Abstract: Described here are devices and methods for suture management. In some variations, the devices comprise an elongate tubular member having a proximal end, a distal end, a lumen therebetween, a cantilever blade positioned near the distal end of the elongate tubular member, and an expandable member positioned adjacent the cantilever blade for actuating the cantilever blade. Also described are devices comprising an elongate tubular member having a proximal end, a distal end, a lumen at least partially therebetween, and an aperture in a wall thereof for passage of a suture therethrough. These devices further comprise a blade connected to a blade housing disposed within the lumen, where the blade is oriented parallel to the longitudinal axis of the lumen. The blade and blade housing may be slidable within the lumen, or an inner shaft for may be slidable within the lumen. Methods of using the devices are also described.

Abstract: There is provided compounds of formula (I), wherein R1, R2, R3 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula (I).

Abstract: Based on received data descriptive of an event, a hierarchical data structure is constructed comprising structural elements associated with components of an event. A file folder hierarchy corresponding to the hierarchical data structure is created. User interfaces facilitate user access to files and folders in the hierarchies. Certain documents may be designated as documents of record and access to those documents is limited to processes that will not modify the original electronic document, thereby preserving it. Facilities for creating working copies of documents of records and associating them within the hierarchies are provided. A scanning information sheet that may have an electronically readable data imprint containing information about a document to be scanned is described for facilitating the migration of paper documents into an electronic file management system.

Abstract: Compounds of formula (I), where: R0 is (C8-C11)-branched alkyl, CH3—(CH2)m—, CH3—O—(CH2CH2O)2CH2—, or phenyl-(CH2)x—; m=6-10; x=1-3; R1, R3, R4, R7, and R8 are independently selected from the formula GF-(CH2)n—; with n=1-4; and GF=—NH2 or —NH—C(?NH)—NH2; R2 is —CH(CH3)(OH), —CH(CH3)2, —CH2NH2 o —CH2OH; R5 and R6 are independently selected among H, —(C1-C4)— linear or branched alkyl, —(CH2)—R10, —CH2—CH2—S—CH3 and —CH—(CH3)—OH; R9 is CONH2, —CH(CH3)(OH) or CONHR11; R10 is phenyl, 3-indolyl, 4-imidazolyl, 4-hydroyiphenyl, ? o ?-naphtyl or 2-, 3- or 4-pyridyl; R11 is a specific peptide sequence; u is CH2 or S; v is NH o S; w is CH2 or CO; with the condition that when R9 is CONH2, then (a) R5 or R6 is —CH(CH3)(OH), or (b) R5 and R6 are H; or (c) the configuration of the C bound to R9 is S or (d) the configuration of the C bound to R5 is R; and with the condition that when R9 is —CH(CH3)OH, then R8 is GF(CH2)n where n is 3 and GF is —NH—C(?NH)—NH2, and R7 is GF(CH2)n where n is 2 and GF is NH2, have been found to

Abstract: Based on received data descriptive of an event, a hierarchical data structure is constructed comprising structural elements associated with components of an event. A file folder hierarchy corresponding to the hierarchical data structure is created. User interfaces facilitate user access to files and folders in the hierarchies. Certain documents may be designated as documents of record and access to those documents is limited to processes that will not modify the original electronic document, thereby preserving it. Facilities for creating working copies of documents of records and associating them within the hierarchies are provided. A scanning information sheet that may have an electronically readable data imprint containing information about a document to be scanned is described for facilitating the migration of paper documents into an electronic file management system.

Abstract: Apparatus and methods to process loss payments are described herein. In one example, an apparatus includes one or more data stores, a rules engine, an audit engine and a payment engine. In another example, the method may include receiving a notice of loss, deriving a payee, processing one or more rules using the information, determining whether an automatic payment can be made and transferring funds if the automatic payment can be made. In a further example, the method may include receiving a notice of loss, the loss having one or more exposures, processing one or more rules for each of the exposures in parallel, determining if an automatic payment can be made for each of the exposures and removing the automatic payment for an exposure if it can not be made while continuing processing payments for the remaining exposures.

Abstract: A method of manufacturing wind turbine blades of variable length with connection means with the rotor hub comprising steps of providing and using enlarged manufacturing moulds (41, 43, 45, 47) having a common zone (13) of a predetermined length and, at least, an adaptive zone (15) arranged with the length needed for manufacturing the blades with a desired length, particularly the length required for optimizing the annual energy production (AEP) of a predetermined wind turbine model in a predetermined site.

Abstract: A composition for delivering edible salts into food products via microcapsules having a protein-polysaccharide shell matrix and an edible salt-containing active material. A method of treating osteoporosis is also disclosed.

Abstract: This invention relates to a new formulation activating the absorption of mineral nutrients by plants. Consequently, it has also an effect on the metabolization of these mineral compounds by the plant. These formulations that have been discovered with this property activating nutrient absorption have as main component the compounds represented by general formula 1 CH3—S—CH2—CH2—CH(OR1)—COR2??1 where R1 is selected from the group formed by hydrogen, alkyl rests, (preferably methyl or ethyl), and aryl: while R2 is selected from the group formed by hydroxyl, amides, alkyl rest esters (preferably methyl or ethyl), or aryl. When the rest is hydroxyl, acid salts with monovalent cations, preferably Na+ and K+, polyvalent cations, preferably Cu++ and Fe+++, and electropositive organic compounds such as amines (e.g., ethanolamine) are also considered.

