Abstract: The present disclosure describes a system, method, and computer program for real-time and computationally efficient calculation of a recommended value range for a quote variable, such as price, discount, volume, or closing time. The system uses the highest-density interval (HDI) of probability density function (PDF) as a recommended or suggested value range for a quote variable. PDFs for the quote variable are precomputed for groups of related inputs, and each PDF is summarized as an array of discrete points. A dimension reduction technique is applied to the PDF inputs in both the training and real-time (non-training) phases to reduce the number of possible combinations of PDFs. During a quote-creation process, a PDF look-up table enables the system to efficiently identify an applicable PDF from the group of precomputed PDFs based on reduced input values.

Abstract: A heat-not-burn tobacco-type device for heating a cigarette has a heater and a vaporizer. The heater heats the cigarette at a heating temperature not greater than 450° C. for discouraging formation of harmful substances, such as tar and carbon monoxide, during heating the cigarette. The vaporizer is used to vaporize a liquid for producing smoke and/or for enhancing a taste of the cigarette. The vaporizer and the heater are arranged to work simultaneously or independently to generate two bodies of aerosol, wherein these two bodies of aerosol pass through two independent gas channels and meet together for a smoker to inhale thereafter. Hence, the device not only meets visual needs of the smoker in the smoke and/or enhances the taste of the cigarette, but also discourages generation of the harmful substance.

Abstract: The present invention relates to a smart office chair with a ventilation function, which comprises a seat back, a seat and a chair leg, a second elastic article of an upper surface of a middle portion of the seat provided thereon with at least one first vent hole, which is provided therein with a third elastic article; the seat frame forms a receiving space comprising therein a circular plate, which is provided thereon with at least one first groove corresponding to the position of the first vent hole, the groove defining therein a vertical connector, the other end of the vertical connector fixedly connected to the third elastic article; the circular plate is provided with a first connection hole at the center, connected to a first motor through the first connection hole; a side of the circular plate is provided with a second groove, the second groove provided therein with a wire rope, the wire rope being a loop rope and looping around a side of a first pulley, the first pulley fixedly connected to the second

Abstract: The present disclosure describes a system, method, and computer program for real-time and computationally efficient calculation of a recommended value range for a quote variable, such as price, discount, volume, or closing time. The system uses the highest-density interval (HDI) of probability density function (PDF) as a recommended or suggested value range for a quote variable. PDFs for the quote variable are precomputed for groups of related inputs, and each PDF is summarized as an array of discrete points. A dimension reduction technique is applied to the PDF inputs in both the training and real-time (non-training) phases to reduce the number of possible combinations of PDFs. During a quote-creation process, a PDF look-up table enables the system to efficiently identify an applicable PDF from the group of precomputed PDFs based on reduced input values.

Abstract: Systems and methods which provide a motion sensor data-driven framework for sports action recognition and/or assessment using a wearable sensor are described. A motion sensor data-driven system may provide real-time kinematical analysis to athletes engaged in active competition or training sessions under typical competition or training conditions. Analysis of motion sensor data provided according to embodiments may operate to recognize instances of one or more particular sports actions performed by an athlete and/or assess the skill of the athlete from analysis of one or more sports actions. A motion sensor data processing platform of embodiments of a motion sensor data-driven system may comprise a processor-based system configured to receive and analyze data regarding the movement of an athlete's limb reported by a wearable sensor device comprising a micro inertial measurement unit configuration for capturing and reporting data regarding the movement of an athlete's limb.

Abstract: The presentation of data models (a story) on a mobile device having limited memory and processing resources includes instantiating widgets one at a time for interaction with a user. When the user completes their interaction, the instance of that widget is removed from memory (destroyed); widgets are therefore stateless. A context framework that manages the application of filters to widgets that comprise the story. When a filter is applied, widget snapshot images used to display corresponding widgets in a collection view can be updated to reflect state changes of affected corresponding widgets so that users can see the state changes despite the widget being stateless.

Abstract: The present disclosure provides a self-healing coating composition precursor that includes a soft segment precursor, a hard segment precursor, and a diol. The present disclosure also provides self-healing coatings including the same for scratches and deep cracks and/or anti-fouling property, and methods of preparation and use thereof.

