Patents by Inventor Marie Bernard

Marie Bernard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRICYCLIC COMPOUNDS
    Publication number: 20220169650
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 22, 2021
    Publication date: June 2, 2022
    Inventors: Sandrine Vendeville, Yannick Debing, Pierre Jean-Marie Bernard Raboisson
  • Pyrazolopyrimidines having activity against the respiratory syncytial virus (RSV)
    Patent number: 11339165
    Abstract: The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. Formula (Ia).
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: May 24, 2022
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: David Francis Alain Lançois, Jérôme Émile Georges Guillemont, Pierre Jean-Marie Bernard Raboisson, Dirk André Emmy Roymans, Peter Rigaux, Antoine Benjamin Michaut, Guillaume Jean Maurice Mercey
  • BICYCLIC PYRIDAZINONES AND METHODS OF USE THEREOF
    Publication number: 20220144811
    Abstract: Disclosed herein are compounds of Formula I: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Applicant: ALIGOS THERAPEUTICS, INC.
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Koen Vandyck, Jerome Deval, Leonid Beigelman
  • 2-PYRIDONES AND METHODS OF USE THEREOF
    Publication number: 20220143032
    Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Applicant: ALIGOS THERAPEUTICS, INC.
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Koen Vandyck, Jerome Deval, Leonid Beigelman
  • OXINDOLES AND METHODS OF USE THEREOF
    Publication number: 20220143031
    Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Applicant: ALIGOS THERAPEUTICS, INC.
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Koen Vandyck, Jerome Deval, Leonid Beigelman
  • Macrocyclic flu endonuclease inhibitors
    Patent number: 11312727
    Abstract: The present invention relates to macrocyclic pyridotriazine derivatives of formula (I) and the pharmaceutically acceptable salts, solvates or polymorph thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: April 26, 2022
    Assignee: Janssen BioPharma, Inc.
    Inventors: Robert Than Hendricks, Antitsa Dimitrova Stoycheva, Jean-François Bonfanti, Pierre Jean-Marie Bernard Raboisson, Jérôme Michel Claude Fortin, Guillaume Jean Maurice Mercey
  • BICYCLIC COMPOUNDS
    Publication number: 20220119385
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 19, 2021
    Publication date: April 21, 2022
    Inventors: Sandrine Vendeville, Pierre Jean-Marie Bernard Raboisson, David McGowan
  • BICYCLIC COMPOUNDS
    Publication number: 20220119395
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 13, 2021
    Publication date: April 21, 2022
    Inventors: Sandrine Vendeville, Yannick Debing, Antitsa Dimitrova Stoycheva, Pierre Jean-Marie Bernard Raboisson
  • Degassing tube and ejection cone for a turbine engine, as well as tool for assembly thereof
    Patent number: 11306679
    Abstract: The invention relates to an aircraft turbine engine module (10), comprising a degassing tube (14) and an ejection cone (12). The tube and the cone comprise centring means engaging together. The invention also relates to a locating and adjusting tool for assembling said module.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: April 19, 2022
    Assignee: SAFRAN AIRCRAFT ENGINES
    Inventor: Samuel Louis-Marie Bernard
  • COMPOUNDS TARGETING PRMT5
    Publication number: 20220112194
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 30, 2021
    Publication date: April 14, 2022
    Inventors: Koen Vandyck, Pierre Jean-Marie Bernard Raboisson, Jerome Deval, Leonid Beigelman, David McGowan, Yannick Debing, Francois Gonzalvez
  • Contrast injection imaging
    Patent number: 11282170
    Abstract: Vasculature modeling systems and methods are disclosed that generate an enhanced 3D model based on a combination of two dimensional, 2D, imaging data of a region of interest and 3D imaging data of the region of interest. A hemodynamic simulation is performed using the enhanced 3D model to derive at least one hemodynamic parameter based on the hemodynamic simulation.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: March 22, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Romane Isabelle Marie-Bernard Gauriau, Christian Haase, Michael Grass, Javier Olivan Bescos, Raoul Florent
  • APPARATUS FOR DETERMINING A FUNCTIONAL INDEX FOR STENOSIS ASSESSMENT
    Publication number: 20220079455
    Abstract: An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface (40) and a processing unit (50). The input interface is configured to obtain image data (30) representing a two-dimensional representation of a vessel (6). The processing unit (50) is configured to determine a course of the vessel (6) and a width (w1, w2) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.
