Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: The present disclosure describes a system, method, and computer program for real-time and computationally efficient calculation of a recommended value range for a quote variable, such as price, discount, volume, or closing time. The system uses the highest-density interval (HDI) of probability density function (PDF) as a recommended or suggested value range for a quote variable. PDFs for the quote variable are precomputed for groups of related inputs, and each PDF is summarized as an array of discrete points. A dimension reduction technique is applied to the PDF inputs in both the training and real-time (non-training) phases to reduce the number of possible combinations of PDFs. During a quote-creation process, a PDF look-up table enables the system to efficiently identify an applicable PDF from the group of precomputed PDFs based on reduced input values.

Abstract: A gesture recognition apparatus includes a sensor unit configured to be worn by a user on a user's body part. The sensor unit includes one or more sensors, a processor unit, the processor unit and the sensor unit are arranged in communication with each other, the processor unit receiving acoustic data from the one or more sensors, wherein the acoustic data corresponds to a gesture performed by a user, and the processor unit is configured to process the acoustic data received from the one or more sensors to determine a gesture performed by the user.

Abstract: Embodiments provide clustering of websocket communications with configurable master-slave servers. A centralized document service accessible to each server functions as a repository for cluster server information, cluster master server IP address, and security information. Upon receiving a first input, a server references the document service to create a first websocket handler as the master (e.g., utilizing a flag). Upon receiving a second input, a different server references the document service to create a slave websocket handler. Using master server IP address information from the document service, the slave websocket handler establishes a websocket cluster channel with the master websocket handler. Additional websocket channels with the master websocket hander may be established as further inputs are received and slave websocket handlers created.

Abstract: The present disclosure relates a computer-implemented method comprising obtaining, at a database application, a selection of one or more database metadata items from a user device, wherein each metadata item includes human-intelligible content and each metadata item identifying an associated database object contained in a database, identifying, based at least partially on the database objects associated with the selected one or more metadata items, one or more predefined database views of the database application, registering the identified one or more predefined database views, monitoring if the one or more predefined database views are updated after the registering operation and triggering pushing of an update notification to the user device in response to a monitored update of the one or more predefined database views.

Abstract: Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.

Abstract: A visual inspection device includes a body having a support portion and a grip portion extending from the support portion. The device also includes a flexible cable having a first end portion coupled to the body and a second end portion, and a camera assembly coupled to the second end portion of the flexible cable. The camera assembly includes an image sensor operable to transmit image data through the flexible cable. The device further includes a display supported by the support portion of the body. The display is electrically connected to the flexible cable to display image date from the image sensor. The device is powered by a rechargeable battery pack removably coupled to the body.

Abstract: Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.

Abstract: The current subject matter describes displaying historical data associated with one or more data values within a business intelligence report. A graphical user interface executed by a computing device can receive, from a user, a request for display of historical data associated with a specified/selected data value in a business intelligence report. Subsequently, a representational state transfer engine (RESTful engine), which can be connected to a server system connected to the computing device, can execute a representational state transfer service (RESTful service) to fetch historical data from current and past instances associated with the data value. Then, the RESTful engine can write the fetched historical data to a file. The RESTful engine can generate or determine a uniform resource locator (URL) to the file, and can send the URL to the computing device. When the URL is selected by the user, the computing device can display the file.

Abstract: Systems and methods are provided for semi-automatic light control systems which support, amongst other features, receiving a light controlling values from one or more users and choosing an optimal light value based on the aggregated preferences of the present users. The lighting elements of the lighting system are further adjusted based on user perception profiles and other parameters. A semi-automatic determination may be made of a second light controlling value based on the first light controlling value and a user perception profile relating light parameter values with perceived light output values. Lighting element operation may be incrementally adjusted to meet the second light parameter value over a predetermined time period.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: Embodiments provide clustering of websocket communications with configurable master-slave servers. A centralized document service accessible to each server functions as a repository for cluster server information, cluster master server IP address, and security information. Upon receiving a first input, a server references the document service to create a first websocket handler as the master (e.g., utilizing a flag). Upon receiving a second input, a different server references the document service to create a slave websocket handler. Using master server IP address information from the document service, the slave websocket handler establishes a websocket cluster channel with the master websocket handler. Additional websocket channels with the master websocket hander may be established as further inputs are received and slave websocket handlers created.

