Patents by Inventor Luk H. Vandenberghe

Luk H. Vandenberghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of delivering an agent to the eye
    Patent number: 10881548
    Abstract: Methods of delivering agents to structures within the eye are provided.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: January 5, 2021
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Jason Comander, Dean Eliott, Leo Kim, Luk H. Vandenberghe
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20200318082
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 8, 2020
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Ancestral virus sequences and uses thereof
    Patent number: 10738087
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: August 11, 2020
    Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • PRODUCTION OF ADENO-ASSOCIATED VIRUSES IN INSECT CELLS
    Publication number: 20200231986
    Abstract: This disclosure relates to the field of high scale production of recombinant Adeno-Associated Viruses (AAVs). The inventors have conceived of specific nucleic acid constructs that allow for high scale production of recombinant AAV particles in insect cells. Importantly, these nucleic constructs do not require the production of a heterologous AAP. This disclosure thus relates to a nucleic acid for producing AAV capsids in insect cells, where the nucleic acid includes a first open reading frame encoding the VP1, VP2, and VP3 proteins, and a second open reading frame encoding the Assembly-Activating Protein (AAP).
    Type: Application
    Filed: September 28, 2018
    Publication date: July 23, 2020
    Inventors: Eduard Ayuso, Cecile Robin, Magalie Penaud-Budloo, Achille Francois, Véronique Blouin, Luk H. Vandenberghe, Anna Claire Maurer
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20200123504
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: December 17, 2019
    Publication date: April 23, 2020
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 10526584
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: January 7, 2020
    Assignees: The Schepens Eye Research Institute, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS AND COMPOSITIONS FOR MODIFYING ASSEMBLY-ACTIVATING PROTEIN (AAP)-DEPENDENCE OF VIRUSES
    Publication number: 20190330278
    Abstract: Methods and compositions are provided that can be used to modify the assembly activating protein (AAP)-dependence of an adeno-associated virus (AAV).
    Type: Application
    Filed: May 10, 2019
    Publication date: October 31, 2019
    Inventors: Luk H. Vandenberghe, Anna Claire Maurer
  • Ancestral Virus Sequences and Uses Thereof
    Publication number: 20190100560
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen opeiably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: July 29, 2016
    Publication date: April 4, 2019
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20190055524
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: November 2, 2018
    Publication date: February 21, 2019
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • MATERIALS AND METHODS FOR DELIVERING NUCLEIC ACIDS TO COCHLEAR AND VESTIBULAR CELLS
    Publication number: 20180369414
    Abstract: Provided herein are materials and methods for efficiently delivering nucleic acids to cochlear and vestibular cells.
    Type: Application
    Filed: December 12, 2016
    Publication date: December 27, 2018
    Inventors: Konstantina Stankovic, Luk H. Vandenberghe, Jeffrey Holt, Gwenaelle Geleoc
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 10119125
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: November 6, 2018
    Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS OF DELIVERING AN AGENT TO THE EYE
    Publication number: 20180116869
    Abstract: Methods of delivering agents to structures within the eye are provided.
    Type: Application
    Filed: May 6, 2016
    Publication date: May 3, 2018
    Inventors: Jason Comander, Dean Eliott, Leo Kim, Luk H. Vandenberghe
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20170298323
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 19, 2017
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Adeno-associated virus (AAV) glades, sequences, vectors containing same, and uses therefor
    Patent number: 9737618
    Abstract: Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: August 22, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: James M. Wilson, Guangping Gao, Mauricio R. Alvira, Luk H. Vandenberghe
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 9719070
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: August 1, 2017
    Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 9695220
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: July 4, 2017
    Assignees: Massachusetts Eye & Ear Infirmary, Schepens Eye Research Institute
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Simian Adenoviruses SAdV-36, -42.1, -42.2, and -44 and Uses Thereof
    Publication number: 20170183636
    Abstract: A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: March 7, 2017
    Publication date: June 29, 2017
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • Simian adenoviruses SAdV-36, -42.1, -42.2, and -44 and uses thereof
    Patent number: 9597363
    Abstract: A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: March 21, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20170051257
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: October 12, 2016
    Publication date: February 23, 2017
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • SIMIAN SUBFAMILY E ADENOVIRUSES SAdV-39, -25.2, -26, -30, -37, AND -38 AND USES THEREOF
    Publication number: 20160244783
    Abstract: A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: May 13, 2016
    Publication date: August 25, 2016
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe