Patents by Inventor Makoto Koizumi

Makoto Koizumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8624019
    Abstract: Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: January 7, 2014
    Assignees: Daiichi Sankyo Company, Limited, Orphan Disease Treatment Institute Co., Ltd.
    Inventors: Masafumi Matsuo, Yasuhiro Takeshima, Makoto Koizumi
  • Patent number: 8593799
    Abstract: A stand includes: a base including a front arm and a rear arm each in which a rod including thread parts at both ends is bent with the both ends facing each other; a hinge unit including two joint members each of which has at least two through-holes, and arranged such that the thread part at the one end of the front arm and the thread part at the one end of the rear arm screw into one of the through-holes of the two joint members, and the thread part at the other end of the front arm and the thread part at the other end of the rear arm screw into the other of the through-holes of the two joint members; and a bracket including an attachment fixed onto an object to be supported, and fixed onto the two joint members.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: November 26, 2013
    Assignee: Sony Corporation
    Inventors: Hiroyuki Ono, Makoto Koizumi, Naoto Sukou, Nobuyuki Hara
  • Publication number: 20130253038
    Abstract: It is intended to provide a polynucleotide that is resistant to RNase and has an RNA interference effect, etc. The present invention provides a single-stranded polynucleotide that is derived from a double-stranded polynucleotide comprising a sense strand polynucleotide corresponding to a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, and has a structure in which the 5?-end of the antisense strand and the 3?-end of the sense strand are linked via a phenyl group-containing linker to form a phosphodiester structure at each of these ends.
    Type: Application
    Filed: December 1, 2011
    Publication date: September 26, 2013
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Makoto Koizumi, Yasuhide Hirota, Makiko Nakayama, Mika Ikeda
  • Publication number: 20130090465
    Abstract: Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides.
    Type: Application
    Filed: November 9, 2012
    Publication date: April 11, 2013
    Inventors: Masafumi MATSUO, Yasuhiro Takeshima, Makoto Koizumi
  • Publication number: 20130075243
    Abstract: A switch device includes: a switch; an operation section disposed to face the switch; a first resilient section that is deformed by first pressing force derived from the operation section; and a second resilient section that is brought into contact with the switch by the deformation of the first resilient section, and is deformed to activate the switch by second pressing force greater than the first pressing force.
    Type: Application
    Filed: September 10, 2012
    Publication date: March 28, 2013
    Applicant: Sony Corporation
    Inventors: Naofumi Tsuchiya, Makoto Koizumi, Hiroyuki Ono
  • Patent number: 8270659
    Abstract: Disclosed herein is a speaker system including a speaker unit with a speaker body incorporated therein; and a speaker panel disposed on the front side of the speaker unit; wherein the speaker panel has a multiplicity of fine holes permitting a sound of the speaker body to pass therethrough, and has an opaque part hiding the presence of the speaker unit, and a transparent part in the periphery of the opaque part.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: September 18, 2012
    Assignee: Sony Corporation
    Inventors: Makoto Koizumi, Hiroyuki Nakamura, Katsuhiro Yamashita
  • Publication number: 20120220649
    Abstract: The present invention provides a double-stranded polynucleotide having a sense strand polynucleotide consisting of a nucleotide sequence complementary to a target sequence in a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, wherein an aryl or heteroaryl compound is bound to a phosphate group at the 5?-end of the antisense strand polynucleotide.
    Type: Application
    Filed: October 29, 2010
    Publication date: August 30, 2012
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Makoto Koizumi, Yasuhide Hirota
  • Publication number: 20110285925
    Abstract: A display device includes: a front-face member having a transparent plate, a frame having a joint face joined to a rear face of the transparent plate by a joint layer and a holding face provided upright from the joint face, and a hook projected from the holding face of the frame to the outer periphery side of the transparent plate; a display panel which is fit in the frame; a sandwiching member having a pair of clipping faces which come into contact with rear and front faces of the display panel, a side face connecting the pair of sandwiching faces, and an opening which is formed in the side face and to which the hook is inserted; and a rear-face casing covering the entire rear face of the transparent plate.
    Type: Application
    Filed: April 27, 2011
    Publication date: November 24, 2011
    Inventors: Hiroyuki ONO, Makoto KOIZUMI, Naoto SUKOU, Nobuyuki HARA
  • Publication number: 20110286164
    Abstract: A stand includes: a base including a front arm and a rear arm each in which a rod including thread parts at both ends is bent with the both ends facing each other; a hinge unit including two joint members each of which has at least two through-holes, and arranged such that the thread part at the one end of the front arm and the thread part at the one end of the rear arm screw into one of the through-holes of the two joint members, and the thread part at the other end of the front arm and the thread part at the other end of the rear arm screw into the other of the through-holes of the two joint members; and a bracket including an attachment fixed onto an object to be supported, and fixed onto the two joint members.
