Abstract: Apparatus and method for forming a three-dimensional object. The apparatus includes a platform on which the three-dimensional object is formed. The apparatus includes an oxygen soluble liquid having a build surface. The build surface and the platform define a build region therebetween. The apparatus includes a photosensitive liquid disposed on the oxygen soluble liquid. The density of the oxygen soluble liquid is greater than the density of the photosensitive liquid. The apparatus includes an optically transparent member. The optically transparent member supports the oxygen soluble liquid. The apparatus includes a radiation source configured to irradiate the build region through the optically transparent member and the oxygen soluble liquid to form a solid polymer from the photosensitive liquid. The apparatus includes a controller configured to advance the platform away from the build surface.

Abstract: Provided herein are beta-TCP binding sequences and chimeric polypeptides that include one or more beta-TCP binding sequences and a mammalian growth factor, compositions comprising any of these chimeric polypeptides (and optionally, beta-TCP), and methods of promoting bone or cartilage formulation, methods of replacing and/or repairing bone or cartilage, and methods of treating a bone fraction or bone loss that include administration of any of these compositions.

Abstract: The invention relates to tumor-targeted trimeric polypeptides based on the homotrimerization region from collagen XV or XVIII and which contain domains capable of specifically binding to and activating receptors of the TNFR family of costimulatory receptors as well as to the uses thereof in the treatment of cancer.

Abstract: A prosthesis system of the present invention includes a monoblock stem extension including a proximal portion having a first neutral axis; and a distal portion defined by a longitudinal cylindrical shaft having a second neutral axis, wherein the second neutral axis is parallel and offset by a distance ? from the first neutral axis; and an eccentric bushing arranged coaxial around the cylindrical shaft of the monoblock stem extension, the eccentric bushing including an external cylindrical shaft having a third neutral axis; and an internal cylinder having a fourth neutral axis that is substantially co-linear with the second neutral axis of the monoblock stem extension, wherein the third neutral axis is parallel and offset by a distance ? from the fourth neutral axis.

Abstract: A system for presenting a collection of objects including a database of images for each of the collection of objects and a computer in data communications with the database. The system also includes a plurality of tags respectively associated with each of the collection of objects and data associated with each of the collection of objects both of which are stored in the database together with the corresponding image. Further, the system has a mosaic created as an array of at least some of the images from each of the collection of objects. The computer includes software that is configured to receive an image selection from an array position of the mosaic or one of the plurality of tags and to retrieve and transmit the corresponding image and data from the database for display.

Abstract: A bone regeneration material has a cotton-wool like structure formed of a plurality of electrospun fibers that contain bound BMP-2 through ?-TCP binding peptide. The electrospun biodegradable fiber contains 25-65 vol % of ?-TCP particles distributed in the fiber such that a portion of the ?-TCP particles is exposed on a surface of the electrospun fiber and the remaining portion of the ?-TCP particles is buried in the fiber. ?-TCP binding peptides that are fused with BMP-2 are bound to the ?-TCP particles so that BMP-2 is tethered to ?-TCP particles on the surface of the fibers. Upon implantation of the bone regeneration material in a bone defect site of a human body, BMP-2 that are tethered to ?-TCP particles on the surface of the bone regeneration material promotes proliferation and differentiation of cells at the bone defect site.

Abstract: Provided herein are polypeptides that include one or more ?-tricalcium phosphate (?TCP)-binding sequence(s) and uses thereof.

Abstract: A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

Abstract: A glass/quartz composite structure comprises quartz grit, quartz powder and glass grit wherein the glass grit is in an amount greater than 50% by weight of the composite structure, and a binding resin. The glass/quartz composite structure may be formed into a 1.2-1.5 cm thick slab for countertops using standard cabinet perimeter support. The slab may be made by mixing the quartz grit, the quartz powder, the glass grit, and the binding resin, pouring the mixture in a mold, and compacting the mixture in the mold. Specific natural mineral components may be added to the glass/quartz/resin composite structure to provide aesthetics of specific natural stones.

