Abstract: A composition comprising poly(amidoamine) (PAMAM) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for the treatment or alleviation of one or more symptoms of a brain tumor have been developed. The dendrimers comprise one or more ethylene diamine-core poly(amidoamine) (PAMAM) hydroxyl-terminated generation-4, 5, 6, 7, 8, 9, or 10, most preferably generation 6 (G4-10-OH) dendrimers. The G6 dendrimers have demonstrated unexpectedly high uptake into the brain. The dendrimers provide a means for selective delivery through the blood brain barrier (“BBB”) of chemotherapeutic, immunotherapeutic and palliative agents. The dendrimers also have the advantage that two different classes of compounds, having one or more mechanisms of action can be bound to the dendrimers, providing simultaneous delivery. The dendrimers may be administered alone by intravenous injection, or as part of a multi-prong therapy with radiation.

Abstract: Systems, methods, and computer-readable media for communicating electronic device secure element data over multiple paths for online payments are provided. In one example embodiment, a method includes, inter alia, at a commercial entity subsystem, receiving, from an electronic device, device transaction data that includes credential data indicative of a payment credential on the electronic device for funding a transaction with a merchant subsystem, accessing a transaction identifier, deriving a transaction key based on transaction key data that includes the accessed transaction identifier, transmitting, to one of the merchant subsystem and the electronic device, merchant payment data that includes a first portion of the credential data and the accessed transaction identifier, and sharing, with a financial institution subsystem using the transaction key, commercial payment data that includes a second portion of the credential data that is different than the first portion of the credential data.

Abstract: An integrated circuit (IC) chip including an array of asymmetrically distributed magnetic field sensing elements. Additionally, an integrated circuit (IC) chip includes a substrate, a sensing coil supported by the substrate and enclosing a portion of substrate, and a Hall effect sensor supported by the portion of the substrate enclosed by the sensing coil.

Abstract: Methods, systems, and computer program products for categorizing log records at run-time are provided herein. A computer-implemented method includes generating one or more template signatures to be associated with each of multiple templates, wherein each of the multiple templates comprises a concatenation of one or more words; processing each of multiple log records derived from a data stream to determine a composition of each of the multiple log records; matching one or more of the generated template signatures to each of the multiple log records based on the determined composition of each of the multiple log records; and outputting an identification of (i) each of the multiple log records and (ii) the one or more generated template signatures matched thereto.

Abstract: In an embodiment, a method comprises: obtaining, by a sensing device on a ferromagnetic surface, a first magnetometer reading of magnetic flux density modified by the ferromagnetic surface in a first direction; obtaining, by the sensing device, a second magnetometer reading of magnetic flux density modified by the ferromagnetic surface in a second direction; obtaining, by the sensing device, sensitivity terms based on the first and second magnetometer readings; and storing, by the sensing device, the sensitivity terms and a location of the sensing device on the ferromagnetic surface.

Abstract: A method of fabricating an integrated circuit (IC) chip is disclosed. The method starts with opening a window on a first surface of the IC chip through a passivation overcoat to expose the copper metallization layer. The window has sidewalls and a bottom that is adjacent the copper metallization layer. The method continues with depositing a barrier conductive stack on the passivation overcoat and exposed portions of the copper metallization layer, then depositing a sacrificial conductive stack on the barrier conductive stack. The sacrificial conductive stack has a thickness between 50 ? and 500 ?. The first surface of the semiconductor chip is polished to remove the sacrificial conductive stack and the barrier conductive stack from the surface of the passivation overcoat.

Abstract: The present disclosure concerns a multi-cable positioning device and a headset with multi-cable positioning device. The device comprises at least a fastening portion for removable attachment to clothing, and a cable management portion. The cable management portion comprises at least a first cable receptacle for a first cable, and a second cable receptacle for a second cable, wherein the cable receptacles are adapted for rotational and translational locking of the cables to increase comfort and stability.

Abstract: The system comprises approving a credit application during a single http session, transmitting an encoded secure token to a web-client participating in the http session, receiving from the mobile communications device the secure token, and transmitting the transaction account data to the mobile communications device, in response to the receiving the secure token. The system may further comprise the mobile communications device decoding the secure token.

Abstract: The invention relates to stable formulations comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4), optionally further containing an anti-human programmed death receptor 1 (PD-1) antibody or antigen binding fragment thereof. Also provided are methods of treating various cancers and chronic infections with the formulations of the invention.

Abstract: The present disclosure concerns a multi-cable positioning device and a headset with multi-cable positioning device. The device comprises at least a fastening portion for removable attachment to clothing, and a cable management portion. The cable management portion comprises at least a first cable receptacle for a first cable, and a second cable receptacle for a second cable, wherein the cable receptacles are adapted for rotational and translational locking of the cables to increase comfort and stability.

