Abstract: Provided is a method for developing a geographic agnostic machine learning model. The method may include selecting transaction data associated with payment transactions conducted by a first plurality of users, wherein the transaction data includes first transaction data associated with payment transactions conducted by a first plurality of users in a first geographic area and second transaction data associated with payment transactions conducted by a second plurality of users in a second geographic area, formatting the first transaction data associated with payment transactions conducted by the first plurality of users in the first geographic area and the second transaction data associated with payment transactions conducted by the second plurality of users in the second geographic area to provide training data, and generating the geographic agnostic machine learning model using the training data. A system and computer program product are also disclosed.

Abstract: A method is provided for characterizing analyte-specific affinity agents having affinity for an analyte. The method includes providing a library of candidate affinity agents, providing a surface suitable for adhesion of the library of candidate affinity agents, and exposing the library of candidate affinity agents to the surface to thereby adhere the library of candidate affinity agents to the surface. It also includes providing an analyte, and causing the analyte to contact the surface to thereby expose the library of candidate affinity agents adhered to the surface to the analyte, to cause selected ones of the candidate affinity agents to react with the analyte to form reaction products, and to create an output fluid that comprises the reaction products. In addition, the method includes analyzing the output fluid to characterize the analyte-specific affinity agents associated with the respective reaction products.

Abstract: A portable system is provided for measuring a ketone, such as an acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding ketone measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user. The application tracks, and generates graphs of, the ketone measurements, and may include various features for facilitating the analysis of the measurements.

Abstract: An apparatus is provided for sensing an analyte in a fluid.

Abstract: A breath analysis device into which a user exhales a breath sample is capable of venting an initial portion of the breath sample from the device, and routing a second portion of the breath sample into a disposable cartridge containing an interactant. The device may include a sensor, such as a pressure sensor, for detecting the initiation of exhalation, and may include a controller that switches a valve during the exhalation process to route a desired portion of the breath sample into the cartridge. After the exhalation process, an LED/photodiode arrangement, or another type of optical sensor, may be used to measure a color change produced by a chemical reaction in the cartridge, to thereby measure a concentration of a ketone or other analyte in the breath sample.

Abstract: A portable system is provided for measuring a ketone, such as an acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding ketone measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user. The application tracks, and generates graphs of, the ketone measurements, and may include various features for facilitating the analysis of the measurements. One such feature compares ketone measurements taken while the user is on a health program to a baseline level determined from pre-program-initiation ketone measurements.

Abstract: A system is provided for sensing an analyte in breath of a user. The system comprises a base; a breath input operatively coupled to the base that receives the breath; a cartridge coupled to the base and in fluid communication with the breath input to receive the breath, wherein the cartridge comprises an interactant subsystem that is selected to undergo a reaction with the analyte when the analyte is present in the breath and to undergo an optical change corresponding to the reaction; and an optical subsystem coupled to the base and configured to sense the optical change, wherein the optical subsystem generates an output comprising information about the analyte in response to the optical detection.

Abstract: Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level.

Abstract: According to one aspect of the invention, an apparatus is provided for sensing an analyte, such as acetone, in breath. The apparatus includes a conditioning device that dehumidifies a breath sample, a sorbent material that extracts the analyte from the dehumidified breath sample, and a nanoparticle-based sensor. The apparatus produces first and second gas streams that flow over the nanoparticle-based sensor. The first gas stream is used to generate a baseline signal, and the second gas stream is used to carry the extracted analyte from the sorbent material to the nanoparticle-based sensor. Various additional designs of analyte sensing devices are also disclosed.

Abstract: A wearable breath analysis device is disclosed that may be worn, for example, around the neck or wrist of a user. The wearable device may be a stand-along device (in which case it may include a display that provides a user interface), or may operate in conjunction with a smartphone or other command device. The wearable device may include auditory and/or vibratory notice and communications features or capabilities, for example, such as a reminder or notice to conduct a breath analyte measurement, instructions to the user in the course of conducting the measurement, and notice of the breath analyte measurement results. The auditory or vibratory notice may be provided at the wearable, and/or at the command device where a command device is used. Related methods also are provided.

Abstract: A method is provided for sensing ammonia in a breath sample. The method comprises conditioning the breath sample so that the conditioned breath sample has a relative humidity greater than a relative humidity corresponding to a first inflection point of a downwardly concave lowest ammonia iso-concentration curve. It also comprises contacting the conditioned breath sample with an interactant that interacts with the ammonia in the conditioned breath sample, wherein the interaction causes a change in an optical characteristic in relation to the amount of the ammonia in the breath sample. It further comprises using the change in the optical characteristic to sense the ammonia in the breath sample. Related apparatuses are also provided.

