Abstract: The invention provides a method for the treatment of EGFRvIII-positive cancer or glioblastoma, comprising administering to a subject in need thereof an initial dose of between about 15 ?g/day to about 6000 ?g/day of an anti-EGFRvIII agent. Diagnostic methods for assessing EGFRvIII expression are also provided.

Abstract: A hybrid propulsion system includes a housing, at least two electrodes, a solid-grain fuel material, a combustion chamber, an oxidizer port, and a nozzle. The housing has a first end and a second end and defines a cavity. The electrodes extend into the cavity. The fuel material is free of an oxidizer and is positioned in the cavity. The fuel material has a combustion surface and is exposed to the electrodes. The combustion chamber is defined between the combustion surface and the second end. The oxidizer port provides a flow of oxidizer to the combustion chamber. The nozzle is positioned at the second end. Combustion of the fuel material in the combustion chamber may be dominated by radiative heat transfer. Combustion of the fuel material in the combustion chamber may generate thrust of no more than 5 N at an oxidizer flow rate of no more than 5 g/s.

Abstract: A hybrid propulsion system includes a housing, at least two electrodes, a solid-grain fuel material, a combustion chamber, an oxidizer port, and a nozzle. The housing has a first end and a second end and defines a cavity. The electrodes extend into the cavity. The fuel material is free of an oxidizer and is positioned in the cavity. The fuel material has a combustion surface and is exposed to the electrodes. The combustion chamber is defined between the combustion surface and the second end. The oxidizer port provides a flow of oxidizer to the combustion chamber. The nozzle is positioned at the second end. Combustion of the fuel material in the combustion chamber may be dominated by radiative heat transfer.

Abstract: A hybrid propulsion system includes a housing, at least two electrodes, a solid-grain fuel material, a combustion chamber, an oxidizer port, and a nozzle. The housing has a first end and a second end and defines a cavity. The electrodes extend into the cavity. The fuel material is free of an oxidizer and is positioned in the cavity. The fuel material has a combustion surface and is exposed to the electrodes. The combustion chamber is defined between the combustion surface and the second end. The oxidizer port provides a flow of oxidizer to the combustion chamber. The nozzle is positioned at the second end. Combustion of the fuel material in the combustion chamber may be dominated by radiative heat transfer. Combustion of the fuel material in the combustion chamber may generate thrust of no more than 5 N at an oxidizer flow rate of no more than 5 g/s.

Abstract: The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure useful for the synthesis of compounds that target KRAS G12C mutations, such as

Abstract: An imaging module (114) of an imaging system comprises a porous silicon membrane (116) with a first side (208), a contact side (210) opposite the first side, columns of silicon (212) configured to extend from the first side to the contact side, and columnar holes (214, 502) interlaced with the columns of silicon and configured to extend from the first side to the contact side. The imaging module further includes quantum dots (118) in the columnar holes. The imaging module further includes a metal pad (120) electrically coupled to the columns of silicon of the porous silicon membrane. The quantum dots in the columnar holes are electrically insulated from the metal pad. The imaging module further includes a substrate (122) with an electrically conductive pad (204) in electrical communication with the metal pad that defines a pixel.

Abstract: The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure useful for the synthesis of compounds that target KRAS G12C mutations, such as

Abstract: The subject matter disclosed herein relates to determining a background location of a mobile device using one or more signal metrics.

Abstract: Methods, systems, and apparatus for periodic water leak detection are disclosed. A method includes obtaining, using a water meter, water meter data representing the occurrence of water usage events at a property; determining, based on the water meter data, a periodicity of water usage events; determining that the periodicity of water usage events satisfies water leak criteria; and based on determining that the periodicity of water usage events satisfies water leak criteria, determining that a water leak exists at the property. Determining the periodicity of water usage events can include determining an average time between a start of sequential water usage events; and determining that the periodicity of water usage events satisfies water leak criteria can include determining that the average time between the start of sequential water usage events is less than a threshold time between the start of sequential water usage events.

Abstract: A circuit for direct current (DC) offset estimation comprises a quantile value circuit and a signal processor. The quantile value circuit determines a plurality of quantile values of an input signal and includes a plurality of quantile filters. Each quantile filter includes a comparator, a level shifter, a monotonic transfer function component, and a latched integrator. The comparator compares the input signal and a quantile value. The level shifter shifts the output of the comparator. The monotonic transfer function component determines the magnitude of the shifted signal and provide a transfer function signal. The latched integrator suppresses transient characteristics of the transfer function signal and provide the quantile value. The signal processor is configured to calculate a weighted average of the quantile values to yield a DC offset estimate.

Abstract: The subject matter disclosed herein relates to determining a background location of a mobile device using one or more signal metrics.

