Abstract: A method of segmenting a plurality of users in a first region based on predicted activity external to the first region. A system and computer program product are also provided.

Abstract: An equine respiratory detection device provides an inexpensive, portable appliance for evaluating equine health. A muzzle or mouthpiece attaches to the equine mouth region for sealably engaging with the respiratory pathway. The mouthpiece attached to a tubular vessel having a volumetric sensing apparatus for measuring respiratory inflow and outflow rates. The sensing apparatus includes a hot wire anemometer and sensing circuit for sensing flow rates based on changing electrical characteristics of a sensing element resulting from a temperature and humidity of the respiratory gases. Inhaling results in inflow gases having a cooling effect on a thermistor which affects the current flow in the sensor circuit. Similarly, exhaled outflow gases have increased temperature and humidity which allow identification of bidirectional flow and computation of an overall respiration volume to the equine patient subject.

Abstract: One aspect of the disclosure provides a method of maneuvering a vehicle in reverse for attachment to a trailer. The method includes: determining, at a computing device in communication with the neural network, a selected trailer in proximity to the vehicle; detecting at least one user input gesture performed by a user and captured in at least one image from at least one camera on the vehicle; selected a maneuver command for the vehicle based on the detected gesture; and executing the maneuver to move the vehicle from the initial position toward a final position adjacent the trailer.

Abstract: Various devices are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a disposable cartridge containing a reactive material that extracts the analyte from a breath sample passed through the cartridge. In some embodiments, the cartridge contains a solid, porous structure (such as a disk, bowl or puck) that contains the reactive material. The porous structure may be created by mixing reactive particles with resin particles, and then using a sintering process to transform the mixture into a solid structure. Also disclosed are devices for routing a breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

Abstract: A breath analyte capture device includes a breath input port into which a user exhales a breath sample, and a cartridge insertion port for receiving a disposable cartridge containing an interactant. During exhalation of a breath sample, at least a portion of the breath sample is routed through the cartridge such that the analyte (such as breath acetone) is captured by the interactant. In some embodiments, the concentration of the analyte in the breath sample is measured by monitoring a chemical reaction that occurs in the disposable cartridge. The chemical reaction may be monitored by illuminating the cartridge at each of multiple light wavelengths while measuring reflected light.

Abstract: A system is provided that includes a portable measurement device for measuring acetone in a breath sample of a user. The measurement device comprises a housing, a user-direct breath input device for engaging in direct fluid communication with a respiratory tract of the user and receiving the breath sample from the respiratory tract, a flow path disposed within the housing, a nanoparticle-based sensor disposed in the housing in fluid communication with the flow path and at an intermediate location between the upstream end and the downstream end, and a flow control device disposed in the housing and in the flow path between the upstream end and the nanoparticle-based sensor that prevents flow of the breath sample in an upstream direction opposite the downstream direction.

Abstract: A user device and a breath analysis device (or other types of portable devices) use a pairing and communication protocol that address user convenience and connectivity issues. For example, a breath analysis device is associated with a unique identifier and the unique identifier is associated with an account corresponding to the user. Likewise, a user device is associated with a user device identifier and the user device identifier is associated with the account corresponding to the user. The breath analysis device and the user device can use at least one of the identifiers to determine whether the user device is authorized to pair with the breath analysis device, and vice-versa. If authorized, the breath analysis device and user device can pair with one another. Once paired, the user device may wirelessly communicate with the breath analysis device for various purposes, such as to retrieve and display breath analysis test results.

Abstract: A ketone measurement and analysis system provides various features for enabling health program participants to interpret their ketone measurements, such as breath acetone measurements. One such feature breaks down ketone measurements into causal components. For example, the system may generate and display an estimate of how much of a participant's ketone measurement is attributable to stored fat metabolism versus consumption of a “confounding substance” such as dietary fat and/or exogenous ketones. The system may also estimate the contributions of specific confounding substances, and/or the contributions of other factors or events (such as exercise, interrupted sleep, a missed medication, etc.) that affect ketone levels. Another feature involves the generation and display of target ketone levels that are personalized for the participants. The system may generate the measurement breakdowns and target ketone levels by applying data mining algorithms to aggregated data of many program participants.

Abstract: A portable system is provided for measuring a ketone, such as an acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding ketone measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user. The application tracks, and generates graphs of, the ketone measurements, and may include various features for facilitating the analysis of the measurements.

Abstract: A disclosed vehicle control system includes a controller disposed within a defined closed area that stores a map with location information for objects within the defined closed area. The controller includes a transceiver for wirelessly transmitting the map in a form usable by navigation systems of vehicles within the defined closed area. A sensor assembly disposed within the defined closed area monitors a location and path of vehicles within the defined closed area and communicate information regarding the location and path of the vehicles to the controller. The controller updates the map responsive to changes in a location of vehicles and other objects within the defined closed area and transmits an updated map to vehicles within the defined closed area.