Abstract: An electronic cigarette for smoldering tobacco materials housed in a cigarette cartridge has a heater, and first and second heat conductors. The heater generates heat by using a resistance wire, or via ionizing air, e.g., an electric arc generator. The first heat conductor, which receives heat from the heater, directly contacts an outer surface of the cigarette cartridge for heating the tobacco materials through the cigarette cartridge's outer surface. The second heat conductor penetrates into a center of the cigarette cartridge, and has a heating element for heating the tobacco materials via the cigarette cartridge's center. Hence, the tobacco materials are heated from both inside and outside of the cigarette cartridge simultaneously, thereby smoldering the tobacco materials more completely and resulting in a better taste. During ionizing the air, the heater may further generate a gaseous air-purifying agent for air purification, e.g., negative ions generated by the electric arc generator.

Abstract: This invention provides methods for non-invasive prenatal testing (NIPT) for determining the probability of aneuploidy in a fetus. The present invention comprises quantification and analysis of autosomal single nucleotide polymorphisms (SNPs) using platforms capable of absolute or relative quantification to determine the probability of aneuploidy in the fetus. In one embodiment, the present methods comprise obtaining a blood sample containing cell-free DNA from a pregnant woman, using the extracted DNA to prepare a library of nucleic acids encompassing a plurality of biallelic autosomal single nucleotide polymorphisms (SNPs) of interest (i.e., target SNPs) using a target enrichment approach, performing targeted next-generation sequencing (NGS) using the library prepared, obtaining the allele counts of the target SNPs in the cell-free DNA and determining the probability of aneuploidy in a fetus.

Abstract: The present disclosure provides a mobile App to provide a runtime environment on a mobile device. As part of start up processing, the mobile App can receive a resource bundle that contains an entry point application module and one or more resource modules. In some embodiments, the resource bundle contains no resource modules. The mobile App can load the entry point application module without loading the resource modules into the runtime environment, and start code execution. When a request for a resource module is encountered during code execution, the mobile App can access the requested resource module and load it into the runtime environment.

Abstract: The present invention is a temperature sensor for cryogenic systems using a fiber optic interrogation system that is capable of a large number of temperature readings across the cryogenic environment at high resolutions. The invention also includes a method of using such a system to measure temperatures in a cryogenic environment and a method of making such a system.

Abstract: Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.

Abstract: Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.

Abstract: A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R3, R4, R6, and R7 are as defined herein.

Abstract: Systems and methods for generating prebuilt machine learning framework objects comprising sets of prebuilt machine learning components and one or more data mapping requirements. The components are associated with a respective machine learning service. One or more datasets are obtained. A user-specified context for creating a particular machine learning application is obtained. A particular prebuilt object is selected based on the datasets and the context. One more candidate data mappings are identified based on the data mapping requirements and the datasets. A particular data mapping is selected. A particular set of prebuilt components is selected from the plurality of prebuilt components. The particular machine learning application is generated from the particular prebuilt object based on the particular data mapping and the particular set of prebuilt components, the particular machine learning application comprising an executable application. The machine learning application is deployed.

Abstract: A compound of Formula (IA), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein A, R6, R7 and R8 are as defined herein.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives a request to perform a set of data processing units on a set of data. The set of data processing units are deployed on a computing system. The program further retrieves the set of data. The program also instructs a background user interface (UI) page to perform the set of data processing units on the set of data. The program further provides results from performing the set of data processing units on the set of data.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program receives a first request for a visualization of data. In response to the first request, the program further retrieves the data from a storage of a computing system. The program also generates the visualization based on the data from the storage of the computing system. The program further stores the data in a storage of the device. The program also receives a second request for the visualization of the data. The program further determines that the device is unable to communicate with the computing system. In response to the determination, the program also retrieves the data from the storage of the device. The program further generates the visualization based on the data retrieved from the storage of the device.

Abstract: Some embodiments provide a non-transitory machine-readable medium that stores a program. The program generates a plurality of background user interface (UI) pages. The program further receives a request for a layout page comprising a set of locations for presenting a set of visualizations. The program also instructs the plurality of background UI pages to process a subset of the set of visualizations. The program further presents the processed subset of the set of visualizations in the corresponding locations of the layout page.