Abstract: The present application relates to compounds according to Formula (I), pharmaceutical compositions comprising at least one of said compounds, their use as a medicament, and their use in treating chronic hepatitis B virus (HBV) infection. The disclosure further pertains to methods for preparing compounds according to Formula (I).

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: An information retrieval system (IPS). The system comprises an input interface (IN) for receiving a query related to an object of interest. A concept mapper (CM) is configured to map the query to one or more associated concept entries of a hierarchic graph data structure (ONTO). The entries in said structure encode linguistic descriptors of components of a model (GM) for said object (OB). A metric-mapper (MM) is configured to map the query to one or more metric relationship descriptors. A geo-mapper (GEO) is configured to map said concept entries against the geometric model linked to the hierarchic graph data structure to obtain spatio-numerical data associated with said linguistic descriptors. A metric component (MTC) is configured to compute one or more metric or spatial relationships between said object components based on the spatio-numerical data and the one or more metric relationship descriptors.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: The present invention relates to macrocyclic pyridotriazine derivatives and the prodrugs thereof, and the pharmaceutically acceptable salts, solvates or polymorph thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family.

Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.

Abstract: During a medical intervention such as an angiography, the X-ray examination equipment (such as that mounted on a C-arm) produces a very large number of imaging frames of the intervention, as it progresses. This information contains frame sequences which can be effectively used to improve a medical report of the intervention. The sequence will contain sequences which contain similar clinical information though, and these frames may be considered to be redundant and not useful for inclusion in the medical report. The aspects detailed herein enable a selection of non-redundant sequences and/or frames, based on contextual information, obtained from the sequence of images, and/or other medical equipment, during an intervention. In this way, the redundancy inherent in the original frame sequence can be removed, leaving a set of prepared candidate sequences for insertion into a multimedia or documentary medical report.

Abstract: The invention concerns compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. (Formula I).

Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a device for interacting with vessel images, the device (14) comprising: an interface unit (22); a processing unit (20); wherein the interface unit (22) comprises: a display (21); and an input setup (23); wherein the display (21) is configured to display a vessel image (24); wherein the input setup (23) is configured to receive a user input in relation to the vessel image (24); wherein the processing unit (20) is configured to: determine, for at least one vessel (26) in the vessel image (24), a vessel contour (30); determine, from the user input, an identifier position (36) in the vessel image (24); indicate at least a portion (38) of the vessel contour (30) in the vessel image (24), if the determined identifier position (36) is spaced apart from the vessel contour (30) by a distance (37) within a predefined distance range; determine, from the user input, a drag direction (42); and move the indicated portion (38) along the vessel contour (30) based on the determined drag direc

Abstract: Electrical harness for a turbomachine, comprising a first termination connected to an apparatus (3) capable of emitting an electrical signal, and a second termination connected to a signal processing apparatus (4), characterised in that it comprises an electronic circuit for filtering the signal, said circuit comprising at least one electronic component associated with an operating temperature threshold, and one thermally triggered electrical interruption means connected in series or in parallel with said electronic component, said electrical interruption means being capable of changing from an open state in which a current cannot flow through it, to a closed state in which a current can flow through it, or reciprocally from a closed state to an open state, from a tripping temperature lower than or equal to the operating temperature threshold of said electronic component.

Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.

Abstract: The present invention relates to purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Abstract: An aircraft turbine engine module, including a degassing tube and an ejection cone. The tube and the cone are engageable together by structures which cause them to be centered when engaged together. Also provided is a locating and adjusting tool for assembling the module.