Abstract: Methods, apparatus, systems, and articles of manufacture are disclosed to generate an asset health quantifier of a turbine engine. An example apparatus includes a health quantifier generator to execute a computer-generated model to simulate an operating condition of a turbine engine using asset monitoring information and generate an asset health quantifier of the turbine engine based on the simulation, and compare the asset health quantifier to a threshold, and a removal scheduler to identify the turbine engine for removal from service based on the comparison to improve an operation of the turbine engine by performing a workscope on the removed turbine engine.

Abstract: Methods, apparatus, systems, and articles of manufacture to generate an asset workscope are disclosed. An example system includes an asset health calculator to identify an asset on which to perform maintenance based on generating a first asset health quantifier corresponding to a first asset health status, a task generator to determine a first workscope including first asset maintenance tasks, and a task optimizer to determine a second workscope including second asset maintenance tasks based on the first asset health quantifier and/or first workscope. The example system includes a workscope effect calculator to generate a second asset health quantifier corresponding to a second asset health status when the second workscope is completed on the asset, and to update the asset health calculator, task generator, and/or task optimizer to improve determination of first and/or second workscopes to improve the second asset health quantifier relative to the first asset health quantifier.

Abstract: The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms.

Abstract: Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices.

Abstract: A method for tracking an object commences by first establishing the object (12) in a current frame. Thereafter, a background region (202) is established encompassing the object in the current frame. The location for the object (12) is then estimated in a next frame. Next, the propagation of the background region (202) is determined. Finally, the object is segmented from its background based on propagation of the background region, thereby allowing tracking of the object from frame to frame.

Abstract: There is described herein use of a compound of formula (I) below to make cyclic peptides.

Abstract: Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines.

Abstract: A system and method facilitates access and payment to a parking facility. The vehicle operator/owner downloads a software application and inputs personal and financial information during registration. The personal and financial information is stored in a parking facility server and a payment server. The system generates an electronic ticket, or a radio frequency identification technology, or Bluetooth networking standard that correspond to the personal and financial information. A reader at the gate controller, in the parking area, scans the electronic ticket or RFID from the mobile communication device or vehicle. The server authorizes the gate controller to enable access for the vehicle to a parking area, based on the information. When the vehicle egresses the parking area, the electronic ticket or RFID is scanned again, and the duration in the parking area is transmitted to payment server to process payment and provide a receipt based on duration in parking area.

Abstract: The present invention relates to a prefabricated construction system and method, for erecting constructions by means of the assembly of prefabricated structural elements obtained by cutting flat materials, forming structural nodes by means of coupling at least a first coupling configuration formed by first slots made in a plurality of parallel boards forming a first structural element with at least a second coupling configuration formed by second slots made in a plurality of parallel boards forming a second structural element, providing a structural core in the form of an array having interstitial openings going through it which allow the coupling of third and fourth coupling configurations of third and fourth structural elements.

Abstract: A system and method for automatically decoupling a security device associated with a product comprising a security device arranged to be coupled to a product comprising a passive RFID element arranged to emit a unique identifier (ID1), passively, and at least one passive communication element arranged to passively communicate another unique identifier (ID2) to a wireless device, a wireless device that scans said identifier communicating said passive element, a central database accessible by said wireless device through a central server including information on the products available to the user and at least the association of the product with said identifiers (ID1, ID2) when said product is coupled to said security device, a means of payment service accessible by said wireless device through the central server and at least one security tower with at least one microprocessor, an RFID antenna and means of communication, arranged for scanning passive RFID elements, wherein said association between said product a

Abstract: The invention provides an overcurrent protection device (1), comprising a current input terminal (2); a central terminal (3) for the output of current overshoots (Is); and a terminal (4) for the output of non impulse currents (Ic) which is outwardly connected to the voltage of the central terminal (3) before the occurrence of the current overshoot (Is) at the input terminal (2); and an electrical conductor element (5) connected between the current input and output terminals (2 and 4); such conductor element showing a reduced self-induction (L) when operating without current overshoots but, which, in case that current overshoots are present at the input terminal (2), produces a high drop of the induction voltage between such input terminal and the output terminal (2 and 4); wherein the central terminal (3) is arranged in the vicinity of the current input terminal (2) at a distance (D) that may be regulated, so that when, as a result of a current overshoot, the inductive voltage drop between the input terminal

