Patents by Inventor Lothar W. Kleiner

Lothar W. Kleiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of making a stent formed from crosslinked bioabsorbable polymer
    Patent number: 8147744
    Abstract: A stent having a stent body made from a crosslinked bioabsorbable polymer is disclosed. A method of making the stent including exposing a tube formed from a bioabsorbable polymer to radiation to crosslink the bioabsorbable polymer and forming a stent body from the exposed tube is disclosed. The tube can include a crosslinking agent which induces crosslinking upon radiation exposure. Additionally or alternatively, the bioabsorbable polymer can be a copolymer that crosslinks upon exposure to radiation in the absence of a crosslinking agent.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: April 3, 2012
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventor: Lothar W. Kleiner
  • Coating Comprising An Elastin-Based Copolymer
    Publication number: 20120046640
    Abstract: The present invention is directed to medical devices including coatings. The coatings include a topcoat which includes a copolymer comprising a block of an elastin pentapeptide. The topcoat is over a layer of poly(vinyl alcohol) on a hydrophobic coating or over a porous coating comprising pores or depots that include a bioactive agent.
    Type: Application
    Filed: September 2, 2011
    Publication date: February 23, 2012
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Syed F.A. Hossainy, Yiwen Tang, Lothar W. Kleiner
  • Post Electron Beam Stabilization Of Polymeric Medical Devices
    Publication number: 20120045362
    Abstract: Methods are disclosed for chemically stabilizing a polymer stent after sterilization. The stent is exposed to a temperature above ambient for a period of time after radiation sterilization. The exposure reduces the concentration of free radicals generated by the radiation.
    Type: Application
    Filed: August 20, 2010
    Publication date: February 23, 2012
    Inventors: Lothar W. Kleiner, Fuh-Wei Tang
  • Merhods of treatment with devices having a coating containing pegylated hyaluronic acid and a pegylated non-hyaluronic acid polymer
    Patent number: 8105391
    Abstract: Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: January 31, 2012
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • TUBE EXPANSION PROCESSES AND SYSTEMS FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS
    Publication number: 20110278771
    Abstract: Methods of and systems for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube along its entire length at the same time and fabricating a stent from the expanded tube are disclosed herein.
    Type: Application
    Filed: July 27, 2011
    Publication date: November 17, 2011
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, James P. Oberhauser, Thierry Glauser, David K. Wrolstad, Yunbing Wang
  • Stabilizing Semi-Crystalline Polymers To Improve Storage Performance Of Medical Devices
    Publication number: 20110260352
    Abstract: Methods are disclosed for improving the storage performance of polymeric stents that reduce or eliminate the effects of long term aging on the properties of the stents. A polymeric stent or a polymeric tube from which a stent is made is heated to a temperature between ambient and the glass transition temperature of the polymer for a period of time. The heating causes densification or an increase in density of the polymer which stabilizes the properties of the polymer in later processing steps and storage. The stent can be made from a polymeric tube that is expanded at a temperature above the glass transition temperature and cooled to maintain an expanded diameter.
    Type: Application
    Filed: April 21, 2010
    Publication date: October 27, 2011
    Inventors: Fuh-Wei Tang, James Oberhauser, Manish Gada, Lothar W. Kleiner, Vincent J. Gueriguian
  • Absorbable Coating For Implantable Device
    Publication number: 20110244017
    Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
    Type: Application
    Filed: March 31, 2010
    Publication date: October 6, 2011
    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
    Inventors: Lothar W. Kleiner, Syed F.A. Hossainy, Mikael Trollsas, Stephen D. Pacetti
  • Medical device coated with a coating containing elastin pentapeptide VGVPG
    Patent number: 8029816
    Abstract: The present invention is directed to medical devices including coatings. The coatings include a topcoat which includes a copolymer comprising a block of an elastin pentapeptide. The topcoat is over a layer of poly(vinyl alcohol) on a hydrophobic coating or over a porous coating comprising pores or depots that include a bioactive agent.
    Type: Grant
    Filed: May 10, 2007
    Date of Patent: October 4, 2011
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Syed Faiyaz Ahmed Hossainy, Yiwen Tang, Lothar W. Kleiner
  • Medical Device Fabrication Process Including Strain Induced Crystallization With Enhanced Crystallization
    Publication number: 20110215505
    Abstract: Methods of fabricating a polymeric implantable device, such as a stent, with improved fracture toughness through annealing a polymer construct below the glass transition temperature of the polymer of the construct prior to a deformation step are disclosed herein. The deformation of the construct induces crystallization in the polymer construct through strain-induced crystallization. The annealing of the polymer construct accelerates the crystallization induced during the deformation and results in an increase in crystallite density with smaller crystallites as compared to deformation of a tube that has not been annealed. A stent scaffolding is then made from the deformed tube.
