Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: A computer-implemented framework and/or system for cyberbullying detection is disclosed. The system includes two main components: (1) A representation learning network that encodes the social media session by exploiting multi-modal features, e.g., text, network, and time; and (2) a multi-task learning network that simultaneously fits the comment inter-arrival times and estimates the bullying likelihood based on a Gaussian Mixture Model. The system jointly optimizes the parameters of both components to overcome the shortcomings of decoupled training. The system includes an unsupervised cyberbullying detection model that not only experimentally outperforms the state-of-the-art unsupervised models, but also achieves competitive performance compared to supervised models.

Abstract: Various embodiments for systems and methods of tracking disaster footprints using social streaming media using nonnegative matrix factorization are disclosed herein. The system extracts a summarization output from historical data and compares the summarization output with incoming data to identify differing or similar topics within the data. The summarization output is projected to adjust a time-dependency of the summarization output to enable a more direct comparison. The system additionally uses the summarization output to encode topic data within historical data to reduce computational overhead.

Abstract: A method for verifying the integrity, continuity, and availability (ICA) of information displayed on an uncertified display is disclosed. The method includes creating application data for display on the uncertified display device that includes a subliminal symbol that is periodically embedded in a few out of multiple tens of frames and that is camouflaged in the application data using steganography; transmitting the application data to the uncertified display device for display; receiving images of the application data displayed on the display screen; determining whether the subliminal symbol is detected in the captured images by extracting the symbol from the captured images and comparing the extracted symbol to an expected symbol; determining that the application data is not corrupted when the extracted symbol matches the expected symbol; and identifying a loss of ICA when the subliminal symbol is not detected or does not match the expected symbol.

Abstract: The disclosure provides a vibration isolation structure for linear oscillating motor and Stirling engine, wherein the said vibration isolation structure comprises a first vibration isolation device and a second vibration isolation device. The first vibration isolation device is set between the fixed hood and the housing of the linear oscillating motor to attenuate the high-frequency and small-amplitude vibrations from the linear oscillating motor. The first vibration isolation device comprises a first set of tension springs and a second set of tension springs, and a lateral gap is formed between the fixed hood and the linear oscillating motor. The second vibration isolation device is set in the said lateral gap to attenuate the low-frequency and large-amplitude vibrations from the linear oscillating motor.

Abstract: A computer-implemented method, a computer system, and computer program product for associating security events. The method includes obtaining a result of implementation of one or more Locality-Sensitive Hashing (LSH) functions to feature data of a first event detected by a first device. The method also includes mapping the result to one or more positions in a data structure. In response to data elements of the one or more positions indicating first information associating with the one or more positions exists in a storage, the method includes obtaining the first information from the storage. The method further includes sending the first information to the first device.

Abstract: A cable management frame includes a main body, a bracket installed on the main body, a hook installed on the main body, and a pressing member located on an end of the main body. The hook and the bracket are located respectively on two sides of the main body. The hook includes a reinforcing rib coupled to the main body.

Abstract: A cable management frame includes a main body, a bracket installed on the main body, a hook installed on the main body, and a pressing member located on an end of the main body. The hook and the bracket are located respectively on two sides of the main body. The hook includes a reinforcing rib coupled to the main body.

Abstract: The present disclosure provides a coating device including a first storage tank for storing a material to be coated, a needle cannula to which the first storage tank is connected by means of a corresponding first line, a gas output device for outputting a first pressurized gas from a gas source, including a first gas output line extending into the first storage tank, wherein the gas output device is capable of outputting the first pressurized gas to the first storage tank through the first gas output line such that the material to be coated stored in the first storage tank is discharged under a gas pressure and enters the needle cannula through the first line.

Abstract: The present invention provides novel pyrazolo[4,3-c]quinoline derivatives exhibiting specifically inhibition activity to microbiota ?-glucuronidase, whereby providing potent activities to prevent chemotherapy-induced diarrhea (CID) of cancers. Therefore, the compounds of the present invention can be used as (1) chemotherapy-adjuvant to prevent chemotherapy-induced diarrhea (CID) and enhance chemotherapeutic efficiency of cancers; (2) health-food supplement to prevent the carcinogens induced colon carcinoma.

Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also disclosed is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. Further disclosed is a method for diagnosing a cell-mediated disorder by administering a PEG engager followed by a PEGylated diagnostic agent.

Abstract: The present invention provides novel pyrazolo[4,3-c]quinoline derivatives exhibiting specifically inhibition activity to microbiota ?-glucuronidase, whereby providing potent activities to prevent chemotherapy-induced diarrhea (CID) of cancers. Therefore, the compounds of the present invention can be used as (1) chemotherapy-adjuvant to prevent chemotherapy-induced diarrhea (CID) and enhance chemotherapeutic efficiency of cancers; (2) health-food supplement to prevent the carcinogens induced colon carcinoma.

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract: The present invention relates generally to genetically modified non-human animals. The present invention relates to a genetically modified non-human animal, in which at least one copy of the endogenous nucleotide sequence encoding Protein C in the genome of said non-human animal has been replaced by a nucleotide sequence encoding human Protein C, encoding a functional fragment of human Protein C or encoding a functional variant of human Protein C. The invention also relates to vectors, cells and methods for the production of such non-human animals. The invention also relates to methods of testing agents for their ability to alter to the level and/or functional activity of human protein C and thus provides methods of testing agents for their potential therapeutic efficacy.

Abstract: The disclosure provides a vibration isolation structure for linear oscillating motor and Stirling engine, wherein the said vibration isolation structure comprises a first vibration isolation device and a second vibration isolation device. The first vibration isolation device is set between the fixed hood and the housing of the linear oscillating motor to attenuate the high-frequency and small-amplitude vibrations from the linear oscillating motor. The first vibration isolation device comprises a first set of tension springs and a second set of tension springs, and a lateral gap is formed between the fixed hood and the linear oscillating motor. The second vibration isolation device is set in the said lateral gap to attenuate the low-frequency and large-amplitude vibrations from the linear oscillating motor.

Abstract: A method executable by an ownship aircraft for probabilistically determining an intended flight route of an other aircraft in the vicinity of the ownship aircraft includes receiving first positional information regarding the other aircraft at a first point in time, receiving second positional information regarding the other aircraft at a second point in time that is temporally subsequent to the first point in time, and determining a historical flight path of the other aircraft based on the first and second positional information. Furthermore, the method includes comparing the historical flight path of the other aircraft to a plurality of navigation routes and, based on the comparing, probabilistically determining one navigation route of the plurality of navigation routes as the intended flight route of the other aircraft.

Abstract: An array substrate, a display panel, and a display are disclosed. At least one metal layer is added to make a contact with a first metal layer of an existing GOA circuit and to partially overlap with a second metal layer and/or poly-silicon layer of the existing GOA circuit in an insulated manner to form a capacitor, which means that at least one capacitor in series connection with existing capacitors is added, so that the capacitance of the GOA circuit is increased while the capacitor area of the GOA circuit is still the area of the existing capacitors, thus, facilitating the narrow-border design of LCDs.

Abstract: A monomeric bispecific polyethylene glycol (PEG) engager that includes an anti-PEG Fab fused to a disulfide stabilized scFv that specifically binds to a cell surface antigen. The PEG engager, in the absence of PEG, remains monomeric upon binding to the cell surface antigen on a cell and remains on the surface of the cell. Also provided is a method for treating cancer by administering a PEG engager followed by a PEGylated anti-cancer agent. A kit that contains a PEG engager and a PEGylated anti-cancer agent is also disclosed. Further disclosed are methods for imaging cells and diagnosing cancer by administering a PEG engager followed by a PEGylated imaging agent. Another kit is provided that includes the PEG engager and the PEGylated imaging agent.

Abstract: Disclosed herein is a hinge antibody capable of being selectively activated in a target cell or tissue to treat a condition therein. The hinge antibody includes a functional antibody, two inhibitory domains and four cleavable linkers. The functional antibody is capable of treating the condition in an activated state, and has two light chains and two heavy chains. Each inhibitory domain includes a hinge domain of an immunoglobulin and consists of two peptide arms. Each cleavable linker includes a peptide substrate cleavable by an enzyme specifically or highly expressed in the target cell or tissue, and connects one of the peptide arms of the inhibitory domains to the N-terminal of one of the light chains and heavy chains of the functional antibody. Also disclosed herein are methods for preparing and using this hinge antibody.