Abstract: The present invention provides a method of treatment using human sequence antibodies against human CTLA-4. In particular, methods of treating cancer are provided.

Abstract: Mechanisms and methods for clamping force generation are disclosed. In one embodiment, a clamping force generator includes a spring coupled to a traction ring and to a load cam roller cage. The traction ring can be provided with a recess to receive the spring. In some embodiments, a relatively short spring is provided. In other embodiments, a spring couples to a wire and the spring-wire combination couples to the traction ring and the load cam roller cage. In some embodiments, the load cam roller cage is provided with tabs adapted to engage the wire and/or the spring. In yet other embodiments, the traction ring is configured to receive a dowel pin for coupling to the spring. One or more of the tabs can include a tab notch that cooperates with a stop pin coupled to the traction ring to provide adjustment of the travel of the load cam roller cage.

Abstract: A rope climbing apparatus (15) comprising a frame (16), a seat (18) supported by the frame and adapted to move relative to the frame from a first position (19) to an elevated second position (20), a lower pulley assembly (21) connected to the seat, an upper pulley assembly (22) connected to the frame, a rope (23) extending between the lower pulley assembly and the upper pulley assembly and having a rope climbing portion (24) graspable by a user (25) when the user is seated on the seat, and the rope, the seat, the lower pulley assembly and the upper pulley assembly configured and arranged such that a downward force (26) on the rope climbing portion of the rope causes an upward force (28) on the seat. The downward force on the rope climbing portion may result in an upward force on the seat at a mechanical advantage provided by the lower pulley assembly and the upper pulley assembly, and the mechanical advantage may be four.

Abstract: An apparatus for attaching a tag to an object. The apparatus may include a body. The apparatus may also include an attachment arm, the attachment arm having a locked position and an unlocked position, and the attachment arm lockably closing to form a first closed loop with the body when the attachment arm is in the locked position. The apparatus may also include a tag loop mechanically coupled to the body. The apparatus may also include a detent arm mechanically engaged with the attachment arm in the locked position of the attachment arm, the detent arm configured so that an application of a force to the detent arm simultaneously unlocks the attachment arm and opens the tag loop.

Abstract: The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention concerns the use of dirhodium (II,II) “paddlewheel complexes, and in particular, dirhodium carboximate and tert-butyl hydroperoxide as catalysts for the reaction. The use of aqueous conditions is particularly advantageous in the allylic oxidation of 7-keto steroids, which could not be effectively oxidized using anhydrous methods, and in extending allylic oxidation to enamides and enol ethers.

Abstract: The present invention provides a method of treatment using human sequence antibodies against human CTLA-4. In particular, methods of treating cancer are provided.

Abstract: The present invention provides a method of treatment using human sequence antibodies against human CTLA-4. In particular, methods of treating cancer are provided.

Abstract: Inventive embodiments are directed to components, subassemblies, systems, and/or methods for continuously variable transmissions (CVT). In one embodiment, a main axle is adapted to receive a shift rod that cooperates with a shift rod nut to actuate a ratio change in a CVT. In another embodiment, an axial force generating mechanism can include a torsion spring, a traction ring adapted to receive the torsion spring, and a roller cage retainer configured to cooperate with the traction ring to house the torsion spring. Various inventive idler-and-shift-cam assemblies can be used to facilitate shifting the ratio of a CVT. Embodiments of a hub shell and a hub cover are adapted to house components of a CVT and, in some embodiments, to cooperate with other components of the CVT to support operation and/or functionality of the CVT. Among other things, shift control interfaces and braking features for a CVT are disclosed.

Abstract: Inventive embodiments are directed to components, subassemblies, systems, and/or methods for continuously variable transmissions (CVT). In one embodiment, a main axle is adapted to receive a shift rod that cooperates with a shift rod nut to actuate a ratio change in a CVT. In another embodiment, an axial force generating mechanism can include a torsion spring, a traction ring adapted to receive the torsion spring, and a roller cage retainer configured to cooperate with the traction ring to house the torsion spring. Various inventive idler-and-shift-cam assemblies can be used to facilitate shifting the ratio of a CVT. Embodiments of a hub shell and a hub cover are adapted to house components of a CVT and, in some embodiments, to cooperate with other components of the CVT to support operation and/or functionality of the CVT. Among other things, shift control interfaces and braking features for a CVT are disclosed.

Abstract: Inventive embodiments are directed to components, subassemblies, systems, and/or methods for continuously variable transmissions (CVT). In one embodiment, a main axle is adapted to receive a shift rod that cooperates with a shift rod nut to actuate a ratio change in a CVT. In another embodiment, an axial force generating mechanism can include a torsion spring, a traction ring adapted to receive the torsion spring, and a roller cage retainer configured to cooperate with the traction ring to house the torsion spring. Various inventive idler-and-shift-cam assemblies can be used to facilitate shifting the ratio of a CVT. Embodiments of a hub shell and a hub cover are adapted to house components of a CVT and, in some embodiments, to cooperate with other components of the CVT to support operation and/or functionality of the CVT. Among other things, shift control interfaces and braking features for a CVT are disclosed.