    Type: Application
    Filed: May 10, 2011
    Publication date: November 24, 2011
    Inventors: Hiroyuki ONO, Makoto Koizumi, Naoto Sukou, Nobuyuki Hara
  • Patent number: 7994152
    Abstract: A method of treating a tumor or a viral disease by administering to a human the following 2?,5?-oligoadenylate analog: Wherein m is 0; n is 0 or 1; R1 is alkoxy substituted by hydroxyl, mercapto, alkylthio substituted by hydroxyl or X1—X2—X3—S—; R2, R3, R4, R5 and R6 are hydroxyl, mercapto, alkylthio substituted by hydroxyl or X1—X2—X3—S—; R7 is oxygen, sulfur, —NH—, or —O(CH2CH2O)q-, wherein q is 2 to 6, or oxyalkyleneoxy; R8 is hydrogen or a 5?-phosphorylated oligonucleotide which has one hydroxyl removed from the 5?-phosphoric acid; E1 is K2; E2 is K1; E3 is K2 or K3 and E4 is K1, K2 or K3; K1 is K2 is K3 is B is adeninyl; A is alkylene; D is alkyl or alkenyl; X1 is alkyl or phenyl; X2 is —C(?O)O—, —OC(?O)— or —C(?O)S—; and X3 is alkylene.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: August 9, 2011
    Assignee: Sankyo Company, Limited
    Inventors: Makoto Koizumi, Koji Morita
  • Publication number: 20110152353
    Abstract: It is intended to provide a double-stranded polynucleotide that is resistant to RNase and has RNA interference effect, etc. The present invention provides a double-stranded polynucleotide comprising sense and antisense strands comprising polynucleotides comprising a nucleotide unit of DNAs and 2?-O-methyl RNAs alternately combined.
    Type: Application
    Filed: June 30, 2009
    Publication date: June 23, 2011
    Inventors: Makoto Koizumi, Yasuhide Hirota
  • Patent number: 7906639
    Abstract: The present invention relates to a method for detecting gene polymorphism by PCR, using, as a primer, an oligonucleotide, wherein the third nucleotide from the 3?-end thereof is a 2?-O,4?-C-ethylene nucleotide (ENA) unit, the other oligonucleotides are natural oligonucleotides, the 3?-end position thereof is a nucleotide complementary to the nucleotide of the reference sequence of a polymorphic sequence of a target gene, and the other positions are nucleotides complementary to the nucleotide sequence of the target gene, or an oligonucleotide, wherein the 3?-end of the nucleotide sequence thereof is a polymorphic position, the second nucleotide from the 3?-end thereof is a nucleotide having a base that is not complementary to a gene to be detected, and the third nucleotide from the 3?-end thereof is a 2?-O,4?-C-ethylene nucleotide (ENA) unit; oligonucleotides used in detection of gene polymorphism; and a kit for detecting gene polymorphism, comprising the above oligonucleotides.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: March 15, 2011
    Assignee: Sankyo Company, Limited
    Inventor: Makoto Koizumi
  • Patent number: 7902160
    Abstract: Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: March 8, 2011
    Assignees: Nonprofit Organization Translational Research Organization of Duchenne Muscular Dystrophy, KNC Laboratories Co., Ltd.
    Inventors: Masafumi Matsuo, Yasuhiro Takeshima, Makoto Koizumi
  • Publication number: 20110046360
    Abstract: Oligonucleotides having a nucleotide sequence complementary to nucleotide numbers such as 2571-2607, 2578-2592, 2571-2592, 2573-2592, 2578-2596, 2578-2601 or 2575-2592 of the dystrophin cDNA (Gene Bank accession No. NM_004006.1) and therapeutic agents for muscular dystrophy comprising such oligonucleotides.
    Type: Application
    Filed: July 30, 2010
    Publication date: February 24, 2011
    Applicants: Nonpro. Org. Trans. Res. Org. of Duch. Musc. Dys., KNC Laboratories Co., Ltd.
