Abstract: In one implementation, a method of displaying a portal is performed by a device including a display, one or more processors, and non-transitory memory. The method includes obtaining a user location in a first three-dimensional coordinate system of a first environment. The method includes obtaining an interest location in a second three-dimensional second coordinate system of a second environment. The method includes transforming the interest location to a transformed interest location in the first three-dimensional coordinate system. The method includes determining a portal location in the first three-dimensional coordinate system based on the user location and the transformed interest location. The method includes displaying, on the display at the portal location, a portal corresponding to at least a partial view of the second environment.

Abstract: A bed comprises substrate support members, each including a load bearing and a base configured to provide contact with a floor. The load bearing member is configured to move vertically relative to the base, while the base and the load bearing member are configured to fit together to maintain lateral alignment of the base and the load bearing member. A load sensor is positioned between the base and the load bearing member, the load bearing member configured to transmit a load from the substrate to the load sensor. A printed circuit board is in communication with the load sensor. A controller is in communication with the printed circuit board of each substrate support member and is configured to receive and process data output by the printed circuit boards.

Abstract: Various implementations disclosed herein include devices, systems, and methods that apply a 3-dimensional (3D) effect to content for rendering. For example, a process may obtain content to render within an extended reality (XR) environment. The process may further generate, via a rendering framework, a two-dimensional (2D) rendering of the content The rendering framework generates 3D information based on the content. The process may further generate a 3D effect for rendering the content based on the 3D information. The process may further determine a location of a display region for the content within the XR environment and a view of the XR environment may be presented. Rendering of the content may be presented with the 3D effect at the location in the view of the XR environment.

Abstract: The invention is generally related to methods and systems to manage Inflammatory Bowel Disease, Irritable Bowel Syndrome and other immune-mediated inflammatory disorders (IMIDs in a subject in need thereof. One embodiment of the present invention contemplates a system and method useful for managing and ameliorating IBD and IBS symptoms encompassing the iterative development of personalized treatment modalities including a diet modality, a psychological behavior module, a stress-reduction modality, a modality related to activity and exercise and the like to aid the participant to reduce or eliminate most IMID symptoms and increase her sense of well-being.

Abstract: Thermoplastic bicomponent binder fiber can be combined with other media, fibers and other filtration components to form a thermally bonded filtration media. The filtration media can be used in filter units, such as breather caps. Such filter units can be placed in the stream of a mobile fluid and can remove a particulate and/or fluid mist load from the mobile stream. The unique combination of media fiber, bicomponent binder fiber and other filtration additives and components provide a filtration media having unique properties in filtration applications.

Abstract: The present disclosure generally relates to methods and interfaces for capturing and viewing immersive media. In some examples, in response to a hardware input, immersive media is captured and generated using multiple sensors of a head-mounted display device. In some examples, while displaying a media item, additional information related to the media item is displayed in response to detecting a viewer's attention departing from the media item.

Abstract: Tissue closure systems are disclosed wherein one variation generally includes a handle, a proximal catheter segment extending from the handle, a deployment segment coupled to the proximal catheter segment, and a distal catheter segment pivotably coupled to the deployment segment such that the distal catheter segment is rotatable at an angle relative to the proximal catheter segment. A receiver member positioned within the deployment segment is configurable between a low-profile configuration and a deployed configuration. Two or more forward needle members and two or more rear needle members are extendable distally from a first side and a second side of the proximal catheter segment. The two or more forward needle members are receivable into the two or more openings along the first receiver portion and the two or more rear needle members are receivable into the two or more openings along the second receiver portion.

Abstract: A bed comprises substrate support members, each including a load bearing and a base configured to provide contact with a floor. The load bearing member is configured to move vertically relative to the base, while the base and the load bearing member are configured to fit together to maintain lateral alignment of the base and the load bearing member. A load sensor is positioned between the base and the load bearing member, the load bearing member configured to transmit a load from the substrate to the load sensor. A printed circuit board is in communication with the load sensor. A controller is in communication with the printed circuit board of each substrate support member and is configured to receive and process data output by the printed circuit boards.

Abstract: A system for adjusting the firmness of a substrate configured to support a subject includes a first rod configured to be movable by a mechanism, a second rod parallel to and spaced from the first rod a distance that spans a majority of a dimension of the substrate, and flexible straps extending between the first rod and the second rod and attached to the first rod and the second rod at respective ends of each flexible strap. The mechanism is configured to move the first rod in a first direction to increase tension on the flexible straps and move the first rod in a second direction to decrease tension on the flexible straps. The mechanism can be manually operated by the subject or can be a motor that is controlled by a controller.

