Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: A system identifies a user, even a user behind a wireless router, and provides a virtual tunnel over the internet for communication with the user. A data center at an Internet Service Provider may work in concert with a central data center to authenticate the user and to provide access, for example using a layer 2 tunneling protocol and a point-to-point data (PPP) link protocol. A layer 2 tunneling protocol network server (LNS) may provide public IP address translation services.

Abstract: According to one aspect of the invention, a connection element, for external, detachable joining of a structural beam element is provided, comprising a bottom plate intended to be in contact with the bottom surface of the structural beam element, a top plate intended to be in contact with the top surface of the structural beam element two side plates, and a rear plate characterized in that the longitudinal thickness of the bottom plate increases from the free edge of the bottom plate towards its edge at the rear plate. Another aspect of the invention describes a detachable structural system which employs a plurality of connection elements rigidly coupled to each other and a plurality of structural beam elements.

Abstract: Disclosed is a system and method for receiving, by a wireless gateway device from a user computing device, a request for network access. In an embodiment, the request is formatted to comply with a different communication protocol, and transmitted to a authentication computing device. The gateway device receives a reply from the authentication computing device that grants the request. The reply is transmitted by the wireless gateway device and to the user computing device. A first communication pathway is established between the authentication computing device and the user computing device, and a request for access to at least one other computing device is received by the authentication device. The request is forwarded, and a reply granting the request is received and forwarded to the user computing device.

Abstract: This application relates to chemical compounds which may act as inhibitors of; or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: A system identifies a user, even a user behind a wireless router, and provides a virtual tunnel over the internet for communication with the user. A data center at an Internet Service Provider may work in concert with a central data center to authenticate the user and to provide access, for example using a layer 2 tunneling protocol and a point-to-point data (PPP) link protocol. A layer 2 tunneling protocol network server (LNS) may provide public IP address translation services.

Abstract: A storage system for storing energy useful in starting and regulating electrical systems, that includes a transmission system to transmit mechanical energy between an electric machine and an energy storage device having at least one coil spring arranged in a rotating shaft; and a braking and holding element connected to the shaft to alternately block the spring or keep it in a released state, wherein the electric machine acts like a motor turning the rotating shaft in a first direction to tense the spring to store mechanical energy, and the rotation of the shaft in the opposite direction releases the mechanical energy stored in the spring and the transmission system turns the electric machine to operate the electric machine like an electric generator.

Abstract: The lift, propulsion and stabilising system for vertical takeoff and landing aircraft of the invention consists of applying during vertical flight on, below or in the interior of the fixed-wing aircraft one or more rotors or large fans each one with two or more horizontal blades, said rotors are activated by means of turboshafts, turbofans or turboprops with a mechanical, hydraulic, pneumatic or electrical transmission, and the respective motors. Using lifting and/or stabilising and/or controlling fans and/or oscillating fins and/or air blasts. Placing the horizontal lifters near at least one end of the longitudinal axis and of the transverse axis of the aircraft. Generally said stabilising elements form 90° with one another and with the central application point of the rotor or application of that which results from the lift forces.

Abstract: A system and method and provided for receiving, by a wireless gateway device from a user computing device, a request for network access and is received via a first communication protocol. The request is formatted to comply with a second communication protocol that is different than the first communication protocol, and transmitted to at least one authentication computing device. The wireless gateway device receives a reply formatted to comply with the second communication protocol from the at least one authentication computing device that grants the request. The device formats the reply to comply with the first communication protocol, and transmits by the wireless gateway device, the formatted reply to the user computing device. A first communication pathway is established between the authentication computing device and the user computing device, and a request for access to at least one other computing device is received by the authentication device.

Abstract: The general field of the invention is that of spintronics, namely the field of electronics using the magnetic spin properties of electrons. The main fields of application are the very large-scale magnetic storage of information and the measurement of local magnetic fields. The object of the invention is to considerably reduce the energy needed to reverse the magnetic domains of the ferromagnetic elements of submicron dimensions using the mechanism of the domain wall displacements that is induced either by just a current of spin-polarized carriers or by the combination of a current of spin-polarized carriers and a magnetic field, at least one of these being variable. This domain wall displacement results in a change of magnetic polarization in a specified switching zone. Several devices according to the invention are described that possess from one switching zone up to a plurality of switching zones according to the invention.

