Patents by Inventor Lothar W. Kleiner

Lothar W. Kleiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Absorbable coating for implantable device
    Patent number: 10076591
    Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: September 18, 2018
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, Syed F. A. Hossainy, Mikael Trollsas, Stephen D. Pacetti
  • Morphology Profiles For Control Of Agent Release Rates From Polymer Matrices
    Publication number: 20180154051
    Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix that include designing and creating a predetermined initial morphology (IM) profile in a polymeric matrix. The teachings indicate, inter alia, that control over the release rate of agents can provide for an improved control over the administration of agents as well as have an effect upon the mechanical integrity and absorption rate of the polymeric matrix.
    Type: Application
    Filed: October 30, 2017
    Publication date: June 7, 2018
    Inventors: Syed F.A. Hossainy, Fuh-Wei Tang, Lothar W. Kleiner, Thierry Glauser, Yiwen Tang, Wouter E. Roorda, Stephen D. Pacetti, Gina Zhang, Yung-Ming Chen, Andrew F. McNiven, Sean A. McNiven, Brandon J. Yoe
  • ABSORBABLE COATING FOR IMPLANTABLE DEVICE
    Publication number: 20180093020
    Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
    Type: Application
    Filed: December 5, 2017
    Publication date: April 5, 2018
    Inventors: Lothar W. Kleiner, Syed F.A. Hossainy, Mikael Trollsas, Stephen D. Pacetti
  • Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance
    Patent number: 9833344
    Abstract: A stent made from an ultra high molecular weight bioabsorbable polymer is disclosed herein. The bioabsorbable polymer can have a Mw greater than 1 million g/mole or greater than 2 million g/mole. Methods of making the ultra high molecular weight polymer stent without degrading the molecular weight are further disclosed.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: December 5, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventor: Lothar W. Kleiner
  • Methods of treatment of polymeric coatings for control of agent release rates
    Patent number: 9821091
    Abstract: The present disclosure teaches methods of controlling the release rate of agents from a polymeric matrix. The methods relate to the application of pressure, and optionally, in combination with heat, to a polymeric coating.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: November 21, 2017
    Assignee: Abbot Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Fuh-Wei Tang, Lothar W. Kleiner, Thierry Glauser, Yiwen Tang, Wouter E. Roorda, Stephen D. Pacetti, Gina Zhang, Yung-Ming Chen, Andrew F. McNiven, Sean A. McNiven, Brandon J. Yoe
  • Polyesteramide platform for site specific drug delivery
    Patent number: 9603943
    Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: March 28, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, Syed Hossainy, Stephen Pacetti, Jessica DesNoyer
  • Multilayer bioabsorbable scaffolds and methods of fabricating
    Patent number: 9561611
    Abstract: A bioabsorbable scaffold composed of a multilayer structure of alternating layers of different polymers is disclosed. The multilayer structure can have 20 to 1000 layers and the individual thickness of the layers can be 0.2 to 5 microns. A method of making the scaffold including a layer multiplying extrusion process is disclosed.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: February 7, 2017
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventor: Lothar W. Kleiner
  • STENT MADE FROM AN ULTRA HIGH MOLECULAR WEIGHT BIOABSORBABLE POLYMER WITH HIGH FATIGUE AND FRACTURE RESISTANCE
    Publication number: 20170014250
    Abstract: A stent made from an ultra high molecular weight bioabsorbable polymer is disclosed herein. The bioabsorbable polymer can have a Mw greater than 1 million g/mole or greater than 2 million g/mole. Methods of making the ultra high molecular weight polymer stent without degrading the molecular weight are further disclosed.
    Type: Application
    Filed: September 29, 2016
    Publication date: January 19, 2017
    Inventor: Lothar W. Kleiner
  • Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance
    Patent number: 9492587
    Abstract: A stent made from an ultra high molecular weight bioabsorbable polymer is disclosed herein. The bioabsorbable polymer can have a Mw greater than 1 million g/mole or greater than 2 million g/mole. Methods of making the ultra high molecular weight polymer stent without degrading the molecular weight are further disclosed.
