Abstract: The invention relates to a method of expanding a population of regulatory T cells in a tissue or organ of a subject, wherein said method comprises administration of IL-2 and a targeting moiety specific for said tissue or organ, and wherein said tissue or organ is the lung. The invention further relates to populations of regulatory T cells produced according to the method and the production of said population in vivo. Also provided is a pharmaceutical composition comprising IL-2 and a targeting moiety as defined herein as well as a method of treating a disease or disorder mediated by inflammation or for the reduction of inflammation which comprises the methods defined herein or administration of a pharmaceutical composition as defined herein.

Abstract: The present invention relates to: a newly developed triazine-cored amphiphilic compound; a preparation method therefor; and a method for extracting, solubilizing, stabilizing, crystallizing or analyzing membrane proteins by using the same. In addition, the compound enables membrane proteins, which have various structures and characteristics, to be efficiently extracted from cell membranes and stably stored in an aqueous solution for a long time, compared to a conventional compound, thereby being usable in functional and structural analysis thereof. Analyzing the structure and function of membrane proteins is closely related to the development of a novel drug, and thus is one of the greatest interests in the biology and chemistry fields.

Abstract: A system is disclosed that monitors participants in health-related programs, such as weight loss or exercise programs, and that provides automated, personalized health coaching to the program participants. The system includes breath analysis devices that are used by the program participants to generate ketone measurements, and includes a mobile application that runs on mobile devices of the participants and communicates with corresponding breath analysis devices. The system operates generally by monitoring ketone levels (such as acetone levels) and other attributes of the participants and by making personalized, machine-generated changes or updates to such programs to maintain program effectiveness and engagement. In some embodiments the system uses artificial intelligence to classify and coach the participants.

Abstract: A method for reducing pathological cardiac hypertrophy and/or inducing physiological cardiac hypertrophy by administering Nigella sativa or an extract thereof to a subject in need thereof, especially to an athletic subject in order to reduce exercise-induced pathological cardiac hypertrophy. A composition comprising Nigella sativa for use in said method.

Abstract: Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level.

Abstract: A wearable breath analysis device is disclosed that may be worn, for example, around the neck or wrist of a user. The wearable device may be a stand-alone device (in which case it may include a display that provides a user interface), or may operate in conjunction with a smartphone or other mobile device. The wearable device may provide auditory and/or vibratory notifications or messages, such as a reminder to conduct a breath analyte measurement, instructions for conducting the measurement, and/or notifications of breath analyte measurement results.

Abstract: Various systems, devices, components, and methods are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a breath sample analysis device having a mouthpiece configured to facilitate engagement with a user's mouth to receive a breath sample. The disclosed devices also include a breath sample capture cartridge containing an interactant that extracts the analyte from a breath sample passed through the cartridge. Also disclosed are devices for routing the breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

Abstract: A breath analysis system comprises a breath analysis device having an analyte sensor, such as a metal oxide semiconductor sensor, that needs to be heated or otherwise prepared before a breath test can be performed. To reduce or avoid a user-perceived delay (typically multiple minutes) associated with the sensor preparation operation, the system predictively initiates a sensor preparation operation based on a determination or prediction of whether the user is in an adequate state for performing a breath test. This prediction may be based on one or more factors, such as the current time, whether the breath analysis device is within wireless communication (e.g., Bluetooth) range of the user's smartphone, data reflective of the user's location and/or activity, etc.

Abstract: A breath analyte capture device includes a breath input port into which a user exhales a breath sample, and a cartridge insertion port for receiving a disposable cartridge containing an interactant. During exhalation of a breath sample, at least a portion of the breath sample is routed through the cartridge such that the analyte (such as breath acetone) is captured by the interactant. In some embodiments, the concentration of the analyte in the breath sample is measured by monitoring a chemical reaction that occurs in the disposable cartridge. The chemical reaction may be monitored by illuminating the cartridge at each of multiple light wavelengths while measuring reflected light.

Abstract: A portable system is provided for measuring an analyte, such as acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user, and the application reports measurement data to a remote system.

Abstract: As described herein, various embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for performing natural language processing operations for generating guided summaries using summarization templates that are mapped to hybrid classes of a hybrid classification space for a hybrid classification machine learning model. In some embodiments, by using summarization templates, a proposed summarization framework is able to vastly reduce the computational complexity of performing summarization on an input document data object, such as an input multi-party communication transcript data object, by defining the set of dynamic data fields that apply to the input document data object based at least in part on an assigned class/category of the input document data object.

