Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for providing responses to queries regarding store observation images. An example computer readable medium includes instructions that, when executed, cause a machine to at least obtain first metadata associated with a set of store dictionaries, select ones of the set of store dictionaries for use based on the associated first metadata, obtain second metadata associated with a set of question templates, select ones of the set of question templates for use based on the associated second metadata, generate question-answer pairs using the selected ones of the set of store dictionaries and the selected ones of the set of question templates, train a machine-learning model using the question-answer pairs, and provide query responses using the trained machine-learning model.

Abstract: The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses there e.g., in treating a condition in a subject in need thereof. The devices may be coated with therapeutic agents, such as those that promo bone growth, and/or seeded with cells to generate devices for use in tissue replacement and grafting.

Abstract: A bone regeneration material has a cotton-wool like structure formed of a plurality of electrospun fibers that contain bound BMP-2 through ?-TCP binding peptide. The electrospun biodegradable fiber contains 25-65 vol % of ?-TCP particles distributed in the fiber such that a portion of the ?-TCP particles is exposed on a surface of the electrospun fiber and the remaining portion of the ?-TCP particles is buried in the fiber. ?-TCP binding peptides that are fused with BMP-2 are bound to the ?-TCP particles so that BMP-2 is tethered to ?-TCP particles on the surface of the fibers. Upon implantation of the bone regeneration material in a bone defect site of a human body, BMP-2 that are tethered to ?-TCP particles on the surface of the bone regeneration material promotes proliferation and differentiation of cells at the bone defect site.

Abstract: The invention relates to trimeric polypeptide complex comprising three monomer polypeptides wherein each monomer polypeptide comprises an anti-4-1BB specific agonistic single-chain antibody fragment (scFv), a homotrimerization domain and a polypeptide region which is capable of specifically binding to a tumor associated antigen. The invention also relates to said trimeric polypeptide complexes for use in the treatment of cancer.

Abstract: A first subject of the present invention has an antiviral formulation with metallic copper particles in an unoxidized form and having a median particle diameter inferior or equal to 200 nm, graphene oxide or reduced graphene oxide, and a bonding matrix material. A second subject of the invention has an antiviral filtering material with a layer of textile and at least one layer of an antiviral coating comprising metallic copper particles in an unoxidized form and having a median particle diameter inferior or equal to 200 nm, graphene oxide or reduced graphene oxide, and a bonding matrix into which both metallic copper particles and graphene oxide or reduced graphene oxide are anchored. The invention also concerns methods of preparation of the antiviral formulation and of the antiviral filtering material. Finally, the invention includes an antiviral face mask with a layer of textile coated with the antiviral formulation.

Abstract: The invention relates to a recombinant bacterium and uses thereof. In particular, it relates to the use of recombinant bacteria to translocate cargo proteins into the cytosol of target cells. Said recombinant bacteria comprises a T3 secretion system under the control of a genetic regulatory circuit and a targeting module which allow the recombinant bacteria to target specific cells, adhere to these and inject their cargo into the cytosol of the target cells.

Abstract: It is provided a method, device and system to facilitate the design or and architecture of a computer project and its subsequent automatic implementation, based on a hand-written/drawn draft (e.g. on paper). This draft directly becomes the tool that will be used, automatically, as the basis for the final computer project implementation.

Abstract: An electrode for electrocoagulation, a method of obtaining it, and an electrocoagulation method using the electrode. Wherein, the electrode allows reducing energy consumption kWh/kg due to the fact that it has a reduced grain size obtained through a heat treatment that gives it the characteristic sought for the reduction in energy consumption.

Abstract: A glass/quartz composite structure may comprise aggregate including glass grit, nano-glass crystals, and/or amorphous silica that may be produced from crystalline quartz. The aggregate may be in an amount greater than any other single material by weight of the composite structure, which may further include quartz powder and/or alumina as well as a binding resin. The glass/quartz composite structure may be devoid of crystalline silica. The structure may be formed into a 1.2-1.5 cm thick slab for countertops using standard cabinet perimeter support. The slab may be made by mixing the aggregate, the quartz powder and/or alumina, and the binding resin, pouring the mixture in a mold, and compacting the mixture in the mold. Specific natural mineral components, decorative chips, and/or wet mixture pieces may be added to the composite structure to provide aesthetics of specific natural stones.

