Abstract: The invention relates to a valve, in particular for a component in microfluid technology, comprising valve bodies (1, 2) which have surfaces (6, 7) intended for contact with each other and which can be moved relative to each other by displacing the contact surfaces (6, 7), wherein channels (4, 5) for the inflow and outflow of a fluid open into one (6) of the contact surfaces (6, 7) and a depression (9) for forming a connection between the channels (4, 5) is provided in the other contact surface (7). According to the invention, a flexible separating film (10), which can be stretched into the depression (9) to form the connection, is arranged between the contact surface (6, 7).

Abstract: The present invention relates to pharmaceutical solid dosage forms for oral administration comprising a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof. The invention also relates to a corresponding method for preparing such dosage forms as well as to their use as medicaments for the treatment of cancer and immune diseases.

Abstract: The invention refers to a method creating a data structure including many data elements comprising the steps of receiving multiple data elements to be stored from an input data structure, providing a continuous array in memory, allocating memory space within the continuous array for the data elements and storing the data elements in the allocated memory space. In particular, the invention refers to a method for creating a tree based dictionary from data elements received from an input structure. Moreover, it refers to a method for searching data structures including tokens by means of a tree based dictionary and a method for annotating tokens in a data structure. The invention does also refer to corresponding computer systems, software and storage media.

Abstract: The invention relates to a microfluid storage device having at least one supply chamber (5) formed by bulging a film (7) or membrane (19), a target break point (10) for forming an opening in the supply chamber (5), and a transport path (9) leading from the supply chamber (5) to an opening (11) in the supply chamber, for example, an interface between the storage device and a microfluid processing unit (2). According to the invention, the initially closed transport path (9) may be opened to form a transport channel (15) corresponding to the fluid stream escaping from the supply chamber (5), preferably by the escaping fluid itself, which allows the fluid to be removed from the storage device in a bubble-free manner.

Abstract: The invention relates to novel tubulysin conjugates (e.g. of tubulysin A) and the use thereof in the treatment of cancer diseases.

Abstract: The invention relates to a micropump comprising a pump membrane (5) which can be moved by modifying the volume of a pump chamber which is adjacent to the pump membrane (5) and a base part (1), also comprising two valves which are arranged in recesses (10,11) in the base part and react to the pressure in the pump chamber in order to alternately open and close an inlet channel (8) and an outlet channel (9) for a medium to be pumped. According to the invention, the valves are formed by functioning valve modules (40,41) without any common components. The pre-manufactured valve modules, base modules comprising the base part and hose connections (2,3) and actuator modules comprising the actuator and the membrane are combined in order to produce said micropumps.

Abstract: The present invention relates to pharmaceutical dosage forms for topical administration comprising a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof. The invention also relates to a corresponding method for preparing such dosage forms as well as to their use as medicaments for the treatment of cancer and immune diseases.

Abstract: The present invention relates to the use of a tri-substituted glycerol compound for the manufacture of a medicament for the treatment of hematological malignancies. The invention also refers to a kit-of-parts comprising such a medicament. Finally, the invention also relates to a corresponding method for the treatment of such conditions as well as to an in vitro method for determining the susceptibility of such malignant cells to a medicament as defined in the invention.

Abstract: The present invention relates to compounds of the formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:

Abstract: The present invention relates to the use of a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention and/or treatment of radiation injuries. Furthermore, the invention relates to in vitro corresponding methods for preventing or treating of radiation damage or injury in one or more cells comprising contacting said cells with a medicament as defined in the invention.

Abstract: A method to determine the utility of small molecules as functional replacements (mimetics) for protein receptor ligands is described. The method uses cellular biological assays on a systematic array of compounds, comprising known protein receptor ligands and other biologically active molecules to determine if a proposed small molecule is a functional equivalent of a receptor ligand, having therapeutic utility as a pharmaceutically relevant and useful agent either alone or in combination with other molecules.

Abstract: Isoindolone derivatives, compositions containing the same, and methods of use thereof for the treatment or prophylaxis of viral infection are disclosed.

Abstract: The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (I) or (Ia) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (I) or (Ia) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.

Abstract: The present invention relates to new Macrocycles of formula (I) and their use for the treatment of cancer.

Abstract: The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (A) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (A) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.

Abstract: This describes a procedure for replicative fabrication and packaging of at least one microstructured molded part as one magazine/molded part composite as well as a magazine with at least one microstructured molded part as one magazine/molded part composite. The first step covers fabrication of at least one microstructured molded part using an initially closed tool which consists of at least one first and one second tool half. In the second step, both tool halves are opened, whereby the molded part remains in the first tool half. In the third step, at least the second tool half is replaced with at least one additional tool half. In the fourth step, the replicative fabrication of the magazine is carried out using the first tool half containing the molded part and the additional tool half. Finally in the fifth step, magazine and molded part are demolded simultaneously as one magazine/molded part composite.

Abstract: The invention relates to a flow cell comprising a layered arrangement of three plates (3-5) in which an intermediate plate (4) consisting of a flexible material is inserted between plates (3, 5) consisting of a more solid material, and at least one of the plates comprises at least one recess (15, 17) for receiving fluid, that is bordered by another plate (3, 5) of the layered arrangement. Such recesses are especially microchannels and reaction chambers. According to the invention, the plates are interconnected by means arranged parallel to the plate plane at a distance to the recess, compressing the intermediate plate.

Abstract: The present invention provides a compound selected from compounds of formula I as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy. Compounds of formula (I) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events, heart valvular degenerative disease Moreover, compounds of formula (I) can be used to decrease the side effects from cytotoxic cancer agents and to treat viral infections.

Abstract: The invention relates to a piezoactuator for miniaturized pumps, atomizers, valves or the like. The piezoactuator comprises a piezoceramic disk (1) and a pressure disk (2) coupled to the piezoceramic disk. Said pressure disk is linked on its rim (18) with a substrate (3) in a fluid-tight manner and can be deflected by the piezoceramic disk (1) while modifying the volume of a cavity (4) formed between the pressure disk (2) and the substrate (3). According to the invention, a weak point (6, 9) is provided which extends along the linked rim (18) of the pressure disk (2) and forms a joint when the pressure disk is deflected.

Abstract: The present invention relates to compounds of the formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria: