Abstract: Disclosed are an antibody combination for one-step screening and/or diagnosis of clonal diseases and application thereof. The antibody combination includes eight groups of antibodies, and is a set of flow cytometry detection panels for one-step screening and/or diagnosis of clonal diseases, and 5-tube parallel is used for one sample, the first group of antibodies and the second group of antibodies are used for samples in different flow cytometry tubes, the third group of antibodies and the sixth group of antibodies are used for samples in the same flow cytometry tube, the fourth group of antibodies and the seventh group of antibodies are used for samples in the same flow cytometry tube, and the fifth group of antibodies and the eighth group of antibodies are used for samples in the same flow cytometry tube.

Abstract: The present invention provides a detection reagent and therapeutic target for B cell tumor after targeted therapy and related applications. The reagent composition comprises 3 groups of antibodies, with the first group of antibodies including an anti-CD38 antibody, an anti-CD10 antibody, an anti-CD34 antibody, an anti-CD19 antibody, an anti-CD24 an antibody, an anti-CD20 antibody, an anti-CD81 antibody, an anti-CD45 antibody; the second group of antibodies including an anti-CD38 antibody, an anti-CD10 antibody, an anti-CD34 antibody, an anti-CD19 antibody, an anti-CD20 antibody, an anti-CD72 antibody, an anti-CD45 antibody; and the third group of antibodies including an anti-cytoplasmic CD79a antibody. The reagent composition of the present invention can be applied for the detection of B-lymphocyte tumors after targeted therapy by flow cytometry.

Abstract: A disassembling device for removing fastening components embedded in a workpiece includes a supporting base, a clamping assembly, and a pushing assembly. The pushing assembly includes a sliding assembly, an adjusting rod, and an ejecting pin. The workpiece defines a first through hole which communicates with a positioning hole. The workpiece is clamped by the clamping assembly, the sliding assembly is connected to the supporting base and can slide along a first direction and a second direction perpendicular to the first direction. The adjusting rod passes through the sliding assembly to connect with the ejecting pin, the ejecting pin is driven to extend into the first through hole and to move in a direction perpendicular to the first and second directions, so as to push the fastening component out of the positioning hole.

Abstract: An electronic device, a method, and a computer-readable recording medium are provided for deactivating a chat room of a messenger application. The electronic device is configured for: receiving a deactivation request for one or more chat rooms, in which the deactivation request is associated with a chat room configuration, and the chat room configuration includes a deactivation condition for the one or more chat rooms; storing the chat room configuration including the deactivation condition for the one or more chat rooms based on the deactivation request; and deactivating the one or more chat rooms based on determining whether or not the deactivation condition for the one or more chat rooms is satisfied.

Abstract: The present disclosure provides a self-adaption faster-than-real-time method for estimating a working condition start-up state of a unit. Firstly, an event recording sequence, an analog measurement point ID, an analog measurement point first-level alarm value and a history scatter point distribution record are read from a time sequence event record table, an analog measurement point table, an alarm threshold table and a historical scatter record table. A measured value slope of the analog measurement point is calculated according to an event recording relative time. Then, an abnormal state estimated value is calculated based on the history scatter point distribution record, the analog measurement point first-level alarm value and the measured value slope of the analog measurement point. Finally, a pre-warning is sent to remind a watchman to perform a preventive operation when the abnormal state estimated value is above the threshold.

Abstract: The present disclosure provides a self-adaptive test method for an intelligent prediction algorithm of analog measured values. Firstly, an event recording sequence, an analog measurement point ID and an analog measurement point alarm value are read from a time sequence event record table, an analog measurement point table and an alarm threshold table. Next, operation records of a normal operation state of a unit within a statistical cycle are acquired to form historical statistics of measured values of the analog measurement point based on switching value signals. Then, simulated measured values of the analog measurement point with time scales are calculated based on the historical statistics, the analog measurement point alarm value and an analog measurement point current measured value. Finally, sensitivity is calculated; and an alarm is sent to remind a technician to adjust the algorithm when the sensitivity is greater than a threshold.

Abstract: Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

Abstract: Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

Abstract: Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

Abstract: Disclosed is a polymer dispersion prepared by controlled radical polymerization and a use of the polymer dispersion as a friction reducer in oil field processes.

Abstract: Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

Abstract: Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.

Abstract: Automatic test equipment with multiple components to generate highly accurate and stable analog test signals and method for operating the test system in semiconductor manufacturing process are disclosed. Output analog signals from existing test systems often fail the stability and accuracy requirement with less than 10 mV variations for testing certain electronic devices, due in part to environmental condition variations such as temperature fluctuations. Traditional compensation mechanisms for temperature variations involve time consuming and disruptive calibration procedures. Disclosed here is a system and method that provides near real-time monitoring and compensation for temperature-induced variations via a digital control mechanism that compensates for environmental variations in a time scale of less than 10 milliseconds and maintains the AC output analog signal with 10 milliVolt accuracy.

Abstract: An apparatus for grinding a mineral includes a head operable to be attached to a bottle. The head includes a radial slider for controlling the coarseness of the grind. The apparatus further includes an inner grinding element, an outer grinding element, a shaft, and a neck sleeve. The inner grinding element is in communication with the head. The outer grinding element is also in communication with the head, wherein the outer grinding element and the inner grinding element are operable to rotate relative to each other. The shaft extends through the inner grinding element and the outer grinding element. The shaft couples with the inner grinding element and comprises a blunt end. The shaft also extends through the neck sleeve, which acts as a spacer between the inner grinding element and the blunt end.

Abstract: A compound of formula (I): R1O—(CH2CH2O)x—(CH2CH(R2)—O)y—SO3M, wherein R1, R2, x, y and M are defined herein. A composition comprising the compound of formula (I) and the use thereof.

Abstract: Automatic test equipment with multiple components to generate highly accurate and stable analog test signals and method for operating the test system in semiconductor manufacturing process are disclosed. Output analog signals from existing test systems often fail the stability and accuracy requirement with less than 10 mV variations for testing certain electronic devices, due in part to environmental condition variations such as temperature fluctuations. Traditional compensation mechanisms for temperature variations involve time consuming and disruptive calibration procedures. Disclosed here is a system and method that provides near real-time monitoring and compensation for temperature-induced variations via a digital control mechanism that compensates for environmental variations in a time scale of less than 10 milliseconds and maintains the AC output analog signal with 10 milliVolt accuracy.

Abstract: Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

Abstract: The present invention discloses a dual-actuator switch, comprising: a base, a first electrical connection member, a second electrical connection member, a first isolation sleeve cylinder, a second isolation sleeve cylinder, a first actuator, a second actuator, and a cover. By pressing one of the two actuators to drive one of the two isolation sleeve cylinders to rotate, the isolation sleeve cylinder is driven to prop one of the two electrical connection members by a protrusion member thereof, such that one of two switching operations is carried out. It is worth noting that, the electrical connection members are isolated from the actuators by the isolation sleeve cylinders during the whole electrical switching procedures. As a result, ambient moisture is absolutely blocked from getting into the base for infiltrating the electrical connection members during the up and/or down motion of the actuators.

Abstract: Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

Abstract: Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.