    Type: Application
    Filed: March 31, 2011
    Publication date: September 8, 2011
    Inventors: Lothar W. Kleiner, Fuh-Wei Tang
  • Tube expansion process for semicrystalline polymers to maximize fracture toughness
    Patent number: 8012402
    Abstract: Methods of fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube along its entire length at the same time and fabricating a stent from the expanded tube are disclosed herein.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: September 6, 2011
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Lothar W. Kleiner, James P. Oberhauser, Thierry Glauser, David K. Wrolstad, Yunbing Wang
  • Coating Construct With Enhanced Interfacial Compatibility
    Publication number: 20110144741
    Abstract: The present invention provides a method of forming a coating on a medical device having a topcoat and a basecoat and an improved compatibility between a topcoat and a basecoat on the medical device.
    Type: Application
    Filed: February 14, 2011
    Publication date: June 16, 2011
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Jessica Renee DesNoyer, Syed Faiyaz Ahmed Hossainy
  • Method Of Fabricating A Low Crystallinity Poly(L-Lactide) Tube
    Publication number: 20110049751
    Abstract: Methods of fabricating a low crystallinity polymer tube for polymers subject to strain-induced crystallization. The low crystallinity tube may be further processed to make an implantable medical device.
    Type: Application
    Filed: August 28, 2009
    Publication date: March 3, 2011
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Manish B. Gada, Lothar W. Kleiner, Bethany E. Steichen
  • Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers
    Publication number: 20110027188
    Abstract: An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the device is implanted in a patient. The smaller particles and the larger particles are made of bioabsorbable metal, glass or ceramic. A substance can be associated with the smaller particles. The larger particles can be embedded within at least a portion of the device.
    Type: Application
    Filed: October 8, 2010
    Publication date: February 3, 2011
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Syed Hossainy, Irina Astafieva, Stephen Pacetti, Thierry Glauser, Jessica DesNoyer, Florian N. Ludwig
  • Stent Made From An Ultra High Molecular Weight Bioabsorbable Polymer With High Fatigue And Fracture Resistance
    Publication number: 20100262224
    Abstract: A stent made from an ultra high molecular weight bioabsorbable polymer is disclosed herein. The bioabsorbable polymer can have a Mw greater than 1 million g/mole or greater than 2 million g/mole. Methods of making the ultra high molecular weight polymer stent without degrading the molecular weight are further disclosed.
    Type: Application
    Filed: April 13, 2009
    Publication date: October 14, 2010
    Inventor: Lothar W. Kleiner
  • Stent Formed from Crosslinked Bioabsorbable Polymer and Methods of Making the Stent
    Publication number: 20100262223
    Abstract: A stent having a stent body made from a crosslinked bioabsorbable polymer is disclosed. A method of making the stent including exposing a tube formed from a bioabsorbable polymer to radiation to crosslink the bioabsorbable polymer and forming a stent body from the exposed tube is disclosed. The tube can include a crosslinking agent which induces crosslinking upon radiation exposure. Additionally or alternatively, the bioabsorbable polymer can be a copolymer that crosslinks upon exposure to radiation in the absence of a crosslinking agent.
    Type: Application
    Filed: April 10, 2009
    Publication date: October 14, 2010
    Inventor: Lothar W. Kleiner
  • Fabricating An Implantable Medical Device From An Amorphous Or Very Low Crystallinity Polymer Construct
    Publication number: 20100252965
    Abstract: Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing, nucleating agents, or both are disclosed herein. A polymeric construct that is completely amorphous or that has a very low crystallinity is annealed with no or substantially no crystal growth to increase nucleation density. Alternatively, the polymer construct includes nucleating agent. The crystallinity of the polymer construct is increased with a high nucleation density through an increase in temperature, deformation, or both. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the increase in crystallinity.
    Type: Application
    Filed: May 13, 2009
    Publication date: October 7, 2010
    Inventors: Yunbing Wang, Lothar W. Kleiner
  • Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers
    Publication number: 20100222872
    Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device. Implantable medical devices manufactured with coatings including the particles or embedded within the medical device are additionally disclosed.
    Type: Application
    Filed: May 18, 2010
    Publication date: September 2, 2010
    Applicant: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Syed Hossainy, Irina Astafieva, Stephen Pacetti, Thierry Glauser, Jessica Desnoyer, Florian N. Ludwig
  • COATING CONTAINING PEGYLATED HYALURONIC ACID AND A PEGYLATED NON-HYALURONIC ACID POLYMER
    Publication number: 20100189758
    Abstract: Provided herein are a method, which comprises implanting in a patient an implantable device comprising a coating that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Application
    Filed: April 1, 2010
    Publication date: July 29, 2010
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • COATING CONTAINING PEGYLATED HYALURONIC ACID AND A PEGYLATED NON-HYALURONIC ACID POLYMER
    Publication number: 20100191325
    Abstract: Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Application
    Filed: April 1, 2010
    Publication date: July 29, 2010
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer
    Patent number: 7713637
    Abstract: Provided herein are a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: May 11, 2010
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Connie S. Kwok