Abstract: Disclosed herein is a technique for preserving an expected lifespan of a non-volatile memory that is communicably coupled with a computing device. According to some embodiments, the technique can be implemented by the computing device, and include (1) receiving metrics associated with the non-volatile memory, (2) for each application of a plurality of applications associated with the computing device: establishing, based on the metrics, a respective write budget for the application. According to some embodiments, the respective write budget for each application can be further based on a count of the plurality of applications. Additionally, the technique can further include (3) receiving, from an application of the plurality of applications, a write request directed to the non-volatile memory, and (4) in response to determining that the write request does not violate the respective write budget for the application: issuing the write request to the non-volatile memory.

Abstract: According to one configuration, an example communication system includes multiple wireless base stations such as a first wireless base station and a second wireless base station. The first wireless base station resides outdoors and receives timing information from remote radio hardware such as a satellite or other suitable resource; the second wireless base station resides indoors and is unable to receive the timing information from the satellite. The communication system includes a communication link or network connecting the second wireless base station to the first wireless base station. In one configuration, the second wireless base station receives the timing information from the first wireless base station over the network. The first wireless base station and the second wireless base station both use the timing information to synchronize wireless communications in the wireless network environment.

Abstract: A mixer assembly for mixing an injected reductant with an exhaust gas output from a combustion engine comprises a mixer housing including a wall defining an exhaust passageway having a longitudinal axis. A tubular swirling device housing extends along a first axis substantially transverse to the longitudinal axis. The tubular swirling device includes a plurality of openings through which exhaust gas enters. The exhaust gas within the tubular swirling device swirls about the first axis and exits at an outlet end of the tubular swirling device. A mixing plate is positioned immediately downstream of the tubular swirling device. The mixing plate swirls the exhaust about a second axis extending parallel to the longitudinal axis.

Abstract: According to one configuration, an example communication system includes a primary wireless station, multiple candidate wireless stations, and a remote network. The primary wireless station is in communication with one or more of the multiple candidate wireless stations. During operation, when the primary wireless station needs to provide one or more communication devices access to a remote network, the primary wireless station monitors presence of the multiple candidate wireless stations. Each of the multiple candidate wireless stations is available to support a wireless backhaul link from the primary wireless station to a remote (such as a core) network. The primary wireless station is operable to select an appropriate candidate wireless station amongst the multiple candidate wireless stations. Via the selected candidate wireless station, the primary wireless station establishes a backhaul link to the remote network.

Abstract: The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations of the invention comprise between 5-200 mg/mL anti-PD-1 antibody, or antigen binding fragment thereof. The invention further provides methods for treating various cancers with stable formulations of the invention. In some embodiments of the methods of the invention, the formulations are administered to a subject by intravenous or subcutaneous administration.

Abstract: According to one configuration, an example communication system includes multiple wireless base stations such as a first wireless base station and a second wireless base station. The first wireless base station resides outdoors and receives timing information from remote radio hardware such as a satellite or other suitable resource; the second wireless base station resides indoors and is unable to receive the timing information from the satellite. The communication system includes a communication link or network connecting the second wireless base station to the first wireless base station. In one configuration, the second wireless base station receives the timing information from the first wireless base station over the network. The first wireless base station and the second wireless base station both use the timing information to synchronize wireless communications in the wireless network environment.

Abstract: The present disclosure relates to the identification of genes and gene combinations that are correlated with patients having or being predisposed to developing pancreatic ductal adenocarcinoma (PDAC). In some instances, methods herein utilize panels of 5 or 10 genes to accurately diagnose PDAC, determine the likelihood of developing PDAC, or determine the severity/stages of PDAC. These panels may be used in a molecular diagnostic test.

Abstract: According to one configuration, an example communication system includes a primary wireless station, multiple candidate wireless stations, and a remote network. The primary wireless station is in communication with one or more of the multiple candidate wireless stations. During operation, when the primary wireless station needs to provide one or more communication devices access to a remote network, the primary wireless station monitors presence of the multiple candidate wireless stations. Each of the multiple candidate wireless stations is available to support a wireless backhaul link from the primary wireless station to a remote (such as a core) network. The primary wireless station is operable to select an appropriate candidate wireless station amongst the multiple candidate wireless stations. Via the selected candidate wireless station, the primary wireless station establishes a backhaul link to the remote network.

Abstract: A method of fabricating an integrated circuit (IC) chip is disclosed. The method starts with opening a window on a first surface of the IC chip through a passivation overcoat to expose the copper metallization layer. The window has sidewalls and a bottom that is adjacent the copper metallization layer. The method continues with depositing a barrier conductive stack on the passivation overcoat and exposed portions of the copper metallization layer, then depositing a sacrificial conductive stack on the barrier conductive stack. The sacrificial conductive stack has a thickness between 50 ? and 500 ?. The first surface of the semiconductor chip is polished to remove the sacrificial conductive stack and the barrier conductive stack from the surface of the passivation overcoat.