Abstract: In the field of hoisting and controlling hoisted loads, a hoisting device for hoisting a load includes a support beam, two load carrying units, structured to be slid along the support beam and being structured to hold the load, at least one counterweight structured to be slid along the support beam, at least one sensor capable of measuring the weight force held by the load carrying units, a first driving unit structured to slide the load carrying units, a second driving unit structured to slide the counterweight, a third driving unit structured to hoist the load, a hooking point structured to be hooked from a crane, and a processing unit structured to receive the information produced by the sensor and structured to operate the first driving unit, the second driving unit and the third driving unit.

Abstract: Compound for treatment of myotonic dystrophy type The present invention relates to a compound, or a salt thereof, and a pharmaceutical composition comprising said compound, or a salt thereof, for use in the prevention and/or treatment of myotonic dystrophy type 1 in a patient, in particular by reducing the levels of autophagy and apoptosis that are elevated in myotonic muscular dystrophy type 1.

Abstract: A method for tracking an object commences by first establishing the object (12) in a current frame. Thereafter, a background region (202) is established encompassing the object in the current frame. The location for the object (12) is then estimated in a next frame. Next, the propagation of the background region (202) is determined. Finally, the object is segmented from its background based on propagation of the background region, thereby allowing tracking of the object from frame to frame.

Abstract: The present invention relates to a structural joint for attaching two boards by their butts, achieving the correct transmission of forces between them by means of a staggered configuration of the butts thereof to increase the contact surface between both boards, allowing the mutual coupling thereof, both being aligned and coplanar, and at least one of the steps of both boards having a finger profile to further increase the contact surface between both boards.

Abstract: An overcurrent protection device comprises a current input terminal; a central terminal for output of current overshoots; and a terminal for output of non-impulse currents connected to a voltage of the central terminal. An electrical conductor element is connected between the input and output terminals at a reduced self-induction when operating without current overshoots. When current overshoots are present at the input terminal, the conductor produces a high drop of induction voltage between the input and output terminals. The central terminal is arranged in the vicinity of the input terminal at a distance that may be regulated. When due to current overshoot, the inductive voltage drop between the input and the non-impulse current output terminals exceeds the dielectric strength of the material present between the input and central terminals, an arc is generated between the input and central terminals to prevent the flow of current overshoots through the conductor element.

Abstract: Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.

Abstract: The present invention relates to a prefabricated construction system and method, for erecting constructions by means of the assembly of prefabricated structural elements obtained by cutting flat materials, forming structural nodes by means of coupling at least a first coupling configuration formed by first slots made in a plurality of parallel boards forming a first structural element with at least a second coupling configuration formed by second slots made in a plurality of parallel boards forming a second structural element, providing a structural core in the form of an array having interstitial openings going through it which allow the coupling of third and fourth coupling configurations of third and fourth structural elements.

Abstract: A method of providing a first set of computer systems with access to a recommendation pertaining to operation of one or more assets based on the one or more assets being in revenue service or in repair is disclosed. Operations data and inspection data is collected at the first set of computer systems. The operations data and inspection data pertains to operating asset states of one or more fleets of aircraft over a time period. The operations data and the inspection data is stored in one or more databases of a second set of computer systems. Assumptions of control input values are derived for use by the first set of computer systems based on the operations data and the inspection data. A financial objective and constraints analysis is performed with a simulation system for one or more assets of the one or more fleets of aircraft. The cost savings analysis includes identifying a modification of at least one of a set of the control input values.

Abstract: A method of providing a recommendation for optimizing operations of a set of industrial assets is disclosed. Digital twins of the set of industrial assets are generated. The digital twins include data structures representing states of each of a plurality of subsystems of the set of industrial assets over a time period. The states are estimated based on an application of simulations using cumulative damage models. The cumulative damage models model the effects of exogenous factors on the operation of the set of industrial assets over the time period. The digital twins are analyzed with respect to simulated operating performances to determine an optimized control of operations of the industrial assets. The optimized control of operations is calculated to jointly and severally to increase the specified operating performance criteria in time present and future of the industrial assets or decrease an economic risk associated with the operation of the industrial assets, within a specified probability.