Abstract: A system is provided that includes a portable measurement device for measuring acetone in a breath sample of a user. The measurement device comprises a housing, a user-direct breath input device for engaging in direct fluid communication with a respiratory tract of the user and receiving the breath sample from the respiratory tract, a flow path disposed within the housing, a nanoparticle-based sensor disposed in the housing in fluid communication with the flow path and at an intermediate location between the upstream end and the downstream end, and a flow control device disposed in the housing and in the flow path between the upstream end and the nanoparticle-based sensor that prevents flow of the breath sample in an upstream direction opposite the downstream direction.

Abstract: The invention comprises a ready to use film dosage form comprising microemulsion of an Active Pharmaceutical Ingredient embedded or immobilized in a thin polymeric matrix as a double microemulsion and a process of making the same. The microemulsion in the film dosage form of this invention is capable of being absorbed through mucosal route. The process of making the film dosage of this invention comprises steps of forming a film forming dispersion containing film forming polymers, excipients and microemulsion of active pharmaceutical ingredient, casting the same in the form of a film and drying the cast of the film being carried out by means of drying conditions that suit to retain stability of the active pharmaceutical ingredient being selected such that drying of the film is achieved retaining the moisture trapped in the microemulsion embedded in the polymeric film.

Abstract: Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level.

Abstract: Various devices are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a disposable cartridge containing a reactive material that extracts the analyte from a breath sample passed through the cartridge. In some embodiments, the cartridge contains a solid, porous structure (such as a disk, bowl or puck) that contains the reactive material. To induce a chemical reaction for measuring the quantity of the extracted analyte, the porous structure may be brought into contact with a sponge or pad that dispenses developer solution to the porous structure. Also disclosed are devices for routing a breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

Abstract: An apparatus and associated method are provided for sensing an analyte, such as acetone, in breath. The apparatus includes a sorbent material that extracts the analyte from a dehumidified breath sample, and a nanoparticle-based sensor. The apparatus produces first and second gas streams that flow over the nanoparticle-based sensor. The first gas stream is used to generate a baseline signal, and the second gas stream is used to carry the extracted analyte from the sorbent material to the nanoparticle-based sensor. Various additional designs of analyte sensing devices are also disclosed.

Abstract: A method for effecting angiogenesis in a subject at risk of or experiencing ischemia related to the heart, brain, kidney, intestine, and/or legs. The method involves administering Nigella sativa to the subject. The method may also treat ischemia.

Abstract: Various systems and devices are disclosed for measuring an analyte, such as acetone, in a breath sample of a human subject. In some embodiments, a system is provided that includes a displosable cartridge having a reaction chamber containing an interactant, such as interactant particles. The interactant reacts with an analyte in a breath sample that is passed along a flow path through the reaction chamber. An optical subsystem measures a color change resulting from a reaction in the reaction chamber; this color change is indicative of a concentration of the analyte in the breath sample. In some embodiments, the optical subsystem illuminates the cartridge using multiple LEDs of different colors or wavelengths.

Abstract: A ketone measurement and analysis system provides various features for enabling health program participants to interpret their ketone measurements, such as breath acetone measurements. One such feature breaks down ketone measurements into causal components. For example, the system may generate and display an estimate of how much of a participant's ketone measurement is attributable to stored fat metabolism versus consumption of a “confounding substance” such as dietary fat and/or exogenous ketones. The system may also estimate the contributions of specific confounding substances, and/or the contributions of other factors or events (such as exercise, interrupted sleep, a missed medication, etc.) that affect ketone levels. Another feature involves the generation and display of target ketone levels that are personalized for the participants. The system may generate the measurement breakdowns and target ketone levels by applying data mining algorithms to aggregated data of many program participants.

Abstract: An apparatus and associated method are provided for sensing an analyte, such as acetone, in breath. The apparatus includes a sorbent material that extracts the analyte from a dehumidified breath sample, and a nanoparticle-based sensor. The apparatus produces first and second gas streams that flow over the nanoparticle-based sensor. The first gas stream is used to generate a baseline signal, and the second gas stream is used to carry the extracted analyte from the sorbent material to the nanoparticle-based sensor. Various additional designs of analyte sensing devices are also disclosed.

Abstract: A wearable breath analysis device is disclosed that may be worn, for example, around the neck or wrist of a user. The wearable device may be a stand-along device (in which case it may include a display that provides a user interface), or may operate in conjunction with a smartphone or other command device. The wearable device may include auditory and/or vibratory notice and communications features or capabilities, for example, such as a reminder or notice to conduct a breath analyte measurement, instructions to the user in the course of conducting the measurement, and notice of the breath analyte measurement results. The auditory or vibratory notice may be provided at the wearable, and/or at the command device where a command device is used. Related methods also are provided.