Abstract: A portable system is provided for measuring a ketone, such as an acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding ketone measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user. The application tracks, and generates graphs of, the ketone measurements, and may include various features for facilitating the analysis of the measurements.

Abstract: Systems and methods of and for portable device for monitoring a plurality of ketones. A system may include a device comprising a first ketone body measurement unit that measures a concentration of a first ketone body, a second ketone body measurement unit different from the first ketone body measurement device that measures a second ketone body different from the first ketone body, and an output device that receives the first and second ketone body concentration measurements and presents information to the user relating to the first and second ketone body concentration measurements, optionally simultaneously. The device may be portable. The method may include using a portable device to obtain a breath acetone concentration measurement of a user and a blood ketone body concentration measurement comprising at least one of an acetoacetate concentration and a ?-HBA concentration of the user. The method may also include various other steps.

Abstract: One aspect of the disclosure provides a method of maneuvering a vehicle in reverse for attachment to a trailer. The method includes: determining, at a computing device in communication with the neural network, a selected trailer in proximity to the vehicle; detecting at least one user input gesture performed by a user and captured in at least one image from at least one camera on the vehicle; selected a maneuver command for the vehicle based on the detected gesture; and executing the maneuver to move the vehicle from the initial position toward a final position adjacent the trailer.

Abstract: A system is disclosed that uses profiles of users, including monitored ketone levels of the users, to assess effectiveness levels of health programs (such as weight loss programs) assigned to the users, and to select health program modifications for the users. The system may use a machine learning (artificial intelligence) algorithm to adaptively learn how to classify users and to select messaging and behavioral modifications for the users. For example, in some embodiments the system classifies the users and provides associated health program recommendations using a computer model trained with expert-classified user data records. As another example, a set of rules may be used to generate the health program recommendations and related messaging, and the set of rules may automatically be modified over time based on feedback data reflective of health program effectiveness levels produced by such rules.

Abstract: A breath capture device for determining the concentration of acetone in a breath sample from a user. In some embodiments, the device includes a controller programmed to use stored data to control flow of a breath sample into an analysis chamber as the user exhales into a port. In other embodiments, the device includes a switch responsive to an action by the user that is operable between a first orientation in which breath entering the port preferentially travels through a second flow path and a second orientation in which breath entering the port preferentially travels through a first flow path. In still other embodiments, the device includes a flow regulator both responsive to user action and operable from a first position in which breath entering a port preferentially travels through a second flow path to a second position in which breath entering the port preferentially travels through a first flow path.

Abstract: A method for effecting angiogenesis in a subject at risk of or experiencing ischemia related to the heart, brain, kidney, intestine, and/or legs. The method involves administering Nigella sativa to the subject. The method may also treat ischemia.

Abstract: A system for dynamic currency conversion is provided. The system includes a bank identifier system determining whether currency conversion is available for a card-issuing bank of a presented card, such as by comparing a bank identifier from the card with a list or table of participating banks. An exchange rate system determines whether an exchange rate has expired, such as an exchange rate associated with the foreign currency of the card-issuing bank. The card holder is presented with an option for selecting a foreign currency transaction after it is determined that currency conversion is available for the card-issuing bank and that the exchange rate has not expired, such that the card holder does not need to see such information unless foreign currency processing is available.

Abstract: A user device and a breath analysis device (or other types of portable devices) use a pairing and communication protocol that address user convenience and connectivity issues. For example, a breath analysis device is associated with a unique identifier and the unique identifier is associated with an account corresponding to the user. Likewise, a user device is associated with a user device identifier and the user device identifier is associated with the account corresponding to the user. The breath analysis device and the user device can use at least one of the identifiers to determine whether the user device is authorized to pair with the breath analysis device, and vice-versa. If authorized, the breath analysis device and user device can pair with one another. Once paired, the user device may wirelessly communicate with the breath analysis device for various purposes, such as to retrieve and display breath analysis test results.

Abstract: An equine respiratory detection device provides an inexpensive, portable appliance for evaluating equine health. A muzzle or mouthpiece attaches to the equine mouth region for sealably engaging with the respiratory pathway. The mouthpiece attached to a tubular vessel having a volumetric sensing apparatus for measuring respiratory inflow and outflow rates. The sensing apparatus includes a hot wire anemometer and sensing circuit for sensing flow rates based on changing electrical characteristics of a sensing element resulting from a temperature and humidity of the respiratory gases. Inhaling results in inflow gases having a cooling effect on a thermistor which affects the current flow in the sensor circuit. Similarly, exhaled outflow gases have increased temperature and humidity which allow identification of bidirectional flow and computation of an overall respiration volume to the equine patient subject.