Patents by Inventor Manish Deshpande

Manish Deshpande has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190317675
    Abstract: Whether a replication relationship is established between a first and a second storage device is determined. If it is determined that the replication relationship is established between the first and second storage device, then whether data in the first region of the first storage device has changed since a previously completed asynchronous data replication process is determined. If the data in the first region of the first storage device has changed since the previously completed asynchronous data replication process, then whether the changed data in the first storage device is data copied from the second region of the first storage device is determined. If the changed data in the first region of the first storage device is data copied from the second region of the first storage device, then data from the second region of the second storage device is replicated to the first region of the second storage device.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 17, 2019
    Inventors: Manish Bansode, Shrirang S. Bhagwat, Pankaj Deshpande, Subhojit Roy
  • Patent number: 10441951
    Abstract: A microfluidic product pouch assembly may be used in a microfluidic chip. The microfluidic product pouch may include a pouch surrounding an inner chamber and having a rupturing portion and an inner membrane positioned within the inner chamber. The inner membrane may separate the inner chamber into a first cavity and a second cavity. A reagent may be positioned within the first cavity and/or the second cavity. The microfluidic product pouch assembly may also include a rupturing structure. The rupturing structure may be configured to selectively break the rupturing portion of the microfluidic product pouch.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 15, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Dafeng Chen, James E. Rasmussen, Manish Deshpande
  • Publication number: 20190311136
    Abstract: The disclosed computer-implemented method for utilizing an information trail to enforce data loss prevention policies on potentially malicious file activity may include (1) recording, by a computing device, one or more current activities associated with a file retrieved from a server, (2) linking, by the computing device, the current activities to one or more previously recorded activities associated with the file, (3) generating, by the computing device, a graph including nodes representing an information trail of related events associated with the current activities and the previously recorded activities, (4) determining, by the computing device, a severity of the information trail based on one or more rules, and (5) performing, by the computing device, a data loss prevention action on one or more operations associated with the file based on potential malicious activity. Various other methods, systems, and computer-readable media are also disclosed.
    Type: Application
    Filed: May 21, 2018
    Publication date: October 10, 2019
    Inventors: Manish Pai, Prahalad Deshpande, Sumesh Jaiswal
  • Patent number: 10427159
    Abstract: A microfluidic device includes a microchannel having an interior bounded by a side wall, an inlet, a switching region, and a plurality of outlet channels downstream of the switching region. The microchannel is formed in a microfluidic chip substrate and configured to accommodate a flow of liquid through the microchannel. The microfluidic device includes a valve operatively coupled to the switching region comprising a sealed reservoir. A side passage extends between the reservoir and the interior of the microchannel via an aperture in the side wall and is configured to accommodate a volume of liquid between the interior of the microchannel and the reservoir. The microfluidic device includes an actuator integrated into the microfluidic chip and configured to increase an internal pressure of the reservoir and move at least a portion of the volume of the liquid from the side passage into the microchannel to deflect a portion of the liquid flowing through the microchannel.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: October 1, 2019
    Assignee: CYTONOME/ST, LLC
    Inventors: John R. Gilbert, Sebastian Böhm, Manish Deshpande
  • Patent number: 10391425