Abstract: A circuit for direct current (DC) offset estimation comprises a quantile value circuit and a signal processor. The quantile value circuit determines a plurality of quantile values of an input signal and includes a plurality of quantile filters. Each quantile filter includes a comparator, a level shifter, a monotonic transfer function component, and a latched integrator. The comparator compares the input signal and a quantile value. The level shifter shifts the output of the comparator. The monotonic transfer function component determines the magnitude of the shifted signal and provide a transfer function signal. The latched integrator suppresses transient characteristics of the transfer function signal and provide the quantile value. The signal processor is configured to calculate a weighted average of the quantile values to yield a DC offset estimate.

Abstract: A detector array (112) includes a detector pixel (206). The detector pixel includes a three dimensional cavity (304 and 306; 432 and 404) having walls (308/602 and 316; 434 and 406/502) that include active regions, which detect light photons traversing within the three dimensional cavity and produce respective electrical signals indicative thereof. The detector pixel further includes a first scintillator (320; 410) disposed in the three dimensional cavity adjacent to a bottom (320; 416) of the at least one detector pixel. The detector pixel further includes a second scintillator (326; 444) disposed in the three dimensional cavity on top of the first scintillator, wherein the first and second scintillators emits the light photons in response to absorbing x-ray photons. At least one of the walls is vertically oriented with respect to detector pixel, maximizing contact area between a corresponding active region and one of the first or second scintillators.

Abstract: A subject support includes a fixed portion and a moveable portion coupled to the fixed portion and configured to move along at least one axis relative to the fixed portion, and the coupling includes one or more points of friction that move during movement of the moveable portion and which wear due to at least movement by the moveable portion. The moveable portion receives and supports at least one of an object or a subject during an imaging procedure with an imaging device. One or more inertial measurement units (IMUs) are affixed to or embedded in the moveable portion that directly measure acceleration of translation of the moveable portion along one or more axes.

Abstract: A static charge filter (522) removes static charge in a cardiac electrical signal. The static charge filter includes a first amplifier (608) configured to amplify an input signal, which includes the cardiac electrical signal and static charge from an electrode, which is in a path of an X-ray beam. The static charge filter further includes a limiter (614) configured to limit a maximum voltage of the signal based on a predetermined clamping threshold, producing a voltage clamped signal. The static charge filter further includes a filter (616) configured to filter high frequency components of the voltage clamped signal, producing a filtered signal. The static charge filter further includes a second amplifier (620) configured to scale an amplitude of the filtered signal so that cardiac electrical signal in an output signal has a same voltage level as a voltage level of the cardiac electrical signal in the input signal.

Abstract: A scintillator layer (206) includes a plurality of scintillator pixels (337), walls of non-scintillation material (336) surrounding each of the plurality of scintillator pixels, and at least one electrically conductive interconnect (224) for a pixel, wherein the at least one electrically conductive interconnect extends within a wall of the pixel along an entire depth of the wall. A multi-energy detector array (114) includes a detector tile (116) with an upper scintillator layer (202), an upper photosensor (204) optically coupled to the upper scintillator layer, a lower scintillator layer (206) electrically coupled to the upper photosensor, and a lower photodetector (208) optically and electrically coupled to the lower scintillator layer.

Abstract: A monitoring system that is configured to monitor a property is disclosed. In one aspect, the monitoring system includes a sensor that is located at the property and that is configured to generate sensor data. The monitoring system further includes a voltage sensor that is configured to generate voltage data by measuring voltage at an electrical outlet located at the property. The monitoring system further includes a monitor control unit that is configured to receive the sensor data; receive the voltage data; determine an action of an electrical device that is located in the property or that is located at a neighboring property in a vicinity of the property; determine whether the electrical device is located at the property or at the neighboring property in the vicinity of the property; and perform a monitoring system action.

Abstract: Electronic devices, interfaces for electronic devices, and techniques for interacting with such interfaces and electronic devices are described. For instance, this disclosure describes an example electronic device that includes sensors, such as multiple front-facing cameras to detect orientation and/or location of the electronic device relative to an object and one or more inertial sensors. Users of the device may perform gestures on the device by moving the device in-air and/or by moving their head, face, or eyes relative to the device. In response to these gestures, the device may perform operations.

Abstract: A radiation detector (100) includes a photovoltaic layer (102) with first and second opposing sides. The photovoltaic layer is configured to absorb first radiation at the first side and produce electrical charge. The detector further includes a porous silicon quantum dot layer (104) disposed at the second side of the photovoltaic layer and configured to receive second radiation and convert the received second radiation into an electrical signal indicative of an energy level of the received second radiation. The detector further includes an acquisition and communication layer (106) disposed adjacent to the porous silicon quantum dot layer and configured to receive the electrical signal and transmit the electrical signal to a device remote from the radiation detector.

Abstract: A radiation detector array (112) of an imaging system (100) comprises a plurality of detector modules (114). Each of the plurality of detector modules includes a plurality of detector pixel (116). Each of the plurality of detector pixels includes an integral pixel border (202, 204, 206, 208) and a direct conversion active area within the integral pixel border. A method comprises receiving radiation with a nano-material detector pixel that includes an integral pixel border, generating, with the detector pixel, a signal indicative of an energy of the received radiation, while reducing pixel signal crosstalk, and reconstructing the signal to construct an image.