Patents by Inventor Man Chen

Man Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9856313
    Abstract: The present invention relates to an epitope peptide (or a variant thereof) which can be used in the prevention of respiratory syncytial virus (RSV) infection, a recombinant protein comprising the epitope peptide (or a variant thereof) and a carrier protein, and uses of the epitope peptide (or a variant thereof) and the recombinant protein. The present invention also relates to an antibody against the epitope peptide, a cell line for generating the antibody, and uses thereof. Furthermore, the present invention also relates to a vaccine or a pharmaceutical composition comprising the recombinant protein or the antibody according to the invention, for preventing one or more symptoms associated with RSV infection.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: January 2, 2018
    Assignees: XIAMEN UNIVERSITY, XIAMEN INNOVAX BIOTECH CO., LTD., THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Zizheng Zheng, Jason S. McLellan, Man Chen, Min Zhao, Liangmin Huang, Barney S. Graham, Ningshao Xia
  • Publication number: 20170298101
    Abstract: Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 19, 2017
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Peter Kwong, Barney Graham, Jason McLellan, Man Chen, Baoshan Zhang, Tongqing Zhou
  • Patent number: 9738689
    Abstract: Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the immunogen to the subject.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: August 22, 2017
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Peter Kwong, Barney Graham, Jason McLellan, Man Chen, Michael Gordon Joyce, Baoshan Zhang, Tongqing Zhou
  • Patent number: 9673001
    Abstract: Differing from the conventional rotary switches, a rotary switch provided by the present invention is design to perform bidirectional rotation by double shaft, such that this rotary switch has the maximum switching levels of 32. Particularly, two retaining members having a spring accommodating trough are adopted for accommodating the compression springs; therefore, when switching the rotary switch from one switching level to another one switching level, each the retaining member does ensured to fully embed into one of the rotary grooves formed around the disk side edge of the corresponding rotary disks; the reason is that the compression springs suffer to pressing force would not bend during switching the novel rotary switch, such that the functions of the electric product can be switch smoothly and completely.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: June 6, 2017
    Assignees: SOLTEAM ELECTRONICS (DONG GUAN) CO., LTD., SOLTEAM ELECTRONICS (SU ZHOU) CO., LTD., SOLTEAM ELECTRONICS CO., LTD.
    Inventors: Ying-Sung Ho, Chien-Man Chen, Chi-Meng Phang, Chih-Wei Chen
  • Publication number: 20160322181
    Abstract: Differing from the conventional rotary switches, a rotary switch provided by the present invention is design to perform bidirectional rotation by double shaft, such that this rotary switch has the maximum switching levels of 32. Particularly, two retaining members having a spring accommodating trough are adopted for accommodating the compression springs; therefore, when switching the rotary switch from one switching level to another one switching level, each the retaining member does ensured to fully embed into one of the rotary grooves formed around the disk side edge of the corresponding rotary disks; the reason is that the compression springs suffer to pressing force would not bend during switching the novel rotary switch, such that the functions of the electric product can be switch smoothly and completely.
    Type: Application
    Filed: April 30, 2015
    Publication date: November 3, 2016
    Inventors: YING-SUNG HO, CHIEN-MAN CHEN, CHI-MENG PHANG, CHIH-WEI CHEN
  • Publication number: 20160046675
    Abstract: Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 18, 2016
    Applicant: The USA, as represented by the Secretary, Departm- ent of Health and Human Service
    Inventors: Peter D. Kwong, Barney S. Graham, Jason S. McLellan, Jeffrey Boyington, Lei Chen, Man Chen, Gwo-Yu Chuang, Ivelin Stefanov Georgiev, Jason Gorman, Michael Gordon Joyce, Masaru Kanekiyo, Gilad Ofek, Marie Pancera, Mallika Sastry, Cinque Soto, Sanjay Srivatsan, Guillaume Stewart-Jones, Yongping Yang, Baoshan Zhang, Tongqing Zhou
  • Publication number: 20160031972
    Abstract: The present invention relates to an epitope peptide (or a variant thereof) which can be used in the prevention of respiratory syncytial virus (RSV) infection, a recombinant protein comprising the epitope peptide (or a variant thereof) and a carrier protein, and uses of the epitope peptide (or a variant thereof) and the recombinant protein. The present invention also relates to an antibody against the epitope peptide, a cell line for generating the antibody, and uses thereof. Furthermore, the present invention also relates to a vaccine or a pharmaceutical composition comprising the recombinant protein or the antibody according to the invention, for preventing one or more symptoms associated with RSV infection.
    Type: Application
    Filed: March 17, 2014
    Publication date: February 4, 2016
    Applicants: XIAMEN INNOVAX BIOTECH CO., LTD., XIAMEN UNIVERSITY
    Inventors: Zizheng Zheng, Jason S. McLellan, Man Chen, Min Zhao, Liangmin Huang, Barney S. Graham, Ningshao Xia
  • Publication number: 20150122925
    Abstract: An apparatus for grinding a mineral includes a head operable to be attached to a bottle. The head includes a radial slider for controlling the coarseness of the grind. The apparatus further includes an inner grinding element, an outer grinding element, a shaft, and a neck sleeve. The inner grinding element is in communication with the head. The outer grinding element is also in communication with the head, wherein the outer grinding element and the inner grinding element are operable to rotate relative to each other. The shaft extends through the inner grinding element and the outer grinding element. The shaft couples with the inner grinding element and comprises a blunt end. The shaft also extends through the neck sleeve, which acts as a spacer between the inner grinding element and the blunt end.
    Type: Application
    Filed: January 13, 2015
    Publication date: May 7, 2015
    Inventors: Allan E. Wade, Aaron F. Fitchko, Chun Man Chen, Alex Liu
  • Patent number: 8878897
    Abstract: A method implemented in a server for sharing video conversion data includes receiving conversion data for a two-dimensional (2D) video and archiving the conversion data. A selection of a 2D video corresponding to the archived conversion data is received from a client, and conversion data corresponding to the selection received from the client is transmitted to the client.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: November 4, 2014
    Assignee: Cyberlink Corp.
    Inventors: Man-Chen Huang, Yen-Po Tseng, Liang-Heng Chen, Kun-Tse Wu, Yi-Chiun Hong, En-Jan Chou
  • Patent number: 8832736
    Abstract: A method for bitstream editing is provided. The method includes steps of: fetching a first original image from a source multimedia bitstream; performing variation processing on the first original image to generate a plurality of transformed pictures; performing keypoint extraction according to comparison results of the transformed pictures to obtain a plurality of candidate pixels; locating a first advertisement bitstream from an advertisement bitstream database according to the plurality of candidate pixels; and inserting the first advertisement bitstream to the source multimedia bitstream.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: September 9, 2014
    Assignee: Wistron Corporation
    Inventors: Mei-Man Chen, Pei-Chen Chin, Chih-Pin Liao
  • Publication number: 20140129633
    Abstract: An interaction system includes a primary interaction device, for receiving a digital stream content and action information and combining the action information, content information of the digital stream content corresponding to the action information and device information to generate combination information. The interaction system also includes a secondary interaction device, for receiving interaction information of an interactive network service and performing an action of the interactive network service to generate the action information; and a server module, which includes a data base; a playing server, for generating the digital stream content; and a data managing server, for receiving the combination information to transfer the action information to the interactive network service, and storing the combination information and the interaction information in the data base.
    Type: Application
    Filed: May 10, 2013
    Publication date: May 8, 2014
    Applicant: Wistron Corporation
    Inventors: Mei-Man Chen, Yu-Yen Chen
  • Publication number: 20130340000
    Abstract: A method for bitstream editing is provided. The method includes steps of: fetching a first original image from a source multimedia bitstream; performing variation processing on the first original image to generate a plurality of transformed pictures; performing keypoint extraction according to comparison results of the transformed pictures to obtain a plurality of candidate pixels; locating a first advertisement bitstream from an advertisement bitstream database according to the plurality of candidate pixels; and inserting the first advertisement bitstream to the source multimedia bitstream.
