Abstract: Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly steroids, are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid; a solubilizer, preferably a vitamin E substance; and a surfactant. The synergistic effect between the hydrophobic drug and the vitamin E substance results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharamaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided.

Abstract: A phased ultrasonic transducer and method for transmitting sound or ultrasound through a gaseous medium into a solid spectrum with ultrasound beam steering and focusing.

Abstract: The present disclosure is drawn to pharmaceutical compositions and oral dosage capsules containing testosterone undecanoate, as well as related methods. The capsule includes a capsule shell and a capsule fill. The capsule fill can include a solubilizer and about 14 wt % to about 35 wt % testosterone undecanoate based on the total capsule fill. The oral dosage capsule is such that when a single oral administration to a male subject of one or more capsules with a total testosterone undecanoate daily dose of about 350 mg to about 650 mg it provides a ratio of serum testosterone Cmax to serum testosterone Cave of about 2.7 or less. In yet another embodiment, a method for providing a serum concentration of testosterone within a target serum testosterone concentration Cave range for a male subject is provided.

Abstract: Disclosed are bioavailable solid state (17-?)-Hydroxy-4-Androsten-3-one esters suitable for pharmaceutical uses and administration to mammals in need of (17-?)-Hydroxy-4-Androsten-3-one.

Abstract: A contoured check valve disc features a pivot portion and a check valve portion. The check valve portion is attached to the pivot portion, and has two sides, a first side to respond to the fluid flow in a first direction and move the check valve portion away from a fluid opening to the one or more open positions depending on the fluid flow to allow the fluid to flow through the fluid opening, and a second and opposing side to respond to fluid flow in an opposite direction through the fluid opening and move the check valve portion towards the fluid opening to the closed position to seal the fluid opening and stop fluid flow.

Abstract: An apparatus for sterilization of objects or materials comprises an enclosure for containing a gaseous atmosphere; an acoustically transparent platform located within the enclosure for supporting the objects or materials to be sterilized; one or more non-contact ultrasound transducers positioned within the enclosure and spaced from the platform; and an electric power amplifier for exciting the one or more transducers.

Abstract: The present disclosure is drawn to pharmaceutical compositions and oral dosage forms containing testosterone undecanoate, as well as related methods of treatment. In one embodiment, the oral dosage form can include a therapeutically effective amount of testosterone undecanoate and a pharmaceutically acceptable carrier. The dosage form can be formulated such that, when measured using a USP Type II apparatus in 1000 mL of 8 wt % Triton X-100 in water at 37° C. and 100 rpm, the oral dosage form releases at least 20% more testosterone undecanoate after the first 120 minutes than an equivalent dose testosterone undecanoate containing oral dosage form without the pharmaceutically acceptable carrier.

Abstract: The present invention provides solid pharmaceutical compositions for improved delivery of a wide variety of pharmaceutical active ingredients contained therein or separately administered. In one embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier including a substrate and an encapsulation cost on the substrate. The encapsulation coat can include different combinations of pharmaceutical active ingredients, hydrophilic surfactant, lipophilic surfactants and triglycerides. In another embodiment, the solid pharmaceutical composition includes a solid carrier, the solid carrier being formed of different combinations of pharmaceutical active ingredients, hydrophilic surfactants, lipophilic surfactants and triglycerides. The compositions of the present invention can be used for improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals and diagnostic agents.

Abstract: The present invention relates to an antioxidant compound having anti atherosclerotic effect and preparation thereof. The present invention more particularly relates to the synthesis of TPP+ coupled esculetin (mitochondria-targeted esculetin [Mito-Esc]) followed by the biological evaluation of Mito-Esc for its ability to attenuate Angiotensin-II-induced atherosclerosis in apolipoproteinE knockout (ApoE?/? mice along with the endothelial cell age-delaying effects of Mito-Esc.

Abstract: An analog multiplexer may be used for sampling an input voltage that is capable of having a higher voltage level than an upper supply voltage. The analog multiplexer includes a plurality of input switch circuits and a shorting switch circuit. The plurality of input switch circuits include n-type or p-type laterally diffused field effect transistors (NLDFETs or PLDFETs). At least one of the input switch circuits includes a level shifting switch circuit that is able to sample an input voltage that is greater than the upper supply voltage for the multiplexer. A shorting switch circuit, at an output of the multiplexer, includes a capacitively coupled gate drive circuit and is configured to short a first differential output to a second differential output after the input voltage is sampled.

Abstract: An air compressor system useful for supplying a stream of compressed air for an end user is disclosed which includes a refrigerated dryer useful to remove moisture and harvest it from the compressed air. The refrigerated dryer includes an evaporator and a condenser, where the evaporator is useful to produce the moisture from the compressed air. The air compressor system includes an expansion tank which collects the harvested moisture from the evaporator. The expansion tank can include a low liquid level sensor useful to determine a low liquid level of condensate in the expansion tank. The low liquid level sensor can produce a signal indicating a low level of condensate which can be used to shut off a pump that pulls water from the expansion tank and provides it to the condenser of the refrigerated dryer.

Abstract: An air compressor system useful for supplying a stream of compressed air for an end user is disclosed which includes a refrigerated dryer useful to remove moisture and harvest it from the compressed air. The refrigerated dryer includes an evaporator and a condenser, where the evaporator is useful to produce the moisture from the compressed air. The air compressor system includes an expansion tank which collects the harvested moisture from the evaporator. The expansion tank can include a low liquid level sensor and a high liquid level sensor useful to determine level of condensate in the expansion tank. The low liquid level sensor can produce a useful to permit ingress of water from a utility water supply into the expansion tank, and the high liquid level sensor can produce a signal useful to venting excess liquid from the tank.

Abstract: A mounting system is provided to allow the attachment of an acoustic collector to a handheld electronic device such that sound is conducted directly to the device's microphone. A fitted case or band encloses part of the device and includes a tube running from the collector to the device's microphone. In certain embodiments, the tube may be embedded in the case, and a detachable mount may be provided to connect the collector to the case. The collector may be a stethoscope chestpiece, or an open air collector, such as a parabolic collector.

Abstract: An air compressor system useful for supplying a stream of compressed air for an end user is disclosed which includes a refrigerated dryer useful to remove moisture and harvest it from the compressed air. The refrigerated dryer includes an evaporator and a condenser, where the evaporator is useful to produce the moisture from the compressed air. The air compressor system includes an expansion tank which collects the harvested moisture from the evaporator and a supply line from a utility water supply, both of which can be used to provide liquid to a condenser of the dryer. A valve is used to bring together either or both of the condensate from the expansion tank and water from the utility water supply. The valve includes an outlet that provides liquid to a condenser of the dryer.

Abstract: An air compressor system useful for supplying a stream of compressed air for an end user is disclosed which includes a refrigerated dryer useful to remove moisture and harvest it from the compressed air. The refrigerated dryer includes an evaporator and a condenser, where the evaporator is useful to produce the moisture from the compressed air. The air compressor system includes an expansion tank which collects the harvested moisture from the evaporator. The expansion tank can provide liquid to a pump that conveys the liquid to a condenser of the dryer. The refrigerated dryer includes a temperature sensor that detects a temperature of refrigerated fluid associated with the condenser and regulates the pump to supply liquid to the condenser to assist in heat rejection.

Abstract: An air compressor system having a refrigerated dryer and a form of a filter is used between a compressor of the air compressor system and the refrigerated dryer. The filter can include a conical shape such as frustoconical, and includes an outer retainer having a plurality of openings and an inner mesh filter. The retainer and mesh filter can be made out of metal. An end cap and a flange can close off both ends of the conical shape, and a handle can extend from a flange to aid in ease of handling. The components extending between the ends (i.e. between the end cap and flange) may only include the retainer and the mesh filter.

Abstract: A method for optimizing a fleet of generating assets in which groupings include remotely located power blocks that operate so to collectively generate a fleet output level. The method may include: receiving real-time and historical measured values of operating parameters; for each of the generating assets, deriving a relational expression between the measured values of the process inputs and the measured values of the process outputs; defining a selected operating period; selecting competing operating modes for the fleet; based on the relational expressions and a generating configuration of the competing operating modes, calculating a result set for the operation of the fleet proposed during the selected operating period; defining a cost function; and evaluating each of the result sets pursuant to the cost function and, based thereupon, designating one of the competing operating modes as an optimized operating mode.

Abstract: Provided herein are methods and systems for managing spatiotemporal uncertainty in image processing. A method can comprise determining motion from a first image to a second image, determining a latency value, determining a precision value, generating an uncertainty element based upon the motion, the latency value, and the precision value, and rendering the uncertainty element.

Abstract: The disclosed apparatus may include (1) a faceplate that facilitates at least one connection between at least one communication cable and a line card that forwards traffic in connection with a network, (2) at least one heatsink that (A) is integrated into the faceplate and (B) absorbs heat dissipated by at least one electronic component included in the line card, and (3) at least one mount that (A) is integrated into the faceplate and (B) enables the electronic component to attach to the heatsink. Various other apparatuses and systems are also disclosed.