Abstract: Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.

Abstract: This disclosure relates to building and finalizing an operating system (OS) image package in a way that allows for flexibility and customization of OS images while preventing certain runtime modifications after deployment of the OS image package on one or more target devices (e.g., embedded devices). For example, the systems described herein can build an OS image package based on information from an OS manifest that provides a declarative summary of a target OS. The systems described herein can further finalize the OS image package by performing one or more actions on the OS image package that prevent an end-user from performing various runtime modifications to the target OS after deployment of the OS image package. This finalization process provides an improved pipeline for implementing OS updates while providing safeguards against a variety of security risks associated with deploying OS image packages on a large scale.

Abstract: A method for generating descriptions of classification results, comprising classifying original inputs in a data set using a classifier. For one or more of the plurality of original inputs, apply an adjustment to one or more features of the original input to produce a respective adjusted input, and classify the respective adjusted input using the classifier. For one or more of the adjusted inputs, record a corresponding original input into a training set, and record information associated with the adjusted input into the training set. The method further comprises training a model based on the training set, such that the model is configured to receive an original model input and identify a hypothetical adjustment that would produce an adjusted model input that would be assigned an adjusted model classification with a different class than a class assigned to the original model input.

Abstract: Intraocular lens (IOL) designs include having an optic with an anterior surface and a posterior surface surrounded by an optic edge. In some examples, the IOL has a plurality of haptics, each attached to the optic at a gusset, where each gusset extends beyond the optic edge toward an optic center such that the gusset at least partially overlaps with the anterior surface of the optic. In some examples, the IOL includes a ring structure integral with the optic and surrounding the perimeter of the optic edge, the ring structure having a thickness and the optic edge having a thickness, the ring structure thickness greater than the optic edge thickness.

Abstract: Processes capable of producing bulk materials suitable for use by the horticulture industry, resulting bulk materials produced thereby, and applications for these processes and materials. Preferred bulk materials have physical properties similar to peat moss and comprise individual materials, each at least partially having a twisted, curled, clumped and rolled structure. The individual materials may further comprise small granular particles dispersed throughout the twisted, curled, clumped and rolled structure. The individual materials may be rolled fibers such that the bulk material has physical properties similar to sphagnum peat moss so as to be particularly suitable as, for example, a soil conditioner, an absorbent material, a chemical carrier, or a filtering material. Alternatively, the individual materials may be rolled particles such that the bulk material has physical properties similar to milled peat moss so as to be particularly suitable as propagation media.

Abstract: A rebar tie wire, including an inner wire portion including a radially outward facing surface, and a coating arranged on the radially outward facing surface, the coating including high density polyethylene (HDPE), and a bonding agent.

Abstract: A stander device with improvements to facilitate and/or make more convenient the adjustment and/or repositioning of various elements of the stander device for sizing and comfort of a patient/user, as well as making the folding, storage, and transportation thereof more convenient.

Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Abstract: Processes capable of producing bulk materials suitable for use by the horticulture industry, resulting bulk materials produced thereby, and applications for these processes and materials. Preferred bulk materials have physical properties similar to peat moss and comprise individual materials, each at least partially having a twisted, curled, clumped and rolled structure. The individual materials may further comprise small granular particles dispersed throughout the twisted, curled, clumped and rolled structure. The individual materials may be rolled fibers such that the bulk material has physical properties similar to Sphagnum peat moss so as to be particularly suitable as, for example, a soil conditioner, an absorbent material, a chemical carrier, or a filtering material. Alternatively, the individual materials may be rolled particles such that the bulk material has physical properties similar to milled peat moss so as to be particularly suitable as propagation media.

Abstract: Provided herein are compositions and methods for detecting the binding of a peptide to an MHC molecule, and the binding of a peptide:MHC complex to a TCR. In preferred embodiments, the compositions and methods are in a highly-multiplexed way. The compositions and methods disclosed herein can be used to provide direct information on which peptides are bound to an MHC molecule. Also provided is a method for simultaneously detecting a large number of peptides for binding to an MHC molecule and/or a T cell. A method for detecting competitive binding of a large number of peptides to an MHC molecule and/or a T cell is also disclosed. Also provided herein is a method for simultaneously detecting a large number of specific TCRs. The compositions and methods of the present invention are useful for vaccine design, research and monitoring of autoimmune and infectious disease, immunogenicity testing of therapeutics, and tissue typing.

Abstract: A dose collection container comprising first and second opposing walls, the first wall comprising an aperture sized to receive a nozzle of a nasal spray, and the second wall comprising at least two diverging impact surfaces which, on actuation of a nasal spray into the dose collection container, deflect the spray along an internal surface. Also included are methods and apparatus for using the described dose collection container.

Abstract: In some implementations, a light blocking material may be applied to a photodetector comprising a microlens array (MLA) component and a photodiode array (PDA) component. The light blocking material may be applied to a first distal end of the MLA component and a second distal end of the MLA component.

Abstract: Systems and methods for image retargeting are provided. Image data may be acquired that includes motion capture data indicative of motion of a plurality of markers disposed on a surface of a first subject. Each of the markers may be associated with a respective location on the first subject. A plurality of blendshapes may be calculated for the motion capture data based on a configuration of the markers. An error function may be identified for the plurality of blendshapes, and it may be determined that the plurality of blendshapes can be used to retarget a second subject based on the error function. The plurality of blendshapes may then be applied to a second subject to generate a new animation.

Abstract: The present invention relates to a computer implemented system for animating a virtual object or digital entity. It has particular relevance to animation using biologically based models, or behavioural models particularly neurobehavioural models. There is provided a plurality of modules having a computational element and a graphical element. The modules are arranged in a required structure and have at least one variable and being associated with at least one connector. The connectors link variables between modules across the structure, and the modules together provide a neurobehavioural model. There is also provided a method of controlling a digital entity in response to an external stimulus.

Abstract: A filter assembly includes an inner filter basket comprising an elongated tubular portion having a first open end and a first closed end. The tubular portion defines a plurality of perforations therethrough. An outer surface of the tubular portion is seamless. A first annular brim extends outwardly from the open end of the tubular portion. The filter assembly also includes an outer filter basket having a second open end in which the inner filter basket is received. A second annular brim extends outwardly from the second open end of the outer filter basket. The first and second brims are configured to retain a fabric filter bag between the inner filter basket and the outer filter basket.

Abstract: The present invention is directed to a computer-implemented method of automatically identifying the presence of one or more elements in a sample via optical emission spectroscopy.

Abstract: A hybrid lithium-ion battery-capacitor (H-LIBC) energy storage device includes a hybrid composite cathode electrode having a lithium ion battery (LIB) cathode active material and a lithium ion capacitor (LIC) cathode active material. An anode electrode having a surface is pre-loaded and pressed with a lithium (Li) thin film source. The anode electrode is pre-lithiated with the lithium film source by positioning the Li film source on the surface of anode electrode after electrolyte filling and soaking processes, a separator and an organic solvent electrolytic solution including a lithium salt electrolyte are also provided. A method of making a hybrid lithium-ion battery-capacitor and a method of making a hybrid composite cathode for a hybrid lithium-ion battery-capacitor are also disclosed.

Abstract: Methods of production of edible filamentous fungal biomat formulations are provided as standalone protein sources and/or protein ingredients in foodstuffs as well as a one-time use or repeated use self-contained biomat reactor comprising a container with at least one compartment and placed within the compartment(s), a feedstock, a fungal inoculum, a gas-permeable membrane, and optionally a liquid nutrient medium.