Abstract: A continuously variable transmission (CVT) having a main shaft configured to support and position various components of the CVT. Shift cam discs cooperate with ball-leg assemblies to shift the transmission ration of the CVT. Load cam discs, a torsion disc, rolling elements, and a hub cap shell are configured to generate axial force, transmit torque, and manage reaction forces. In one embodiment, a splined input shaft and a torsion disc having a splined bore cooperate to input torque into the variator of the CVT. Among other things, various ball axles, axle-ball combinations, and reaction force grounding configurations are disclosed. In one embodiment, a CVT having axial force generation means at both the input and output elements is disclosed.

Abstract: Traction planets and traction rings can be operationally coupled to a planetary gearset to provide a continuously variable transmission (CVT). The CVT can be used in a bicycle. In one embodiment, the CVT is mounted on the frame of the bicycle at a location forward of the rear wheel hub of the bicycle. In one embodiment, the CVT is mounted on and supported by members of the bicycle frame such that the CVT is coaxial with the crankshaft of the bicycle. The crankshaft is configured to drive elements of the planetary gearset, which are configured to operationally drive the traction rings and the traction planets. Inventive component and subassemblies for such a CVT are disclosed. A shifting mechanism includes a plurality of pivot arms arranged to pivot about the centers of the traction planets as a shift pin hub moves axially.

Abstract: Traction planets and traction rings can be operationally coupled to a planetary gearset to provide a continuously variable transmission (CVT). The CVT can be used in a bicycle. In one embodiment, the CVT is mounted on the frame of the bicycle at a location forward of the rear wheel hub of the bicycle. In one embodiment, the CVT is mounted on and supported by members of the bicycle frame such that the CVT is coaxial with the crankshaft of the bicycle. The crankshaft is configured to drive elements of the planetary gearset, which are configured to operationally drive the traction rings and the traction planets. Inventive component and subassemblies for such a CVT are disclosed. A shifting mechanism includes a plurality of pivot arms arranged to pivot about the centers of the traction planets as a shift pin hub moves axially.

Abstract: The I-beam of this invention is formed from a pair of parallel flange members and a continuous web material affixed to and joining the flange members. The web material is formed so as to define a plurality of differently shaped holes therein that provide access for mechanical elements without compromising the compressive and tensile load capability of the I-beam. The web material is preferably formed from OSB and even more preferably ? inch thick OSB. In addition, the I-beam of this invention preferably has one end where the web material is continuous and does not define any openings therein. This portion of the I-beam thus allows the I-beam to be trimmed so standard lengths of the I-beam can be cut to the desired length for a particular application.

Abstract: The present invention provides devices or implants that comprise anti-scarring drug combinations, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that comprise anti-fibrotic drug combinations, and their uses in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.

Abstract: A size-adjustable, foldable hamstring stretching apparatus of unitary construction provides for easily, effectively, and efficiently exercising (stretching) the hamstrings. The apparatus consists of a unitary frame and is used in a prone position, thus, avoiding back strain. The apparatus provides means for supporting the user's foot and means for assuring that the user's leg is maintained in a straight position. Means for holding allows for ease in grasping the apparatus allowing the user to pull or push the apparatus as desired. The means for supporting a foot, maintaining the leg in a straight position, and for holding may all be padded or made of a soft material for increased ease of use and comfort. The frame is made of any strong, lightweight material, such as plastic or aluminum and it is contemplated that the apparatus be made using a molding process to reduce the cost of manufacturing.

Abstract: The present invention provides devices or implants that comprise anti-scarring drug combinations, methods or making such devices or implants, and methods of inhibiting fibrosis between the devices or implants and tissue surrounding the devices or implants. The present invention also provides compositions that comprise anti-fibrotic drug combinations, and their uses in various medical applications including the prevention of surgical adhesions, treatment of inflammatory arthritis, treatment of scars and keloids, the treatment of vascular disease, and the prevention of cartilage loss.

Abstract: Soft tissue implants (e.g., breast, pectoral, chin, facial, lip, and nasal implants) are used in combination with an anti-scarring drug combination in order to inhibit scarring that may otherwise occur when the implant is placed within an animal.

Abstract: Pumps and sensors for contact with tissue are used in combination with an anti-scarring agent or a composition that comprises an anti-scarring agent to inhibit scarring that may otherwise occur when the pumps and sensors are implanted within an animal.

Abstract: Electrical devices (e.g., cardiac rhythm management and neurostimulation devices) for contact with tissue are used in combination with an anti-scarring drug combination or a composition that comprises an anti-scarring drug combination to inhibit scarring that may otherwise occur when the devices are implanted within an animal.