Abstract: The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

Abstract: An apparatus for molding a plastic closure includes a male mold assembly including a forming pin and an outer pin sleeve which cooperate with a female mold for defining a mold cavity. To facilitate mechanical stripping of a molded closure from the forming pin, pressurized air is introduced into the molded closure through at least one air passageway which extends axially between the forming pin and pin sleeve. By outwardly expanding and forming the plastic closure during ejection from the forming pin, forces to which the closure is subjected during ejection are significantly reduced, thereby desirably reducing the amount of cooling of the closure that is required during the molding cycle prior to ejection. Significantly increased operating speeds for the compression molding apparatus can thus be achieved.

Abstract: The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to dysfunction or dysregulation of B-lymphocyte activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating B-lymphocyte activation.

Abstract: An apparatus for molding a plastic closure includes a male mold assembly including a forming pin and an outer pin sleeve which cooperate with a female mold for defining a mold cavity. To facilitate mechanical stripping of a molded closure from the forming pin, pressurized air is introduced into the molded closure through at least one air passageway which extends axially between the forming pin and pin sleeve. By outwardly expanding and forming the plastic closure during ejection from the forming pin, forces to which the closure is subjected during ejection are significantly reduced, thereby desirably reducing the amount of cooling of the closure that is required during the molding cycle prior to ejection. Significantly increased operating speeds for the compression molding apparatus can thus be achieved.

Abstract: A storage cabinet employing a door formed in one monolithic piece from a thin sheet of light-weight but relatively rigid material, such as compressed resin-bonded plastic fibers. The door has a pair of panels, such as upper and lower door panels, integrally joined through a living hinge.

Abstract: A product package embodying the principles of the present invention includes an integrated circuit device which is configured for radio frequency interfacing with associated equipment. The package is configured such that the integrated circuit device is disposed within the package, thus assuring that the device remains associated with the package's contents. Notably, this arrangement facilitates use of the device for applications apart from product tracking and inventory control, including product promotions, storage, and dissemination of product information, and quality assurance including tamper-indication. A packaging machine for writing information on, and or reading information from, the integrated circuit device is also disclosed.

Abstract: Smokable rods of cigarettes are manufactured using wrapping materials that incorporate at least one fibrous material (e.g., flax fibers, hardwood pulp fibers and/or softwood pulp fibers) at least one filler material (e.g., calcium carbonate in particulate form). The wrapping materials possess multi-layer coatings. The wrapping materials possess coatings in the form of series of spaced apart bands, each band possessing a series of layers. At least one of the coating layers can have a filler material dispersed or suspended within a film-forming material of that layer. For a representative wrapping material, a pattern of applied to the wire side major surface of the wrapping material substrate as a plurality of layers, and at least one of the layers includes ethylcellulose and calcium carbonate. For that layer, the calcium carbonate is present in an amount greater than the ethylcellulose, on a weight basis.

Abstract: A dispensing closure assembly includes an outer closure body having an upper tubular portion which can function as a mouthpiece for users. The closure assembly includes a flexible valve member mounted within the tubular portion of the closure body for dispensing of liquids or like contents by either the application of suction by a consumer, or by squeezing the associated container. By the provision of a liquid seal lip which coacts with an inside surface of the flexible valve member, the closure assembly can be configured to facilitate convenient use by consumers, while avoiding undesirable leakage attendant to normal handling during use.

Abstract: A shaped charge explosive device (10) comprising an explosive charge body including an explosive charge (18) defining a cavity particulate material (44) dispersible by the explosive charge when detonated, eg in a liner lining the cavity. In a preferred embodiment of this device of particular applicability to use in avalanche control, the particulate medium is aluminium. This is energized by the liner collapse and jetting process such that on impact and interaction with a snow/ice target it gererates a directed blast effect extending beyond that achievable with a simple blast charge of the same mass. Direct application to hand charge avalanche control methods and modified ammunition for Avalauncher ammunition are presented. Two of such charges with a conical liner can be positioned either facing each other or facing away form each other to obtain a particular blast pattern.

Abstract: A method of making an interactive information package, including an interactive information closure including a radio frequency identification device, contemplates that a microelectronics assembly be provided, and positioned on an associated substrate for positioning adjacent an inside surface of the top wall portion of the closure of the package. In one embodiment, the mounting substrate is provided in the form of a disc-shaped sealing liner for the closure. In an alternate embodiment, the mounting substrate is laminated to an associated sealing liner, with the substrate, and microelectronics assembly positioned thereon, inserted together with the sealing liner into the associated molded closure.

Abstract: An apparatus for molding a plastic closure includes a male mold assembly including a forming pin and an outer pin sleeve which cooperate with a female mold for defining a mold cavity. To facilitate mechanical stripping of a molded closure from the forming pin, pressurized air is introduced into the molded closure through at least one air passageway which extends axially between the forming pin and pin sleeve. By outwardly expanding and forming the plastic closure during ejection from the forming pin, forces to which the closure is subjected during ejection are significantly reduced, thereby desirably reducing the amount of cooling of the closure that is required during the molding cycle prior to ejection. Significantly increased operating speeds for the compression molding apparatus can thus be achieved.

Abstract: A dispensing closure assembly includes an outer closure body having an upper tubular portion which can function as a mouthpiece for users. The closure assembly includes a flexible valve member mounted within the tubular portion of the closure body for dispensing of liquids or like contents by either the application of suction by a consumer, or by squeezing the associated container. By the provision of a liquid seal lip which coacts with an inside surface of the flexible valve member, the closure assembly can be configured to facilitate convenient use by consumers, while avoiding undesirable leakage attendant to normal handling during use.

Abstract: An unlicensed wireless service is adapted to generate the interface protocols of a licensed wireless service to provide transparent transition of communication sessions between a licensed wireless service and an unlicensed wireless service. In one embodiment, a mobile station includes level 1, level 2, and level 3 protocols for licensed wireless service and an unlicensed wireless service. An indoor base station and indoor network controller provide protocol conversion for the unlicensed wireless service into a standard base station controller interface of the licensed wireless service.

Abstract: An apparatus for extruding plastic, including a plastic feed, an extruder, a colored liquid additive supply, a positive displacement metering pump, and a controller. The extruder has a housing receiving plastic from the plastic feed, a heat source, and a screw adapted to drive plastic through the housing The pump supplies colored liquid additive from the supply to the plastic in the phase change section of the extruder housing. The controller controls the drive rate of the screw and the pump to supply a selected volume of colored liquid additive per unit of time which is based on the drive rate of the screw. In use, the extruder is converted to adding a different color without cleaning the housing feeding section.

Abstract: The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

Abstract: The present invention provides compositions and methods for modulating B-lymphocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating B-lymphocyte activation are provided. Compositions and methods for the treatment of disorders related to dysfunction or dysregulation of B-lymphocyte activation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating B-lymphocyte activation.

Abstract: The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of disorders related to leukocyte dysfunction or dysregulation are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating leukocyte activation.

Abstract: A method of making an interactive information package, including an interactive information closure including a radio frequency identification device, contemplates that a microelectronics assembly be positioned within a mold cavity within which a plastic closure is subsequently molded. The microelectronics assembly is thus integrated with the closure, such as by disposition on either the exterior or interior of a top wall portion of the closure. The closure can be provided with a sealing liner positioned adjacent an inside surface of the top wall portion.