Patents by Inventor Luk H. Vandenberghe

Luk H. Vandenberghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene therapy for NMNAT1-associated retinal degeneration
    Patent number: 12257320
    Abstract: Methods and compositions for gene therapy of retinal degeneration related to mutations in nicotinamide mononucleotide adenylyltransferase 1 (NMNAT1).
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: March 25, 2025
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Eric A. Pierce, Luk H. Vandenberghe, Scott Greenwald, Emily Brown
  • Ancestral virus sequences and uses thereof
    Patent number: 12227543
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: February 18, 2025
    Assignees: Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Compositions and methods for modulating transduction efficiency of adeno-associated viruses
    Patent number: 12195745
    Abstract: Methods and compositions for modulating the transduction efficiency of an adeno-associated vims (AAV) into a cell or tissue are provided.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: January 14, 2025
    Assignees: Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
    Inventors: Luk H. Vandenberghe, Amanda Dudek, Nerea Zabaleta Lasarte
  • METHODS OF DELIVERING AN AGENT TO THE EYE
    Publication number: 20240390182
    Abstract: Methods of delivering agents to structures within the eye are provided.
    Type: Application
    Filed: April 2, 2024
    Publication date: November 28, 2024
    Inventors: Jason Comander, Dean Eliott, Leo A. Kim, Luk H. Vandenberghe
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 12134786
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: April 27, 2023
    Date of Patent: November 5, 2024
    Assignees: Schepens Eye Research Institute, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Materials and methods for delivering nucleic acids to cochlear and vestibular cells
    Patent number: 12102692
    Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: October 1, 2024
    Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute, Children's Medical Center Corporation
    Inventors: Konstantina Stankovic, Luk H. Vandenberghe, Jeffrey Holt, Gwenaelle Geleoc
  • Methods of making and using combinatorial barcoded nucleic acid libraries having defined variation
    Patent number: 12037707
    Abstract: This disclosure describes compositions, methods, and systems for constructing defined variation in a contiguous functional genetic unit in association with a unique sequence identifier (“a barcode”) in a combinatorial manner.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: July 16, 2024
    Assignees: Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
    Inventors: Luk H. Vandenberghe, Eric Zinn, Heikki Turunen
  • Altering tissue tropism of adeno-associated viruses
    Patent number: 11987801
    Abstract: This disclosure provides compositions and methods for altering or changing the tissue tropism, e.g., liver tropism, of adeno-associated viruses (AAV).
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: May 21, 2024
    Assignees: Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
    Inventors: Luk H. Vandenberghe, Pauline Schmit, Christopher Tipper, Carmen Unzu, Eric Zinn
  • Methods of delivering an agent to the eye
    Patent number: 11963905
    Abstract: Methods of delivering agents to structures within the eye are provided.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: April 23, 2024
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Jason Comander, Dean Eliott, Leo Kim, Luk H. Vandenberghe
  • Methods and compositions for modifying assembly-activating protein (AAP)-dependence of viruses
    Patent number: 11958884
    Abstract: Methods and compositions are provided that can be used to modify the assembly activating protein (AAP)-dependence of an adeno-associated virus (AAV).
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: April 16, 2024
    Assignees: Massachusetts Eye and Ear Infirmary, The Schepens Eye Research Institute, Inc.
    Inventors: Luk H. Vandenberghe, Anna Claire Maurer
  • METHODS AND COMPOSITIONS FOR MODULATING THE INTERACTION BETWEEN ADENO-ASSOCIATED VIRUS (AAV) AND THE AAV RECEPTOR (AAVR) FOR ALTERED BIO-DISTRIBUTION OF AAV
    Publication number: 20240060087
    Abstract: This disclosure describes compositions and methods for altering the bio-distribution of adeno-associated viruses (AAVs) in subjects.
    Type: Application
    Filed: January 7, 2022
    Publication date: February 22, 2024
    Inventors: Eric Zinn, Christopher Tipper, Luk H. Vandenberghe
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20230287359
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: April 27, 2023
    Publication date: September 14, 2023
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • ALTERING TISSUE TROPISM OF ADENO-ASSOCIATED VIRUSES
    Publication number: 20230051611
    Abstract: This disclosure provides compositions and methods for altering or changing the tissue tropism, e.g., liver tropism, of adeno-associated viruses (AAV).
    Type: Application
    Filed: May 10, 2019
    Publication date: February 16, 2023
    Inventors: Luk H. Vandenberghe, Pauline Schmit, Christopher Tipper, Carmen Unzu, Eric Zinn
  • METHODS AND COMPOSITIONS FOR MODULATING THE INTERACTION BETWEEN ADENO-ASSOCIATED VIRUS (AAV) AND THE AAV RECEPTOR (AAVR) FOR ALTERED BIO-DISTRIBUTION OF AAV
    Publication number: 20220411820
    Abstract: This disclosure describes compositions and methods for altering the bio-distribution of adeno-associated viruses (AAVs) in subjects.
    Type: Application
    Filed: September 9, 2020
    Publication date: December 29, 2022
    Inventors: Eric Zinn, Christopher Tipper, Luk H. Vandenberghe
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 11466258
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: October 11, 2022
    Assignees: The Schepens Eye Research Institute, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS AND COMPOSITIONS FOR IMPROVING THE ASSEMBLY OF ADENO-ASSOCIATED VIRUSES (AAVs)
    Publication number: 20220186193
    Abstract: Described herein are methods and compositions for modifying cells to improve the assembly of adeno-associated viruses (AAVs).
    Type: Application
    Filed: April 13, 2020
    Publication date: June 16, 2022
    Inventors: Anna Maurer, Luk H. Vandenberghe
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20220017875
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: August 20, 2021
    Publication date: January 20, 2022
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • MATERIALS AND METHODS FOR DELIVERING NUCLEIC ACIDS TO COCHLEAR AND VESTIBULAR CELLS
    Publication number: 20220016262
    Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.
    Type: Application
    Filed: October 5, 2021
    Publication date: January 20, 2022
    Inventors: Konstantina Stankovic, Luk H. Vandenberghe, Jeffrey Holt, Gwenaelle Geleoc
  • Materials and methods for delivering nucleic acids to cochlear and vestibular cells
    Patent number: 11167042
    Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: November 9, 2021
    Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute, Children's Medical Center Corporation
    Inventors: Konstantina Stankovic, Luk H. Vandenberghe, Jeffrey Holt, Gwenaelle Geleoc
  • COMPOSITIONS AND METHODS FOR MODULATING TRANSDUCTION EFFICIENCY OF ADENO-ASSOCIATED VIRUSES
    Publication number: 20210317478
    Abstract: Methods and compositions for modulating the transduction efficiency of an adeno-associated vims (AAV) into a cell or tissue are provided.
    Type: Application
    Filed: August 21, 2019
    Publication date: October 14, 2021
    Inventors: Luk H. Vandenberghe, Amanda Dudek, Nerea Zabaleta Lasarte