Abstract: Transgenic silkworms comprising at least one nucleic acid encoding a chimeric silk polypeptide comprising one or more spider silk elasticity and strength motifs are disclosed. Expression cassettes comprising nucleic acids encoding a variety of chimeric spider silk polypeptides (Spider 2, Spider 4, Spider 6, Spider 8) are also disclosed. A piggyBac vector system is used to incorporate nucleic acids encoding chimeric spider silk polypeptides into the mutant silkworms to generate stable transgenic silkworms. Chimeric silk fibers having improved tensile strength and elasticity characteristics compared to native silkworm silk fibers are also provided. The transgenic silkworms greatly facilitate the commercial production of chimeric silk fibers suitable for use in a wide variety of medical and industrial applications.

Abstract: The invention relates to benzodiazepine derivatives of formula (A) useful as CCK2/gastrin receptor antagonists, their preparation and their use in the treatment or prevention of disorders associated with CCK2/gastrin receptors, disorders caused by or associated with hypergastrinaemia, and gastric acid-related disorders.

Abstract: Transgenic silkworms comprising at least one nucleic acid encoding a chimeric silk polypeptide comprising one or more spider silk elasticity and strength motifs are disclosed. Expression cassettes comprising nucleic acids encoding a variety of chimeric spider silk polypeptides (Spider 2, Spider 4, Spider 6, Spider 8) are also disclosed. A piggyBac vector system is used to incorporate nucleic acids encoding chimeric spider silk polypeptides into the mutant silkworms to generate stable transgenic silkworms. Chimeric silk fibers having improved tensile strength and elasticity characteristics compared to native silkworm silk fibers are also provided. The transgenic silkworms greatly facilitate the commercial production of chimeric silk fibers suitable for use in a wide variety of medical and industrial applications.

Abstract: Transgenic silkworms comprising at least one nucleic acid encoding a chimeric silk polypeptide comprising one or more spider silk elasticity and strength motifs are disclosed. Expression cassettes comprising nucleic acids encoding a variety of chimeric spider silk polypeptides (Spider 2, Spider 4, Spider 6, Spider 8) are also disclosed. A piggyBac vector system is used to incorporate nucleic acids encoding chimeric spider silk polypeptides into the mutant silkworms to generate stable transgenic silkworms. Chimeric silk fibers having improved tensile strength and elasticity characteristics compared to native silkworm silk fibers are also provided. The transgenic silkworms greatly facilitate the commercial production of chimeric silk fibers suitable for use in a wide variety of medical and industrial applications.

Abstract: Aspects of the subject matter described herein relate to storage systems and aliased memory. In aspects, a file system driver or other component may send a request to a memory controller to create an alias between two blocks of memory. One of the blocks of memory may be used for main memory while the other of the blocks of memory may be used for a storage system. In response, the memory controller may create an alias between the blocks of memory. Until the alias is severed, when the memory controller receives a request for data from the block in main memory, the memory controller may respond with data from the memory block used for the storage system. The memory controller may also implement other actions as described herein.

Abstract: The techniques and systems described herein reduce the amount of storage resources consumed by containers by creating placeholder files in container namespaces. The placeholder files are associated with read-only access to corresponding shared files stored in a read-only namespace. The read-only namespace can be accessible to multiple different containers. This increases the storage density for a storage unit because more containers can be executed from the same storage unit. The techniques and systems described herein further reduce the amount of storage resources consumed by containers by creating placeholder directories. The techniques and systems described herein also reduce the amount of memory storage resources consumed by containers to execute files by using a shared execution memory area.

Abstract: A method of encoding adaptive audio, comprising receiving N objects and associated spatial metadata that describes the continuing motion of these objects, and partitioning the audio into segments based on the spatial metadata. The method encodes adaptive audio having objects and channel beds by capturing a continuing motion of a number N objects in a time-varying matrix trajectory comprising a sequence of matrices, coding coefficients of the time-varying matrix trajectory in spatial metadata to be transmitted via a high-definition audio format for rendering the adaptive audio through a number M output channels, and segmenting the sequence of matrices into a plurality of sub-segments based on the spatial metadata, wherein the plurality of sub-segments are configured to facilitate coding of one or more characteristics of the adaptive audio.

Abstract: The invention relates to benzodiazepine derivatives of formula (A) useful as CCK2/gastrin receptor antagonists, their preparation and their use in the treatment or prevention of disorders associated with CCK2/gastrin receptors, disorders caused by or associated with hypergastrinaemia, and gastric acid-related disorders.

Abstract: Methods which uses interpolated primitive matrices to decode encoded audio to recover (losslessly) content of a multichannel audio program and/or to recover at least one downmix of such content, and encoding methods for generating such encoded audio. In some embodiments, a decoder performs interpolation on a set of seed primitive matrices to determine interpolated matrices for use in rendering channels of the program. Other aspects are a system or device configured to implement any embodiment of the method.