    Type: Grant
    Filed: April 13, 2009
    Date of Patent: November 15, 2016
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventor: Lothar W. Kleiner
  • Absorbable coating for implantable device
    Patent number: 9387282
    Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
    Type: Grant
    Filed: February 17, 2014
    Date of Patent: July 12, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, Syed F. A. Hossainy, Mikael Trollsas, Stephen D. Pacetti
  • Soluble implantable device comprising polyelectrolyte with hydrophobic counterions
    Patent number: 9327062
    Abstract: The present invention provides an implantable device having a biosoluble coating comprising a polyelectrolyte and a counterion and the methods of making and using the same.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: May 3, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, O. Mikael Trollsas, Lothar W. Kleiner
  • Tube expansion processes for semicrystalline polymers to maximize fracture toughness
    Patent number: 9278477
    Abstract: Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: March 8, 2016
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, James P. Oberhauser, Thierry Glauser, David Wrolstad, Yunbing Wang
  • MULTILAYER BIOABSORBABLE SCAFFOLDS AND METHODS OF FABRICATING
    Publication number: 20150352768
    Abstract: A bioabsorbable scaffold composed of a multilayer structure of alternating layers of different polymers is disclosed. The multilayer structure can have 20 to 1000 layers and the individual thickness of the layers can be 0.2 to 5 microns. A method of making the scaffold including a layer multiplying extrusion process is disclosed.
    Type: Application
    Filed: June 15, 2015
    Publication date: December 10, 2015
    Inventor: Lothar W. Kleiner
  • Medical device fabrication process including strain induced crystallization with enhanced crystallization
    Patent number: 9205575
    Abstract: Methods of fabricating a polymeric implantable device, such as a stent, with improved fracture toughness through annealing a polymer construct below the glass transition temperature of the polymer of the construct prior to a deformation step are disclosed herein. The deformation of the construct induces crystallization in the polymer construct through strain-induced crystallization. The annealing of the polymer construct accelerates the crystallization induced during the deformation and results in an increase in crystallite density with smaller crystallites as compared to deformation of a tube that has not been annealed. A stent scaffolding is then made from the deformed tube.
    Type: Grant
    Filed: May 15, 2014
    Date of Patent: December 8, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, Fuh-Wei Tang
  • POLYESTERAMIDE PLATFORM FOR SITE SPECIFIC DRUG DELIVERY
    Publication number: 20150290336
    Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
    Type: Application
    Filed: June 25, 2015
    Publication date: October 15, 2015
    Inventors: Lothar W. Kleiner, Syed Hossainy, Stephen Pacetti, Jessica DesNoyer
  • Polyesteramide platform for site specific drug delivery
    Patent number: 9095619
    Abstract: A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the therapeutic agent delivery system by delivering the therapeutic agent delivery system formed of a PEA polymer, a therapeutic agent, and a water miscible solvent to a physiological environment and separating the phase of the therapeutic agent delivery system to form a membrane from the polymer to contain the therapeutic agent within the physiological environment is also described. Additionally disclosed is a kit including a syringe and a therapeutic agent delivery system within the syringe.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: August 4, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, Syed Hossainy, Stephen Pacetti, Jessica DesNoyer
  • Multilayer bioabsorbable scaffolds and methods of fabricating
    Patent number: 9089412
    Abstract: A bioabsorbable scaffold composed of a multilayer structure of alternating layers of different polymers is disclosed. The multilayer structure can have 20 to 1000 layers and the individual thickness of the layers can be 0.2 to 5 microns. A method of making the scaffold including a layer multiplying extrusion process is disclosed.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: July 28, 2015
    Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventor: Lothar W. Kleiner
  • Depot stent comprising an elastin-based copolymer
    Patent number: 9078958
    Abstract: A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. The copolymer may be used as a coating on a stent. Methods of using a stent coated with the copolymer are also provided.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: July 14, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F. A. Hossainy, Yiwen Tang, Lothar W. Kleiner
  • Tailored aliphatic polyesters for stent coatings
    Patent number: 9067002
    Abstract: An aliphatic polyester polymer for stent coating is described.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: June 30, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: O. Mikael Trollsas, Lothar W. Kleiner, Syed F. A. Hossainy
  • Coatings having an elastic primer layer
    Patent number: 9056155
    Abstract: Provided herein is a coating an elastic primer layer and the method of making and using the same.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: June 16, 2015
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, Yiwen Tang, Mikael O. Trollsas, Syed F. A. Hossainy, Santosh Prabhu