Patents by Inventor Manfred Plempel

Manfred Plempel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4472421
    Abstract: Compositions are prepared which are useful for treating skin conditions caused, in whole or in part, by Pityrosporum ovale which comprise a therapeutically-effective amount of an azole antimycotic in combination with a diluent or carrier suitable for application to human skin.
    Type: Grant
    Filed: March 31, 1980
    Date of Patent: September 18, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl H. Buchel, Manfred Plempel
  • Patent number: 4470994
    Abstract: The invention relates to pharmaceutical compositions containing an active antimicrobial compound of Formula (I). Also included in the invention are methods for combatting mycoses utilizing the above-identified pharmaceutical composition.
    Type: Grant
    Filed: January 27, 1982
    Date of Patent: September 11, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kr/a/ mer, Karl H. B/u/ chel, Hans-Ludwig Elbe, Udo Kraatz, Wolf Reiser, Erik Regel, Andreas Schulze, Manfred Plempel
  • Patent number: 4457938
    Abstract: The invention relates to stick formulations of antimycotic azole derivatives containing, in addition to the antimycotic azole derivatives, 3 to 5% by weight relative to the formulation, of benzyl alcohol, 2.5 to 10% by weight, relative to the formulation of spreading agent and one or more auxiliaries.
    Type: Grant
    Filed: February 5, 1982
    Date of Patent: July 3, 1984
    Assignee: Bayer Aktiengesellschaft
    Inventors: Miklos von Bittera, Karl H. Buchel, Manfred Plempel, Erik Regel
  • Patent number: 4418072
    Abstract: The invention relates to diastereoisomeric 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanol and methods for its preparation. Also included in the invention are compositions containing said diastereoisomeric 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanol and methods for the use of said compound and compositions as antimycotic agents.
    Type: Grant
    Filed: March 25, 1981
    Date of Patent: November 29, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Ingo Haller, Manfred Plempel
  • Patent number: 4381306
    Abstract: The invention relates to hydroxypropyl-triazole compounds and methods for their preparation. Also included are compositions containing said hydroxypropyl-triazoles and methods for the use of the said active compounds and compositions, as antimycotic agents.
    Type: Grant
    Filed: November 9, 1979
    Date of Patent: April 26, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Karl H. Buchel, Ingo Haller, Manfred Plempel
  • Patent number: 4381310
    Abstract: The invention relates to substituted 2,4-dichlorophenyl-imidazolyl-vinyl-carbinols of formula (I) as defined herein. The invention also includes methods for the manufacture of said compounds of formula (I), compositions containing said compounds of formula (I) and methods for the use of said compounds and compositions as antimycotic agents.
    Type: Grant
    Filed: August 24, 1981
    Date of Patent: April 26, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolf Reiser, Ludwig Elbe, Karl H. Buchel, Manfred Plempel
  • Patent number: 4349560
    Abstract: The invention relates to imidazolyl-indenothiophene compounds of Formula (I) and a process for their production. Also included in the invention are antimycotic compositions containing said imidazolyl-indenothiophene compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: April 17, 1982
    Date of Patent: September 14, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Karl H. Buchel, Wilfried Draber, Ingo Haller, Manfred Plempel
  • Patent number: 4301166
    Abstract: The invention relates to hydroxyethyl-azole compounds and methods for their preparation. Also included in the invention are compositions containing said hydroxyethyl-azole compounds and methods for the use of said compounds and compositions as antimycotic agents.
    Type: Grant
    Filed: November 9, 1979
    Date of Patent: November 17, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Karl H. Buchel, Ingo Haller, Manfred Plempel
  • Patent number: 4289771
    Abstract: The invention relates to 3-sulphonyl-benzo-1,2,4-triazines and their 1-oxides, useful as antibacterial and antifungal agents. Also included in the invention are methods for the preparation of said benzo-1,2,4-triazine compounds, pharmaceutical compositions containing said benzo-1,2,4-triazines and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: February 29, 1980
    Date of Patent: September 15, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Sasse, Ingo Haller, Manfred Plempel, Hans-Joachim Zeiler, Karl G. Metzger
  • Patent number: 4284639
    Abstract: 1-Phenoxy-2-(2,4-dichlorophenyl)-1-(1,2,4-triazol-1-yl)-ethan-2-ones and -ols of the formula ##STR1## in which A is --C(O)-- or --CH(OH)--,X each independently is halogen, alkyl or optionally substituted phenyl, andn is 0, 1, 2 or 3,or a salt thereof, which possess fungicidal and antimicrobial properties rendering them useful in agriculture and pharmacy.
    Type: Grant
    Filed: February 28, 1980
    Date of Patent: August 18, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Wilhelm Brandes, Paul-Ernst Frohberger, Manfred Plempel
  • Patent number: 4246274
    Abstract: The invention includes as a series of 2-(substituted-phenyl)-1-aryl-3-(imidazol-1-yl)-propan-2-ols useful as antimicrobial agents. Also included in the invention are methods for the manufacture of the above-identified imidazol-1-yl-propan-2-ols, compositions containing said compounds and the use of said compounds and compositions for antimicrobial use.