    Type: Application
    Filed: January 18, 2013
    Publication date: December 19, 2013
    Applicant: WISTRON CORPORATION
    Inventors: Mei-Man Chen, Pei-Chen Chin, Chih-Pin Liao
  • Publication number: 20120315270
    Abstract: The present invention provides immunogens that protect against RSV infection. The present invention also provides antibody proteins that protect against RSV infection. Such immunogens and antibody proteins are produced based on three-dimensional models also included in the invention. One model is of a complex between motavizumab and its antibody-binding domain on RSV fusion (F) protein. A second model is of a complex between 10 IF antibody and its antibody-binding domain on RSV F protein. The immunogens disclosed herein have been modified to elicit a humoral response against RSV F protein without eliciting a significant cell-mediated response against RSV. Such immunogens can comprise a scaffold into which RSV contact residues are embedded. The present invention also includes methods that utilize the disclosed three-dimensional models to produce immunogens and antibody proteins of the present invention.
    Type: Application
    Filed: October 21, 2010
    Publication date: December 13, 2012
    Applicants: UNIVERSITY OF WASHINGTON, SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Jason S. McLellan, Peter D. Kwong, Barney S. Graham, William R. Schief, Joe Jardine, Bruno Correia, Man Chen
  • Patent number: 8246827
    Abstract: A hollow-fiber membrane assembly having the function of preventing the membrane filaments from cracking, which comprises: hollow-fiber membrane filaments (1), protective film(s) (2) and fastening material (3), wherein the protective film (2) enwraps the outside of the hollow-fiber membrane filament(s) (1) near the end head (5), and a portion of the protective film (2) is immobilized in the fastening material (3), while the rest portion of the protective film (2) outside of the fastening material (3) is left free.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: August 21, 2012
    Assignee: Suzhou Litree Purifying Technology Co. Ltd.
    Inventors: Lianggang Chen, Man Chen, Qing Chen
  • Publication number: 20120162363
    Abstract: A method implemented in a server for sharing video conversion data is described. The method comprises receiving one or more sets of conversion data for one or more two-dimensional (2D) videos, archiving the one or more sets of conversion data, and receiving, from a client, a selection of a 2D video corresponding to one or more of the archived one or more conversion data. The method further comprises transmitting, to the client, conversion data corresponding to the selection received from the client.
    Type: Application
    Filed: December 22, 2010
    Publication date: June 28, 2012
    Applicant: CYBERLINK CORP.
    Inventors: Man-Chen Huang, Yen-Po Tseng, Liang-Heng Chen, Kun-Tse Wu, Yi-Chiun Hong, En-Jan Chou
  • Publication number: 20100206805
    Abstract: A hollow-fiber membrane assembly having the function of preventing the membrane filaments from cracking, which comprises: hollow-fiber membrane filaments (1), protective film(s) (2) and fastening material (3), wherein the protective film (2) enwraps the outside of the hollow-fiber membrane filament(s) (1) near the end head (5), and a portion of the protective film (2) is immobilized in the fastening material (3), while the rest portion of the protective film (2) outside of the fastening material (3) is left free.
    Type: Application
    Filed: May 15, 2008
    Publication date: August 19, 2010
    Applicant: SUZHOU LITREE PURIFYING TECHNOLOGY CO. LTD.
