Abstract: This disclosure is directed to methods for preparing thermoplastic surfaces suitable for the application of paint, adhesives, or surfacing films and the structures derived or derivable from these methods. The disclosure is also directed to composite structures comprising a thermoplastic substrate comprising a chemical sealant direct bonded to a surface thereof, the chemical sealant providing a surface suitable for adhering adhesives, paints, and/or surfacing films to the thermoplastic surfaces.

Abstract: Embodiments of the disclosure encompass adoptive immunotherapy related to cells expressing multiple chimeric antigen receptors (CARs). In specific embodiments, T cells express a HER2-specific CAR, an IL13 R?2-specific CAR, and an EphA2-specific CAR. In particular embodiments, the cells are utilized for cancer treatment, including for glioblastoma.

Abstract: Methods and kits including writable and cleanable articles, wherein in one embodiment, a method of replenishing a hydrophilic surface on a writable and cleanable article is provided. The method comprising: providing a writable and cleanable article that includes a hydrophilic overcoat that has an at least partially depleted (i.e., at least partially exhausted) hydrophilic surface; and applying a cleaning and protecting composition to at least a portion of the hydrophilic overcoat; and drying the cleaning and protecting composition to provide a dried surface having a replenished hydrophilic surface.

Abstract: A method and system provide for automated counting of prescription product and enables virtual verification of the dispensed prescription product. The method and system include counting a quantity of pills of a prescription product on a first portion of a tray, retaining the quantity of pills after the counting in a second portion of the tray, receiving at least the second portion of the tray into an imaging device, and capturing, with a first camera, an image of the quantity of pills in the second portion of the tray.

Abstract: A method and system provide for automated counting of prescription product and enables virtual verification of the dispensed prescription product. The method and system include capturing by a camera at a first site an image of the prescription product to be dispensed according to a prescription to a patient, electronically displaying the image on a display at a second site remote from the first site, and electronically transmitting a verification from the second site to the first site in response to the image of the prescription product being determined at the second site to be consistent with the prescription.

Abstract: A negative pressure surgical apparatus. The apparatus includes a mask configured to cover a portion of the face of a patient and including a first port and an instrument port. The first port is configured to draw negative pressure from between the mask and the face of the patient. The instrument port is configured to receive a medical instrument therethrough and form a seal therewith. The instrument port is positioned on the mask so as to permit surgery at a surgical site.

Abstract: Provided herein are compositions and methods for down-regulating mTORC1 signaling in a subject, comprising administering to the subject an effective amount of one or more compositions that promote increased levels or activity of CIB32 or a biologically active fragment or variant thereof in the subject.

Abstract: Provided herein are retroreflective colored article having a predetermined pattern of beaded and unbeaded regions and at least one polymeric color layer (130) covering at least a portion of the beaded and unbeaded regions, a reflector layer (140) covering the colour layer, and a carrier (150). Also disclosed are methods for making the articles.

Abstract: Embodiments of the disclosure concern methods and compositions for delivering therapeutic, diagnostic or interventional moieties, such as complex and simple entities such as biologies, including at least cells, for example. The methods employ targeted delivery by employing at least one ALCAM-binding moiety on the therapeutic, diagnostic or interventional moiety to be delivered. In specific cases, the ALCAM-binding moiety is present on or with the therapeutic moiety in multiple iterations. In certain embodiments, the ALCAM-binding moiety comprises at least one SRCR domain from CD6 and a stalk, such as from CD6, of the secretable or molecular form thereof.

Abstract: The present disclosure is directed to compositions and methods for coating, particularly protecting and optionally cleaning, metallic surfaces, and articles containing such surfaces.

Abstract: This invention relates to an autodeposition bath composition comprising a nitrogen containing compound, said bath being suitable for generating a uniform autodeposition coating on two or more of ferrous, aluminum, magnesium and zinciferous multi-metal substrate surfaces, treated either sequentially or simultaneously. The invention also provides autodeposition concentrate compositions for use in the bath, methods of making and using the concentrate and bath, as well as metal articles comprising an autodeposition coating according to the invention.