    Type: Grant
    Filed: April 17, 1979
    Date of Patent: January 20, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Karl H. Buchel, Ingo Haller, Manfred Plempel
  • Patent number: 4243670
    Abstract: The present invention relates to novel .alpha.-(4-biphenylyl)-benzyl-azolium salts of the general formula ##STR1## in which A represents the CH group or a N atomR.sup.1 and R.sup.2 are identical or different and each represents hydrogen, alkyl or optionally substituted phenyl,R.sup.3 represents hydrogen, alkyl, or an optionally substituted phenyl, phenylalkyl, phenylcarbonyl or phenylcarbonylalkyl group,X represents halogen, alkyl, halogenoalkyl, alkoxy, alkylthio, nitro or cyano,Y represents X or optionally substituted phenyl,m and n each represents 0 or an integer from1 to 5 andZ represents the anion of an inorganic or organic acid.The invention also includes processes for the preparation of the compounds and, in addition includes compositions containing the compounds and methods for their use. The compounds of the invention exhibit antimicrobial activity and sporicidal activity.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: January 6, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Wilfried Draber, Karl H. Buchel, Manfred Plempel
  • Patent number: 4239767
    Abstract: Diaryloxy-imidazolyl-O,N-acetals of the formula ##STR1## or pharmaceutically-acceptable, nontoxic salts thereof wherein X and Y are each halo, alkyl, alkoxy, haloalkylthio, nitro, amino, alkylamino or dialkylamino;Z is a direct bond, methylene, oxygen, sulphur, sulphonyl, alkoxymethylene or a keto moiety;A is a keto moiety or a moiety of the formula C(OH)R, wherein R is hydrogen or alkyl; anda and b are each integers from 0 to 3;are useful for their antimycotic activity and their sporocidal action.
    Type: Grant
    Filed: November 6, 1975
    Date of Patent: December 16, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl H. Buchel, Wolfgang Kramer, Manfred Plempel
  • Patent number: 4239765
    Abstract: The invention relates to fluorenylazolylmethylcarbinols and methods for their preparation. Also included are compositions containing said fluorenylazolylmethyl-carbinols and methods for the use of said carbinols and compositions containing them as antimycotic agents.
    Type: Grant
    Filed: November 9, 1979
    Date of Patent: December 16, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Karl Buchel, Ingo Haller, Manfred Plempel
  • Patent number: 4238498
    Abstract: The invention provides a series of substituted diphenyl-imidazolyl-methanes useful as antimycotic agents. Also included in the invention are pharmaceutical compositions containing said diphenyl-imidazolyl-methanes and methods for the use of said compounds and compositions. The invention additionally includes methods for the manufacture of the diphenyl-imidazolyl-methanes.
    Type: Grant
    Filed: February 1, 1979
    Date of Patent: December 9, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Karl H. Buchel, Wilfried Draber, Manfred Plempel, Ingo Haller
  • Patent number: 4233311
    Abstract: The invention involves the provision of compositions containing a 3,3-dialkyl- or 3-aryl-phenoxy-1-(1,2,4-triazol-1-yl)- and (imidazol-1-yl-alkan-2-ol) ethers which are particularly effective as antimicrobial especially antimycotic, agents. The invention also includes use of said compositions for providing antimicrobial, particularly antimycotic effect.
    Type: Grant
    Filed: April 18, 1978
    Date of Patent: November 11, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Manfred Plempel, Ingo Haller
  • Patent number: 4215131
    Abstract: Pharmaceutical compositions free from pathogenic microorganisms which could be harmful to warm-blooded animals, are provided containing, as an active ingredient, an antimicrobially effective amount of at least one compound of the formula ##STR1## in which R represents hydrogen, --CO--R.sup.1 or --SO.sub.2 --R.sup.2, whereinR.sup.1 represents optionally substituted alkyl, alkenyl or alkinyl, optionally substituted phenyl, optionally substituted phenoxyalkyl, phenylalkyl, cycloalkyl, alkylamino, dialkylamino or optionally substituted phenylamino,R.sup.2 represents alkyl or optionally substituted phenyl,A represents a keto group or a --CH(OH)-- grouping,X represents hydrogen or an --OR grouping, whereinR is as defined above,X.sup.
    Type: Grant
    Filed: March 16, 1979
    Date of Patent: July 29, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Manfred Plempel, Ingo Haller
  • Patent number: 4207328
    Abstract: This invention relates to new 2,4-dichlorophenyl-imidaziolyl-ethan-ones and -ols useful as antimycotic and fungicidal agents. The compounds are useful as medicaments as well as in the plant protection area.
    Type: Grant
    Filed: January 27, 1978
    Date of Patent: June 10, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Manfred Plempel, Wilhelm Brandes, Paul-Ernst Frohberger
  • Patent number: 4183940
    Abstract: The invention provides new azolyl-9,10-dihydroanthracene derivatives of the formula ##STR1## in which A represents a CH group or a nitrogen atom,B represents a CO group or a group of the formula: ##STR2## X, Y and Z are identical or different and represent halogen, alkyl, halogenoalkyl, alkoxy, or alkylthio and n represents 0 or an integer of from 1 to 4,and their salts.Also included in the invention are methods for the preparation of said compounds, compositions containing said compounds and methods for their use. The compounds of the invention have antimycotic activity.
    Type: Grant
    Filed: October 7, 1977
    Date of Patent: January 15, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl H. Buchel, Wolfgang Kramer, Manfred Plempel, Ingo Haller
  • Patent number: 4153708
    Abstract: Acylated imidazolyl-O,N-acetals of the formula ##STR1## and their pharmaceutically acceptable salts and metal complexes wherein R is alkyl, alkenyl, alkinyl, cycloalkyl, halogenoalkyl, optionally substituted phenyl, optionally substituted phenoxyalkyl, alkylamino, dialkylamino or optionally substituted phenylamino;X is halogen, alkyl, cycloalkyl, alkoxy, halogenoalkyl, alkylthio, alkoxycarbonyl, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl, amino, cyano or nitro; andN is 0 or an integer of from 1 to 5; are useful as antimicrobial agents, particularly for their use in treating mycotic infectins in humans and animals.
    Type: Grant
    Filed: February 2, 1977
    Date of Patent: May 8, 1979
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Manfred Plempel