Abstract: A visual inspection device includes a body having a support portion and a grip portion extending from the support portion. The device also includes a flexible cable having a first end portion coupled to the body and a second end portion, and a camera assembly coupled to the second end portion of the flexible cable. The camera assembly includes an image sensor operable to transmit image data through the flexible cable. The device further includes a display supported by the support portion of the body. The display is electrically connected to the flexible cable to display image date from the image sensor. The device is powered by a rechargeable battery pack removably coupled to the body.

Abstract: A process of pretreatment for selective application of electroless metallization to a surface of a non-conductive material and a solution useful for the pretreatment are provided. The process achieves good coverage in areas to be plated on the surface of non-conductive materials without skip plating or over plating.

Abstract: Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. A methylation profile can be deduced for fetal/tumor tissue based on a comparison of plasma methylation (or other sample with cell-free DNA) to a methylation profile of the mother/patient. A methylation profile can be determined for fetal/tumor tissue using tissue-specific alleles to identify DNA from the fetus/tumor when the sample has a mixture of DNA. A methylation profile can be used to determine copy number variations in genome of a fetus/tumor. Methylation markers for a fetus have been identified via various techniques. The methylation profile can be determined by determining a size parameter of a size distribution of DNA fragments, where reference values for the size parameter can be used to determine methylation levels. Additionally, a methylation level can be used to determine a level of cancer.

Abstract: A piezoceramic based atomizer for atomizing high viscosity liquid is provided. The atomizer comprises a storing tank as a reservoir for storing the liquid, a receiving tank connecting to the storing tank, a piezoceramic based nozzle for forming micro-droplets of the liquid, and an external ultrasonic oscillation circuit. The nozzle comprises a liquid absorbing medium with at least one sunk area at one end for pumping and delivering the liquid, a holder for holding the absorbing medium, a micro-perforated membrane whose one side is attached on the side of the liquid absorbing medium having the sunk area, and an annular piezoceramic adhered to the other side of the membrane. The nozzle is configured such that the sunk area can balance the feeding rate and atomization rate of the liquid as well as hold the back pressure underneath the micro-perforated membrane, facilitating forming micro-droplets of the high viscosity liquid continuously.

Abstract: A visual inspection device includes a body having a support portion and a grip portion extending from the support portion. The device also includes a flexible cable having a first end portion coupled to the body and a second end portion, and a camera assembly coupled to the second end portion of the flexible cable. The camera assembly includes an image sensor operable to transmit image data through the flexible cable. The device further includes a display supported by the support portion of the body. The display is electrically connected to the flexible cable to display image date from the image sensor. The device is powered by a rechargeable battery pack removably coupled to the body.

Abstract: A bubble atomizer includes a cartridge having an open end, a liquid absorbing member provided inside the cartridge, a firing chamber covering the open end and formed with liquid outlets and liquid inlets through which liquid enters the firing chamber from the cartridge, and heaters mounted inside the firing chamber. The heaters are connected with a power electronics unit through a cable. Each heater has a thickness in micron to sub-micron scale. When a pulse signal generated is applied to the heaters, current generated heats up the heaters and vapor bubbles are formed on the heaters that generate pressure and push the liquid out of the firing chamber through the liquid outlets to thereby form droplets.

Abstract: A device for tagging an object includes a tag body having an engagement arrangement with a removable strap for engaging the tag body to the object. The engagement arrangement further includes a sensing arrangement having a strap sensor arrv banged to be connected to the removable strap to detect a disengagement of the tag body from the object. The removable strap further includes a conductive member arranged to connect with the strap sensor and disconnect from the strap sensor when the tag body is disengaged from the object.

Abstract: The present invention is an improved fiber optic sensing system (FOSS) having the ability to provide both high spatial resolution and high frequency strain measurements. The inventive hybrid FOSS fiber combines sensors from high acquisition speed and low spatial resolution Wavelength-Division Multiplexing (WDM) systems and from low acquisition speed and high spatial resolution Optical Frequency Domain Reflection (OFDR) systems. Two unique light sources utilizing different wavelengths are coupled with the hybrid FOSS fiber to generate reflected data from both the WDM sensors and OFDR sensors operating on a single fiber optic cable without incurring interference from one another. The two data sets are then de-multiplexed for analysis, optionally with conventionally-available WDM and OFDR system analyzers.