user devices comprises communicating a request for point of interest data; receiving the point of interest data from the remote network device wherein a size of the point of interest zone is determined based on a density of points of interest in the proximity of the user, and wherein the shape of the point of interest zone is expanded in a direction of travel and contracted in the opposite direction; and presenting the received point of interest data.

Abstract: A geofence management system obtains location data for points of interest. The geofence management system determines, at the option of the user, the location of a user mobile computing device relative to specific points of interest and alerts the user when the user nears the points of interest. The geofence management system, however, determines relationships among the identified points of interest, and associates or “clusters” the points of interest together based on the determined relationships. Rather than establishing separate geofences for multiple points of interest, and then alerting the user each time the user's mobile device enters each geofence boundary, the geofence management system establishes a single geofence boundary for the associated points of interest. When the user's mobile device enters the clustered geofence boundary, the geofence management system notifies the user device to alert the user of the entrance event. The user then receives the clustered, geofence-based alert.

Abstract: A data processing system includes a system memory and a cache hierarchy that caches contents of the system memory. According to one method of data processing, a storage modifying operation having a cacheable target real memory address is received. A determination is made whether or not the storage modifying operation has an associated bypass indication. In response to determining that the storage modifying operation has an associated bypass indication, the cache hierarchy is bypassed, and an update indicated by the storage modifying operation is performed in the system memory. In response to determining that the storage modifying operation does not have an associated bypass indication, the update indicated by the storage modifying operation is performed in the cache hierarchy.

Abstract: Embodiments of the present invention concern methods related to treating, prognosticating and/or diagnosing at least brain metastatic breast cancer. Embodiments of the methods include characterizing circulating tumor cells for the presence or absence of EpCAM and, upon identification of EpCAM negative cells and identification of the status of other markers (such as heparanase and/or Notch1, for example), treating the individual based on the determination of the characterization.

Abstract: A semiconductor device with a current sampler and a start-up structure, comprises first, second and third high-voltage transistors, and a resistor, wherein: a drain terminal of the first transistor is respectively connected to a drain terminal of the second transistor, a drain terminal of the third transistor and one end of the resistor; a source terminal of the first transistor is grounded, and a gate terminal of the first transistor is connected to a gate terminal of the second transistor; the other end of the resistor is connected to a gate terminal of the third transistor; wherein the resistor is wound and formed in a common voltage withstand region of the first transistor, the second transistor and the third transistor, or in a voltage withstand region of the first transistor only, or in the voltage withstand region of the third transistor only.

Abstract: A mechanism is provided in a cache for providing a read and write aware cache. The mechanism partitions a large cache into a read-often region and a write-often region. The mechanism considers read/write frequency in a non-uniform cache architecture replacement policy. A frequently written cache line is placed in one of the farther banks. A frequently read cache line is placed in one of the closer banks. The size ratio between read-often and write-often regions may be static or dynamic. The boundary between the read-often region and the write-often region may be distinct or fuzzy.

Abstract: Receiving point of interest zones and alerts on user devices comprises communicating, by a user computing device to a remote computing device, a request for point of interest data corresponding to points of interest within a proximity of the user device; presenting the received point of interest data; identifying a particular point of interest; and outputting an alert regarding the particular point of interest. Receiving point of interest zones on user devices comprises communicating a request for point of interest data; receiving the point of interest data from the remote network device wherein a size of the point of interest zone is determined based on a density of points of interest in the proximity of the user, and wherein the shape of the point of interest zone is expanded in a direction of travel and contracted in the opposite direction; and presenting the received point of interest data.

Abstract: Receiving point of interest zones and alerts on user devices comprises communicating, by a user computing device to a remote computing device, a request for point of interest data corresponding to points of interest within a proximity of the user device; presenting the received point of interest data; identifying a particular point of interest; and outputting an alert regarding the particular point of interest. Receiving point of interest zones on user devices comprises communicating a request for point of interest data; receiving the point of interest data from the remote network device wherein a size of the point of interest zone is determined based on a density of points of interest in the proximity of the user, and wherein the shape of the point of interest zone is expanded in a direction of travel and contracted in the opposite direction; and presenting the received point of interest data.

Abstract: Provided are articles of manufacture, compositions and methods for prophylaxis and/or therapy for disorders involving dizziness and/or vertigo. The articles of manufacture and compositions contain lamotrigine and/or bupropion and pharmaceutically acceptable salts thereof. The compositions include pharmaceutical compositions which are intended to alleviate dizziness and/or vertigo. In certain aspects the disclosure includes articles of manufacture and kits which include printed material which provides an indication that the articles or compositions are intended to be used for prophylaxis and/or therapy of Meniere's disease or a symptom thereof.

Abstract: A geofence management system obtains location data for points of interest. The geofence management system determines, at the option of the user, the location of a user mobile computing device relative to specific points of interest and alerts the user when the user nears the points of interest. The geofence management system, however, determines relationships among the identified points of interest, and associates or “clusters” the points of interest together based on the determined relationships. Rather than establishing separate geofences for multiple points of interest, and then alerting the user each time the user's mobile device enters each geofence boundary, the geofence management system establishes a single geofence boundary for the associated points of interest. When the user's mobile device enters the clustered geofence boundary, the geofence management system notifies the user device to alert the user of the entrance event. The user then receives the clustered, geofence-based alert.

