Abstract: Imidazolylacetic acid amides of the formula: ##SPC1##Or pharmaceutically acceptable nontoxic salts thereof whereinEitherR.sup.1 is phenyl or cycloalkyl, unsubstituted or substituted by one or more substituents; andR.sup.2 is hydrogen;OrR.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, form a saturated 5 to 7-membered heterocyclic ring which ring may contain an --SO.sub.2 -- or --NY-- moiety wherein Y is alkoxycarbonyl, dialkylaminocarbonyl, or phenyl or diphenylmethyl, unsubstituted or substituted by one or more substituents and wherein said 5 to 7-membered heterocyclic ring itself is otherwise unsubstituted or substituted by one or more substituents; andX.sup.1, x.sup.2, x.sup.3 and X.sup.4 are the same or different and are each hydrogen or halogen,Are antimycotic agents.

Abstract: Pharmaceutical compositions are produced which comprise an antimycotically effective amount of a compound of the formula ##SPC1##Or a pharmaceutically acceptable non-toxic salt thereof whereinR.sup.1 is an unsubstituted or substituted aryl moiety,R.sup.2 is hydrogen, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl, andR.sup.3 is hydrogen, alkyl or cycloalkyl,Provided that when R.sup.3 is hydrogen, R.sup.2 cannot be hydrogen, in combination with a pharmaceutically acceptable nontoxic inert diluent or carrier.

Abstract: Pharmaceutical compositions are produced which comprise an antimycotically effective amount of a compound of the formula ##EQU1## or a pharmaceutically acceptable non-toxic salt thereof wherein R.sup.1 is an unsubstituted or substituted aryl moiety,R.sup.2 is hydrogen, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl, andR.sup.3 is hydrogen, alkyl or cycloalkyl,Provided that when R.sup.3 is hydrogen, R.sup.2 cannot be hydrogen, in combination with a pharmaceutically acceptable non-toxic inert diluent or carrier.

Abstract: Bis-imidazolyl-bisphenylmethane derivatives and pharmaceutically acceptable non-toxic salts thereof are useful as antimycotics especially against dermatomycosis caused by Trichophyton and Microsporium species and also against yeast infections of the skin and internal organs.

Abstract: Antimicrobial compositions comprising 1-(1,2,4-triazolyl-1')-2-phenoxy alkane derivatives as the active ingredient.The compositions are well tolerated and combine their non-toxic effect within an especially good antimycotic activity.

Abstract: N-methyl-imidazole derivatives of the formula: ##EQU1## or a pharmaceutically acceptable non-toxic salt thereof, wherein X is an unsubstituted or substituted 6-membered heteroaromatic moiety having two nitro heteroatoms,Y is an unsubstituted or substituted aliphatic moiety, an unsubstituted or substituted cycloaliphatic moiety, an unsubstituted or substituted aralkyl moiety or an unsubstituted or substituted aryl moiety, andZ is an unsubstituted or substituted aliphatic moiety, an unsubstituted or substituted cycloaliphatic moiety, an unsubstituted or substituted aralkyl moiety, an unsubstituted or substituted aryl moiety, an unsubstituted or substituted pyridyl moiety or an alkoxycarbonyl moiety,Are useful as antimycotic agents.

Abstract: Phenyl-imidazolyl-fatty acid derivatives of the formula ##EQU1## wherein R.sup.1, R.sup.2, and R.sup.3 are the same or different, and are hydrogen or lower alkyl;R.sup.4 is hydrogen, alkyl, lower alkoxy, alkylmercapto, or an electro negative moiety;R.sup.5 is benzene, benzene substituted by alkyl, lower alkoxy, alkylmercapto or an electro negative moiety, or R.sup.5 is an aliphatic moiety;X is a carboxyl moiety or a grouping of a functional carboxylic acid derivative;m is 0, 1, 2, 3, 4, 5 or 6; andn is 0, 1 or 2,And pharmaceutically acceptable non-toxic salts thereof.These phenyl-imidazolyl-fatty acid derivatives exhibit antimycotic activity.