Abstract: The invention is directed to a composition comprising all or a portion of a beta-tricalcium phosphate (?-TCP) bound to all or a portion of a ?-TCP binding peptide and methods of use thereof.

Abstract: The invention is directed to a composition comprising all or a portion of a beta-tricalcium phosphate (?-TCP) bound to all or a portion of a ?-TCP binding peptide and methods of use thereof.

Abstract: The present invention relates to the field of biomedicine and antibody engineering. Specifically, it relates to mono and multispecific multivalent single chain polypeptide molecules and derivatives thereof, preferably to multispecific single chain (tandem) trimerbodies with defined stoichiometry, to nucleic acid sequences and vectors encoding thereof, and host cells expressing the same. It further relates to methods of producing thereof, pharmaceutical compositions, kits, methods of treatment, use as diagnostics or imaging reagents and combination therapies using thereof.

Abstract: The present invention relates to a modular system of closed photobioreactors, intended for indoor operation with LED lighting, in an uninterrupted and completely automated manner, with continuous monitoring of process variables, and feedback control of the CO2 and nutrients, of water temperature along the entire route of the photobioreactor, allowing maximum use of the indoor space where the system is arranged.

Abstract: In one embodiment, the present invention provides an augment comprising: a. a side configured to contact and attach to a receiving bone; b. a side configured to contact an implant; and c. an exterior profile, wherein the side configured to contact a receiving bone and the side configured to contact an implant are separated by a thickness; and wherein the augment is configured to anchor to the receiving bone.

Abstract: A prosthesis system (100) of the present invention includes a monoblock stem extension (10) comprising a proximal portion (20) having a first neutral axis (20a); and a distal portion (30) defined by a longitudinal cylindrical shaft (31) having a second neutral axis (30a), wherein the second neutral axis (30a) is parallel and offset by a distance a from the first neutral axis (20a): and an eccentric bushing (50) arranged coaxial around the cylindrical shaft (31) of the monoblock stem extension (10), the eccentric bushing (50) comprising an external cylindrical shaft (51) having a third neutral axis (51a); and an internal cylinder (53) having a fourth neutral axis (50a) that is substantially co-linear with the second neutral axis (30a) of the monoblock stem extension (10), wherein the third neutral axis (5 1 a) is parallel and offset by a distance ? from the fourth neutral axis (50a).

Abstract: The present invention provides a tire rim detailing tool configured to removably adhere to an inner edge of a wheel to enclose a tire rim. In this way, the tire rim is protected from any cleaning supplies that may damage the tire rim during car detailing. The tire rim detailing tool includes a body portion that is preferably circular and includes a front side and a rear side. The rear side includes an absorbent pad that extends along an outer edge of the body portion. The absorbent pad is removably attached to an inner edge of a wheel via an adhesive to prevent any cleaning supplies from damaging the tire rim. The front side includes a handle that extends along a diameter of the body portion. Furthermore, the body portion is foldable along the diameter and a pair of chords that are equally spaced from and parallel to the diameter.

Abstract: The invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XVIII protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes.

Abstract: The invention relates generally to a new trimerization domain useful for developing multifunctional and multivalent complexes. Particularly, the invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XV protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes.

Abstract: This application provides nanoparticles and methods of making nanoparticles using pre-functionalized poly(ethylene glycol)(also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. Ring opening polymerization yields the desired poly(ester)-poly (ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization from” approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling to” that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonal” chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest.

Abstract: The device of the invention consists in a telescopic element with two arms, one of them movable within the other, having in its corresponding ends attachment means (3), so that the shorter arm (2) has means with an axial groove (5) which in the normal working situation is operatively opposite in respect to an axial chamber (6) of the internal portion of the longer arm (1), so that in said chamber a blocking element is movable vertically in respect to the groove, preferably a cylinder (7) opposing the effort of an elastic element located within the corresponding housing (11) which is encased in said groove (5) blocking the device and permitting its unblocking once the effort of the elastic means on the cylinder is exceeded. The device is reusable and it is easily adjustable to different levels of effort for its unblocking.