Abstract: A method of decomposing a matrix of dimension L-by-N, where L is less than or equal to N, into a sequence of N-by-N unit primitive matrices and a permutation matrix comprising a sequence that is the product of the primitive matrices and the permutation matrix, containing L rows that are substantially close to the provided L-by-N matrix, where the choice of the permutation matrix and the indices of the non-trivial rows in the primitive matrices are chosen to limit the coefficient values in the primitive matrices.

Abstract: Aspects of the subject matter described herein relate to storage systems and aliased memory. In aspects, a file system driver or other component may send a request to a memory controller to create an alias between two blocks of memory. One of the blocks of memory may be used for main memory while the other of the blocks of memory may be used for a storage system. In response, the memory controller may create an alias between the blocks of memory. Until the alias is severed, when the memory controller receives a request for data from the block in main memory, the memory controller may respond with data from the memory block used for the storage system. The memory controller may also implement other actions as described herein.

Abstract: Described is a unique class of antiviral molecule that can be applied to control and eliminate HIV infection in patients using myeloablation therapies and replenishment with transformed bone marrow stem cells programmed to express the antiviral molecule. These anti-viral molecules target the HIV genome in a highly conserved domain, and when expressed in cells prior to infection will cause the cell to die upon infection with HIV. Cell death insures no proliferation of new virus. Reconstituting the immune system with cells expressing these antivirals prevents re-establishment of HIV infection from reservoirs in the re-established lymphocyte and macrophage populations. Over time, reservoirs will be depleted entirely, effectively eliminating the virus. In effect, this new type of antiviral can be used to cure HIV infections.

Abstract: An apparatus including at least one concealable sanitary fixture, such as a toilet bowl (2), moveable between a concealed position and an extended/exposed position. A hinged conduit (4) provides a fluid tight connection between the toilet bowl (2) and a waste outlet (5). Hinges (6, 7) allow the conduit (4) to adjust with the movement of the toilet bowl (2).

Abstract: Aspects of the subject matter described herein relate to storage systems and aliased memory. In aspects, a file system driver or other component may send a request to a memory controller to create an alias between two blocks of memory. One of the blocks of memory may be used for main memory while the other of the blocks of memory may be used for a storage system. In response, the memory controller may create an alias between the blocks of memory. Until the alias is severed, when the memory controller receives a request for data from the block in main memory, the memory controller may respond with data from the memory block used for the storage system. The memory controller may also implement other actions as described herein.

Abstract: The techniques and systems described herein reduce the amount of storage resources consumed by containers by creating placeholder files in container namespaces. The placeholder files are associated with read-only access to corresponding shared files stored in a read-only namespace. The read-only namespace can be accessible to multiple different containers. This increases the storage density for a storage unit because more containers can be executed from the same storage unit. The techniques and systems described herein further reduce the amount of storage resources consumed by containers by creating placeholder directories. The techniques and systems described herein also reduce the amount of memory storage resources consumed by containers to execute files by using a shared execution memory area.

Abstract: A method of encoding adaptive audio, comprising receiving N objects and associated spatial metadata that describes the continuing motion of these objects, and partitioning the audio into segments based on the spatial metadata. The method encodes adaptive audio having objects and channel beds by capturing a continuing motion of a number N objects in a time-varying matrix trajectory comprising a sequence of matrices, coding coefficients of the time-varying matrix trajectory in spatial metadata to be transmitted via a high-definition audio format for rendering the adaptive audio through a number M output channels, and segmenting the sequence of matrices into a plurality of sub-segments based on the spatial metadata, wherein the plurality of sub segments are configured to facilitate coding of one or more characteristics of the adaptive audio.

Abstract: A method of decomposing a matrix of dimension L-by-N, where L is less than or equal to N, into a sequence of N-by-N unit primitive matrices and a permutation matrix comprising a sequence that is the product of the primitive matrices and the permutation matrix, containing L rows that are substantially close to the provided L-by-N matrix, where the choice of the permutation matrix and the indices of the non-trivial rows in the primitive matrices are chosen to limit the coefficient values in the primitive matrices.

Abstract: Aspects of the subject matter described herein relate to file system technology. In aspects, a mechanism is described that allows a file system to handle corrupted file system metadata in a way that provides high availability. When corrupted metadata is detected, the corrupted metadata may be deleted while the file system remains online and available to service file input/output operations that involve non-corrupted metadata.

Abstract: An apparatus for holding radioactive objects includes a base and a central pillar extending upwardly between a bottom end coupled to the base and a top end above the base. A plurality of inner segments are spaced around the central pillar, and a plurality of outer segments are spaced around the inner segments to form pairs. The inner segments, the outer segments and the central pillar may be coupled together to permit limited radial movement of at least one of the segments of each pair. Each pair may define a generally vertical, object-receiving channel arranged between the inner and outer segment of the pair. The segments of each pair may be adapted to bear against an object in the channel of the pair to laterally restrain the object and facilitate heat transfer from the object.

Abstract: Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering PYY or an agonist thereof and GLP-1 or an agonist thereof to the subject, simultaneously or sequentially, thereby decreasing the calorie intake of the subject.