Patents by Inventor Luk H. Vandenberghe

Luk H. Vandenberghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Predicting Ancestral Virus Sequences and Uses Thereof
    Publication number: 20160215024
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: April 11, 2016
    Publication date: July 28, 2016
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Simian subfamily E adenoviruses SAdV-39, -25.2, -26, -30, -37, and -38 and uses thereof
    Patent number: 9359618
    Abstract: A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -383 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: June 7, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • Simian Subfamily B Adenoviruses SAdV-28, -27, -29, -32, -33, and -35 and Uses Thereof
    Publication number: 20160051603
    Abstract: A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-28, -27, -32, -33, or -35 genes is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: November 3, 2015
    Publication date: February 25, 2016
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • Simian subfamily B adenoviruses SAdV-28, -27, -29, -32, -33, and -35 and uses thereof
    Patent number: 9206238
    Abstract: A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-28, -27, -32, -33, or -35 genes is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: December 8, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • ADENO-ASSOCIATED VIRUS (AAV) CLADES, SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR
    Publication number: 20150315612
    Abstract: Sequences of novel adeno-associated virus capsids and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV-mediated delivery of therapeutic and immunogenic genes using the vectors of the invention is also provided.
    Type: Application
    Filed: July 20, 2015
    Publication date: November 5, 2015
    Inventors: James M. Wilson, Guangping Gao, Mauricio R. Alvira, Luk H. Vandenberghe
  • SIMIAN SUBFAMILY E ADENOVIRUSES SAdV-39, -25.2, -26, -30, -37, AND -38 AND USES THEREOF
    Publication number: 20140155476
    Abstract: A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-39, -25.2, -26, -30, -37, and -383 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: February 12, 2014
    Publication date: June 5, 2014
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe
  • Simian Subfamily B Adenoviruses SAdV-28, -27, -29, -32, -33, and -35 and Uses Thereof
    Publication number: 20140044680
    Abstract: A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-28, -27, -32, -33, or -35 genes is also disclosed. Methods of using the vectors and cell lines are provided.
    Type: Application
    Filed: August 16, 2013
    Publication date: February 13, 2014
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Soumitra Roy, James M. Wilson, Luk H. Vandenberghe