Patents by Inventor Marie Bernard

Marie Bernard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Three dimensional model of a body part
    Patent number: 11200750
    Abstract: An apparatus provides a patient specific 3D model of a body part. At least one 2D X-ray image including 2D X-ray image data of a vascular structure of a patient's body part is provided. A 3D model of the body part is provided, the 3D model including a 3D modelled vascular structure. At least one parameter commands an appearance of the 3D modelled vascular structure. The 3D modelled vascular structure is compared with the 2D X-ray image data of the vascular structure to determine the at least one parameter. The 3D model is updated as a function of the determined at least one parameter. A medical report is generated based on information determined from the 3D model.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: December 14, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Vincent Maurice André Auvray, Raoul Florent, Romane Isabelle Marie-Bernard Gauriau, Alexandra Groth, Juergen Weese
  • ORIENTATION DETECTION FOR 2D VESSEL SEGMENTATION FOR ANGIO-FFR
    Publication number: 20210383539
    Abstract: An apparatus for assessing a vessel of interest and a corresponding method are provided in which the modeling of the hemodynamic parameters using a fluid dynamics model can be verified by deriving feature values from the segmented vessel of interest and inputting these feature values into a classifier. The classifier may then determine, based on the feature values whether the segmentation has been performed from proximal to distal, from distal to proximal or cannot be determined from the provided data. An incorrect segmentation order can thus be identified and potentially be corrected, thereby avoiding inaccurate simulation results.
    Type: Application
    Filed: October 25, 2019
    Publication date: December 9, 2021
    Inventors: Christian HAASE, Michael GRASS, Martijn Anne VAN LAVIEREN, Cornelis Willem Johannes Immanuël SPOEL, Romane Isabelle Marie-Bernard GAURIAU, Holger SCHMITT, Javier OLIVAN BESCOS
  • Apparatus for determining a functional index for stenosis assessment
    Patent number: 11179043
    Abstract: An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface (40) and a processing unit (50). The input interface is configured to obtain image data (30) representing a two-dimensional representation of a vessel (6). The processing unit (50) is configured to determine a course of the vessel (6) and a width (w1, w2) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: November 23, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Christian Haase, Michael Grass, Bram Antonius Philomena Van Rens, Roland Wilhelmus Maria Bullens, Peter Maria Johannes Rongen, Arjen Van Der Horst, Raoul Florent, Romane Isabelle Marie-Bernard Gauriau, Javier Olivan Bescos, Holger Schmitt, Vincent Maurice André Auvray
  • Substituted indoline derivatives as dengue viral replication inhibitors
    Patent number: 11180450
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: November 23, 2021
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Pierre Jean-Marie Bernard Raboisson, Jean-François Bonfanti, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • Heterocyclic compounds as antibacterials
    Patent number: 11179396
    Abstract: The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: November 23, 2021
    Assignee: Janssen Sciences Ireland UC
    Inventors: Jérôme Émile Georges Guillemont, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • Substituted indoline derivatives as dengue viral replication inhibitors
    Patent number: 11179368
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: November 23, 2021
    Assignees: JANSSEN PHARMACEUTICALS, INC., KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Dorothée Alice Marie-Eve Bardiot, Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Pierre Jean-Marie Bernard Raboisson, Arnaud Didier M Marchand
  • Antibacterial compounds
    Patent number: 11180472
    Abstract: The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: November 23, 2021
    Assignee: Janssen Sciences Ireland UC
    Inventors: Jérôme Émile Georges Guillemont, Magali Madeleine Simone Motte, Pierre Jean-Marie Bernard Rabiosson, Abdellah Tahri
  • MODULATORS OF THR-BETA AND METHODS OF USE THEREOF
    Publication number: 20210355112
    Abstract: Disclosed herein are compounds of Formula I: TL-La-CE-HD??(I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IIa, IIb, IIIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.
    Type: Application
    Filed: May 25, 2021
    Publication date: November 18, 2021
    Applicant: ALIGOS THERAPEUTICS, INC.
    Inventors: Koen Vandyck, Pierre Jean-Marie Bernard RABOISSON, David McGowan, Jerome Deval
  • Inter-turbine casing comprising mounted splitter blades
    Patent number: 11143044
    Abstract: The invention relates to an inter-turbine casing (1) comprising: an inner shell (10), an outer shell (20), and an assembly of arms (2) extending radially between the timer (10) and outer (20) shells; and an assembly of splitter blades (30) positioned between the arms (2), each splitter blade (30) comprising an inner platform (33) and an outer platform (36). The inner shell (10) comprises at least one inner groove (11) for slidably receiving one or more inter platforms (33). The outer shell (20) comprises at least one outer groove (21) for slidably receiving one or more outer platforms (36). The inter-turbine casing further comprises locking means (4, 5) for locking the splitter blades (30) in the inner (11) and outer (21) grooves. The splitter blades are arranged using multiple tenons (39) that extend in corresponding ribs (12, 22).