Abstract: The present invention relates to a pharmaceutical composition comprising a therapeutically effective dose of Lenvatinib mesylate having sodium wherein the weight ratio of Lenvatinib mesylate to sodium carbonates ranges from 1:1.5 to 1:5.

Abstract: An advanced manufactured transwell (AM-transwell), the AM-transwell comprises: a lower chamber; an upper chamber; a membrane disposed between the lower chamber and the upper chamber; and one or more legs. The one or more legs form at least a portion of the lower chamber. One or more of the lower chambers, the upper chamber, the membrane and the one or more legs is printed using a synthetic bioink. Methods for making and using the AM-transwell are also disclosed.

Abstract: Provided herein are polypeptides that include one or more ?-tricalcium phosphate (?TCP)-binding sequence(s) and uses thereof.

Abstract: A controller for an imaging device is configured to control an optical detection unit to receive fluorescence light emitted by first and second fluorophore species excited by first and second excitation light, respectively, to separate the fluorescence light into at least two spectral detection channels corresponding to two wavelength bands, respectively. A first wavelength band includes an emission spectrum of the first fluorophore species. A second wavelength band includes an emission spectrum of the second fluorophore species. The controller is further configured to control the optical detection unit to detect photon arrival times of the fluorescence light relative to light pulses of the second excitation light, to determine a temporal correlation between the light pulses and the photon arrival times, and to determine a first number and a second number of photons received in the first spectral detection channel and/or the second spectral detection channel based on the temporal correlation.

Abstract: Provided herein are polypeptides that include one or more ?-tricalcium phosphate (?TCP)-binding sequence(s) and uses thereof.

Abstract: A platform form an apparatus for printing a 3D model comprises a base and a print layer. The base has a first side where the first side of the base has a first surface roughness thereon. The print layer is coupled first side of the base and includes a surface. The surface of the print layer is distal from the base and has a second surface roughness which is greater than the first surface roughness so as to promote adhesion of the 3D model being printed on the platform.

Abstract: A method of producing an osteoinductive bone graft formed of a plurality of electrospun biodegradable fibers is disclosed. The method includes preparing a fibrous scaffold material formed of the plurality of electrospun biodegradable fibers, wherein the plurality of electrospun biodegradable fibers are entangled with each other to form a cotton-wool like structure having inter-fiber spaces forming a microenvironment for cell growth therein, and immersing the fibrous scaffold in a solution containing BMP-2 so that the BMP-2 is bound to the calcium particles exposed on the surface of the fibers. Area of binding site for BMP-2 on calcium particles exposed on a surface of the electrospun biodegradable fibers is adjusted by an amount of the calcium particles contained in the electrospun biodegradable fibers.

Abstract: Provided herein are polypeptides comprising a therapeutic targeted for delivery to an organ or tissue, and uses thereof.

Abstract: A glass/quartz composite structure comprises quartz grit, quartz powder and glass grit wherein the glass grit is in an amount greater than any other single material by weight of the composite structure (e.g. a combined weight of the quartz grit, quartz powder, glass grit, resin, and coupling agent). Natural stone components, which may include the quartz grit and quartz powder, may be in an amount greater than 30% by weight of the composite structure. The structure may be formed into a 1.2-1.5 cm thick slab for countertops using standard cabinet perimeter support. The slab may be made by mixing the quartz grit, quartz powder, glass grit, and binding resin, pouring the mixture in a mold, and compacting the mixture in the mold. Specific natural mineral components, decorative chips, and/or wet mixture pieces may be added to the composite structure to provide aesthetics of specific natural stones.

Abstract: Provided herein are polypeptides that include one or more ?-tricalcium phosphate (?TCP)-binding sequence(s) and uses thereof.

Abstract: A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.