Abstract: A method for fast remote communication and computation between processors is provided in the illustrative embodiments. A direct core to core communication unit (DCC) is configured to operate with a first processor, the first processor being a remote processor. A memory associated with the DCC receives a set of bytes, the set of bytes being sent from a second processor. An operation specified in the set of bytes is executed at the remote processor such that the operation is invoked without causing a software thread to execute.

Abstract: A spar hull for a floating vessel can include a hard tank having a belly portion, a fixed strake coupled to the outer surface of the tank and a folding strake coupled to the belly portion of the tank, the folding strake having one or more strake panels and one or more support frames. A method for installing folding belly strakes on a spar hull may include providing a floating spar hull having a hard tank with a belly side, rotating the spar so that the belly side is in a first workable position, coupling at least one folding strake to the belly side of the spar, and coupling the strake in a folded position for transport. The method may include positioning the spar hull offshore in a transport position, upending the spar hull, unfolding the strake, fixing the strake in the unfolded position and installing the spar hull.

Abstract: A method, a system, an apparatus, and a computer program product for allocating resources of one or more shared devices to one or more partitions of a virtualization environment within a data processing system. At least one user defined resource assignment is received for one or more devices associated with the data processing system. One or more registers, associated with the one or more partitions are dynamically set to execute the at least one resource assignment, whereby the at least one resource assignment enables a user defined quantitative measure (number and/or percentage) of devices to operate when the one or more transactions are executed via the partition. The system enables the one or more devices to execute one or more transactions at a bandwidth/capacity that is less than or equal to the user defined resource assignment and minimizes performance interference among partitions.

Abstract: A geofence management system obtains location data for points of interest. The geofence management system determines, at the option of the user, the location of a user mobile computing device relative to specific points of interest and alerts the user when the user nears the points of interest. The geofence management system, however, determines relationships among the identified points of interest, and associates or “clusters” the points of interest together based on the determined relationships. Rather than establishing separate geofences for multiple points of interest, and then alerting the user each time the user's mobile device enters each geofence boundary, the geofence management system establishes a single geofence boundary for the associated points of interest. When the user's mobile device enters the clustered geofence boundary, the geofence management system notifies the user device to alert the user of the entrance event. The user then receives the clustered, geofence-based alert.

Abstract: A mechanism is provided in a virtual machine monitor for providing cache partitioning in virtualized environments. The mechanism assigns a virtual identification (ID) to each virtual machine in the virtualized environment. The processing core stores the virtual ID of the virtual machine in a special register. The mechanism also creates an entry for the virtual machine in a partition table. The mechanism may partition a shared cache using a vertical (way) partition and/or a horizontal partition. The entry in the partition table includes a vertical partition control and a horizontal partition control. For each cache access, the virtual machine passes the virtual ID along with the address to the shared cache. If the cache access results in a miss, the shared cache uses the partition table to select a victim cache line for replacement.

Abstract: A mechanism is provided in a virtual machine monitor for providing cache partitioning in virtualized environments. The mechanism assigns a virtual identification (ID) to each virtual machine in the virtualized environment. The processing core stores the virtual ID of the virtual machine in a special register. The mechanism also creates an entry for the virtual machine in a partition table. The mechanism may partition a shared cache using a vertical (way) partition and/or a horizontal partition. The entry in the partition table includes a vertical partition control and a horizontal partition control. For each cache access, the virtual machine passes the virtual ID along with the address to the shared cache. If the cache access results in a miss, the shared cache uses the partition table to select a victim cache line for replacement.

Abstract: Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal sequence upstream of a tumor antigen upstream of CD40 ligand, which is missing all or substantially all of the transmembrane domain rendering CD40L secretable. Also provided are methods of generating an immune response against cells expressing a tumor antigen by administering an effective amount of the invention vector. Further provided are methods of generating an immune response against cancer expressing a tumor antigen in an individual by administering an effective amount of the invention vector. Still further provided are methods of generating immunity to infection by human papilloma virus (HPV) by administering an effective amount of the invention vector which encodes the E6 or E7 protein of HPV. The immunity generated is long term.

Abstract: A method is provided for treating an individual for a malarial infection, in particular drug-resistant species of Plasmodium, including administering to the individual in need of such treatment a composition comprising an extract containing an effective amount of one or more anti-malarial di- or tri-terpene compounds. Potent and effective extracts containing the anti-malarial compounds can be derived from Luo Han fruit and Stevia leaves, including combinations of the same, for the purpose of treating and preventing malaria in an inexpensive manner from readily available commodities. In one embodiment, the composition is administered orally in a solid or liquid ingestible form.

Abstract: A mechanism for assigning memory to on-chip cache coherence domains assigns caches within a processing unit to coherence domains. The mechanism assigns chunks of memory to the coherence domains. The mechanism monitors applications running on cores within the processing unit to identify needs of the applications. The mechanism may then reassign memory chunks to the cache coherence domains based on the needs of the applications running in the coherence domains. When a memory controller receives the cache miss, the memory controller may look up the address in a lookup table that maps memory chunks to cache coherence domains. Snoop requests are sent to caches within the coherence domain. If a cache line is found in a cache within the coherence domain, the cache line is returned to the originating cache by the cache containing the cache line either directly or through the memory controller.

Abstract: A mechanism is provided within a 3D stacked memory organization to spread or stripe cache lines across multiple layers. In an example organization, a 128B cache line takes eight cycles on a 16B-wide bus. Each layer may provide 32B. The first layer uses the first two of the eight transfer cycles to send the first 32B. The next layer sends the next 32B using the next two cycles of the eight transfer cycles, and so forth. The mechanism provides a uniform memory access.