    Type: Application
    Filed: November 22, 2021
    Publication date: March 17, 2022
    Inventors: Christian HAASE, Michael GRASS, Bram Antonius Philomena VAN RENS, Roland Wilhelmus Maria BULLENS, Peter Maria Johannes RONGEN, Arjen VAN DER HORST, Raoul FLORENT, Romane Isabelle Marie-Bernard GAURIAU, Javier OLIVAN BESCOS, Holger SCHMITT, Vincent Maurice André AUVRAY
  • Spirothietane nucleosides
    Patent number: 11267844
    Abstract: The present invention relates to 2?-spirothietane nucleosides, and the phosphates and the prodrugs thereof, and the pharmaceutically acceptable salts and solvates thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Flaviviridae family and/or to the alphavirus genus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Flaviviridae family and/or to the alphavirus genus. The invention also relates to processes for the preparation of the compounds.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: March 8, 2022
    Assignee: Janssen Pharmaceutica NV
    Inventors: Abdellah Tahri, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • COMPOUNDS TARGETING PRMT5
    Publication number: 20220048922
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: October 28, 2021
    Publication date: February 17, 2022
    Inventors: Koen Vandyck, Pierre Jean-Marie Bernard Raboisson, Jerome Deval, Leonid Beigelman, David McGowan, Yannick Debing
  • FURTHER HETEROAROMATIC COMPOUNDS HAVING ACTIVITY AGAINST RSV
    Publication number: 20220033396
    Abstract: The invention concerns compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial vims (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment or prevention of respiratory syncytial vims infection.
    Type: Application
    Filed: November 25, 2019
    Publication date: February 3, 2022
    Inventors: Jérome Émile Georges GUILLEMONT, David Francis Alain LANÇOIS, Sovy CHAO, Patrick René ANGIBAUD, Guillaume Jean Maurice MERCEY, Pierre Jean-Marie Bernard RABOISSON, Antoine Benjamin MICHAUT, Peter RIGAUX
  • ANTI-VIRAL COMPOUNDS
    Publication number: 20220009903
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 8, 2021
    Publication date: January 13, 2022
    Inventors: Koen Vandyck, Pierre Jean-Marie Bernard Raboisson, Leonid Beigelman, Vladimir Serebryany, Antitsa Dimitrova Stoycheva, Dorothée Alice Marie-Eve Bardiot, Sandro Boland, Arnaud Didier Marie Marchand
  • MODULATORS OF THR-BETA AND METHODS OF USE THEREOF
    Publication number: 20220009924
    Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a patient with one or more of the above compounds.
    Type: Application
    Filed: July 8, 2021
    Publication date: January 13, 2022
    Applicant: ALIGOS THERAPEUTICS, INC.
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Koen Vandyck, Jerome Deval
  • Pyrrolo[3,2-d] pyrimidine derivatives for the treatment of viral infections and other diseases
    Patent number: 11220504
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: January 11, 2022
    Assignee: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
    Inventors: David Craig McGowan, Stefaan Julien Last, Serge Maria Aloysius Pieters, Werner Embrechts, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • DIHYDROPYRANOPYRIMIDINES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20210387997
    Abstract: This invention relates to dihydropyranopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: June 23, 2021
    Publication date: December 16, 2021
    Inventors: Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Jérôme Émile Georges GUILLEMONT, David Craig MC GOWAN, Werner Constant Johan EMBRECHTS, Ludwig Paul COOYMANS, Laurent CALMUS
  • Compounds targeting PRMT5
    Patent number: 11198699
    Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: December 14, 2021
    Assignee: Aligos Therapeutics, Inc.
    Inventors: Koen Vandyck, Pierre Jean-Marie Bernard Raboisson, Jerome Deval, Leonid Beigelman, David McGowan, Yannick Debing