    Inventors: Masafumi MATSUO, Yasuhiro TAKESHIMA, Makoto KOIZUMI
  • Publication number: 20100035976
    Abstract: A method of treating a tumor or a viral disease by administering to a human the following 2?,5?-oligoadenylate analog: Wherein m is 0; n is 0 or 1; R1 is alkoxy substituted by hydroxyl, mercapto, alkylthio substituted by hydroxyl or X1—X2—X3—S—; R2, R3, R4, R5 and R6 are hydroxyl, mercapto, alkylthio substituted by hydroxyl or X1—X2—X3—S—; R7 is oxygen, sulfur, —NH—, or —O(CH2CH2O)q-, wherein q is 2 to 6, or oxyalkyleneoxy; R8 is hydrogen or a 5?-phosphorylated oligonucleotide which has one hydroxyl removed from the 5?-phosphoric acid; E1 is K2; E2 is K1; E3 is K2 or K3 and E4 is K1, K2 or K3; K1 is K2 is K3 is B is adeninyl; A is alkylene; D is alkyl or alkenyl; X1 is alkyl or phenyl; X2 is —C(?O)O—, —OC(?O)— or —C(?O)S—; and X3 is alkylene.
    Type: Application
    Filed: October 9, 2009
    Publication date: February 11, 2010
    Applicant: SANKYO COMPANY, LIMITED
    Inventors: Makoto Koizumi, Koji Morita
  • Patent number: 7651999
    Abstract: A 2-5A analog represented by the formula (1): wherein m is 0 or 1; n is 0 to 2; R1 represents an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R2, R3, R4, R5 and R6 represent an unprotected hydroxyl group, a hydroxyl group protected by a nucleic acid synthesis protecting group, an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R7 represents an oxygen atom, or a —O(CH2CH2O)q- group, wherein q is 2 to 6; R8 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms which may be substituted, or a 5?-phosphorylated oligonucleotide analog which has one hydroxyl group removed from the 5
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: January 26, 2010
    Assignee: Sankyo Company, Limited
    Inventors: Makoto Koizumi, Koji Morita
  • Patent number: 7339132
    Abstract: A puffer type gas circuit breaker has a piston, which is connected with a center shaft via a link mechanism. At an initial stage of an interruption operation, the link mechanism drives a puffer cylinder and the piston both in an interruption direction while maintaining an almost constant distance therebetween. Even when a pressure rise occurs in a compression chamber by the heat of an arc generated in accordance with opening between a fixed arc contact and a movable arc contact, the pressure rise does not become an operation counterforce to an operator. At a final stage of the interruption operation where the fixed arc contact is removed from a throat of an insulating nozzle, the link mechanism drives the piston in an almost stopped status.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: March 4, 2008
    Assignee: Japan AE Power Systems Corporation
    Inventors: Hajime Urai, Youichi Ohshita, Makoto Koizumi, Naoki Osawa, Hiroaki Hashimoto, Junzo Kida
  • Publication number: 20070195286
    Abstract: Disclosed herein is a rear projection display apparatus including, a screen, a projection mirror; a video apparatus for projecting a picture, an optical unit including a projection lens, a light source, a drive and control circuit, and a structure body for holding the screen, wherein the projection mirror is adjustably provided on the structure body fitted with the screen or on a structure body holding the screen.
    Type: Application
    Filed: December 28, 2006
    Publication date: August 23, 2007
    Inventors: Yoichi Hiramatsu, Yoshikazu Kidokoro, Kenichiro Utsumi, Makoto Koizumi
  • Publication number: 20070147648
    Abstract: Disclosed herein is a speaker system including a speaker unit with a speaker body incorporated therein; and a speaker panel disposed on the front side of the speaker unit; wherein the speaker panel has a multiplicity of fine holes permitting a sound of the speaker body to pass therethrough, and has an opaque part hiding the presence of the speaker unit, and a transparent part in the periphery of the opaque part.
    Type: Application
    Filed: December 12, 2006
    Publication date: June 28, 2007
    Inventors: Makoto Koizumi, Hiroyuki Nakamura, Katsuhiro Yamashita
  • Publication number: 20070131168
    Abstract: The invention relates to a gas supplying unit to be arranged to hermetically fit in an opening formed at a ceiling part of a processing container for conducting a process to a substrate. The gas supplying unit includes a plurality of nickel members. A large number of gas-supplying holes is formed at a lower surface of the gas supplying unit, a process gas is adapted to be supplied from the large number of gas-supplying holes into the processing container, and the plurality of nickel members is fixed to each other via an intermediate member for preventing sticking made of a material different from nickel.
    Type: Application
    Filed: October 27, 2006
    Publication date: June 14, 2007
    Inventors: Hisashi Gomi, Tetsuya Saito, Takashi Kakegawa, Takahisa Mase, Makoto Koizumi, Kunihiro Tada, Satoshi Wakabayashi, Kensaku Narushima, Fang Cheng