    Abstract: A fluidic device and a method for degassing a fluidic device are presented. The fluidic device includes a plurality of fluidic components such as channels, chambers, and integrated valves and pumps, etc. A porous membrane is disposed on a degassing area of the fluidic device for removing gas (such as, for example, bubbles) contained in a liquid. A fluid control device monitors a pressure profile indicating a pressure in the fluidic device over time and applies a pressure differential between two sides of the membrane when activated. The membrane is permeable to gas in the fluidic device and is impermeable to liquids through the pores under the pressure differential. The disclosed method enables degassing large volume of gas at a high flow rate and provides a bubble free filling in a fluidic device which is critical to precision sample metering, mixing, fluid control, reaction, and detection, etc.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: August 27, 2019
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Dafeng Chen, James E. Rasmussen, Manish Deshpande
  • Patent number: 10353605
    Abstract: Whether a replication relationship is established between a first and a second storage device is determined. If it is determined that the replication relationship is established between the first and second storage device, then whether data in the first region of the first storage device has changed since a previously completed asynchronous data replication process is determined. If the data in the first region of the first storage device has changed since the previously completed asynchronous data replication process, then whether the changed data in the first storage device is data copied from the second region of the first storage device is determined. If the changed data in the first region of the first storage device is data copied from the second region of the first storage device, then data from the second region of the second storage device is replicated to the first region of the second storage device.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: July 16, 2019
    Assignee: International Business Machines Corporation
    Inventors: Manish Bansode, Shrirang S. Bhagwat, Pankaj Deshpande, Subhojit Roy
  • Publication number: 20190195876
    Abstract: A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Inventors: John R. Gilbert, Hugh Lewis, Derek Beaupre, Jaishree Trikha, Manish Deshpande
  • Publication number: 20190169175
    Abstract: The present invention relates to novel pyridinium compounds, their isomers, steroisomers, atropisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses process for preparing novel compounds and pharmaceutical composition of said compounds. The invention further relates to the use of the above mentioned compounds for the preparation of medicament for use as pharmaceuticals.
    Type: Application
    Filed: February 4, 2019
    Publication date: June 6, 2019
    Applicant: TORRENT PHARMACEUTICALS LIMITED
    Inventors: Chaitanya DUTT, Rameshchandra GUPTA, Manish PATEL, Jaya ABRAHAM, Vivek MISHRA, Amit KESARWANI, Shailesh DESHPANDE, Shital Kumar ZAMBAD, Anoop MATHUR, Jignesh KOTECHA, Sachin LATAD, Anita CHAUDHARI
  • Publication number: 20190099755
    Abstract: An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.
    Type: Application
    Filed: August 31, 2018
    Publication date: April 4, 2019
    Inventors: Andrew Johnson, John R. Gilbert, Manish Deshpande, Hugh Lewis, Bernard Bunner
  • Patent number: 10222378
    Abstract: A single disposable cartridge for performing a process on a particle, such as particle sorting, encapsulates all fluid contact surfaces in the cartridge for use with microfluidic particle processing technology. The cartridge interfaces with an operating system for effecting particle processing. The encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The cartridge may employ any suitable technique for processing particles.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: March 5, 2019
    Assignee: CYTONOME/ST, LLC
    Inventors: John R. Gilbert, Hugh Lewis, Derek Beaupre, Jaishree Trikha, Manish Deshpande
  • Publication number: 20190015841
    Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
    Type: Application
    Filed: July 19, 2018
    Publication date: January 17, 2019
    Inventors: Sebastian Böhm, John R. Gilbert, Manish Deshpande
  • Publication number: 20180368876
    Abstract: A thrombectomy catheter system is disclosed which includes a catheter having an exhaust lumen, an infusion lumen and a high pressure tube. The high pressure tube includes a nozzle orifice for forming a high pressure jet of fluid for cutting occlusive material from within a body lumen. The nozzle orifice is positioned to direct the high pressure jet of fluid into the distal end of the exhaust lumen which creates a suctioning effect. The infusion lumen replaces fluid that is removed from the body lumen through the exhaust lumen by a suctioning effect created by the fluid jet.
