Abstract: A platform form an apparatus for printing a 3D model comprises a base and a print layer. The base has a first side where the first side of the base has a first surface roughness thereon. The print layer is coupled first side of the base and includes a surface. The surface of the print layer is distal from the base and has a second surface roughness which is greater than the first surface roughness so as to promote adhesion of the 3D model being printed on the platform.

Abstract: Provided herein are polypeptides comprising a therapeutic targeted for delivery to an organ or tissue, and uses thereof.

Abstract: A method of producing an osteoinductive bone graft formed of a plurality of electrospun biodegradable fibers is disclosed. The method includes preparing a fibrous scaffold material formed of the plurality of electrospun biodegradable fibers, wherein the plurality of electrospun biodegradable fibers are entangled with each other to form a cotton-wool like structure having inter-fiber spaces forming a microenvironment for cell growth therein, and immersing the fibrous scaffold in a solution containing BMP-2 so that the BMP-2 is bound to the calcium particles exposed on the surface of the fibers. Area of binding site for BMP-2 on calcium particles exposed on a surface of the electrospun biodegradable fibers is adjusted by an amount of the calcium particles contained in the electrospun biodegradable fibers.

Abstract: A glass/quartz composite structure comprises quartz grit, quartz powder and glass grit wherein the glass grit is in an amount greater than any other single material by weight of the composite structure (e.g. a combined weight of the quartz grit, quartz powder, glass grit, resin, and coupling agent). Natural stone components, which may include the quartz grit and quartz powder, may be in an amount greater than 30% by weight of the composite structure. The structure may be formed into a 1.2-1.5 cm thick slab for countertops using standard cabinet perimeter support. The slab may be made by mixing the quartz grit, quartz powder, glass grit, and binding resin, pouring the mixture in a mold, and compacting the mixture in the mold. Specific natural mineral components, decorative chips, and/or wet mixture pieces may be added to the composite structure to provide aesthetics of specific natural stones.

Abstract: Provided herein are polypeptides that include one or more ?-tricalcium phosphate (?TCP)-binding sequence(s) and uses thereof.

Abstract: A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

Abstract: An apparatus is configured to count N-photon events within a time-dependent sequence of events of interactions of a plurality of photons with a light sensitive detector. The apparatus includes a signal-processing device and the light sensitive detector. An N-photon event represents an occurrence of at least N timely overlapping single photon events. The light sensitive detector is adapted to generate a time-dependent digital signal comprising digital patterns representing the time-dependent sequence of events from the detection of the plurality of photons with the light sensitive detector. Each digital pattern in the digital signal comprises a digital pattern width having a continuous sequence of digital values representing at least one event of interaction of at least one photon with the light sensitive detector. The signal-processing device is adapted to identify N-photon events from the digital patterns in the digital signal in dependence from the respective digital pattern width.

Abstract: A vehicle proctor includes a first sheet sized to cover a pair of headlights of the vehicle. A second sheet sized to be within 80% of the same surface area as the first sheet arranged in an opposing relationship. The first sheet and the second sheets are joined around their periphery. The first sheet has a heavier material than the second sheet. A flap is interconnected with the first sheet. The flap fits under the hood of the vehicle. The flap has an interior deformable material and has a thickness greater than the combination of the first and second sheets.

Abstract: The present invention relates to a method for obtaining covalently modified graphene. The invention also describes covalently modified graphene obtained by this method and use thereof as an anchoring surface for bioreceptors in biosensor devices. Lastly, the invention describes a biosensor device comprising covalently modified graphene obtainable according to the method of the invention.

Abstract: A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

Abstract: A glass/quartz composite structure comprises quartz grit (and/or nan-glass crystals), quartz powder and glass grit wherein the glass grit is in an amount greater than any other single material by weight of the composite structure (e.g. a combined weight of the quartz grit, quartz powder, glass grit, resin, and coupling agent). Natural stone components, which may include the quartz grit and quartz powder, may be in an amount greater than 30% by weight of the composite structure. The structure may be formed into a 1.2-1.5 cm thick slab for countertops using standard cabinet perimeter support. The slab may be made by mixing the quartz grit, quartz powder, glass grit, and binding resin, pouring the mixture in a mold, and compacting the mixture in the mold. Specific natural mineral components, decorative chips, and/or wet mixture pieces may be added to the composite structure to provide aesthetics of specific natural stones.