Abstract: The elastodynamic energy accumulator-regulator comprises a sheet (1) that is wound or capable of being wound in radioida spiral form with increasing or decreasing curvature along the length of the spiral, capable of absorbing energy at variable torque and supply a practically constant torque in broad working areas The laminate or set of sheets that are wound or capable of being wound about themselves as a spring has variable thickness and/or width and/or reinforcement along its length, and is held at both ends. The laminate or set of sheets is made of composite materials with polymer matrix and fiber reinforcement This elastodynamic energy accumulator-regulator has application as an energy accumulator or regulator in many applications such as wind energy production and other renewable energies, applications in transport, applications in uninterruptible power supply systems, applications in electric network regulation, etc.

Abstract: The general field of the invention is that of spintronics, namely the field of electronics using the magnetic spin properties of electrons. The main fields of application are the very large-scale magnetic storage of information and the measurement of local magnetic fields. The object of the invention is to considerably reduce the energy needed to reverse the magnetic domains of the ferromagnetic elements of submicron dimensions using the mechanism of the domain wall displacements that is induced either by just a current of spin-polarized carriers or by the combination of a current of spin-polarized carriers and a magnetic field, at least one of these being variable. This domain wall displacement results in a change of magnetic polarization in a specified switching zone. Several devices according to the invention are described that possess from one switching zone up to a plurality of switching zones according to the invention.

Abstract: The lifesaving system for buildings of the present invention includes a tubular device having opened crowns or circular radial curved crowns attached to an inside wall of the tubular device, the crowns having flexible vanes or fins through which inverted bell-shaped elements pass, the elements larger in size than the inner size of the crowns, and are braked or slowed as they move downwards, a foam rubber element added at an end of the tubular device, and an annular element having an outside perimeter forming a tapered cone and curved, and which adapts to a top of a user's chest and is positionable under user's armpits.

Abstract: A lifting arrangement for aircraft fuselages that consists of placing longitudinal vertical or slanted fins or plates on the lower and lateral lower part of the whole fuselage, said fins forming a channel with the underside of the fuselage, including nose, fuselage and tail, open on their lower area. Further adding longitudinal horizontal or laterally slanted fins on the lateral middle or middle-to-low area of the fuselage and with a positive slope up to the nose with said fins arranged in such a way that the upper fins are projected increasingly laterally, and because of this arrangement and their slope up to the nose, the air flow is directed downward and backward.

Abstract: Aerodynamic profile that comprises two zones or main sections: one is the front surface inclined with a positive angle, generating the totality or greater part of the lift, and the other is the rear portion or zone to the front surface, profiled or streamlined, formed by two curved, generally hollow surfaces and, which does not generate lift, but leads the air flow properly reducing drag and avoiding boundary layer separation.

Abstract: A wind energy catchment device comprising a central vertical shaft that rotates, the bottom end of which is secured by means of bearings to a rigid support fixed to the ground, the upper and lower part of the shaft have radial arms secured to it, evenly spaced one from the other, the outer ends of the upper arms are connected by cables or cords with its contiguous outer ends of the lower arms, between the upper and lower radial arms and the central shaft there are rectangular parallelepiped sails secured at their outer vertices. In all cases the furthest external vertical side of these sails or plates is secured and the sails or plates rotates from 90° to 180° with or around their shafts, cables or ropes that connect the ends of the arms, having both internal vertices loose, between the central shaft and two contiguous arms are arranged some parallel cords or mesh that support the sails or plates when they receive the air on the side of the mesh furthest from the wind.

Abstract: The golf ball having either a smooth or dimpled surface is disclosed including a sphere with peripheral channels spaced and intersected at distances on the surface, with part of the air flow on the front over-pressure area communicating with the rear depression of the ball in its forward movement, facilitating aerodynamic air circulation through it, resulting in reduced resistance, thereby facilitating rotation and lift, enhancing the advance of the ball.

Abstract: Lifting arrangement for lateral aircraft surfaces that consists of numerous lateral flutings, grooves, splines, flutes or riblets parallel to each other, arranged on the lateral surfaces of fuselages, fin units, pylons and gondolas of aircraft with a downward slope from the nose to the tail, with the flow of air passing through such flutings, grooves, etc., towards the rear and downwards, generating lifting by reaction, using small planes or fins to support the engines and flight control fins.