Abstract: Diaryl-pyridyl-imidazolyl methanes of the formula ##SPC1##And pharmaceutically acceptable non-toxic salts thereof, wherein R.sup.1 and R.sup.2 are the same or different alkyl of 1 to 4 carbon atoms, are produced either byA. reacting a (dialkylphenyl-phenyl-pyridyl)-methanol of the formula ##SPC2##Wherein R.sup.1 and R.sup.2 are as above defined, with thionyl-bis-imidazole in the presence of an inert organic diluent at a temperature of from -20.degree. C to about 150.degree. C; orB. reacting a (dialkylphenyl-phenyl-pyridyl)-methyl halide of the formula ##SPC3##Wherein R.sup.1 and R.sup.2 are as above defined and Hal is chlorine or bromine, with imidazole in the presence of an acid binding agent at a temperature of from 20.degree. C to about 180.degree.C. The diaryl-pyridyl-imidazole methanes of the present invention are useful for their antimycotic activity.

Abstract: Pharmaceutical compositions are produced which comprise combining an antimycotically effective amount of a compound of the formula ##EQU1## or a pharmaceutically acceptable, nontoxic salt thereof, wherein R.sup.1 is unsubstituted or substituted aryl,R.sup.2 is hydrogen, alkyl or unsubstituted or substituted aryl,R.sup.3 is hydrogen, alkyl, cycloalkyl, unsubstituted or substituted aryl or unsubstituted or substituted aralkyl, andR.sup.4 is hydrogen, alkyl, alkenyl, cycloalkyl, unsubstituted or substituted aryl, or unsubstituted or substituted aralkyl,Provided that R.sup.3 and R.sup.4 are not both hydrogen atoms, in combination with a pharmaceutically-acceptable, nontoxic, inert diluent or carrier.

Abstract: Imidazolylacetic acid amides of the formula: ##SPC1##Or pharmaceutically acceptable nontoxic salts thereof whereinEitherR.sup.1 is phenyl or cycloalkyl, unsubstituted or substituted by one or more substituents; andR.sup.2 is hydrogen;OrR.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, form a saturated 5 to 7-membered heterocyclic ring which ring may contain an --SO.sub.2 -- or --NY-- moiety wherein Y is alkoxycarbonyl, dialkylaminocarbonyl, or phenyl or diphenylmethyl, unsubstituted or substituted by one or more substituents and wherein said 5 to 7-membered heterocyclic ring itself is otherwise unsubstituted or substituted by one or more substituents; andX.sup.1, x.sup.2, x.sup.3 and X.sup.4 are the same or different and are each hydrogen or halogen,Are produced byA. reacting a halodiphenylacetic acid amide of the formula: ##SPC2##WhereinR.sup.1, r.sup.2, x.sup.1, x.sup.2, x.sup.3 and X.sup.4 are as above defined, andHal is halogen,With imidazole; orB.

Abstract: Pharmaceutical compositions comprising a triazolyl-O,N-acetal as the active ingredient and method of using same. The said compositions are useful as antimicrobials and are especially useful as antimycotic agents.

Abstract: 1-Ethyl-imidazoles of the formula ##SPC1##Or a pharmaceutically acceptable nontoxic salt thereof, are produced byA. reacting a compound of the formula ##SPC2##With imidazole; orB. when R.sup.1 is hydrogen, reacting a compound of the formula ##SPC3##With imidazole in the presence of an acid binding agent. In the case of the salts the free base produced is reacted with an appropriate acid.The 1-ethyl-imidazoles are useful for their antimycotic activity.

Abstract: N-methyl-imidazole derivatives of the formula: ##EQU1## or a pharmaceutically acceptable non-toxic salt thereof, wherein X is an unsubstituted or substituted 6-membered heteroaromatic moiety having two nitro heteroatoms,Y is an unsubstituted or substituted aliphatic moiety, an unsubstituted or substituted cycloaliphatic moiety, an unsubstituted or substituted aralkyl moiety or an unsubstituted or substituted aryl moiety, andZ is an unsubstituted or substituted aliphatic moiety, an unsubstituted or substituted cycloaliphatic moiety, an unsubstituted or substituted aralkyl moiety, an unsubstituted or substituted aryl moiety, an unsubstituted or substituted pyridyl moiety or an alkoxycarbonyl moiety,Are useful as antimycotic agents.