Abstract: Autodeposition coating compositions that deposit uncured coatings, on metallic surfaces of a substrate, which are curable at oven temperatures of less than 130° C., are provided as well as autodeposition methods, compositions and components for depositing such autodeposition coatings. More particularly, the invention relates to autodeposition coatings that cure at temperatures lower than conventional autodeposition coatings, while achieving chemical and corrosion performance comparable to higher temperature cure autodeposition coatings, as well as being directed to autodeposition coating compositions possessing improved storage stability and coating thermal stability, and articles of manufacture having cured and uncured autodeposited coatings deposited thereon.

Abstract: According to one embodiment of the present invention, during database replication from a source database to a target database, operations applied to the source database are transferred as target operations and applied to the target database. A request from a requestor to idle a specified database object is received during the database replication. In response to receiving the request, transference of the target operations for the specified database object from the source database to the target database is terminated and target operations for the specified database object on the target database are monitored. In response to no target operations being applied to the specified database object on the target database, replication of the specified database object is suspended and the requestor is notified when the idling of the specified database object has completed.

Abstract: According to one embodiment of the present invention, during database replication from a source database to a target database, operations applied to the source database are transferred as target operations and applied to the target database. A request from a requestor to idle a specified database object is received during the database replication. In response to receiving the request, transference of the target operations for the specified database object from the source database to the target database is terminated and target operations for the specified database object on the target database are monitored. In response to no target operations being applied to the specified database object on the target database, replication of the specified database object is suspended and the requestor is notified when the idling of the specified database object has completed.

Abstract: The present disclosure is directed towards having a user interface that displays a number of cards or windows. A user can implement a command where the user interface will automatically change the position of the displayed cards to show regions of interest which are the parts of the cards that a user may have interested in. The user interest can be determined in accordance with user preference information. Optionally, cards which do not have regions of interest are removed from a display area and such cards are replaced with new cards that do have regions of interest.

Abstract: The subject invention pertains to agonist peptides of type I interferons and methods of using the peptides. These peptides are based on the amino acid sequence of the C-terminus region of the type I IFN molecules and are capable of binding to the cytoplasmic domain of type I IFN receptors. Surprisingly, these peptides were found to possess the same or similar biological activity as that associated with the full-length, mature type I IFN proteins, even though these peptides do not bind to the extracellular domain of the type I IFN receptors. In one embodiment, the peptide is a peptide of IFN?. In another embodiment, the peptide is a peptide of IFN?. Exemplified peptides of the invention include those having SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:38, SEQ ID NO:39, and SEQ ID NO:40. The subject peptides have been shown to effect increased resistance to viral infection.

Abstract: Embodiments of the disclosure encompass adoptive immunotherapy related to cells expressing multiple chimeric antigen receptors (CARs). In specific embodiments, T cells express a HER2-specific CAR, an IL13 R?2-specific CAR, and an EphA2-specific CAR. In particular embodiments, the cells are utilized for cancer treatment, including for glioblastoma.

Abstract: Embodiments of the disclosure include immune cells expressing HER2-specific chimeric antigen receptors (CAR) and treatment of cancer therewith. In specific embodiments, sarcoma or glioblastoma are treated. In specific embodiments, such as for glioblastoma, for example, T-cells expressing a HER2-specific CAR are pp65CMV-specific T cells.

Abstract: A coated article comprising a metal surface, a first layer of an uncured autodeposition coating and a second uncured paint layer deposited sequentially on the surface without intermediate curing of the autodeposition coating, a process of co-curing said autodeposition coating and paint layer or layers, and a cured coated article having chemical bonds between the cured autodeposition coating layer and at least the cured paint layer immediately adjacent to the cured autodeposition coating layer.

Abstract: A conduit assembly and method of utilizing the assembly generally extends along a centerline for detachable engagement to a component in an axial direction. The assembly may include a body having an internal, cylindrical, surface with a first surface portion located axially adjacent to a second surface portion. The first portion is circumferentially continuous and the second portion extends circumferentially by about 180 degrees or less. A saddle is axially aligned to the second portion and detachably connects to the body. The saddle extends circumferentially by about 180 degrees or more. A conduit is received in the body and rigidly secured to the body via the saddle. A circumferentially continuous sealing interface is carried between the first portion and the conduit, and is constructed and arranged to slide axially with respect to the first portion and the conduit.