Abstract: A wearable breath analysis device is disclosed that may be worn, for example, around the neck or wrist of a user. The wearable device may be a stand-along device (in which case it may include a display that provides a user interface), or may operate in conjunction with a smartphone or other command device. The wearable device may include auditory and/or vibratory notice and communications features or capabilities, for example, such as a reminder or notice to conduct a breath analyte measurement, instructions to the user in the course of conducting the measurement, and notice of the breath analyte measurement results. The auditory or vibratory notice may be provided at the wearable, and/or at the command device where a command device is used. Related methods also are provided.

Abstract: Control systems and methods for an electric power steering (EPS) system of a vehicle include obtaining, by a controller of the vehicle and from a set of sensors, a set of parameters of an electric motor of the EPS system, the EPS system further comprising a steering column and a steering wheel, and controlling, by the controller, the EPS system by based on the set of measured parameters of the electric motor, performing vector type recursive least squares estimation (RLSE) of a plurality of lumped EPS parameters including applying a variable forgetting factor, generating steering angle torque commands based on the estimated plurality of lumped EPS parameters, and controlling the electric motor of the EPS based on the generated steering angle torque commands for more accurate control of a trajectory of the vehicle.

Abstract: A breath analysis device into which a user exhales a breath sample is capable of venting an initial portion of the breath sample from the device, and routing a second portion of the breath sample into a disposable cartridge containing an interactant. The device may include a sensor, such as a pressure sensor, for detecting the initiation of exhalation, and may include a controller that switches a valve during the exhalation process to route a desired portion of the breath sample into the cartridge. After the exhalation process, an LED/photodiode arrangement, or another type of optical sensor, may be used to measure a color change produced by a chemical reaction in the cartridge, to thereby measure a concentration of a ketone or other analyte in the breath sample.

Abstract: A portable system is provided for measuring an analyte, such as acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user. The application tracks, and generates graphs of, the measurements, and may include various features for facilitating the analysis of the measurements.

Abstract: A system is disclosed that monitors participants in health-related programs, such as weight loss or exercise programs, and that provides automated, personalized health coaching to the program participants. The system includes breath analysis devices that are used by the program participants to generate ketone measurements, and includes a mobile application that runs on mobile devices of the participants and communicates with corresponding breath analysis devices. The system operates generally by monitoring ketone levels (such as acetone levels) and other attributes of the participants and by making personalized, machine-generated changes or updates to such programs to maintain program effectiveness and engagement. In some embodiments the system uses primary and secondary process flows to collect from the participants information that is used to select or recommend health program modifications.

Abstract: A breath analysis system comprises a breath analysis device having a semiconductor sensor, such as a metal oxide semiconductor sensor, that needs to be heated or otherwise prepared before a breath test can be performed. To reduce or avoid a user-perceived delay (typically multiple minutes) associated with the sensor preparation operation, the system predictively initiates a sensor preparation operation based on a determination or prediction of whether the user is in an adequate state to perform a breath test. This prediction may be based on one or more factors, such as the current time, whether the breath analysis device is within wireless communication (e.g., Bluetooth) range of the user's smartphone, data reflective of the user's location and/or activity, etc.

Abstract: Described herein are systems and methods for modeling fluid flow. The systems may comprise a plurality of chambers, a plurality of sensors, a pump, a plurality of valves, and a flow limiting operator (FLO). The respective sensor of the plurality of sensors may be configured to sense a respective monitoring parameter associated with the respective chamber. The pump may be configured to move media to or from the respective chamber. The respective valve of the plurality of valves may be configured to control a fluid velocity of the media flowing through the respective chamber. The FLO may be electrically connected to the plurality of sensors, the pump, and the plurality of valves. The FLO may be configured to independently control the respective chamber by manipulating one or more controllable parameters associated with the respective chamber based on the respective monitoring parameter associated with the respective chamber.

Abstract: A system is disclosed that monitors participants in health-related programs, such as weight loss or exercise programs, and that provides automated, personalized health coaching to the program participants. The system includes breath analysis devices that are used by the program participants to generate ketone measurements, and includes a mobile application that runs on mobile devices of the participants and communicates with corresponding breath analysis devices. The system operates generally by monitoring ketone levels (such as acetone levels) and other attributes of the participants and by making personalized, machine-generated changes or updates to such programs to maintain program effectiveness and engagement. In some embodiments the system uses artificial intelligence to classify and coach the participants.