Abstract: Tissue closure systems are disclosed wherein one variation generally includes a handle, a proximal catheter segment extending from the handle, a deployment segment coupled to the proximal catheter segment, and a distal catheter segment pivotably coupled to the deployment segment such that the distal catheter segment is rotatable at an angle relative to the proximal catheter segment. A receiver member positioned within the deployment segment is configurable between a low-profile configuration and a deployed configuration. Two or more forward needle members and two or more rear needle members are extendable distally from a first side and a second side of the proximal catheter segment. The two or more forward needle members are receivable into the two or more openings along the first receiver portion and the two or more rear needle members are receivable into the two or more openings along the second receiver portion.

Abstract: Tissue closure systems are disclosed wherein one variation generally includes a handle, a proximal catheter segment extending from the handle, a deployment segment coupled to the proximal catheter segment, and a distal catheter segment pivotably coupled to the deployment segment such that the distal catheter segment is rotatable at an angle relative to the proximal catheter segment. A receiver member positioned within the deployment segment is configurable between a low-profile configuration and a deployed configuration. Two or more forward needle members and two or more rear needle members are extendable distally from a first side and a second side of the proximal catheter segment. The two or more forward needle members are receivable into the two or more openings along the first receiver portion and the two or more rear needle members are receivable into the two or more openings along the second receiver portion.

Abstract: A method of processing blood includes receiving from a touch screen user input data for a protocol for a wash procedure. The user input data includes a numeric value. The method includes storing the protocol in a memory, receiving an identifier from a user, determining if the identifier permits the user to modify the protocol and receiving a modification of the protocol from the user. The method includes providing a plurality of authorizations, a second authorization being a default and an administrator authorization permitting the user to change a setting. The method includes comparing a password to a password stored in memory and, if there is a match, determining that the password is associated with an administrator. If a command to change the setting is received, the command is applied to change the setting. The blood is processed employing a wash procedure using the modified protocol and the changed setting.

Abstract: Tissue localization devices and methods of localizing tissue using tissue localization devices are disclosed. The tissue localization device can comprise a handle comprising a delivery control, a delivery needle extending out from the handle, and a localization element within the delivery needle. The localization element can be deployed out of the delivery needle or retracted back into the delivery needle when the delivery control is translated in a first direction or a second direction, respectively. The localization element can be coupled to a flexible tracking wire.

Abstract: In some embodiments, an electronic device selectively de-emphasizes a three-dimensional environment in which content is presented. In some embodiments, an electronic device modifies the boundaries of content in a user interface. In some embodiments, an electronic device shares content with users in a three-dimensional environment.

Abstract: Mesothelin (MSLN) is expressed on pancreatic cancers, ovarian cancers and mesotheliomas. The present disclosure provides antigen-binding molecules, including anti-MSLN antibodies, and bispecific antigen-binding molecules that bind to both MSLN and a T cell antigen (e.g., CD3) and activate T cells in the presence of MSLN-expressing tumor cells. The antigen-binding molecules of this disclosure are useful for the treatment of diseases and disorders in which a MSLN-targeted immune response is desired and/or therapeutically beneficial. For example, the antigen-binding molecules of the present disclosure are useful for the treatment of various cancers, including pancreatic cancer, ovarian cancer and mesotheliomas.

Abstract: The present disclosure relates to techniques for displaying representations of physical input devices and overlaying visual features on the representations of physical input devices in a computer-generated reality (CGR) environment. The techniques include displaying a virtual application in a CGR environment and, in response to detecting an input field in the displayed virtual application, displaying at least a portion of the displayed application on a representation of a physical input device. The at least a portion of the displayed application includes the detected input field. In response to detecting an input received at the physical input device, the input field is updated with the input, and the updated input field is displayed.

Abstract: Single-domain antibodies that bind receptor tyrosine kinase (ROR1) are described. The single-domain antibodies can be used for multiple purposes including in research, imaging, diagnosis, and treatment of ROR1-related conditions. The disclosed single-domain antibodies can be used as anti-cancer therapeutics such as antibody-drug conjugates, multi-domain binding molecules, or recombinant receptors or can be used as cancer imaging/diagnostic agents.

Abstract: Anti-Epstein Barr Virus (EBV) vaccines are described herein. The EBV vaccine antigens are linked to a multimerization domain, for example, presented on a circular tandem repeat protein (cTRP) scaffold or linked to a C4b multimerization domain. The vaccines can be used to treat and/or reduce the risk of EBV infection and to treat and/or reduce the risk of complications associated with EBV infection, such as infectious mononucleosis, lymphoproliferative disorders, carcinomas, and smooth muscle tumors.

Abstract: Thermoplastic bicomponent binder fiber can be combined with other media, fibers and other filtration components to form a thermally bonded filtration media. The filtration media can be used in filter units. Such filter units can be placed in the stream of a mobile fluid and can remove a particulate load from the mobile stream. The unique combination of media fiber, bicomponent binder fiber and other filtration additives and components provide a filtration media having unique properties in filtration applications.