    Type: Application
    Filed: August 31, 2018
    Publication date: December 27, 2018
    Inventors: Arnaz S. Malhi, Daniel Hutton, Manish Deshpande, Phillip Shaltis
  • Publication number: 20180297085
    Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises actuators and chambers for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
    Type: Application
    Filed: June 21, 2018
    Publication date: October 18, 2018
    Inventors: Manish Deshpande, John R. Gilbert
  • Patent number: 10065188
    Abstract: An improved actuator for use in a microfluidic particle sorting system utilizes a staggered packing scheme for a plurality of actuators used to selectively deflect a particle in an associated sorting channel from a stream of channels. An actuator block may be provided for housing a two-dimensional array of actuators, each configured to align with an actuation port in an associated sorting chip containing a plurality of sorting channels. The actuator block may include a built-in stressing means to pre-stress each actuator housed by the block. An actuator comprising a piezo-electric stack may employ contact-based electrical connection rather than soldered wires to improve packing density. The actuator may be an external actuator. That is, the external actuator is external to the substrate in which the sorting channels are formed.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: September 4, 2018
    Assignee: CYTONOME/ST, LLC
    Inventors: Andrew Johnson, John R. Gilbert, Manish Deshpande, Hugh Lewis, Bernard Bunner
  • Patent number: 10064643
    Abstract: A thrombectomy catheter system is disclosed which includes a catheter having an exhaust lumen, an infusion lumen and a high pressure tube. The high pressure tube includes a nozzle orifice for forming a high pressure jet of fluid for cutting occlusive material from within a body lumen. The nozzle orifice is positioned to direct the high pressure jet of fluid into the distal end of the exhaust lumen which creates a suctioning effect. The infusion lumen replaces fluid that is removed from the body lumen through the exhaust lumen by a suctioning effect created by the fluid jet.
    Type: Grant
    Filed: January 18, 2016
    Date of Patent: September 4, 2018
    Assignee: Covidien LP
    Inventors: Arnaz Malhi, Daniel Hutton, Manish Deshpande, Phillip Shaltis
  • Publication number: 20180221879
    Abstract: A microfluidic device includes a microchannel having an interior bounded by a side wall, an inlet, a switching region, and a plurality of outlet channels downstream of the switching region. The microchannel is formed in a microfluidic chip substrate and configured to accommodate a flow of liquid through the microchannel. The microfluidic device includes a valve operatively coupled to the switching region comprising a sealed reservoir. A side passage extends between the reservoir and the interior of the microchannel via an aperture in the side wall and is configured to accommodate a volume of liquid between the interior of the microchannel and the reservoir. The microfluidic device includes an actuator integrated into the microfluidic chip and configured to increase an internal pressure of the reservoir and move at least a portion of the volume of the liquid from the side passage into the microchannel to deflect a portion of the liquid flowing through the microchannel.
    Type: Application
    Filed: March 30, 2018
    Publication date: August 9, 2018
    Inventors: John R. Gilbert, Sebastian Böhm, Manish Deshpande
  • Publication number: 20180208412
    Abstract: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
    Type: Application
    Filed: October 30, 2017
    Publication date: July 26, 2018
    Inventors: John R. Gilbert, Manish Deshpande, Bernard Bunner
  • Patent number: 10029283
    Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: July 24, 2018
    Assignee: CYTONOME/ST, LLC
    Inventors: Manish Deshpande, John R. Gilbert
  • Patent number: 10029263
    Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: July 24, 2018
    Assignee: CYTONOME/ST, LLC
    Inventors: Sebastian Böhm, John R. Gilbert, Manish Deshpande
  • Publication number: 20180104138
    Abstract: A method of controlling a compression device controls a vent phase of a compression device having an inflatable bladder capable of being pressurized for applying compression to a part of a subject's body. The method includes delivering pressurized fluid from a source of pressurized fluid to a first inflatable bladder disposed about a portion of the subject's body and venting the pressurized fluid from the first inflatable bladder by opening a first valve. The method further includes monitoring fluid pressure in the first inflatable bladder during the venting of the first inflatable bladder. Based at least in part on the monitored fluid pressure, the first valve is selectively closed and selectively reopened to control fluid pressure in the first inflatable bladder to remain within a desired residual pressure range.
    Type: Application
    Filed: December 18, 2017
    Publication date: April 19, 2018
    Applicant: KPR U.S., LLC
    Inventors: ARNAZ MALHI, MANISH DESHPANDE