Patents by Inventor M. Bret Schneider

M. Bret Schneider has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10682529
    Abstract: Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: June 16, 2020
    Assignee: Zap Surgical Systems, Inc.
    Inventors: M. Bret Schneider, John R. Adler, Jr.
  • Publication number: 20200139153
    Abstract: Various systems and methods are implemented for in vivo use in a living animal. One such method involves stimulating target cells having light-responsive proteins and includes providing an elongated light-delivery structure in a narrow passageway in the animal, the elongated light-delivery structure having separately-activatable light sources located along the length of the elongated light-delivery structure. The method also includes activating less than all the light sources to deliver light to light-responsive proteins adjacent to the activated light sources along the length of the elongated light-delivery structure, thereby stimulating target cells in vivo.
    Type: Application
    Filed: August 15, 2019
    Publication date: May 7, 2020
    Inventors: Karl Deisseroth, M. Bret Schneider
  • Patent number: 10589118
    Abstract: Methods of stimulating a target deep brain region using multiple Transcranial Magnetic Stimulation (TMS) electromagnets positioned over a predetermined cortical regions each having a first-order connection to a target deep brain region and applying TMS so that the applied TMS induces spatial summation and thereby modulation of the target deep brain region.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: March 17, 2020
    Assignees: BRAINSWAY LTD., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventor: M. Bret Schneider
  • Publication number: 20200072817
    Abstract: A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.
    Type: Application
    Filed: September 5, 2019
    Publication date: March 5, 2020
    Inventors: Karl Deisseroth, Feng Zhang, Viviana Gradinaru, M. Bret Schneider
  • Patent number: 10569099
    Abstract: Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. According to an example embodiment of the present invention, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo.
    Type: Grant
    Filed: November 10, 2014
    Date of Patent: February 25, 2020
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, M. Bret Schneider, David J. Mishelevich
  • Publication number: 20190366123
    Abstract: Methods of treatment and treatment systems for performing radiomodulatory stereotactic radiosurgery to treat brain disorders in which target neural tissues associated with the brain disorder are sensitized to radiation by administration of a molecular substance and/or non-targeted critical structures are protected from radiation by a molecular substance, in order to treat disorders of brain circuitry. Specific embodiments disclose means for treating pain, obesity and drug addiction.
    Type: Application
    Filed: May 30, 2019
    Publication date: December 5, 2019
    Applicant: Zap Surgical Systems, Inc.
    Inventors: John R. Adler, Jr., M. Bret Schneider
  • Patent number: 10451608
    Abstract: A variety of applications, systems, methods and constructs are implemented for use in connection with screening of ion-channel modulators. Consistent with one such system, drug candidates are screened to identify their effects on cell membrane ion channels and pumps. The system includes screening cells having light responsive membrane ion switches, voltage-gated ion switches and fluorescence producing voltage sensors. A chemical delivery device introduces the drug candidates to be screened. An optical delivery device activates the light responsive ion switches. An optical sensor monitors fluorescence produced by the voltage sensors. A processor processes data received from the optical sensor. A memory stores the data received from the optical sensor.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: October 22, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Feng Zhang, Viviana Gradinaru, M. Bret Schneider
  • Patent number: 10434327
    Abstract: Various systems and methods are implemented for in vivo use in a living animal. One such method involves stimulating target cells having light-responsive proteins and includes providing an elongated light-delivery structure in a narrow passageway in the animal, the elongated light-delivery structure having separately-activatable light sources located along the length of the elongated light-delivery structure. The method also includes activating less than all the light sources to deliver light to light-responsive proteins adjacent to the activated light sources along the length of the elongated light-delivery structure, thereby stimulating target cells in vivo.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: October 8, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, M. Bret Schneider
  • Patent number: 10426970
    Abstract: Various systems and methods are implemented for in vivo use in a living animal. One such method involves stimulating target cells having light-responsive proteins and includes providing an elongated light-delivery structure in a narrow passageway in the animal, the elongated light-delivery structure having separately-activatable light sources located along the length of the elongated light-delivery structure. The method also includes activating less than all the light sources to deliver light to light-responsive proteins adjacent to the activated light sources along the length of the elongated light-delivery structure, thereby stimulating target cells in vivo.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: October 1, 2019
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, M. Bret Schneider
  • Publication number: 20190090888
    Abstract: A system for decorticating at least one bone surface includes an elongated soft tissue protector, an elongated drive shaft and a cutter. The elongated soft tissue protector has a bore extending therethrough. The bore has a non-circular lateral cross-section, a maximum lateral extent and a minimum lateral extent. The cutter may be located on or near a distal end of the drive shaft. The cutter has a non-circular lateral cross-section, a maximum lateral extent and a minimum lateral extent. The maximum lateral extent of the cutter is greater than the minimum lateral extent of the bore but is no greater than the maximum lateral extent of the bore. The bore of the soft tissue protector is configured to slidably receive the cutter therethrough. Other systems and methods for decorticating at least one bone surface are also provided.
    Type: Application
    Filed: September 26, 2018
    Publication date: March 28, 2019
    Applicant: SI-Bone Inc.
