Patents by Inventor Marie Bernard

Marie Bernard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10611755
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: April 7, 2020
    Assignee: Janssen Sciences Ireland UC
    Inventors: Tim Hugo Maria Jonckers, David Craig McGowan, Jérôme Émile Georges Guillemont, Werner Constant J Embrechts, Guillaume Jean Maurice Mercey, Christophe Francis Robert Nestor Buyck, Wendy Mia Albert Balemans, Pierre Jean-Marie Bernard Raboisson
  • Patent number: 10611769
    Abstract: The invention concerns novel substituted pyrazolo- and triazolo-pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: April 7, 2020
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: David Francis Alain Lançois, Jérôme Émile Georges Guillemont, Pierre Jean-Marie Bernard Raboisson, Dirk André Emmy Roymans, Boris Rogovoy, Vadim Bichko, Delphine Yvonne Raymonde Lardeau, Antoine Benjamin Michaut, Anil Koul
  • Patent number: 10597390
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: March 24, 2020
    Assignee: Janssen Sciences Ireland UC
    Inventors: Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Jérôme Émile Georges Guillemont, David Craig McGowan, Werner Constant Johan Embrechts, Ludwig Paul Cooymans, Antoine Benjamin Michaut
  • Publication number: 20200061059
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 27, 2020
    Inventors: David McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Publication number: 20200054606
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: March 29, 2018
    Publication date: February 20, 2020
    Applicants: JANSSEN PHARMACEUTICALS, INC., KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Dorothée Alice Marie-Eve Bardiot, Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Pierre Jean-Marie Bernard Raboisson, Arnaud Didier M. Marchand
  • Publication number: 20200039931
    Abstract: Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: October 14, 2019
    Publication date: February 6, 2020
    Inventors: Koen VANDYCK, Geerwin Yvonne Paul HACHÉ, Stefaan Julien LAST, David Craig MCGOWAN, Geert ROMBOUTS, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • Publication number: 20200031779
    Abstract: This invention relates to pyrimidine prodrug derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 30, 2020
    Inventors: Jérôme Émile Georges GUILLEMONT, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, David Craig MC GOWAN, Werner Constant Johan EMBRECHTS, Bart Henri Theresia STOOPS, Florence Marie HERSCHKE, Jacques Armand Henri BOLLEKENS, Laurent Jacques Emile CALMUS
  • Publication number: 20200029830
    Abstract: An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface (40) and a processing unit (50). The input interface is configured to obtain image data (30) representing a two-dimensional representation of a vessel (6). The processing unit (50) is configured to determine a course of the vessel (6) and a width (w1, w2) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.
    Type: Application
    Filed: October 2, 2017
    Publication date: January 30, 2020
    Inventors: Christian HAASE, Michael GRASS, Bram Antonius Philomena VAN RENS, Roland Wilhelmus Maria BULLENS, Peter Maria Johannes RONGEN, Arjen VAN DER HORST, Raoul FLORENT, Romane Isabelle Marie-Bernard GAURIAU, Javier OLIVAN BESCOS, Holger SCHMITT, Vincent Maurice André AUVRAY
  • Patent number: 10544184
    Abstract: The present invention relates to compound of the formula I: including any possible stereoisomers thereof, wherein R9 has the meaning as defined herein, or a pharmaceutically acceptable salt or solvate thereof. The present invention also related to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HCV inhibitors, in HCV therapy.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: January 28, 2020
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Ioannis Nicolaos Houpis, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • Publication number: 20200020079
    Abstract: Vasculature modeling systems and methods are disclosed that generate an enhanced 3D model based on a combination of two dimensional, 2D, imaging data of a region of interest and 3D imaging data of the region of interest. A hemodynamic simulation is performed using the enhanced 3D model to derive at least one hemodynamic parameter based on the hemodynamic simulation.
    Type: Application
    Filed: March 29, 2018
    Publication date: January 16, 2020
    Inventors: Romane Isabelle Marie-Bernard GAURIAU, Christian HAASE, Michael GRASS, Javier OLIVAN BESCOS, Raoul FLORENT
  • Publication number: 20200002342
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Application
    Filed: June 14, 2019
    Publication date: January 2, 2020
    Inventors: David Craig MC GOWAN, Serge Maria Aloysius PIETERS, Stefaan Julien LAST, Werner EMBRECHTS, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON
  • Patent number: 10501445
    Abstract: Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: December 10, 2019
    Assignee: Janssen Sciences Ireland UC
    Inventors: Abdellah Tahri, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Samuel Dominique Demin
  • Publication number: 20190367474
    Abstract: This invention relates to pyridone derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
    Type: Application
    Filed: June 5, 2019
    Publication date: December 5, 2019
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson
  • Publication number: 20190359614
    Abstract: The present invention relates to purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: May 6, 2019
    Publication date: November 28, 2019
    Inventors: Jean-François BONFANTI, Frédéric Marc Maurice DOUBLET, Werner EMBRECHTS, Jérôme Michel Claude FORTIN, David Craig MC GOWAN, Pierre Jean-Marie Bernard RABOISSON
  • Publication number: 20190345145
    Abstract: Potent 5-HT2B antagonist of Formula (A), including stereochemically isomeric forms, and salts, hydrates, solvates thereof and their use wherein R1 to R4 and Ar have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them, alone or in combination with other drugs, in fibrosis and/or cirrhosis prevention or therapy.
    Type: Application
    Filed: February 6, 2018
    Publication date: November 14, 2019
    Inventors: Zhao-Kui WAN, Haibing GUO, Koen VANDYCK, Pierre Jean-Marie Bernard RABOISSON, Abdellah TAHRI
  • Publication number: 20190330217
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Application
    Filed: April 12, 2019
    Publication date: October 31, 2019
    Inventors: David Craig MC GOWAN, Stefaan Julien LAST, Serge Maria Aloysius PIETERS, Werner EMBRECHTS, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON
  • Publication number: 20190330222
    Abstract: This invention relates to macrocyclic deaza-purinones derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: April 19, 2019
    Publication date: October 31, 2019
    Inventors: Jean-François BONFANTI, Jérôme Michel Claude FORTIN, Philippe MULLER, Frédéric Marc Maurice DOUBLET, Pierre Jean-Marie Bernard RABOISSON, Eric Pierre Alexandre ARNOULT
  • Publication number: 20190330227
    Abstract: This invention relates to thieno[3,2-d]pyrimidines derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: May 7, 2019
    Publication date: October 31, 2019
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson
  • Publication number: 20190330234
    Abstract: This invention relates macrocyclic purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: May 6, 2019
    Publication date: October 31, 2019
    Inventors: Jean-François BONFANTI, Jérôme Michel Claude FORTIN, Frédéric Marc Maurice DOUBLET, Pierre Jean-Marie Bernard RABIOSSON, Eric Pierre Alexandre ARNOULT
  • Publication number: 20190330189
    Abstract: The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
    Type: Application
    Filed: July 2, 2019
    Publication date: October 31, 2019
    Applicant: Janssen Sciences Ireland UC
    Inventors: Jérôme Émile Georges Guillemont, Magali Madeleine Simone Motte, Pierre Jean-Marie Bernard Rabiosson, Abdellah Tahri