Abstract: A method of manufacturing a semiconductor package is provided, with an integrated heatsink and electrical connection feature. The semiconductor die can be attached to the terminal using eutectic bonding, preferably CuSn eutectic, Ag containing adhesives or Ag sintering material. These bondings are lead (Pb) free connection methods, which make the finished semiconductor package RoHS compliant (restriction of hazardous materials).

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: Embodiments described herein generally relate to assemblies, systems, and methods for cell culture and production of biologics. Disclosed herein are multi-purpose assemblies that facilitate combination of perfusion processes and harvest processes. The multi-purpose assemblies and systems comprising the same simplify and streamline the biomanufacturing process, at least by improving automation capabilities, reducing physical footprint, reducing risk of contamination, and reducing consumable use rates. Also disclosed herein are methods of using the aforementioned assemblies and systems.

Abstract: The present invention provides an antibacterial and antiviral fabric includes a fabric substrate and an antimicrobial coating. The antimicrobial coating formed on the fabric substrate having an antimicrobial agent embedded or surface-adherent in a three dimensional porous network of nano-binder particles. The three dimensional porous network is formed by connecting the nano-binder particles to each other via van der Waals force or coulombic force. The antibacterial and antiviral fabric has an antimicrobial effect of at least 99% while maintaining physical properties comparable to an uncoated fabric. The present invention also provides an antibacterial and antiviral formulation and a method of preparing antibacterial and antiviral nanoparticles.

Abstract: The present invention relates to methods and compositions for the treatment of BAF-related disorders such as cancers and viral infections.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: A method, system, and computer program product for managing user identification codes in an internet advertising environment. One aspect implements a system including a database engine to store a plurality of signals comprising characteristics and/or values received from a user device. A user ID generator calculates collision statistics and/or fragmentation statistics to form a first mapping function that is in turn used to generate a plurality of identification codes based at least in part a first set of selected signals. A calibration module produces measurements determined from collision quantities and/or fragmentation quantities using the first mapping function, wherein the measurements are determined by comparing the plurality of identification codes to entries in a known ID database. A sequencing module generates updated sequences of mapping functions.

Abstract: A system and method are provided for managing multiple transactional workflows. The method includes saving each transactional workflow with a unique identifier, mapping the unique identifier to an entity associated with the client device used to initiate the corresponding transactional workflow, providing a first option for the client device to retrieve from the server device details of the plurality of transactional workflows, and receiving a request at a later time to retrieve details of the plurality of transactional workflows. The method also includes performing an authentication process, using the predetermined identifying information to determine unique identifiers of the corresponding saved transactional workflows, providing a second option for the client device to resume one or more of the transactional workflows, and resuming the corresponding one or more transactional workflows. Each transactional workflow is saved in a format that permits the server device to execute and complete a binding outcome.

Abstract: The presentation of data models (a story) on a mobile device having limited memory and processing resources includes instantiating widgets one at a time for interaction with a user. When the user completes their interaction, the instance of that widget is removed from memory (destroyed); widgets are therefore stateless. A context framework that manages the application of filters to widgets that comprise the story. When a filter is applied, widget snapshot images used to display corresponding widgets in a collection view can be updated to reflect state changes of affected corresponding widgets so that users can see the state changes despite the widget being stateless.

Abstract: The present disclosure describes a system, method and software applications for predicting the KAM of a subject for a plurality of gait cycles of a subject. At least one sensor attachable adjacent to the ankle of at least one leg of the subject provides accelerometer and gyroscopic data for the plurality of gait cycles. A processing means receives subject parameters and accelerometer and gyroscopic data from the at least one sensor for evaluation by a neural network of predicted KAM values for the plurality of gait cycles of the subject. The neural network is configured via determining KAM values for each of the plurality of subjects from measurements during a plurality of gait cycles and other parameters.