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: October 12, 2021
    Assignee: SAFRAN AIRCRAFT ENGINES
    Inventors: Sébastien Jean Laurent Prestel, Simon Jean-Marie Bernard Cousseau, Alice Pages, Cyril Verbrugge
  • SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
    Publication number: 20210300868
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: May 28, 2021
    Publication date: September 30, 2021
    Applicants: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Jean-François Bonfanti, Bart Rudolf Romanie Kesteleyn, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand, Erwin Coesemans, Benoît Christian Albert Ghislain De Boeck, Pierre Jean-Marie Bernard Raboisson
  • Aryl substituted pyrimidines for use in influenza virus infection
    Patent number: 11117887
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: September 14, 2021
    Assignee: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
    Inventors: Tim Hugo Maria Jonckers, David Craig McGowan, Jérôme Émile Georges Guillemont, Werner Constant J Embrechts, Guillaume Jean Maurice Mercey, Christophe Francis Robert Nestor Buyck, Wendy Mia Albert Balemans, Pierre Jean-Marie Bernard Raboisson
  • Purine derivatives for the treatment of viral infections
    Patent number: 11104678
    Abstract: The present invention relates to purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: May 6, 2019
    Date of Patent: August 31, 2021
    Assignee: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
    Inventors: Jean-François Bonfanti, Frédéric Marc Maurice Doublet, Werner Embrechts, Jérôme Michel Claude Fortin, David Craig McGowan, Pierre Jean-Marie Bernard Raboisson
  • Modulators of THR-? and methods of use thereof
    Patent number: 11091467
    Abstract: Disclosed herein are compounds of Formula I: TL-La-CE-HD??(I) or a pharmaceutically acceptable salt, prodrug, amide or ester thereof, where i) TL is a moiety of Formula IIa, IIb, IIIa, IIIb, IIIc, or IIId; ii) CE is a moiety of Formula IV; iii) HD is a moiety of Formula V or VI; where the substituents are as defined herein. Disclosed are also pharmaceutical compositions comprising the above compounds, and methods of treating disease by administering or contact a patient with one or more of the above compounds.
    Type: Grant
    Filed: May 7, 2020
    Date of Patent: August 17, 2021
    Assignee: Aligos Therapeutics, Inc.
    Inventors: Koen Vandyck, Pierre Jean-Marie Bernard Raboisson, David McGowan, Jerome Deval
  • Substituted indoline derivatives as dengue viral replication inhibitors
    Patent number: 11083707
    Abstract: The present invention relates to substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: August 10, 2021
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Erwin Coesemans, Pierre Jean-Marie Bernard Raboisson, Arnaud Didier M Marchand, Dorothée Alice Marie-Eve Bardiot
  • RSV antiviral pyrazolo- and triazolo-pyrimidine compounds
    Patent number: 11084826
    Abstract: The invention concerns novel substituted pyrazolo- and triazolo-pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: August 10, 2021
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: David Francis Alain Lançois, Jérôme Émile Georges Guillemont, Pierre Jean-Marie Bernard Raboisson, Dirk André Emmy Roymans, Boris Rogovoy, Vadim Bichko, Delphine Yvonne Raymonde Lardeau, Antoine Benjamin Michaut, Anil Koul
  • Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
    Patent number: 11078193
    Abstract: Inhibitors of HBV replication of Formula (A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R5 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: August 3, 2021
    Assignee: Janssen Sciences Ireland UC
    Inventors: Koen Vandyck, Geerwin Yvonne Paul Haché, Stefaan Julien Last, Geert Rombouts, Wim Gaston Verschueren, Pierre Jean-Marie Bernard Raboisson
  • PYRIMIDINE PRODRUGS FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
    Publication number: 20210214317
    Abstract: This invention relates to pyrimidine prodrug derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
    Type: Application
    Filed: March 25, 2021
    Publication date: July 15, 2021
    Inventors: Jérôme Émile Georges GUILLEMONT, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, David Craig MC GOWAN, Werner Constant Johan EMBRECHTS, Bart Henri Theresia STOOPS, Florence Marie HERSCHKE, Jacques Armand Henri BOLLEKENS, Laurent Jacques Emile CALMUS
  • Dihydropyranopyrimidines for the treatment of viral infections
    Patent number: 11053256
    Abstract: This invention relates to dihydropyranopynmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: July 6, 2021
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Jérôme Émile Georges Guillemont, David Craig McGowan, Werner Constant Johan Embrechts, Ludwig Paul Cooymans, Laurent Calmus
  • Substituted indoline derivatives as dengue viral replication inhibitors
    Patent number: 11053196
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: July 6, 2021
    Assignees: Janssen Pharmaceuticals, Inc., Kathalieke Universiteif Leuven
    Inventors: Jean-François Bonfanti, Bart Rudolf Romanie Kesteleyn, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand, Erwin Coesemans, Benoît Christian Albert Ghislain De Boeck, Pierre Jean-Marie Bernard Raboisson
  • CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20210179635
    Abstract: Inhibitors of HBV replication of Formula (I-A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 17, 2021
    Inventors: Sandrine Marie Helene VENDEVILLE, Stefaan Julien LAST, Samuël Dominique DEMIN, Sandrine Céline GROSSE, Geerwin Yvonne Paul HACHÉ, Lili HU, Serge Maria Aloysius PIETERS, Geert ROMBOUTS, Koen VANDYCK, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON