Abstract: This describes a procedure for replicative fabrication and packaging of at least one microstructured molded part as one magazine/molded part composite as well as a magazine with at least one microstructured molded part as one magazine/molded part composite. The first step covers fabrication of at least one microstructured molded part using an initially closed tool which consists of at least one first and one second tool half. In the second step, both tool halves are opened, whereby the molded part remains in the first tool half. In the third step, at least the second tool half is replaced with at least one additional tool half. In the fourth step, the replicative fabrication of the magazine is carried out using the first tool half containing the molded part and the additional tool half. Finally in the fifth step, magazine and molded part are demolded simultaneously as one magazine/molded part composite.

Abstract: This describes a procedure for replicative fabrication and packaging of at least one microstructured molded part as one magazine/molded part composite as well as a magazine with at least one microstructured molded part as one magazine/molded part composite. The first step covers fabrication of at least one microstructured molded part using an initially closed tool which consists of at least one first and one second tool half. In the second step, both tool halves are opened, whereby the molded part remains in the first tool half. In the third step, at least the second tool half is replaced with at least one additional tool half. In the fourth step, the replicative fabrication of the magazine is carried out using the first tool half containing the molded part and the additional tool half. Finally in the fifth step, magazine and molded part are demolded simultaneously as one magazine/molded part composite.

Abstract: The invention relates to a piezoactuator for miniaturized pumps, atomizers, valves or the like. The piezoactuator comprises a piezoceramic disk (1) and a pressure disk (2) coupled to the piezoceramic disk. Said pressure disk is linked on its rim (18) with a substrate (3) in a fluid-tight manner and can be deflected by the piezoceramic disk (1) while modifying the volume of a cavity (4) formed between the pressure disk (2) and the substrate (3). According to the invention, a weak point (6, 9) is provided which extends along the linked rim (18) of the pressure disk (2) and forms a joint when the pressure disk is deflected.

Abstract: Isoindolone derivatives, compositions containing the same, and methods of use thereof for the treatment or prophylaxis of viral infection are disclosed.

Abstract: The invention relates to a flow cell comprising a layered arrangement of three plates (3-5) in which an intermediate plate (4) consisting of a flexible material is inserted between plates (3, 5) consisting of a more solid material, and at least one of the plates comprises at least one recess (15, 17) for receiving fluid, that is bordered by another plate (3, 5) of the layered arrangement. Such recesses are especially microchannels and reaction chambers. According to the invention, the plates are interconnected by means arranged parallel to the plate plane at a distance to the recess, compressing the intermediate plate.

Abstract: A tissue penetration device and method of using same that may include a lancet module or sampling module. The sampling module may optionally be in a cartridge configuration and include sampling and analyzing functions, which may be integrated.

Abstract: The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: wherein R1, E, X1 to X4 and G1 and G2 are as defined in the description and the claims, as well as hydrates or solvates and physiologically usable salts thereof.

Abstract: The invention relates to a micropump comprising a pump membrane (5) which can be moved by modifying the volume of a pump chamber which is adjacent to the pump membrane (5) and a base part (1), also comprising two valves which are arranged in recesses (10,11) in the base part and react to the pressure in the pump chamber in order to alternately open and close an inlet channel (8) and an outlet channel (9) for a medium to be pumped. According to the invention, the valves are formed by functioning valve modules (40,41) without any common components. The pre-manufactured valve modules, base modules comprising the base part and hose connections (2,3) and actuator modules comprising the actuator and the membrane are combined in order to produce said micropumps.

Abstract: The present invention relates to new Macrocycles of formula (I) and their use for the treatment of cancer.

Abstract: A tissue penetration device and method of using same that may include a lancet module or sampling module. The sampling module may optionally be in a cartridge configuration and include sampling and analyzing functions, which may be integrated.

Abstract: The present invention relates to new compounds of formula (I): These compounds are very effective factor VIIa inhibitors and are therefore of interest in the treatment and/or prevention of thromboses, stroke, heart attack, inflammation, arteriosclerosis and tumour conditions.

Abstract: The invention relates to novel tubulysin conjugates (e.g. of tubulysin A) and the use thereof in the treatment of cancer diseases.

Abstract: The present invention relates to compounds of the Formula or a pharmaceutically acceptable salt, solvate, hydrate or formulation thereof. These compounds can be used for the inhibition of tryptase and for the treatment and/or prevention of diseases that are mediated by tryptase activity.

Abstract: A preferred embodiment of the present invention comprises method for planning the synthesis of one or more chemical compounds with specified chemical properties, comprising the steps of: (a) representing a space of synthesis plans, wherein each synthesis plan in the space of synthesis plans represents one or more vitual reaction schemas applied to one or more classes of virtual input reactants; (b) representing a space of virtual compounds, wherein each compound in the space of virtual compounds is a product of one or more of said synthesis plans; (c) constructing a first mapping from the space of virtual compounds to range space representing the desirability of a compound, wherein the first mapping is determined by one or more compound properties being measured; and (d) searching the space of synthesis plans for desirable compounds as represented in the range space.

Abstract: The object of the invention is to produce multipole magnetic systems that are composed of a plurality of individual magnetic components that preferably are made of rare-earth magnetic material. The invention relates to a method for producing and magazining at least one individual magnetic component, a magazine for at least one individual magnetic component by molding and for conventionally magnetizing the same. The invention further relates to a method of assembly for producing a magnetic system and to the resulting magnetic systems. The invention teaches that extremely flat multipole magnetic systems in the form of magnet rings or magnet strips and three-dimensional magnet bodies such as a magnetic scale, for example, can be produced by means of individual magnetic components that are directly adjacent to each other or are arranged at a distance by means of a molding material, for example.

Abstract: The present invention related to compounds of formula (I): or pharmaceutically acceptable salts, hydrates or pharmaceutically acceptable formulations thereof. Those compounds can be used in inhibiting factor Xa and in the prevention and/or treatment of thromboembolic conditions.

Abstract: Disclosed is a method to simplify the handling of micro-components, wherein a micro-component is initially produced on a micro-component base plate. At least the open side surfaces of the micro-component are then cast using a hardening molding material whereupon the base plate and/or the molding material covering the micro-component is removed. The magazine for at least one micro-component comprises of a disk-shaped plate encompassing the micro-component at least one its lateral surfaces is positive joint. The assembly method for micro-components includes a magazine which is configured in the form of a disk-shaped plate containing at least one micro-component which encompasses at least on one of its sides in positive fit. Said magazine is held and maintained by a retaining device, whereupon the micro-component which is to be assembled is squeezed out of the magazine and simultaneously positioned in a specific location.

Abstract: The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: 1

Abstract: The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula: wherein R1, E, X1 to X4 and G1 and G2 are as defined in the description and the claims, as well as hydrates or solvates and physiologically usable salts thereof.

Abstract: Disclosed is a method to simplify the handling of micro-components (1, 18), wherein a micro-component (1, 18) is initially produced on a micro-component base plate (2). At least the open side surfaces of the micro-component (1, 18) are then cast using a hardening moulding material (4) whereupon the base plate (2) and/or the moulding material (4) covering the micro-component (1, 18) is removed. The magazine (5) for at least one micro-component (1, 18) comprises of a disk-shaped plate (5a) encompassing the micro-component (1,18) at least one its side surfaces (1c) is positive fit. The assembly method for micro-components (1, 18) includes a magazine (5) which is configured in the form of a disk-shaped plate containing at least one micro-component (1, 18) which encompasses at least on one of its sides in positive fit.