Abstract: The present disclosure describes a system, method, and computer program for real-time and computationally efficient calculation of a recommended value range for a quote variable, such as price, discount, volume, or closing time. The system uses the highest-density interval (HDI) of probability density function (PDF) as a recommended or suggested value range for a quote variable. PDFs for the quote variable are precomputed for groups of related inputs, and each PDF is summarized as an array of discrete points. A dimension reduction technique is applied to the PDF inputs in both the training and real-time (non-training) phases to reduce the number of possible combinations of PDFs. During a quote-creation process, a PDF look-up table enables the system to efficiently identify an applicable PDF from the group of precomputed PDFs based on reduced input values.

Abstract: Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.

Abstract: Time-varying scent determined by audio-meaningful events, such as gun firing, in an audio signal is generated by first computing a spectrogram thereof. A fingerprint, each having feature points, can be extracted from the spectrogram over a time window. The plurality of feature points is hashed to give a hash code. A sequence of hash codes obtained over multiple time windows is correlated with predetermined hash-code segments of known audio-meaningful events stored in a database. A matched audio-meaningful event having a highest correlation is identified. The scent-generating recipe corresponding to the matched audio-meaningful event is retrieved. Atomizers are used to vaporize scent-generating substances to generate the time-variant scent. Since the hash code has a fixed length and a smaller size than the plurality of feature points, storage requirements of the database and computation requirements of correlation calculation are reduced by using the hash code rather than the plurality of feature points.

Abstract: A system and a method for a security strap device including a strap; a lock, the lock comprising a locking mechanism; a fixed portion of the strap being secured inside the lock; a free end of the strap insertable into the lock to form a loop in the strap, the lock is configured to lock a portion of the strap to form the loop in the strap, wherein; the locking mechanism comprises a plurality of latches moveable between a locking position and an unlocking position; the plurality of latches engaging one or more locking slots within the lock when in the locking position to the lock the strap within the lock; and wherein the latches are all simultaneously biased toward the locked position and the latches are required to be simultaneously displaced to an unlocking position to unlock the strap.

Abstract: A system and a method for rendering an image including an image gateway arranged to receive content data representative of one or more objects and style data representative of one or more desired rendering styles; and an image manipulation engine arranged to process the content data and the style data to render a target image, wherein the target image includes a representation of the one or more objects and includes the one or more desired rendering styles.

Abstract: A method, system, and computer program product for managing user identification codes in an interne advertising environment. One aspect implements a system including a database engine to store a plurality of signals comprising characteristics and/or values received from a user device. A user ID generator calculates collision statistics and/or fragmentation statistics to form a first mapping function that is in turn used to generate a plurality of identification codes based at least in part a first set of selected signals. A calibration module produces measurements determined from collision quantities and/or fragmentation quantities using the first mapping function, wherein the measurements are determined by comparing the plurality of identification codes to entries in a known ID database. A sequencing module generates updated sequences of mapping functions.

Abstract: The present disclosure features useful methods to treat an ALT-positive cancer and/or a cancer having a deficiency in ATRX and/or DAXX, e.g., in a subject in need thereof. In some embodiments, the methods described herein are useful in the treatment of cancer in combination with anti-cancer therapies.

Abstract: A method of navigating a visually impaired user, a navigation system and a guiding robot used in the system. The method includes the steps of: receiving a plurality of location referencing signals from a plurality of signal sources; processing the location referencing signals to determine a current location of the user in a predetermined area; planning an optimal path for the user to travel from the current location to a destination location; providing guiding information associated with the optimal path to the user; obtaining a travel instruction from the user to travel along the optimal path; and moving a guiding robot according to the travel instruction provided by the user along the optimal path until the next travel instruction is required to further move the guiding robot.

Abstract: The present invention provides a multi-layered interlaced membrane comprising at least one substrate layer including a plurality of first polymer-based microfibers; at least one nanofibrous layer including a plurality of second polymer-based nanofibers where each of the nanofibers has one or more nano-branches; at least one interlaced layer including a plurality of third polymer-based submicron fibers where each of the submicron fibers has one or more nano-branches and a plurality of fourth polymer-based nanofibers where each of the nanofibers has one or more nano-branches, wherein the third polymer-based submicron fibers are interlaced with the fourth polymer-based nanofibers; at least one submicron fibrous layer including a plurality of fifth polymer-based submicron fibers where each of the submicron fibers has one or more nano-branches.

Abstract: Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.