Abstract: Provided are telomerase inhibitor compounds. Some compounds include a lactone or lactam group that is covalently bonded to a phenyl ring, which is itself bonded to a pyrazole group. In other cases, a sulfonamide-containing moiety is covalently bonded to a phenyl ring, which is itself bonded to a pyrazole group. In some embodiments, the telomerase inhibitor compound has a vinyl sulfonamide group bonded to an amide moiety and an aromatic group. In other cases, the inhibitor compound has an isothiazolidine 1,1-dioxide core that is bonded to a phenyl group. Aspects of the invention also include pharmaceutical compositions comprising the subject telomerase inhibitor compounds, as well as methods of treating telomerase-related diseases or conditions.

Abstract: A system for directing projections within a vehicle includes a projector for producing a projected image. The system also includes a projection directing module in optical communication with the projector for directing the projected image to a predetermined location. The system also includes a projection surface upon which the projected image is projected. The system also includes a controller in electrical communication with the projector and the projection directing module. The controller is programmed to configure the projection directing module to direct the projected image to a projection region of the projection surface. The controller is further programmed to project the projected image on the projection region using the projector and the projection directing module.

Abstract: Disclosed herein are system, apparatus, article of manufacture, method and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for training a heterogenous graph neural network (GNN) to generate user embeddings corresponding to users and item embeddings corresponding to items. An example embodiment generates a first user interaction graph for a first time window and a second user interaction graph for a second time window, wherein each graph represents users and items as nodes and user-item interactions within the respective time window as edges, samples user-item node pairs from the second user interaction graph, and trains the heterogeneous GNN based on user-item node pairs from the first user interaction graph that correspond to the sampled user-item node pairs from the second user interaction graph. User and item embeddings generated by the trained GNN may be used to determine a relevancy of a given item with respect to a given user.

Abstract: One embodiment of the present disclosure may include a method for providing access to resources by a resource provider computer during a first web session with a client device. The resource provider can provide a first web page to the client device, the first web page including a first option to complete a first access request with the resource provider computer as a guest for access to a first resource. The resource provider computer can receive a first selection of the first option from the client device and provide a second web page including a second option to remember the user device. The resource provider computer can, in response to receiving a second selection of the second option from the client device, send a remember flag to a server computer. The resource provider computer can then receive a recognition identifier from the server computer and store the recognition identifier.

Abstract: A method comprises receiving an image of an update for a software module, a rate parameter, an index parameter, and a public key, generating a 32-byte aligned string, computing a state parameter using the 32-byte aligned string, generating a modified message representative, computing a Merkle Tree root node, and in response to a determination that the Merkle Tree root node matches the public key, forwarding, to a remote device, the image of the update for a software module, the state parameter; and the modified message representative.

Abstract: It is an object of the present invention to provide an apparatus that allows for improving the self-healing capability of a network, wherein the apparatus is adapted to be part of a network (100), like a ZigBee network. The operation apparatus (110) is adapted to operate a network device (101) and comprises a network information providing unit (111), wherein the network information refers to information with respect to maintenance messages (105, 106, 107) sent and/or received by a network device (101) and/or a neighboring network device (103, 104) to maintain the network, a determination unit (112) for determining self-related connection information from the network information, wherein the self-related connection information refers to information on the connection of the network device itself with the network, and a control unit (113) for controlling the network device based on the self-related connection information.

Abstract: A method by one or more electronic devices for spinning up a scoring container on demand. The method includes receiving, from an orchestrator component via an application programming interface (API), a request to spin up the scoring container, wherein the scoring container is configured to provide scoring functionality, spinning up the scoring container responsive to receiving the request to spin up the scoring container, and providing, to the orchestrator component via the API, a response to the request to spin up the scoring container, wherein the response includes a uniform resource locator (URL) to use to submit scoring requests to the scoring container.

Abstract: An inline vending machine for ice and water vending installed within a store wall allowing a user to purchase ice and water without entering the store. A shipping frame for shipping and installation of the insulated wall into the store wall is also disclosed.

Abstract: Methods and systems for validating cache coherence in a data processing system are described. A processing element may detect a load instruction requesting the processing element to transfer data from a global memory location to a local memory location. The processing element may apply, in response to detecting the load instruction requesting the processing element to transfer data from the global memory location to the local memory location, a delay to the transfer of the data from the global memory location to the local memory location. The processing element may execute the load instruction and transferring the data from the global memory location to the local memory location with the applied delay. The processing element may validate, in response to executing the load instruction and transferring the data with the applied delay, a cache coherence of the data processing system.

Abstract: Examples described herein provide wake-up of a network device. Examples include receiving, by a network interface of a first network device having a first Media Access Control (MAC) address, a request to wake-up a second network device having a second MAC address that is assigned to a same subnet as the first MAC address, and in response to the request, generating, by the first network device, a first wake-up frame having a destination address of the second MAC address and configured to cause the second network device to transition from operating in the first power mode to operating in the second power mode. Examples include transmitting, by the network interface of the first network device, the first wake-up frame to the second MAC address of the second network device.

