Patents by Inventor Marie Bernard

Marie Bernard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MONO- OR DI-SUBSTITUTED INDOLE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
    Publication number: 20200270209
    Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: May 13, 2020
    Publication date: August 27, 2020
    Applicants: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie KESTELEYN, Jean-François BONFANTI, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Dorothée Alice Marie-Eve BARDIOT, Arnaud Didier M MARCHAND
  • SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20200255373
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: April 24, 2020
    Publication date: August 13, 2020
    Inventors: Koen VANDYCK, Stefaan Julien LAST, Geert ROMBOUTS, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • Influenza virus neutralizing peptidomimetic compounds
    Patent number: 10738083
    Abstract: The present invention relates to novel peptidomimetic compounds that are capable of binding to and/or neutralizing influenza viruses, in particular influenza A viruses of phylogenetic group 1, and to pharmaceutical compositions comprising such compounds. The invention also relates to the use of the peptidomimetic compounds in the diagnosis, prophylaxis and/or treatment of influenza virus infections.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: August 11, 2020
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Maria Van Dongen, Christophe Francis Robert Nestor Buyck, Wim Bert Griet Schepens, Jaroslaw Juraszek, Bart Rudolf Romanie Kesteleyn, Pierre Jean-Marie Bernard Raboisson, Boerries Brandenburg
  • Substituted indole compound derivatives as dengue viral replication inhibitors
    Patent number: 10730884
    Abstract: The present invention concerns substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: August 4, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand, Erwin Cosemans
  • ANTIBACTERIAL COMPOUNDS
    Publication number: 20200239434
    Abstract: The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
    Type: Application
    Filed: April 14, 2020
    Publication date: July 30, 2020
    Applicant: Janssen Sciences Ireland UC
    Inventors: Jérôme Émile Georges Guillemont, Magali Madeleine Simone Motte, Pierre Jean-Marie Bernard Rabiosson, Abdellah Tahri
  • Heterocyclic substituted 2-amino quinazoline derivatives for the treatment of viral infections
    Patent number: 10723707
    Abstract: This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: July 28, 2020
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Stefaan Julien Last, David Craig McGowan, Werner Embrechts, Serge Maria Aloysius Pieters, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • ARYL SUBSTITUTED PYRIMIDINES FOR USE INFLUENZA VIRUS INFECTION
    Publication number: 20200231577
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Application
    Filed: April 3, 2020
    Publication date: July 23, 2020
    Inventors: Tim Hugo Maria JONCKERS, David Craig MC GOWAN, Jérôme Émile Georges GUILLEMONT, Werner Constant J EMBRECHTS, Guillaume Jean Maurice MERCEY, Christophe Francis Robert Nestor BUYCK, Wendy Mia Albert BALEMANS, Pierre Jean-Marie Bernard RABOISSON
  • RSV ANTIVIRAL PYRAZOLO- AND TRIAZOLO-PYRIMIDINE COMPOUNDS
    Publication number: 20200223855
    Abstract: The invention concerns novel substituted pyrazolo- and triazolo-pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.
    Type: Application
    Filed: March 30, 2020
    Publication date: July 16, 2020
    Inventors: David Francis Alain LANÇOIS, Jérôme Émile Georges GUILLEMONT, Pierre Jean-Marie Bernard RABOISSON, Dirk André Emmy ROYMANS, Boris ROGOVOY, Vadim BICHKO, Delphine Yvonne Raymonde LARDEAU, Antoine Benjamin MICHAUT, Anil KOUL
  • ELECTRICAL HARNESS
    Publication number: 20200224593
    Abstract: Electrical harness for a turbomachine, comprising a first termination connected to an apparatus (3) capable of emitting an electrical signal, and a second termination connected to a signal processing apparatus (4), characterised in that it comprises an electronic circuit for filtering the signal, said circuit comprising at least one electronic component associated with an operating temperature threshold, and one thermally triggered electrical interruption means connected in series or in parallel with said electronic component, said electrical interruption means being capable of changing from an open state in which a current cannot flow through it, to a closed state in which a current can flow through it, or reciprocally from a closed state to an open state, from a tripping temperature lower than or equal to the operating temperature threshold of said electronic component.
    Type: Application
    Filed: July 23, 2018
    Publication date: July 16, 2020
    Inventors: George Alex KWAKYE, Benoit Marie Bernard KIEFFER, Jacques Paul Michel GAUVRIT, Jean-François Jean-Paul Clément SCHIELIN
  • Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
    Patent number: 10696632
    Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: June 30, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • METHOD OF BUILDING A TIRE WITH NO BEAD TURNUP
    Publication number: 20200198276
    Abstract: A method of building a tire having no ply turnup is described. The method includes the steps of applying an inner liner and chafer onto a tire building drum; radially expanding the center portion of the drum and applying a first column bead, applying a layer of ply followed by a second column bead, turning up the chafer and then inflating the carcass under low pressure below 150 mbars, applying the tread, applying the sidewall. A method of molding a green tire having a first and second bead area is described herein, wherein the method includes the steps of: inserting a tire clamping device inside a tire bladder and then inserting the tire clamping device and the bladder into the green tire, aligning the outer surfaces of the tire clamping device are in engagement with a respective bead area of the tire so that each tire bead area is clamped between a respective upper and lower mold ring and the tire clamping device during cure.