    Inventors: Lianggang Chen, Man Chen, Qing Chen
  • Patent number: 7776223
    Abstract: This present invention is related to a method of collecting high-level radioactive contaminated uranium powder underwater. It utilizes a long rod fixed to the pipe of the sewage pump at bottom, and takes another end of the sewage pump to connect to the sediment bag to collect uranium powder which is dispersed and contaminates the pond. Inhaling the pond water contains uranium powder into the sediment bag by sewage pump that is joined to a collecting can under it and waiting for precipitation of the powder. When the uranium powder in the sediment bag is completely precipitated into the collecting can, operator can utilize submersible pump to drain the pond water from the sediment bag. Operator may hold the cable wire of the uranium powder collecting can manually to move it to the collecting shelf and repeat the process several times until the high-level radioactive uranium powder in the contaminated pond are all collected on the uranium powder collecting shelf.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: August 17, 2010
    Assignee: Institute of Nuclear Energy Research
    Inventors: Kuo-Yung Chang, Heng-Shiung Shen, Li Ma, Chung-Sheng Chen, Tsu-Man Chen
  • Publication number: 20100065485
    Abstract: The invention provides a shaft type submerged hollow fiber membrane module, comprising a hollow aerating shaft (1), an aerating head (2), hollow fiber membranes (4), an upper end head (5), a lower end head (6), an upper end cap (7), a lower end cap (8), a water-producing opening (9), an aerating gas inlet (10), a protective net (11) and adhesive material (12), wherein the hollow fiber membranes (4), the hollow aerating shaft (1), the upper end head (5), the lower end head (6) and the adhesive material (12) are fixed together; the aerating head (2), the number of which is at least one, is connected to the hollow aerating shaft (1); the water-producing opening (9) is disposed at the top and/or the bottom of the membrane module; the aerating gas inlet (10) is disposed at one or both ends of the hollow aerating shaft (1); and the protective net (11) covers the periphery of the membrane module. The invention further provides a filter comprising the shaft type submerged hollow fiber membrane module.
    Type: Application
    Filed: November 17, 2009
    Publication date: March 18, 2010
    Inventors: Lianggang CHEN, Man Chen, Qing Chen
  • Publication number: 20100012594
    Abstract: This present invention is related to a method of collecting high-level radioactive contaminated uranium powder underwater. It utilizes a long rod fixed to the pipe of the sewage pump at bottom, and takes another end of the sewage pump to connect to the sediment bag to collect uranium powder which is dispersed and contaminates the pond. Inhaling the pond water contains uranium powder into the sediment bag by sewage pump that is joined to a collecting can under it and waiting for precipitation of the powder. When the uranium powder in the sediment bag is completely precipitated into the collecting can, operator can utilize submersible pump to drain the pond water from the sediment bag. Operator may hold the cable wire of the uranium powder collecting can manually to move it to the collecting shelf and repeat the process several times until the high-level radioactive uranium powder in the contaminated pond are all collected on the uranium powder collecting shelf.
    Type: Application
    Filed: July 15, 2008
    Publication date: January 21, 2010
    Inventors: KUO-YUAN CHANG, Heng-Shiung Shen, Li Ma, Chung-Sheng Chen, Tsu-Man Chen
  • Patent number: 7648633
    Abstract: A hollow fiber membrane module with a fixed structure comprises: a bearing shell (7), an inlet (8), a concentrated water outlet (10), a produced water outlet (9), a central tube (1) and hollow fiber membranes (6), in which the hollow fiber membranes (6), the central tube (1) and the bearing shell (7) are fixed together, the inlet (8) is located at one end of the hollow fiber membranes (6), the concentrated water outlet (10) is located at the other end of the hollow fiber membranes (6), the produced water outlet(s) (9) is(are) located at one end or both ends of the central tube (1), and there are small holes drilled on the side wall of the central tube (1). The module also comprises at least one separate fixed ring(s) (2) for fixing the hollow fiber membranes (6), with the separate fixed ring(s) (2) fixed on the central tube (1) and the hollow fiber membranes (6) arranged in parallel through the separate fixed ring(s) (2).
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: January 19, 2010
    Assignee: Shanghai Litree Purifying Equipment Co., Ltd.
    Inventors: Lianggang Chen, Man Chen, Qing Chen