Abstract: The present invention relates to ?-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure ?-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.

Abstract: A storage stable pharmaceutical composition comprising a solution of Oxaliplatin in water and a catalytic amount of a carbohydrate. A process for forming such pharmaceutical composition comprising dissolving a known amount of Oxaliplatin in water; adding an amount of carbohydrate in the range of 0.0010% to 0.05% w/v with respect to such solution; agitating the mixture to get clear solution; filtering it through a filter membrane under aseptic conditions; and filling the solution resulting into glass vials sealed with elastomeric stoppers and aluminium flip-off seals.

Abstract: Described herein are starch hydrolysis processes for obtaining fermentable sugars from starch in milled plant material at temperatures below the starch gelatinization temperature and using exogenous plant alpha amylases further to the fermentation of the sugars to produce end products, such as ethanol.

Abstract: Apparatus and methods are provided for debugging an integrated circuit. Local multiplexer circuits are provided near first and second circuit blocks in the integrated circuit. Each multiplexer circuit includes input nodes, a control node, and an output node. A first input node of the first multiplexer circuit is coupled to an internal node of the first circuit block, a first input node of the second multiplexer circuit is coupled to an internal node of the second circuit block, second input nodes of the first and second multiplexer circuits are coupled to logical 0, and the control signal nodes of the first and second multiplexer circuits are coupled to a control signal. An OR gate is provided that includes an input node coupled to the output node of the first multiplexer circuit, another input node coupled to the output node of the second multiplexer circuit, and an output node.

Abstract: An X-ray tube anode assembly and an X-ray tube assembly are disclosed that include an X-ray target and a drive assembly configured to provide an oscillatory motion to the X-ray target. The drive assembly is configured to provide an oscillatory motion to the target assembly.

Abstract: Ultrasound inspection methods for noisy materials and related probes are disclosed to inspect a defect in a cast material that use polycarbonate delay layers having a first surface configured to be disposed on a surface of the cast material; and an acoustic crystal element disposed on a second surface of the polycarbonate delay layer.

Abstract: The present invention includes a system for simulating the performing of data storage operations. The system may include a storage manager component, at least one media management component directed by the storage manager component to manage storage operations to at least one storage device, and a storage emulation module adapted to simulate the characteristics of the at least one storage device. Under the direction of the storage manager, the emulation module may be adapted to simulate storage operations to one or more storage devices performed by one or more of the media management components.

Abstract: Disclosed herein is a bio-assisted method for treatment of hydrocarbon contaminated soil employing novel microbes which are capable of decontaminating hydrocarbon contaminated soil having free flowing water or in slurry form or having large amount of gravels. The method comprises adding hydrocarbon releasing microbes followed by adding the microbes capable of degrading the released hydrocarbon to decontaminate the soil, wherein said microbes are grown separately in suitable vessels containing a suitable nutrient medium.

Abstract: The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.

Abstract: Disclosed herein is a process for producing bisphosphonic acids and salts thereof. The process comprising reacting a carboxylic acid of Formula [I] with phosphorous acid and halophosphorus compound in the presence of a solvent selected from aliphatic hydrocarbon or water miscible cyclic ether. Further, the present invention also provides novel forms of bisphosphonic acids and process for preparation thereof.

Abstract: A method and a system for relating of a value network analysis of a mission to a knowledge base of dependencies of data objects, applications and information technology resources required for achieving of such mission, such method used for optimization of provisioning for information technology resources and for prioritizing of control of data and application security and integrity of such mission.

Abstract: A method, system, computer program product, and computer program storage device for transforming a high-level policy associated with a high layer to a low-level policy associated with a low layer. Mapping between high-level objects in a high layer and low-level objects in a low layer is derived by an automated discovery tool. The high-level policy is mapped to the low-level policy according to the mapping (e.g., by substituting the high-level objects with the low-level objects and by performing a syntax transformation). In one embodiment, a low-level policy is transformed to a high-level policy according to the mapping. As exemplary embodiments, policy transformations in traffic shaping and data retention are disclosed.

Abstract: A composite of one or more repeat sequence protein polymers and either one or more metal oxides or one or more plasticizers alters material properties of the repeat sequence protein polymers, including the morphology of the polymers as well as the elastic modulus and tensile strength. The morphology of the composite is aligned, generally parallel nanofibers.

Abstract: An electronic device has software for protecting the electronic device from unauthorized utilization. When executed, the software causes the electronic device to execute an application component, wherein the application component is configured to automatically ascertain whether the electronic device has been reported stolen, based on information received from a server system. The electronic device also automatically determines whether the application component is operating correctly, and if so, automatically provides a basic input/output system (BIOS) component of the electronic device with information indicating that the application component is operating correctly. During a subsequent boot process for the electronic device, the software automatically prevents the electronic device from completing the boot process if the BIOS component does not find the information from the application component indicating that the application component was operating correctly. Other embodiments are described and claimed.

Abstract: A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.

Abstract: Selecting one or more marketing messages for optimal display at marketing locations in a marketing environment is performed on the basis of information relating to a user to whom the messages are to be displayed, the marketing messages, and the marketing locations. Dynamic selection and display of marketing messages in this manner can be advantageously performed for online environments for which relevant information is readily accessed and used as a basis for selection and display of marketing messages.

Abstract: A processing device and a method for processing structure data representing a physical structure are disclosed to obtain information about physical properties of the physical structure faster and with high quality and accuracy. The processing device for processing structure data representing a physical structure comprises an obtainer module for obtaining structure data representing a physical structure; a parts defining module for subdividing said structure data into at least two parts including a connection part and a material part; a meshing module for generating a mesh model approximating said physical structure by transforming said connection part and said material part into mesh elements having different sizes, wherein the mesh element sizes of said connection part are smaller than the mesh element sizes of said material part; and a processing module for processing said mesh model to estimate physical properties of said physical structure.

Abstract: The ubiquitous nature of wireless devices has given rise to among other things an explosive growth in messaging including, among other categories of messaging, Application-to-Peer messaging. It is inevitable that various errors (e.g., misspellings, typographic errors, transpositions, etc.) will occur as a mobile subscriber adds one or more keywords, codes, indicators, responses, etc. to an Application-to-Peer message. An error-laden message will likely be dropped, discarded, ignored, etc. when it is processed contributing to among other things a poor user experience. An infrastructure that offers possibly among other things an intelligent syntax matching capability accommodates (by, for example, automatically identifying, correcting or otherwise resolving, etc.) such errors so that messages containing such errors may be processed. The infrastructure may optionally leverage the capabilities of a centrally-located Messaging Inter-Carrier Vendor.

Abstract: The present invention discloses two new related substances (6) and (7) of Anastrozole synthesis from Q. A. Salt (5) as in Scheme—1 and purification procedures to get Anastrozole (1) free from (6) and (7).

Abstract: A nanocomposite of a repeat sequence protein polymer, such as a copolymer of silk and elastin, is produced by Supercritical Antisolvent Precipitation with Enhanced Mass Transfer (SAS-EM). The nanocomposite may include an active agent, such as a protein or hormone, that is releasably bound to the repeat sequence protein polymer.