Abstract: Apparatus and methods to process loss payments are described herein. In one example, an apparatus includes one or more data stores, a rules engine, an audit engine and a payment engine. In another example, the method may include receiving a notice of loss, deriving a payee, processing one or more rules using the information, determining whether an automatic payment can be made and transferring funds if the automatic payment can be made. In a further example, the method may include receiving a notice of loss, the loss having one or more exposures, processing one or more rules for each of the exposures in parallel, determining if an automatic payment can be made for each of the exposures and removing the automatic payment for an exposure if it can not be made while continuing processing payments for the remaining exposures.

Abstract: Apparatus and methods to process loss payments are described herein. In one example, an apparatus includes one or more data stores, a rules engine, an audit engine and a payment engine. In another example, the method may include receiving a notice of loss, deriving a payee, processing one or more rules using the information, determining whether an automatic payment can be made and transferring funds if the automatic payment can be made. In a further example, the method may include receiving a notice of loss, the loss having one or more exposures, processing one or more rules for each of the exposures in parallel, determining if an automatic payment can be made for each of the exposures and removing the automatic payment for an exposure if it can not be made while continuing processing payments for the remaining exposures.

Abstract: The present invention relates to novel metal complexes comprising: at least one metal selected from the metal trace elements essential for the development of plants; at least one first ligand selected from the lignosulfonates, and derivatives thereof; at least one second ligand selected from the multidentate organic ligands. These complexes are useful in the area of agriculture, notably as agents for treating metal deficiency.

Abstract: A power closure actuator especially suitable for use in powering various automotive closure devices. The actuator includes a brushless pancake electric motor having an output shaft; a sun gear on the output shaft; a plurality of compound planet gears each having a large diameter lower portion meshingly engaging the sun gear and a small diameter upper portion; a ring gear surrounding and meshingly engaging the small diameter upper portions of the planet gears, and a cable drum splined to the ring gear. A mounting plate positioned in overlying confronting relation to the flat upper face of the motor mounts a plurality of planet shafts extending upwardly from the mounting plate in circumferentially spaced relation to the motor output shaft with one of the compound planet gears journaled on each planet shaft.

Abstract: Cosmetic or dermopharmaceutical compositions containing Pseudoalteromonas ferment extract for the treatment and/or care of the skin, scalp and/or nails, preferably to improve the barrier function of the skin, scalp and/or nails, and specifically for the treatment and/or care of those conditions, disorders and/or pathologies of the skin, scalp and/or nails associated with an alteration in the keratinization process.

Abstract: There is provided compounds of formula (I), wherein Z, M, R1, X, R2, R3 and B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PIM family kinase or PI3-K) is desired and/or required, and particularly in the treatment of cancer.

Abstract: An equipment for the automatic assessment of road signs and panels, the equipment performing, for the purpose, a retroreflection measurement of the white element of the signs or panels, and a measurement of the contrast between the white element of the sign or panel and a characteristic element of same (borders or text) in order to ensure a particular level of legibility. To this end, a vehicle (1) is equipped with a pulsed infrared illumination system (3), a system of stereoscopic cameras (2), a GPS (11), an odometer (12), a computer (5) mounted on an industrial rack, a data storage system (8), an event keyboard (7), and a TFT monitor (6) for viewing results. The infrared illumination system (3) is synchronized with the cameras (2). In this way, the infrared illuminator (3) illuminates the road area in alternate images, thereby providing illuminated road images and non-illuminated road images.

Abstract: The present disclosure describes a method for the revaluation of aqueous waste streams generated in the propylene oxide and styrene co-production processes. In particular, it discloses a method of reducing the organic contaminant load from a highly contaminated aqueous stream and recovery from said stream of organic compounds that may be recirculated or used as fuel in the co-generation of energy, and which comprises: acidification of said aqueous stream with inorganic acid at a pH less than 4.5; separation of the two resulting phases at a temperature greater than 40° C.; washing of the organic phase produced in the previous step with an aqueous solution of excess acid and separation of the two resulting phases.

Abstract: Heteromolecular metal-humic organic complexes of the type: (A)n-(Metal)x-(B)m where A is one or several humic complexes which may be totally or partially sulfonated or may have been treated with an amine in order to protect the carboxylic groups from interacting with polyvalent cations, and B is a non-humic complexing (organic chelating agent) compound, the biological and chemical stability whereof allows for protection of the metal and the multitoothed or multi-valent molecule involved in the complex against degradation phenomena, both chemical and microbiological, having the beneficial effect of humic acid, as an effective plant growth and nutrition stimulant and as a metabolic and immune system activator in animals and humans.

Abstract: The invention relates to cosmetic compositions which are intended to improve the firmness of the skin by increasing adhesion of cutaneous cells in relation to one another and the basal lamina. The aforementioned compositions comprise a cosmetically-effective quantity of peptides having general formula X-isoleucyl-lysyl-valyl-alanyl-valine-Y, known as X-SEQ ID No. 1-Y (FIG. 1). The invention also relates to the use of X-SEQ ID No. 1-Y peptides in the preparation of cosmetic compositions which are intended to improve the firmness of the skin.

Abstract: Described here are devices for closing one or more tissues, and handles for controlling these devices. Generally, the devices described here comprise a snare loop assembly, wherein the snare loop assembly comprises a snare and a suture loop, and a handle for controlling the snare loop assembly. In some variations the snare loop assembly may comprise a retention member that may releasably connect the suture loop to the snare. In other variations the devices comprise one or more force-reducing suture locks to help prevent the suture loop from inadvertently disengaging from the snare loop assembly. In still other variations, the excess-suture management features. The handles described here may be configured to remove excess suture from a suture loop, and may also be configured to release the suture loop from the snare loop assembly.