Abstract: Time recovery techniques are described. A method comprises receiving messages from the first device by the second device in the first network domain, the messages to comprise time information to synchronize a first clock for the first device and a second clock for the second device to a network time, determining the second clock is to recover the network time for the second device without new messages from the first device, retrieving a first set of timestamps previously stored for events in the first network domain using the network time from the second clock, retrieving a second set of timestamps previously stored for the events in the first network domain using a redundant time from a third clock, where the third clock is not synchronized with the first and second clocks, and recovering the network time using a regression model and the redundant time from the third clock.

Abstract: An example file server manager disclosed herein receives a registration for a distributed file server, where the distributed file server is hosted in a virtualization environment and includes a cluster of file server virtual machines configured to provide access to a file system. The file server manager further synchronizes metadata with the distributed file server, the metadata including identification of each of the file server virtual machines of the cluster of file server virtual machines, the metadata including information regarding the file system and receiving a management request for the distributed file server. The file server manager further formats the management request for the virtualization environment based on the metadata and utilizing information from the registration to access the distributed file server with the formatted management request.

Abstract: An electronic device includes a UDC and a UDC controller configured to determine an optimal number of frames required to be captured for a scene to compensate at least one parameter to optimize an output media using the UDC, obtain a multi-frame fusion media by performing at least one multi-frame fusion on the determined optimal number of frames, perform a light source spread correction on the multi-frame fusion media, and optimize the output media based on the light source spread correction on the multi-frame fusion media.

Abstract: One embodiment provides a method for providing simplified user management within a software application, the method including: receiving, within a user management interface of the software application, input from an editing user to perform an action corresponding to a user within the software application, wherein the action comprises modifying the user within the software application; validating, within the software application, the editing user is authorized to perform the action within the software application, wherein the validating includes determining the editing user is an existing user within the software application and determining the user is associated with the editing user; and performing, responsive to validating the editing user is authorized to perform the action, the action with respect to the user in the software application. Other aspects are described and claimed.

Abstract: Multi-strain probiotic formulation for ameliorating and preventing symptoms of treatment resistant depression The current invention more specifically relates to methods and compositions comprising a multi-strain probiotic formulation that can be used for alleviating symptoms of treatment-resistant depression in humans. The multi-strain probiotic formulation disclosed herein for use as treatment for treatment-resistant depression symptoms comprises Bacillus coagulans, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium lactis, Bifidobacterium breve, and Bifidobacterium infantis. More specifically, the multi-strain probiotic formulation comprises Bacillus coagulans Unique IS-2, Lactobacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58, Bifidobacterium lactis UBBLa-70, Bifidobacterium breve UBBr-01, and Bifidobacterium infantis UBBI-01.

Abstract: The present invention provides a stable pharmaceutical composition comprising apomorphine and one or more pharmaceutically acceptable carriers in an injectable device. The present invention also provides a process for preparing the stable pharmaceutical composition.

Abstract: A disclosed framework enables virtually any aggressive Recovery Point Objective (RPO) to be enforced for a production database, without limitation on type of database management system (DBMS) or size of the production database. The framework overcomes technological barriers of the prior art, such as bottlenecks presented by a storage manager computer that traditionally managed database backups. To avoid the bottlenecks, an illustrative data storage management system does not engage the storage manager computer in storage operations that could impact the database RPO. Certain components are added and enhanced to autonomously capture database transaction logs, which are stored securely and persistently away from the DBMS. In a separate and less frequent operation, and with involvement of the storage manager computer, the illustrative system generates secondary copies in their final form. Meanwhile, temporary backup files can be used in restore operations without first being converted into secondary copies.

Abstract: A method for dynamically controlling the alignment of multi-nested Objectives and Key Results (OKRs) is implemented via an application service provider server including a processor. The method includes executing, via a network, an enterprise application on a remote computing system and causing surfacing of a user interface on the display of the remote computing system during the execution of the enterprise application, where the user interface corresponds to a goal-setting feature of the enterprise application. The method also includes receiving, via the surfaced user interface, user input including an alignment permission policy for a multi-nested OKR of an enterprise, where the alignment permission policy defines a list of enterprise users who are allowed to align child OKR objects to a parent objective of the multi-nested OKR. The method further includes applying the alignment permission policy to the multi-nested OKR.

Abstract: This disclosure describes methods of operating a leaf node device, such as a switch device, connected to a switch fabric of a network. The leaf node device receives, from another leaf node device via the switch fabric, an indication of a secure route to a host device. In response to receiving the indication of the secure route, the leaf node device creates or updates a routing entry for the host device in a routing information base of the leaf node device and creates or updates an entry for the host device in a Dynamic Host Configuration Protocol (DHCP) snoop database of the leaf node device. The leaf node may thereby communicate with the host device that is attached to the leaf node device as a result of moving from the other leaf node device.

Abstract: There is provided a method for operating a renewable energy power plant comprising a plurality of renewable energy generators, the method comprising: calculating a rate of change of reactive power reference level for transitioning between a present reactive power reference level, output by a reactive power controller, and a target reactive power reference level, the target reference level being suitable for normal operation of the renewable energy power plant; and, following a fault on a power network to which the renewable energy power plant is connected, dispatching a control signal for controlling the renewable energy power plant to generate or consume reactive power at the calculated rate of change to transition the reactive power level of the renewable energy power plant to the target reactive power reference level.