Abstract: A bone regeneration material has a cotton-wool like structure formed of a plurality of electrospun fibers that contain bound BMP-2 through ?-TCP binding peptide. The electrospun biodegradable fiber contains 25-65 vol % of ?-TCP particles distributed in the fiber such that a portion of the ?-TCP particles is exposed on a surface of the electrospun fiber and the remaining portion of the ?-TCP particles is buried in the fiber. ?-TCP binding peptides that are fused with BMP-2 are bound to the ?-TCP particles so that BMP-2 is tethered to ?-TCP particles on the surface of the fibers. Upon implantation of the bone regeneration material in a bone defect site of a human body, BMP-2 that are tethered to ?-TCP particles on the surface of the bone regeneration material promotes proliferation and differentiation of cells at the bone defect site.

Abstract: Embodiments of this disclosure relate to bioinks and bioink compositions. These bioinks may be 3D printed into a hydrogel. The printed hydrogel may support primary cell and induced pluripotent stem cell attachment, proliferation, and spreading. Compounds in the bioink may be modified to incorporate chemical functionality, such as by chemical synthesis means. Incorporating chemical functionality may allow the incorporation of modified material as a component in the bioink. The modifications may allow chemical conjugation of a desired component. The desired component may maintain its cell interactive feature to aid in cell attachment and proliferation. Such incorporation may allow modulation of the bioprinted object's mechanical properties without interfering with cell adhesion.

Abstract: The present disclosure provides printable compositions comprising: about 1 weight percent (wt %) to about 40 wt % of one or more hydrophilic monomers; a swelling control agent selected from a hydrophobic monomer, a short chain crosslinker, or a combination thereof; about 0.01 wt % to about 2 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition. The disclosure also includes methods of use and manufacture related to printable compositions.

Abstract: Provided herein are methods which alter the mechanical and biological properties of polymeric materials. Also provided are compositions comprising the polymeric materials having said properties.

Abstract: The systems and methods of the present disclosure can be used to generate systems and models that are physiologically relevant to the human and animal system. These physiological conditions can be designed to mimic the actual human condition for cell differentiation and proliferation. The system and methods of this present disclosure allow the formation of an appropriate biomaterial to mimic that which exists in a human or animal scaffold. Utilizing 3D printing technology, a hydrogel scaffold can be printed at various resolution very close to human physiological geometry. Additionally, the architecture can be optimized for the selected application and appropriate cells can be seeded on the scaffold prior to testing.

Abstract: The present disclosure provides reinforced hydrogel structures, methods of reinforcing hydrogel structures, and methods of treating ischemic disorders using the reinforced hydrogel structures.

Abstract: The present invention relates to a method for generating a result image. The method comprises the steps of: acquiring a STED image of a sample, the STED image comprising pixels; calculating Fourier coefficients of arrival times for the pixels of the image, resulting in real coefficients representing a first image and in imaginary coefficients representing a second image; deriving an intensity image from the STED image; applying a spatial filter to the first image, the second image and the intensity image, resulting in a filtered first image, a filtered second image, and filtered intensity image, respectively; calculating an image G based on the filtered first image and the filtered intensity image; calculating an image S based on the filtered second image and the filtered intensity image; and calculating a result image based on the image G and the image S.

Abstract: The present disclosure provides devices comprising a therapeutic agent bound to a printed three-dimensional structure. The printed three-dimensional structure comprises about 50% to about 100% by weight ceramic and about 0% to about 50% by weight N polymer. Ink formulations for three-dimensional printing are also disclosed. Additionally, provided herein are methods for manufacturing devices and uses thereof, e.g., in treating a condition in a subject in need thereof.

Abstract: An additive manufacturing device includes an output device and a controller. The output device is configured to receive at least one material to generate a component. The controller includes one or more processors configured to receive a model including a plurality of pixels representing the component, identify at least one pixel of the plurality of pixels corresponding to a first surface of the component, modify the model to adjust an exposure corresponding to the at least one pixel based on a target exposure, and control operation of the output device to cause the output device to generate the component based on the modified model.