    Inventors: Paul SAND, M. Bret SCHNEIDER, Patrick KAHN, Scott A. YERBY, Gerard LIBRODO, Khalid SETHI, Craig MEYER, Michael DIDINSKY, Thomas A. MCNALLY, Robert MCLAIN, Nikolas KERR, Eric SWICK, Yale VAN DYNE, Jen KASLER
  • Publication number: 20190022425
    Abstract: One embodiment involves modifying neural transmission patterns between neural structures and/or neural regions in a noninvasive manner. In a related exemplary method, sound waves are directed toward a first targeted neural structure and characteristics of the sound waves are controlled at the first target neural structure with respect to characteristics of sound waves at the second target neural structure. In response, neural transmission patterns modified to produce the intended effect (e.g., long-term potentiation and long-term depression of the neural transmission patterns). In a related embodiment, a transducer produces the sound for stimulating the first neural structure and the second neural structure, and an electronically-based control circuit is used to control characteristics of the sound waves as described above to modify the neural transmission patterns between the first and second neural structures.
    Type: Application
    Filed: July 17, 2018
    Publication date: January 24, 2019
    Inventors: Karl Deisseroth, M. Bret Schneider
  • Publication number: 20180326221
    Abstract: Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in vivo and in vitro environments).
    Type: Application
    Filed: July 20, 2018
    Publication date: November 15, 2018
    Inventors: Karl Deisseroth, Feng Zhang, David J. Mishelevich, M. Bret Schneider
  • Patent number: 10052497
    Abstract: Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in in vivo and in vitro environments).
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: August 21, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Feng Zhang, David J. Mishelevich, M. Bret Schneider
  • Patent number: 10046174
    Abstract: In one example, a system electrically stimulates target cells of a living animal using an elongated structure, a modulation circuit and a light pathway such as provided by an optical fiber arrangement. The elongated structure is for insertion into a narrow passageway in the animal such that an end of the elongated structure is sufficiently near the target cells to deliver stimulation thereto. The modulation circuit is for modulating the target cells while the elongated structure is in the narrow passageway, where the modulation circuit is adapted to deliver viral vectors through the elongated structure for expressing light responsive proteins in the target cells. The light pathway is used for stimulating the target cells by delivering light to the light-responsive proteins in the target cells.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: August 14, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Alexander Aravanis, Feng Zhang, M. Bret Schneider, Jaimie M. Henderson
  • Patent number: 10035027
    Abstract: One embodiment involves modifying neural transmission patterns between neural structures and/or neural regions in a noninvasive manner. In a related exemplary method, sound waves are directed toward a first targeted neural structure and characteristics of the sound waves are controlled at the first target neural structure with respect to characteristics of sound waves at the second target neural structure. In response, neural transmission patterns modified to produce the intended effect (e.g., long-term potentiation and long-term depression of the neural transmission patterns). In a related embodiment, a transducer produces the sound for stimulating the first neural structure and the second neural structure, and an electronically-based control circuit is used to control characteristics of the sound waves as described above to modify the neural transmission patterns between the first and second neural structures.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: July 31, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, M. Bret Schneider
  • Publication number: 20180178042
    Abstract: Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder (“OCD”), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.
    Type: Application
    Filed: February 23, 2018
    Publication date: June 28, 2018
    Inventors: M. Bret Schneider, John R. Adler, JR.
  • Publication number: 20180154165
    Abstract: Methods of stimulating a target deep brain region using multiple Transcranial Magnetic Stimulation (TMS) electromagnets positioned over a predetermined cortical regions each having a first-order connection to a target deep brain region and applying TMS so that the applied TMS induces spatial summation and thereby modulation of the target deep brain region.
    Type: Application
    Filed: January 18, 2018
    Publication date: June 7, 2018
    Inventor: M. Bret SCHNEIDER
  • Patent number: 9808651
    Abstract: Medical systems, devices, and methods provide improved radiosurgical techniques for treatment of anxiety disorders (such as Post-Traumatic Stress Disorder (PTSD), Generalized Anxiety Disorder (GAD), Panic Disorder, Social Phobia, Specific Phobia, and the like). Radiation can be directed from a radiation source outside the patient toward a target tissue deep within the patient's brain using a stereotactic radiosurgical platform, typically without having to impose the surgical trauma associated with accessing deep brain tissues. The target will often include at least a portion of the amygdala, with exemplary treatments being directed to targets that are limited to a sub-region of the amygdala. Rather than applying sufficient radiation to kill the neural tissue within the target, a cellularly sub-lethal dose of the radiation may be applied.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: November 7, 2017
    Inventors: M. Bret Schneider, John R. Adler, Jr.
  • Publication number: 20170211040
    Abstract: According to one aspect and example, a method for facilitating cellular interactions in biological tissue provides controllable activation of a selected type of stem cell among a plurality of cell types present in the tissue. The method includes various steps including the introduction of a microbial opsin into a region of the tissue that includes a selected type of stem cell, by expressing the microbial opsin in the stem cell. A light source is then introduced near the stem cell, and the light source is used to controllably activate thejight source to direct pulses of illumination from the light source to the selected type of stem cell, for selectively controlling the growth and development of the stem cell in a manner that is independent of the growth and development of the other types of cells.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 27, 2017
    Inventors: Karl Deisseroth, Albrecht Stroh, M. Bret Schneider, Raag D. Airan
  • Publication number: 20170151443
    Abstract: Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.
    Type: Application
    Filed: July 5, 2016
    Publication date: June 1, 2017
    Inventors: David J. MISHELEVICH, M. Bret SCHNEIDER