Abstract: The invention discloses a pharmaceutical combination comprising epidermal growth factor (EGF) and the hexapeptide secretagogue GHRP6, useful for the restoration of brain damage, by stimulating mechanisms of differentiation and neuronal specialization in undifferentiated cells residing in the central nervous system or in neuronal cells. The invention also encompasses the use of the above mentioned biomolecules in the manufacture of a pharmaceutical combination for the restoration of brain damage. In addition, the invention provides a method of restoring brain damage in which a therapeutically effective amount of a pharmaceutical combination comprising EGF and GHRP6 is administered to a patient in need thereof. The efficacy of the pharmaceutical combination has a broad therapeutic window: it is independent of whether the pharmacological intervention occurs in the first or further hours after the brain damage, which broadens the therapeutic window.

Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.

Abstract: This disclosure pertains to a non-living biological product. Particularly, exosomes derived from stem cells can help restore heart function. According to certain embodiments, a fluid-induced shear stress mechanical stimulation process of stem cells is used to augmented quantity and quality of exosomes produced from stem cells. These exosomes serve as a therapeutic agent for the regenerative repair of diseases, such as diseased heart tissues. Therefore, compositions comprising the exosomes derived from stem cells and methods of treating a degenerative disease by administering the exosomes isolated from stem cells are also provided.

Abstract: A system for current measurement and ground fault detection is disclosed. In embodiments, the system includes a plurality of Hall Effect sensors configured to detect phase currents associated with at least one portion of a multi-phase system. The system further includes a plurality of phase current measurement circuits and a ground fault detection circuit connected to the Hall Effect sensors. The phase current measurement circuits are configured to measure the phase currents detected by the Hall Effect sensors, and the ground fault detection circuit is configured to measure a summation of the phase currents detected by the Hall Effect sensors.

Abstract: The present invention relates to a heat exchanger device for EGR (“Exhaust Gas Recirculation”) systems, with a constructive solution which minimizes thermal fatigue when boiling occurs. The invention is characterized by a specific configuration of the inner space of the shell divided into a first exchange sub-space and a second degassing space communicated with one another, and wherein the inlet and outlet ports are located at the end where the cold baffle is located.

Abstract: A method for modulating angiogenesis in a cancer or tumor refractory to anti-VEGF, including identifying a cancer cell as being referactory to anti-VEGF, and then contacting the cancer cell refractory to anti-VEGF with an effective amount of an agent that modulates interaction between Gal1 or a Gal1 fragment and the natural binding partner of Gal1 or the Gal1 fragment to thereby modulate angiogenesis.

Abstract: An electronic device is provided to include a user interface, a communication circuitry that supports Bluetooth (BT) communication and store a first BT address, a processor operatively connected with the user interface and the communication circuitry, and a memory operatively connected with the processor.

Abstract: A magnet fastener assembly includes a base, a magnet carrier held in the base and a magnet held in the magnet carrier. The base includes a one-piece body having an upstanding doghouse on a support. The support is made from a first material and the doghouse is made from a second material. The first material has more flexibility than the second material and the second material has a greater rigidity than the first material.

Abstract: Systems and methods related to cutting electrodes (e.g. lithium metal) and electrode precursors are generally provided. The electrodes or electrode precursors may involve, for example, a lithium metal electrode or a lithium composite electrode, e.g., for use in an electrochemical cell or battery.

Abstract: The invention provides a nanovehicle, comprising: a core, wherein the core comprises at least one iron oxide: a shell surrounding the core, wherein the shell comprises at least one polymer; and at least one boron cluster. The invention provides a method of treating a disease, disorder, or disease condition in a subject, comprising administering a therapeutically effective amount of the nanovehicle to the subject; and radiating the nanovehicle with neutrons. In various embodiments, the invention provides a method for detecting a cancer in a subject, comprising administering an effective amount of at least one nanoparticle of the present invention to the subject. The invention also provides the nanovehicles (e.g., nanoparticles) described herein in the form of various pharmaceutical formulations. The invention provides a kit, the kit comprises: a quantity of the nanovehicle (e.g., nanoparticle) described herein.

Abstract: An electronic apparatus and a method for controlling the electronic apparatus are disclosed. The method includes: obtaining a neural network model trained to detect an object corresponding to at least one class; obtaining a user command for detecting a first object corresponding to a first class; and based on the first object not corresponding to the at least one class, obtaining a new neural network model based on the neural network model and information of the first object.

Abstract: The present invention provides a nanoparticle, comprising: a core, wherein the core comprises at least one iron oxide; a shell surrounding the core, wherein the shell comprises at least one polymer; and at least one targeting moiety attached to the shell, wherein the nanoparticle does not comprise boron, for use in methods for detecting and treating cancer in a subject.

Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.

Abstract: Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.

Abstract: Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.

Abstract: The present invention is intended for the use of a probiotic composition comprising Bifidobacterium animalis subs. lactis (B. lactis), Bifidobacterium longum and Lactobacillus rhamnosus, in particular the strains B. lactis CECT 8145, B. longum ES1 CECT 7347 and/or L. rhamnosus CECT 8361, in the treatment and/or prevention of psoriasis outbreaks or psoriasis.

Abstract: An electronic device includes a display, a wireless communication circuit configured to support a protocol capable of short-range wireless communication between electronic devices, at least one processor operatively connected with the display and the wireless communication circuit, and a memory operatively connected to the at least one processor, wherein the memory is configured to store instructions that, when executed, cause the at least one processor to broadcast a first control packet used for an inquiry procedure through the wireless communication circuit, receive a plurality of second control packets in response to the first control packet through the wireless communication circuit, identify a plurality of clock values in the plurality of second control packets, and display, on the display, a user interface indicating inquiry results of a plurality of external electronic devices that transmitted the plurality of second control packets based on the plurality of clock values.

Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.

Abstract: The present invention provides methods for fabricating field-effect devices and sensor arrays. The field of the invention also pertains to methods of using the sensors individually, in combination, and in array fashion to detect molecules. The present invention also provides for products produced by the methods of the present invention and for apparatuses used to perform the methods of the present invention.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed to generate a workscope. An example apparatus includes a workscope mapper, workscope strategy analyzer, and workscope selector. The workscope strategy analyzer is to evaluate each of the plurality of workscopes using dynamic optimization to determine a maintenance value and benefit to an asset associated with each workscope based on a stage in a remaining life of a constraint at which the evaluation is executed and a state of the asset. The dynamic optimization is to determine a prediction of the maintenance value based on a probability of a future change in state and associated workscope value until the end of life of the constraint. The maintenance value, used to select a workscope from the plurality of workscopes, is to be determined by the dynamic optimization as a sum of the associated workscope values until the end of life of the constraint.