    Type: Application
    Filed: October 17, 2019
    Publication date: June 25, 2020
    Inventors: George Michael Stoila, John Edward Anderson, Michael James Hogan, Philippe Joseph Auguste Muller, Gilles Bonnet, Gilles Reichling, Robert Edward Lionetti, Frederic Marie Bernard Marechal, Olivier Di Prizio, Nicolas Soultis
  • TIRE WITH NO PLY TURNUP
    Publication number: 20200198411
    Abstract: A method of building a tire having no ply turnup is described. The method includes the steps of applying an inner liner and chafer onto a tire building drum; radially expanding the center portion of the drum and applying a first column bead, applying a layer of ply followed by the winding of a second column bead and the application of an apex, turning up the chafer and then inflating the carcass under low pressure below 150 mbars, applying the tread, applying the sidewall. A method of molding a green tire having a first and second bead area is described herein, wherein the method includes the steps of: inserting a tire clamping device inside a tire bladder and then inserting the tire clamping device and the bladder into the green tire, aligning the outer surfaces of the tire clamping device are in engagement with a respective bead area of the tire so that each tire bead area is clamped between a respective upper and lower mold ring and the tire clamping device during cure.
    Type: Application
    Filed: October 17, 2019
    Publication date: June 25, 2020
    Inventors: Gilles Reichling, Gilles Bonnet, Philippe Joseph Auguste Muller, Olivier Di Prizio, Nicolas Soultis, Robert Edward Lionetti, Frederic Marie Bernard Marechal, Hubert Anna Johanes Cox, Germain Dehez
  • Substituted indoline derivatives as dengue viral replication inhibitors
    Patent number: 10689340
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: June 23, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Pierre Jean-Marie Bernard Raboisson, Jean-François Bonfanti, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
    Publication number: 20200181083
    Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: May 18, 2018
    Publication date: June 11, 2020
    Applicants: JANSSEN PHARMACEUTICALS, INC., KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Jean-Francois Bonfanti, Bart Rudolf Romanis Kesteieyn, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand, Erwin Coesemans, Benoit Christian Albert Ghi De Boeck, Pierre Jean-Marie Bernard Raboisson
  • Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis B
    Patent number: 10676429
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: June 9, 2020
    Assignee: Janssen Sciences Ireland UC
    Inventors: Koen Vandyck, Stefaan Julien Last, Geert Rombouts, Wim Gaston Verschueren, Pierre Jean-Marie Bernard Raboisson
  • Sulphamoylaryl derivatives and use thereof as medicaments for the treatment of liver fibrosis
    Patent number: 10654837
    Abstract: Potent 5-HT2B antagonist of Formula (A), including stereochemically isomeric forms, and salts, hydrates, solvates thereof and their use wherein R1 to R4 and Ar have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them, alone or in combination with other drugs, in fibrosis and/or cirrhosis prevention or therapy.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: May 19, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Zhao-Kui Wan, Haibing Guo, Koen Vandyck, Pierre Jean-Marie Bernard Raboisson, Abdellah Tahri
  • 2-aminopyrimidine derivatives for the treatment of viral infections
    Patent number: 10647684
    Abstract: This invention relates to 2-aminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: May 12, 2020
    Assignee: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
    Inventors: David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Tim Hugo Maria Jonckers
  • Substituted indole derivatives as dengue viral replication inhibitors
    Patent number: 10646469
    Abstract: The present invention concerns substituted indole derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 12, 2020
    Assignees: Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Pierre Jean-Marie Bernard Raboisson, Dorothée Alice Marie-Eve Bardiot, Arnaud Didier M Marchand
  • SUBSTITUTED INDOLINE DERIVATIVES AS DENGUE VIRAL REPLICATION INHIBITORS
    Publication number: 20200121647
    Abstract: The present invention relates to substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.
    Type: Application
    Filed: March 29, 2018
    Publication date: April 23, 2020
    Applicants: JANSSEN PHARMACEUTICALS, INC., KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Bart Rudolf Romanie Kesteleyn, Jean-François Bonfanti, Erwin Coesemans, Pierre Jean-Marie Bernard Raboisson, Arnaud Didier M Marchand, Dorothée Alice Marie-Eve Bardiot
  • Heterocyclic indoles for use in influenza virus infection
    Patent number: 10626108
    Abstract: The current invention relates to a compound of formula (I) which can be used for the treatment of, or against viral influenza infections.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: April 21, 2020
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Tim Hugo Maria Jonckers, David Craig McGowan, Jérôme Émile Georges Guilllemont, Ludwig Paul Cooymans, Werner Constant Johan Embrechts, Christophe Francis Robert Nestor Buyck, Wendy Mia Albert Balemans, Pierre Jean-Marie Bernard Raboisson