Abstract: To enable detection of occurrence of abnormality in a more preferable manner when the abnormality occurs in signal processing applied to pixel signals.

Abstract: The present invention provides an immunity-inducing agent comprising, as an active component, a polynucleotide/peptide conjugate in which a single-chain polynucleotide or polynucleotide derivative comprising a CpG motif, and an antigenic peptide are bound via a spacer, wherein the spacer is covalently bound at one end thereof to the polynucleotide or polynucleotide derivative and covalently bound at the other end thereof to the antigenic peptide, as well as a pharmaceutical composition comprising said immunity-inducing agent.

Abstract: The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).

Abstract: The present technology relates to a signal processing device, an imaging device, and a signal processing method which are capable of recognizing a blinking target object reliably and recognizing an obstacle accurately, in a situation in which a luminance difference is very large. Signals of a plurality of images captured at different exposure times are added using different saturation signal amounts, and signals of a plurality of images obtained as a result of the addition are synthesized, and thus it is possible to recognize a blinking target object reliably and recognize an obstacle accurately, in a situation in which a luminance difference is very large. The present technology can be applied to, for example, a camera unit or the like that captures an image.

Abstract: The present invention establishes a method for treating cardiac dysfunction. An oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to a part of the intron 55 region of a dystrophin gene, which comprises the sequence of 5?-TGTCTTCCT-3? or 5?-CAGCTTGAACCGGGC-3? (SEQ ID NO: 64) (wherein “T” may be “U” in either sequence), a pharmacologically acceptable salt thereof, or a solvate thereof. A prophylactic and/or a therapeutic for cardiac dysfunction, comprising the above-described oligonucleotide, a pharmacologically acceptable salt thereof, or a solvate thereof. A suppressor of Dp116 expression, comprising the above-described oligonucleotide, a pharmacologically acceptable salt thereof, or a solvate thereof.

Abstract: The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3?-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and ?-1,3-glucan.

Abstract: The imaging apparatus includes a remaining battery level detection unit, a solid-state imaging element, and a control unit. In the imaging apparatus, the remaining battery level detection unit detects a remaining battery level of the battery. Furthermore, in the imaging apparatus, the solid-state imaging element captures image data. Moreover, in the imaging apparatus, the control unit controls the solid-state imaging element to capture image data so that the lower the remaining battery level measured by a remaining battery level measurement unit, the smaller the data amount of the image data to be captured in synchronization with a predetermined synchronization signal.

Abstract: The present technology relates to an image capture device, a method of image capture, a signal processing device, a method of signal processing, and a program capable of capturing reliably a blinking image capture target. A predetermined image capture timing of an image capture unit is controlled so that image capture is performed N times during an exposure time in which at least a part of a turn-on period in which an image capture target is on overlaps with an exposure time of image capture of at least one time at a timing of dividing a blinking cycle in which the image capture target to be captured by the image capture unit configured to perform image capture at the image capture timing blinks into N equal parts where N represents more than one. The present technology is applicable to, in one example, a camera unit or the like used to capture an image.

Abstract: An object of the present invention is to provide a vector capable of oligodendrocyte-specifically suppressing expression of the PLP1 gene for treating PMD caused by abnormality of the PLP1 gene, and a promoter and miRNA therefor, and a pharmaceutical composition comprising the vector. The oligodendrocyte-specific promoter of the present invention comprises a nucleic acid having a sequence identity of at least 90% to a nucleotide sequence set forth in SEQ ID NO: 1. The miRNA of the present invention specific to the PLP1 gene comprises a pair of nucleotide sequences consisting of a specific antisense sequence and sense sequence.

Abstract: To enable detection of occurrence of abnormality in a more preferable manner when the abnormality occurs in signal processing applied to pixel signals.

Abstract: The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to the cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5? end of exon 5 of the G6PC gene with c.648G>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).

Abstract: The present technology relates to a signal processing apparatus, an imaging apparatus, and a signal processing method capable of reliably imaging a blinking imaging target in a scene having a very large difference in brightness. By detecting a difference between a plurality of images captured with different exposure times, calculating a combination coefficient indicating a combination ratio between the plurality of images on the basis of the difference, and combining the plurality of images on the basis of the combination coefficient, it is possible to reliably image a blinking imaging target in a scene having a very large difference in brightness. The present technology can be applied to, for example, a camera unit that captures an image.

Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

Abstract: The objective of the present invention is to provide nucleic acid therapeutics which exhibits more excellent effect and which shows a substantivity for a prolonged period to suppress an expression of ?-synuclein. The oligonucleotide or a pharmacologically acceptable salt thereof according to the present invention is characterized in comprising at least one 2?-O,4?-C-ethylene nucleoside, wherein the oligonucleotide can hybridize with ?-synuclein gene, has an activity to suppress an expression of the ?-synuclein gene, and is complementary to the ?-synuclein gene, 5? end of the oligonucleotide is a nucleotide complementary to the specific nucleotide, the oligonucleotide is complementary to at least a part of SEQ ID NO: 1, and the oligonucleotide has a length of 13 or more and 15 or less nucleotides.

Abstract: The present invention aims at establishing a molecular therapy for Alport syndrome. The present invention provides an oligonucleotide of 15-30 bp comprising a nucleotide sequence complementary to the cDNA of COL4A5 gene, wherein the oligonucleotide is capable of inducing skipping of an exon which has a truncating mutation found in COL4A5 gene in Alport syndrome patients and whose nucleotide number is a multiple of 3, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical drug comprising the above oligonucleotide, a pharmaceutically acceptable salt thereof, or a solvate thereof (therapeutic drug for Alport syndrome).

Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

Abstract: The present technology relates to an image capture device, a method of image capture, a signal processing device, a method of signal processing, and a program capable of capturing reliably a blinking image capture target. A predetermined image capture timing of an image capture unit is controlled so that image capture is performed N times during an exposure time in which at least a part of a turn-on period in which an image capture target is on overlaps with an exposure time of image capture of at least one time at a timing of dividing a blinking cycle in which the image capture target to be captured by the image capture unit configured to perform image capture at the image capture timing blinks into N equal parts where N represents more than one. The present technology is applicable to, in one example, a camera unit or the like used to capture an image.

Abstract: The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

Abstract: The present technology relates to a signal processing apparatus, an imaging apparatus, and a signal processing method capable of reliably imaging a blinking imaging target in a scene having a very large difference in brightness. By detecting a difference between a plurality of images captured with different exposure times, calculating a combination coefficient indicating a combination ratio between the plurality of images on the basis of the difference, and combining the plurality of images on the basis of the combination coefficient, it is possible to reliably image a blinking imaging target in a scene having a very large difference in brightness. The present technology can be applied to, for example, a camera unit that captures an image.

Abstract: The present technology relates to an image capture device, a method of image capture, a signal processing device, a method of signal processing, and a program capable of capturing reliably a blinking image capture target. A predetermined image capture timing of an image capture unit is controlled so that image capture is performed N times during an exposure time in which at least a part of a turn-on period in which an image capture target is on overlaps with an exposure time of image capture of at least one time at a timing of dividing a blinking cycle in which the image capture target to be captured by the image capture unit configured to perform image capture at the image capture timing blinks into N equal parts where N represents more than one. The present technology is applicable to, in one example, a camera unit or the like used to capture an image.